This review argues that nutrition is an integral component of food security, and should be embedded within all four of its dimensions – availability, access, utilization, and stability. The review highlights current food insecurity in the Middle East and North Africa (MENA) region, as exacerbated by the triple burden of malnutrition, where undernutrition, micronutrient deficiencies, and overweight/obesity coexist. Previous efforts to address food security in MENA have focused on food
availability, overlooking the other three dimensions and leaving nutrition considerations aside. Meanwhile, the literature has recognized the need to highlight nutrition as fundamental, and opted for the term ‘food and nutrition security’. To achieve food and nutrition security in MENA, a nutrition lens must be applied across all four dimensions – from assessment, to policy and programming, to capacity building. For example, MENA countries can adopt policies and programs including well-structured food subsidies, dietary guidelines, public awareness, and education campaigns to increase availability and accessibility of nutritious and safe foods, and stimulate consumer demand for those. To accomplish this, MENA needs to build stakeholders’ capacity and equip them to address
the challenges that are hindering the achievement of food and nutrition security now and into the future.
Workshop 3: The Agriculture Nutrition Nexus and the Way Forward at The Caribbean-Pacific Agri-Food Forum 2015 (CPAF2015) taking place 2-6 November in Barbados with support from the Intra-ACP Agricultural Policy programme, organized in partnership with the Barbados Agricultural Society (BAS) and the Inter-American Institute for Cooperation on Agriculture (IICA). http://www.cta.int/en/news/caribbean-pacific-agri-food-forum.html
Food and nutrition are cornerstones that affect and define the health of all people, rich and poor. The right to food is one of the most consistently mentioned items in international human rights documents
Workshop 3: The Agriculture Nutrition Nexus and the Way Forward at The Caribbean-Pacific Agri-Food Forum 2015 (CPAF2015) taking place 2-6 November in Barbados with support from the Intra-ACP Agricultural Policy programme, organized in partnership with the Barbados Agricultural Society (BAS) and the Inter-American Institute for Cooperation on Agriculture (IICA). http://www.cta.int/en/news/caribbean-pacific-agri-food-forum.html
Food and nutrition are cornerstones that affect and define the health of all people, rich and poor. The right to food is one of the most consistently mentioned items in international human rights documents
Food security exists when all people, at all times, have physical, social and economic access to sufficient, safe and nutritious food to meet their dietary needs and food preferences for an active and healthy life.
Food is essential to the survival of the human race. Reducing hunger and achieving food
security have been the major concern of national governments as well as international organizations. Food
security is year-round access to an adequate supply of safe and nutritious food. The components of food security
include availability, access, utilization, and stability. These four pillars must be met to ensure food security. This
paper provides a short introduction on food security.
Food security a global & national perspective by ayaz soomroAyaz Ali
Food insecurity in Pakistan specially in Sindh province which is contributing high share of oil & gas but majority of masses is facing food insecurity.
