This study aimed to determine the prevalence of knee osteoarthritis (OA) in India through a community-based cross-sectional study of 5,000 subjects across five regions of India. The overall prevalence of knee OA was found to be 28.7%, with higher rates in females, older individuals, those with higher BMI, sedentary lifestyles, and those who used western toilets. Risk factors associated with knee OA included age, gender, BMI, physical activity level, occupation, and lifestyle. The results were consistent with prior studies showing knee OA is common and prevalence increases with age, especially in females over 45 years old.
Ramadan fasting is ritual for all muslims worldwide , where there is abstinace from eating , drinking and smoking from dawn to dusk , daily for one month, frequently , hypertensives asking about their fasting and medications during Ramadan, in the lecture , some focus on the effect of Ramadan on blood pressure , heart rate and other cardiovascular risk factors and lastly general instruction for hypertensives during Ramadan .
Hypertension is a silent, invisible killer that rarely causes symptoms. Increasing public awareness is key, as is access .Raised blood pressure is a warning sign that significant lifestyle changes are urgently needed. People need to know why raised blood pressure is dangerous, and how to take steps to control it.
The Pathophysiology of Obesity and its medical management in detail with future strategies for Prohibitin binding and the destruction of the blood supply to Adipose Tissue
Ramadan fasting is ritual for all muslims worldwide , where there is abstinace from eating , drinking and smoking from dawn to dusk , daily for one month, frequently , hypertensives asking about their fasting and medications during Ramadan, in the lecture , some focus on the effect of Ramadan on blood pressure , heart rate and other cardiovascular risk factors and lastly general instruction for hypertensives during Ramadan .
Hypertension is a silent, invisible killer that rarely causes symptoms. Increasing public awareness is key, as is access .Raised blood pressure is a warning sign that significant lifestyle changes are urgently needed. People need to know why raised blood pressure is dangerous, and how to take steps to control it.
The Pathophysiology of Obesity and its medical management in detail with future strategies for Prohibitin binding and the destruction of the blood supply to Adipose Tissue
SGLT2 inhibitors in Heart failure: A prized addition to HF treatment optionsahvc0858
Early Diabetes and Dyslipidaemia Treatment Optimisation.
Presentation by Dr Chan Wan Xian
Cardiologist, Echocardiologist
Heart Failure Intensivist
Asian Heart & Vascular Centre
www.ahvc.com.sg
Guidelines in Obesity management
By Dr. Usama Ragab Youssif
Obesity-related counseling should be offered to those with BMI ≥25 kg/m2
A 3% to 5% weight loss can result in meaningful reductions in triglycerides, blood glucose, hemoglobin A1c, and the risk of developing type 2 diabetes
Set an initial weight loss goal of 5% to 10% of current body weight over 6 mo
After 6 mo, focus on weight maintenance before attempting further weight loss
Participating in a weight loss program long-term can help improve weight maintenance
Disturbances of piturtary adrenal gonadal axis in hemodialysis ptalaa wafa
The kidneys play an important role in hormonal management. Endocrine disorders are one of the most crucial elements of ‘uraemic syndrome’ which is underestimated and has not been fully examined.
In CRF, there are complex endocrinal disorders related to hypothalamus and pituitary functions, and their relations to adrenal and gonadal functions also as far as sex hormones and adipose tissue hormones .
There is a great need for more randomized clinical trials to evaluate new and old treatment approaches, with the goal of developing better evidence-based practice guidelines.
Digestive Problems in GP part 1 – By Prof.Dr.R.R.Deshpande
These ppts will be very useful for Medical students & New Practioners ,for rapid revisions of topic & as ready reference through their smart phones .This ppt contains 1) Anorexia 2) Indigestion 3) Aerophagy ( Gas) 4) Stomatitis 5) Hiccoup 6) Constipation
7) Diarrhoea 8) Vomiting
Visit – www.ayurvedicfriend.com M- 9226810630
Irritable Bowel Syndrome Part 1 - Dr Vivek BaligaDr Vivek Baliga
In this presentation, Dr Vivek Baliga discusses the important aspects of irritable bowel syndrome - a common medical problem in clinical practice. For more articles, visit http://baligadiagnostics.com/author/drbvb/
Review of new alerts on PROTON PUMP INHIBITORS (PPI) adverse effects 2016 UPD...PAWAN V. KULKARNI
Last Updated: 15th MAY: ALL NEW STUDIES INCLUDED. After more than 2 decades of USE, ABUSE, OVERUSE.... PPIs are under scanner. Not just Osteoporosis, other complications but Proton pump inhibitors have been confirmed to cause insistent Kidney failure/disease, heart attacks to name a few. This new revelations should open the eyes of so many consumers and several doctors.