Presented by Stacia Nordin, FAO
Presented at Report Launch "Mapping Linkages Between Agriculture, Food Security and Nutrition in Malawi"
Ufulu Gardens, 28th April, 2015
Food security is a situation that exists when all people, at all times, have physical, social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy life
As part of the IFPRI Egypt Seminar in partnership with the National Nutrition Committee (ASRT affiliated): "100 million healthy lives: Scientific evidence on the double burden of malnutrition in Egypt"
Abstract
Biofortification, which is the development and dissemination of micronutrient-dense staple crops such as orange-fleshed sweetpotato (OFSP), is an effective approach to provide rural households with a low-cost source of vitamin A-rich food. Given that sweetpotato is cultivated twice a year in Western Kenya, high OFSP uptake should increase the frequency of intake of vitamin A among young children and women. The current study aimed to understand the influence of OFSP adoption and its intensity (i.e. share of OFSP in sweetpotato area) in improving women and children’s dietary diversity and intake of vitamin A-rich food. Data were analysed from the endline study of a 5-year, integrated agriculture–health project in Western Kenya. The project linked access to OFSP vines to public health services for pregnant women. In total, 1,924 mother–child pairs (children <2 years of age) were randomly selected in four intervention areas and four control areas. Two-stage instrumental variable and ordered logit regression models were employed to test the effect of adoption. Diagnostic tests for endogeneity and misspecification were conducted to confirm model validity. Two indices were identified: first, a dietary diversity index (9 food groups consumed in the previous 24 hr); second, an index of the frequency of consumption of vitamin A-rich foods during the 7 days prior to the interview. Not surprising, staple foods are the dominant food group, with less frequent consumption of nutrient-rich fruits and vegetables. The surveyed households reported consuming starchy staples (91%), dark green leafy vegetables (80%), fruits and vegetables rich in vitamin A (26%), other fruits and vegetables (58%), organ meat (2%), meat and fish (32%), egg (11%), legumes (31%), and milk products (80%). Women and children in households growing OFSP had 15% and 18% higher dietary diversity index scores, respectively, than those not growing OFSP. Similarly, the index capturing frequency of intakes of vitamin A-rich food was 10% and 20%, higher for women and children in OFSP growing households, respectively, than those who do not grow. Age of household head, mother’s education, wealth index, and the sweetpotato plots have a positive effect on the dietary diversity and frequency of vitamin A intake. Households with limited access to a health facility, larger household size, and mother engaged in casual labour have less diversified diets and consume vitamin A-rich food less frequently. Both OFSP adoption and the share of OFSP area have positive influence on dietary diversity and vitamin A intake for both women and children under 2 years in Western Kenya
Temesgen F. Bocher
Food security exists when all people, at all times, have physical, social and economic access to sufficient, safe and nutritious food to meet their dietary needs and food preferences for an active and healthy life.
Food is essential to the survival of the human race. Reducing hunger and achieving food
security have been the major concern of national governments as well as international organizations. Food
security is year-round access to an adequate supply of safe and nutritious food. The components of food security
include availability, access, utilization, and stability. These four pillars must be met to ensure food security. This
paper provides a short introduction on food security.
Food security a global & national perspective by ayaz soomroAyaz Ali
Food insecurity in Pakistan specially in Sindh province which is contributing high share of oil & gas but majority of masses is facing food insecurity.
Presented by Stacia Nordin, FAO
Presented at Report Launch "Mapping Linkages Between Agriculture, Food Security and Nutrition in Malawi"
Ufulu Gardens, 28th April, 2015
Food security is a situation that exists when all people, at all times, have physical, social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy life
As part of the IFPRI Egypt Seminar in partnership with the National Nutrition Committee (ASRT affiliated): "100 million healthy lives: Scientific evidence on the double burden of malnutrition in Egypt"
Abstract