WHO defines Quality of Life as an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns.
Jonathan Wells
POLICY SEMINAR
Virtual Event - The New Nutrition Reality: Time to Recognize and Tackle the Double Burden of Malnutrition!
DEC 1, 2020 - 09:30 AM TO 11:15 AM EST
OJAS offers a comprehensive suite of medical writing services to support marketing strategies. Driven with spirit to grow and with extensive experience in medical communication solutions, we provide innovative and customized platform to the clients, helping them to engage their customers beyond regular marketing promotions. Our pursuit is on a daily basis for innovation in solution to your medical communications strategies.
This slides contains 3 sections:
a. measurement of renal dysfuntion in cirrhosis
b. Evolution of hepatorenal syndrome
c. treatment of hepatorenal Syndrome
SGLT2 inhibitors in Heart failure: A prized addition to HF treatment optionsahvc0858
Early Diabetes and Dyslipidaemia Treatment Optimisation.
Presentation by Dr Chan Wan Xian
Cardiologist, Echocardiologist
Heart Failure Intensivist
Asian Heart & Vascular Centre
www.ahvc.com.sg
Guidelines in Obesity management
By Dr. Usama Ragab Youssif
Obesity-related counseling should be offered to those with BMI ≥25 kg/m2
A 3% to 5% weight loss can result in meaningful reductions in triglycerides, blood glucose, hemoglobin A1c, and the risk of developing type 2 diabetes
Set an initial weight loss goal of 5% to 10% of current body weight over 6 mo
After 6 mo, focus on weight maintenance before attempting further weight loss
Participating in a weight loss program long-term can help improve weight maintenance
Disturbances of piturtary adrenal gonadal axis in hemodialysis ptalaa wafa
The kidneys play an important role in hormonal management. Endocrine disorders are one of the most crucial elements of ‘uraemic syndrome’ which is underestimated and has not been fully examined.
In CRF, there are complex endocrinal disorders related to hypothalamus and pituitary functions, and their relations to adrenal and gonadal functions also as far as sex hormones and adipose tissue hormones .
There is a great need for more randomized clinical trials to evaluate new and old treatment approaches, with the goal of developing better evidence-based practice guidelines.
Digestive Problems in GP part 1 – By Prof.Dr.R.R.Deshpande
These ppts will be very useful for Medical students & New Practioners ,for rapid revisions of topic & as ready reference through their smart phones .This ppt contains 1) Anorexia 2) Indigestion 3) Aerophagy ( Gas) 4) Stomatitis 5) Hiccoup 6) Constipation
7) Diarrhoea 8) Vomiting
Visit – www.ayurvedicfriend.com M- 9226810630
Irritable Bowel Syndrome Part 1 - Dr Vivek BaligaDr Vivek Baliga
In this presentation, Dr Vivek Baliga discusses the important aspects of irritable bowel syndrome - a common medical problem in clinical practice. For more articles, visit http://baligadiagnostics.com/author/drbvb/
Review of new alerts on PROTON PUMP INHIBITORS (PPI) adverse effects 2016 UPD...PAWAN V. KULKARNI
Last Updated: 15th MAY: ALL NEW STUDIES INCLUDED. After more than 2 decades of USE, ABUSE, OVERUSE.... PPIs are under scanner. Not just Osteoporosis, other complications but Proton pump inhibitors have been confirmed to cause insistent Kidney failure/disease, heart attacks to name a few. This new revelations should open the eyes of so many consumers and several doctors.
WHO defines Quality of Life as an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns.
Jonathan Wells
POLICY SEMINAR
Virtual Event - The New Nutrition Reality: Time to Recognize and Tackle the Double Burden of Malnutrition!
DEC 1, 2020 - 09:30 AM TO 11:15 AM EST
OJAS offers a comprehensive suite of medical writing services to support marketing strategies. Driven with spirit to grow and with extensive experience in medical communication solutions, we provide innovative and customized platform to the clients, helping them to engage their customers beyond regular marketing promotions. Our pursuit is on a daily basis for innovation in solution to your medical communications strategies.