Biofortification, which is the development and dissemination of micronutrient-dense staple crops such as orange-fleshed sweetpotato (OFSP), is an effective approach to provide rural households with a low-cost source of vitamin A-rich food. Given that sweetpotato is cultivated twice a year in Western Kenya, high OFSP uptake should increase the frequency of intake of vitamin A among young children and women. The current study aimed to understand the influence of OFSP adoption and its intensity (i.e. share of OFSP in sweetpotato area) in improving women and children’s dietary diversity and intake of vitamin A-rich food. Data were analysed from the endline study of a 5-year, integrated agriculture–health project in Western Kenya. The project linked access to OFSP vines to public health services for pregnant women. In total, 1,924 mother–child pairs (children <2 years of age) were randomly selected in four intervention areas and four control areas. Two-stage instrumental variable and ordered logit regression models were employed to test the effect of adoption. Diagnostic tests for endogeneity and misspecification were conducted to confirm model validity. Two indices were identified: first, a dietary diversity index (9 food groups consumed in the previous 24 hr); second, an index of the frequency of consumption of vitamin A-rich foods during the 7 days prior to the interview. Not surprising, staple foods are the dominant food group, with less frequent consumption of nutrient-rich fruits and vegetables. The surveyed households reported consuming starchy staples (91%), dark green leafy vegetables (80%), fruits and vegetables rich in vitamin A (26%), other fruits and vegetables (58%), organ meat (2%), meat and fish (32%), egg (11%), legumes (31%), and milk products (80%). Women and children in households growing OFSP had 15% and 18% higher dietary diversity index scores, respectively, than those not growing OFSP. Similarly, the index capturing frequency of intakes of vitamin A-rich food was 10% and 20%, higher for women and children in OFSP growing households, respectively, than those who do not grow. Age of household head, mother’s education, wealth index, and the sweetpotato plots have a positive effect on the dietary diversity and frequency of vitamin A intake. Households with limited access to a health facility, larger household size, and mother engaged in casual labour have less diversified diets and consume vitamin A-rich food less frequently. Both OFSP adoption and the share of OFSP area have positive influence on dietary diversity and vitamin A intake for both women and children under 2 years in Western Kenya
Temesgen F. Bocher
Presented at Michigan State University's WorldTAP International Short Course in Food Safety on July 31, 2009. (http://foodsafetyknowledgenetwork.org/worldtap/foodsafety09)
Presented at the Pulses for Sustainable Agriculture and Human Health” on 31 May-1 June 2016 at NASC, New Delhi, India. The conference was jointly organised by the International Food Policy Research Institute (IFPRI), National Academy of Agricultural Sciences (NAAS), TCi of Cornell University (TCi-CU) and Agriculture Today.
Presented at the Pulses for Sustainable Agriculture and Human Health” on 31 May-1 June 2016 at NASC, New Delhi, India. The conference was jointly organised by the International Food Policy Research Institute (IFPRI), National Academy of Agricultural Sciences (NAAS), TCi of Cornell University (TCi-CU) and Agriculture Today.
Presented at Michigan State University's WorldTAP International Short Course in Food Safety on July 31, 2009. (http://foodsafetyknowledgenetwork.org/worldtap/foodsafety09)
Presented at the Pulses for Sustainable Agriculture and Human Health” on 31 May-1 June 2016 at NASC, New Delhi, India. The conference was jointly organised by the International Food Policy Research Institute (IFPRI), National Academy of Agricultural Sciences (NAAS), TCi of Cornell University (TCi-CU) and Agriculture Today.
,the control system ,negative feedback versus positive feedback ,servo problem versus regulator problem ,development of block diagram ,measuring element ,controller and final control element
Die and die materials /orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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Food safety and food security is a determinant of the well-being of the citizens of a country and how it translates to the development and transformation of the economy in a country specifically Nigeria was critically examined. Recent FAO figures indicate that over 60% of the world undernourished people live in Asia, and a quarter in Africa. Also there are 22 countries, 16 of which are in Africa, in which the undernourishment prevalence rate is over 35%. Hunger, food insecurity (chronic or transitory), malnutrition involving micronutrient malnutrition (MNM) and protein energy malnutrition (PEM) are some of the issues arising from food insecurity. Lack or absence of minerals and vitamins like Iodine, Iron and Vitamin A affects the growth and development of humans. The study revealed that several factors contributing to food insecurity includes wars, natural disasters, unemployment inadequate technological deployment and high post-harvest losses. Steps were taken to examine how agriculture contributes to food security, effects of various policies by past and present government on the food security and food safety situation in Nigeria. Also the emerging issue in combating food insecurity especially the use of biotechnology was further explained. Useful recommendations for enhancement of food security and safety includes: reduction of post-harvest losses through proper utilisation, processing and packaging of agricultural products, food fortification and supplementation to combat micronutrient and protein energy malnutrition, increased use of biotechnology; formulation of good agricultural policies including creation of agric cooperatives and the new Nigerian Agricultural Transformation Agenda (ATA) that can lead to transformation of the economy.
as part of the IFPRI-Egypt Seminar Series- funded by the United States Agency for International Development (USAID) project called “Evaluating Impact and Building Capacity” (EIBC) that is implemented by IFPRI.
Note on Critical and Emerging Issues for Food Security and NutritionNE Kim
Committee on World Food Security (CFS) the High Level Panel of Experts on Food Security and Nutrition (HLPE) has conducted a process to identify a wide range of issues of importance for food security and nutrition, as well as their interrelations, in a systemic way. Within the diversity of issues, the HLPE has identified, in addition to the nine issues that have already been the topic of an HLPE report, the following five critical and emerging issues of particular importance, both in their own right and as drivers of other issues.
Dietary diversity, nutritional status, and agricultural commercialization: ev...Olutosin Ademola Otekunrin
Access tohealthyandaffordablediethingedontherealizationofSustainableDevelopmentGoal2,higherproductivity and, economic prosperity while it is difficult for a poorly nourished people to achieve optimum production of goods and services. This study assessed whether dietary diversity (DD) and nutritional status of adult men are associated with crop commercialization index (CCI) levels of agricultural households in two states of Southwestern Nigeria. This research utilized 352 farm households, comprising 277 adult malemembers. The individualversionofdietary diversity score (DDS)of9foodgroupswasusedtocalculateadultmen’sDDSovera24-hrecall.Anthropometricdatawas obtained using bodymass index(BMI)whileCCIlevelswas estimatedfor eachagricultural household. Logistic regression and ordered logit models were used to examine the determinants of adult men’s dietary diversity and nutritional status respectively. Hundred percent of adult men consumed starchy staples, with 11.2% consuming egg, 5.8% milk andmilkproducts and 0.4%consumingorganmeatover24-hrecall. Adultmen ofCCI2andCCI4agriculturalhouseholds recorded overweight prevalence of >20% in Ogun state while the association between DDS and CCI was statistically insignificant suggesting that being a member of any of the CCI households may not guarantee the consumption of healthy diets among adult men. From Logit regression analysis, it is more likely for adult men with higher farm size toattaintheminimumDDSof4foodgroupsthanthosewithsmallersizeoffarmland(OR=4.78;95%CI:1.94,11.76; p =0.001). The age, farm experience, and cassava marketing experience were positively related to the likelihood of obtaining the minimum DDS. For adult men to achieve a healthy diet, their diet pattern must incorporate a more diversifiedintakeoffoodfromdifferentfoodgroupscapableofimprovingtheirnutritionalstatus.Thisstudyemphasized the need for relevant stakeholders to provide adequate nutrition knowledge intervention programmes capable of improving the diets and nutrition of adult men and other members of farm households.
Global food production and consumption have witnessed significant changes in the past five decades. Paying attention to rising crop yields and enhancing cultivation practices have brought about enhanced life expectancy, reduced rates of infant and child mortality, and reduced world poverty (Whitmee et al. 2015; Steffen et al. 2015; Willett et al. 2019). However, these health-related advantages are being jeopardized by global shifts toward unhealthy diets mostly in the developed countries and carbohydrate dense foods in the developing countries (Global Panel 2016; IFPRI 2017). These dietary shifts are partly caused by increasing urbanization, rise in incomes, and inadequate or lack of access to nutritious and healthy foods. Movement toward unhealthy diets increases the burden of obesity and diet-related NCDs coupled with imparting the environment negatively (Tilman and Clark 2014; Springmann et al. 2016; Willett et al. 2019). With increased growth and progress in food industry, food systems are becoming more complex with possible adverse effects on human health and nutrition especially in low-and middle-income countries (LMICs) already faced with chronic hunger and multiple forms of malnutrition (Global Panel 2016; HLPE 2017; Otekunrin et al. 2019a, b, c; Otekunrin et al. 2020c; Global Nutrition Report 2020). Sustainable food systems will lead to sustainable healthy diets.