This slides contains 3 sections:
a. measurement of renal dysfuntion in cirrhosis
b. Evolution of hepatorenal syndrome
c. treatment of hepatorenal Syndrome
EFFICACY OF HYPERICUM 30 IN MANAGEMENT OF CERVICAL.pptxDrswetha Bp
The study was done aiming the clinical confirmation of Hypericum perforatum 30 in treatment of Cervical Spondylotic Radiculopathy.
With increasing development of Information technology field there is an increase in use of computers which demand a particular posture for long hours and does not include any physical activity which in turn leads to postural deformities like cervical spondylosis and later radiculopathy.
Analytical Study of Clinicopathological Data of Saudi Patients with Osteoarth...Prof. Hesham N. Mustafa
SUMMARY: Knee osteoarthritis (OA) is a common disabling disease. Epidemiological studies have revealed various risk
factors for OA, including sex, aging, obesity, occupational illnesses, and chronic diseases. Here we evaluate the clinical, pathological,
and radiological findings of knee OA in a subset of Saudi patients who were subjected to total knee replacement (TKA). The study
population included 30 Saudi patients with knee OA who were operated by TKA (from June 2014 to December 2015) in the Department
of Orthopedics, Faculty of Medicine, King Abdulaziz University, Saudi Arabia. Patient’s clinical and radiological data were collected
from the hospital files. Pathological examination of the excised superior articular surface of tibia and femoral condyles were done.
Pearson Chi-squared analysis was used to test for differences between the variables in associated risk factors. There were more women
than men. Sixty per cent of patients were older than 60 years [mean age, 59.2 (females) and 61.7 (men) years-old]. All patients exceeded
obesity class 1, with females being more obese than males. Pathological examination of the superior articular surface of tibia and femoral
condyles showed high score lesions, which was more apparent in females than in males. Radiological findings showed that most lesions
were high grade. The findings of this study will help to understand the pathogenesis of OA and improve treatment decision making
relevant to TKA in knee OA in Saudi Arabia and elsewhere.
KEY WORDS: Osteoarthritis; Knee; Arthroplasty.
ABSTRACT- Introduction: Low back pain (LBP) is an important clinical, social, economic, and public health problem
affecting the population indiscriminately. It is a disorder with many possible etiologies, occurring in many groups of the
population, and with many definitions. Nearly everyone will experience some form of back pain in his or her lifetime.
Materials ans& Methods: The current study is a cross sectional study undertaken at Lord Buddha Koshi Medical
College, Saharsa, Bihar, India from Aug 2015 to Dec 2015. The objective of this study was to see the age specific
prevalence of low back pain among 400 subjects visiting the Orthopedics OPD of the hospital. The age range of the study
participants were 25 years to 65 years. The national guidelines of LBP diagnosis is used as diagnostic criteria.
Results: Overall prevalence of LBP was found as 31.25%. The highest prevalence was seen in 55-65 years age group.
Age had positive association & important risk factors of increasing burden of LBP.
Conclusion: LBP is an important health problem & affecting all age groups and it is responsible for a great economic loss
of any country.
Key-words- Low Back Pain, Prevalence, Public Health
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
2. BACKGROUND:
Among the chronic rheumatic diseases, hip and knee OA is the most prevalent & is a leading cause of
pain & disability in most countries worldwide.
Prevalence - Increases with age & generally affects women > men.
OA is strongly associated with aging & heavy physical occupational activity.
Determining region-specific OA prevalence & risk factor profiles will help in planning future cost
effective preventive strategies & health care services.
3. Introduction - OSTEOARTHRITIS
Loss of articular cartilage
Hypertrophy of bone at the
margins
Subchondral sclerosis
biochemical and morphological
alterations of the synovial
membrane & joint capsule
Chronic
degenerative
disorder of
multifactorial
etiology
4. Pathological changes in late stage of OA
include softening, ulceration, & focal
disintegration of the articular cartilage.
Synovial inflammation also may occur.
5. Introduction
Typical clinical symptoms are pain, particularly after
prolonged activity & weight-bearing; whereas stiffness is
experienced after inactivity.
It is probably not a single disease but represents the final
end result of various disorders leading to joint failure.
It is also known as degenerative arthritis, which commonly
affects the hands, feet, spine,& large weight-bearing joints.
6. Introduction
Most cases of OA have no known cause are referred to as
primary OA.
• Primary OA is mostly related to aging.
• It can present as localized, generalized, or as erosive OA.
• Secondary OA is caused by another disease or condition.
OA – 2nd M/C common rheumatologic problem & most frequent
joint disease with a prevalence of 22% to 39% in India.
OA is more common - women> men, prevalence increases
dramatically with age.
7. • OA knee is a major cause
of mobility impairment,
particularly among
females.
• OA was estimated to be
the 10th leading cause of
nonfatal burden.
>65 years
45% of women
have
symptoms
>65 years
radiological
evidence is
found in 70%
8. • Self report surveys may not accurately estimate OA as there could be
unknown cases in the community.
• There are few studies of OA that have used a radiological
classification of disease.
• X-ray findings do not always match symptoms, but prevalence based
on radiography is probably a reasonable population estimate.
• OA of the knee is more prevalent as per the literature available.
• Therefore, for finding the current burden of OA and its association
with lifestyle related factors, it was essential to undertake such a
study on the prevalence of knee OA in Indian population.
Need for study
9. MATERIALS AND METHODS:
community based
cross sectional
study
To find out the prevalence of
primary knee OA in India
which has a population of
1.252 billion.
The total sample
size was 5000
subjects.
Tools consisted of a structured
questionnaire & plain skiagrams
for confirmation of OA.
Diagnosis Kellgren and
Lawrence scale for OA.
10. Geographical representation from all over India
Each site comprised one metropolis, one small city, one block
headquarters (town), & 5 villages from that block.
North hilly
Dehradun/Nainital
Central Agra
Western Pune +
Pimpri
South
Bengaluru/Hyderabad
East Kolkata
11. MATERIALS AND METHODS- Sample size calculation
• The WHO technical report “The Burden of Musculoskeletal Conditions
at the start of the New Millennium” containing the Community-
oriented Program for Control of Rheumatic Diseases (COPCORDs)
Bhigwan data on the prevalence of rheumatoid arthritis (RA) and OA
among the Indian population was taken as a reference for sample size
estimation.
• It was based on clinical American College of Rheumatology criteria
• This was a community-based study and it estimated a total
prevalence of 5.5. Thus, we considered this for calculating sample
size.
12. MATERIALS AND METHODS
• We calculated a minimum sample size of n = 4680.
• This sample was further divided into five sites equally (936 from each
site). It was rounded to a sample of 1000 from each site. Therefore,
the total sample size was 5000. The further division of sample within
each site was done proportionate to the population.
• This evaluation study was conducted using the household as the
primary sampling unit of the quantitative survey.
• The respondents for the study were above 40 years.
• One respondent from each household was selected based on the last
birthday method. This method was used to ensure no bias and equal
age and sex composition in the sample.
13. MATERIALS AND METHODS
exclusion
criteria
Age <40 years,
RA,
inflammatory arthritis,
bilateral end stage,
knee OA,
unable to walk without aids,
SLE,
polyarthralgia,
previous h/o # of lower limb or spine,
any other surgical or medical condition that severely
limits subjects functional ability.
14. MATERIALS AND METHODS
• Quantitative data were collected using structured questionnaire and X-ray
investigation.
• This also included screening to rule out people who belonged to the
exclusion criteria.
• Structured questionnaire was in the local language and consisted of the
following sections
• informed consent,
• demographic profile age and sex,
• socioeconomic profile education,
• occupation, income,
• housing conditions, type of work and lifestyle related information,
• physical parameters height and weight,
• family history about OA and osteoporosis,
• respondents’ history related to osteoporosis presence of symptoms,
• whether diagnosed already and taking treatment, if not diagnosed, since when
symptoms present.
15. MATERIALS AND METHODS
This was followed by an X-ray investigation of both the knee
joints in two views –
• anteroposterior view and lateral view.
OA was graded using the Kellgren and Lawrence scale for OA.
Analysis was done based on the X-ray grading.
• Grade 1 was considered sub-threshold for OA.
• Grade 2 and 3 were considered as a positive finding for OA.
16. RESULTS
• The present study shows a prevalence of 28.7% in the overall sample
villages (31.1%)
big cities
(33.1%) towns (17.1%)
small cities
(17.2%)
17. RESULTS
Asso. of gender & OA of this
study is in congruence with the
available literatures on knee
OA.
OA knees - females (31.6%) than in
males (28.1%). This finding is statistically
significant (P = 0.007).
The study found that the
prevalence of OA knees increased
with increase in BMI.
Knee OA prevalence was
significantly (P = 0.007) low in
underweight people (28%) as
compared to normal weight
and obese participants (33%).