Why Nutrition Education Matters
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For more information, Please see websites below:
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Organic Edible Schoolyards & Gardening with Children
http://scribd.com/doc/239851214
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Double Food Production from your School Garden with Organic Tech
http://scribd.com/doc/239851079
`
Free School Gardening Art Posters
http://scribd.com/doc/239851159`
`
Companion Planting Increases Food Production from School Gardens
http://scribd.com/doc/239851159
`
Healthy Foods Dramatically Improves Student Academic Success
http://scribd.com/doc/239851348
`
City Chickens for your Organic School Garden
http://scribd.com/doc/239850440
`
Simple Square Foot Gardening for Schools - Teacher Guide
http://scribd.com/doc/239851110
Dietary diversity, nutritional status, and agricultural commercialization: ev...Olutosin Ademola Otekunrin
Access tohealthyandaffordablediethingedontherealizationofSustainableDevelopmentGoal2,higherproductivity and, economic prosperity while it is difficult for a poorly nourished people to achieve optimum production of goods and services. This study assessed whether dietary diversity (DD) and nutritional status of adult men are associated with crop commercialization index (CCI) levels of agricultural households in two states of Southwestern Nigeria. This research utilized 352 farm households, comprising 277 adult malemembers. The individualversionofdietary diversity score (DDS)of9foodgroupswasusedtocalculateadultmen’sDDSovera24-hrecall.Anthropometricdatawas obtained using bodymass index(BMI)whileCCIlevelswas estimatedfor eachagricultural household. Logistic regression and ordered logit models were used to examine the determinants of adult men’s dietary diversity and nutritional status respectively. Hundred percent of adult men consumed starchy staples, with 11.2% consuming egg, 5.8% milk andmilkproducts and 0.4%consumingorganmeatover24-hrecall. Adultmen ofCCI2andCCI4agriculturalhouseholds recorded overweight prevalence of >20% in Ogun state while the association between DDS and CCI was statistically insignificant suggesting that being a member of any of the CCI households may not guarantee the consumption of healthy diets among adult men. From Logit regression analysis, it is more likely for adult men with higher farm size toattaintheminimumDDSof4foodgroupsthanthosewithsmallersizeoffarmland(OR=4.78;95%CI:1.94,11.76; p =0.001). The age, farm experience, and cassava marketing experience were positively related to the likelihood of obtaining the minimum DDS. For adult men to achieve a healthy diet, their diet pattern must incorporate a more diversifiedintakeoffoodfromdifferentfoodgroupscapableofimprovingtheirnutritionalstatus.Thisstudyemphasized the need for relevant stakeholders to provide adequate nutrition knowledge intervention programmes capable of improving the diets and nutrition of adult men and other members of farm households.
Dietary diversity, nutritional status, and agricultural commercialization: ev...Olutosin Ademola Otekunrin
Access to healthy and affordable diet hinged on the realization of Sustainable Development Goal 2, higher productivity and, economic prosperity while it is difficult for a poorly nourished people to achieve optimum production of goods and services. This study assessed whether dietary diversity (DD) and nutritional status of adult men are associated with crop commercialization index (CCI) levels of agricultural households in two states of Southwestern Nigeria. This research utilized 352 farm households, comprising 277 adult male members. The individual version of dietary diversity score (DDS) of 9 food groups was used to calculate adult men’s DDS over a 24-h recall. Anthropometric data was obtained using body mass index (BMI) while CCI levels was estimated for each agricultural household. Logistic regression and ordered logit models were used to examine the determinants of adult men’s dietary diversity and nutritional status respectively. Hundred percent of adult men consumed starchy staples, with 11.2% consuming egg, 5.8% milk and milk products and 0.4% consuming organ meat over 24-h recall. Adult men of CCI 2 and CCI 4 agricultural households recorded overweight prevalence of >20% in Ogun state while the association between DDS and CCI was statistically insignificant suggesting that being a member of any of the CCI households may not guarantee the consumption of healthy diets among adult men. From Logit regression analysis, it is more likely for adult men with higher farm size to attain the minimum DDS of 4 food groups than those with smaller size of farmland (OR = 4.78; 95% CI: 1.94, 11.76; p = 0.001). The age, farm experience, and cassava marketing experience were positively related to the likelihood of obtaining the minimum DDS. For adult men to achieve a healthy diet, their diet pattern must incorporate a more diversified intake of food from different food groups capable of improving their nutritional status. This study emphasized the need for relevant stakeholders to provide adequate nutrition knowledge intervention programmes capable of improving the diets and nutrition of adult men and other members of farm households.