18. RESULTS
The prevalence
was highest > 60
yrs & lowest 40–
50 years (P =
0.001).
Unemployed
participants high
prevalence.
Although
statistically
significant (P =
0.0001), a cause–
effect relationship
cannot be derived.
Bcoz unemployed
gp – retired people.
In such cases, the OA
due to age rather
than being
unemployed.
19. RESULTS
Prevalence was highest in participants who have a sedentary lifestyle followed by
participants with a physically demanding lifestyle and active lifestyle.
This difference was statistically significant (P = 0.001) showing that the prevalence
of OA was lowest in participants who had a fairly active physical activity level
Since the study recorded the current level of physical activity, it may be possible of
having OA that may be more due to age rather than lifestyle.
Moreover, people with severe OA may have changed their lifestyle.
20. OA prevalence was found to be significantly more (P = 0.001) in participants who
used Western toilet (42.1%) as compared to those who used Indian toilet (29.7%) or
both types (38.8%), but it reflects more a condition of difficulty to use Indian toilet
than a predisposition to OA.
Prevalence was higher in participants who do not exercise (83.9%) compared to
participants who exercise (36.0%).
Although the questionnaire gathered information on the type of exercises done,
there was no significant difference in the prevalence of OA among different exercise
groups
21. DiscussionOA indeterminately occurs in elderly age group.
OA occurs commonly in females above 45 years of age while before 45 years, it is common in males.
The studies done on females for identifying the relation between estrogen and the prevalence of
OA in menopausal age showed contradictory results.
The prevalence of OA is available for the USA and European populations, but there are scare studies
done in other regions.
In 1990, it was the 10th leading cause of nonfatal diseases contributed 2.8% years of disability. An
estimated prevalence of symptomatic OA is 18% in females and 9.6% in men. In global burden of
diseases, in 2000, it was the 4th leading cause of years lived with disability (YLD) leading to 3% YLD.
22. DISCUSSION
• The COPCORD study:
higher prevalence in urban as compared to rural prevalence of OA in
Bangladesh.
In a study done in Beijing's urban population and Wuchuan's rural
population, it was observed that Wuchuan men had a prevalence ratio
(PR) 2.5, 95% confidence interval (CI) (1.6-3.8) and symptomatic knee
OA (PR 1.9, 95% CI 1.3-2.9).
A Chinese cohort study showed two to three times higher bilateral knee
prevalence as compared to a Framingham study
23. • . In an observational study done in rural Tibetan region, prevalence of
knee pain was 25% and significantly asso. in 50 years as compared to
younger people.
• Similarly, a study done by Muraki et al. on Japanese population in
symptomatic and radiographically confirmed knee OA cases, it was
evidenced to have higher prevalence in two mountain regions as
compared to rural and urban population.
24. Salve et al
260 perimenopausal
women
house-to-house
survey done in
South Delhi
Prevalence of OA was found
to be higher in lower
socioeconomic than higher
socioeconomic population.
Sharma et al. had
similar results, but with
lesser prevalence than
this study
25. Discussion
Martin et al cohort
study
BMI is positively asso. with
knee OA in women &
suggested that more active
individuals have lower risk of
knee OA.
26. Blagojevo
et al BMI is a risk factor for OA
metaanalysis
Modifiable risk
factors are
repetitive
movement of
joints, obesity,
infection, and
injuries.
Occupational physical
activities include
monotonous motions &
great forces such as
kneeling, squatting on
joints,climbing, and
heavy weight lifting.
27. Kellgren
First-degree relatives of probands had
twice higher risk than others.
Riyazi et al
Genetic OA & progression study in
multiple sites showed - evidence of familial
hereditability of OA of hand, hip, & spine,
but not in knee.
28. Discussion
• This study has evidenced a large percentage of subthreshold population, that
is, K-L Grade 1 which is considered as borderline or doubtfull as far as OA
diagnosis is considered. This needs to be addressed.
• Awareness program should be initiated at community level which is needed
for the prevention of OA of knee at early age.
• We would like to suggest that a longitudinal cohort study can be planned
which, in long run, will prove the impact of physical activity, habits, and
lifestyles.
• Stress on early diagnosis on the onset of symptoms should be encouraged
among the general population.
• Studies to understand how many people with symptoms of OA seek medical
advice are required to understand the Rx seeking behavior & pain tolerance
asso. with OA.