Food security is a multifaceted and manifold paradox that includes social,
biological, nutritional and economic aspects. Food is not only related to dietetic
sources but also plays numerous roles in social life and is closely linked to cultural
differentials. Despite its multi-dimensional approach, food security has been
molded in a number of ways since its dawn. However, food security was
transformed from a micro to a macro level during the World Food Conference of
1974. Food security exists “when all people at all times have physical, economic
and social access to sufficient, safe and nutritious food, essential for meeting their
dietary needs and food preferences for an active and healthy life”. The present
study was conducted in light of a sociological perspective in the district of Torghar,
Northern Khyber Pukhtunkhwa, Pakistan to assess the household food security
status. A sample of 379 household head was selected out of 26464 as per the
proportional allocation method. Moreover, descriptive and inferential statistics was
further used at descriptive and bivariate analysis. With regards to demographic
profile of the respondents 37% of household heads were between the ages of 46-
55, with 42% of illiterates, 70% of household heads were part of a joint family
system, and 84 percent were waiting for rain to irrigate their agricultural area.
Association Between Bio-fortification and Child Nutrition Among Smallholder H...Premier Publishers
We explored the empirical relationship between bio-fortification and child nutrition in Uganda. The research expanded the traditional approach used to address child nutrition by including in the model a categorical dependent variable for a household growing bio-fortified crop varieties. We used three waves of panel data from the Feed. The Future Innovation Lab for Nutrition, collected from 6 districts in Uganda. We performed univariate analysis and also estimated a panel logistic regression model to study the association between child stunting and production of bio-fortified crop varieties among smallholder farmers in Uganda. The results confirmed a very strong association between production of bio-fortified crop varieties and child stunting among children aged 0-59 months of age. The strength of the relationship, however was insensitive to the number of bio-fortified crop varieties grown by a particular household. Other important covariates of child stunting were male gender, 24-59 months age bracket, child birth weight, dietary diversity, education of caregiver, antenatal care, household size, access to improved water and household livestock score. These results can be used to vindicate current government policy of promoting production of bio-fortified crop varieties and underscore the need for intensified efforts to promote bio-fortification as a complementary means of addressing long-term child malnutrition in Uganda.
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
insect taxonomy importance systematics and classification
Nutrition security is an integral component of food security
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Frontiers in Life Science
ISSN: 2155-3769 (Print) 2155-3777 (Online) Journal homepage: http://www.tandfonline.com/loi/tfls20
Nutrition security is an integral component of food
security
Nahla Hwalla, Sibelle El Labban & Rachel A. Bahn
To cite this article: Nahla Hwalla, Sibelle El Labban & Rachel A. Bahn (2016): Nutrition
security is an integral component of food security, Frontiers in Life Science, DOI:
10.1080/21553769.2016.1209133
To link to this article: http://dx.doi.org/10.1080/21553769.2016.1209133
Published online: 03 Aug 2016.
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3. 2 N. HWALLA ET AL.
Food and Agriculture Organization (FAO) as nutrition
security, hence emphasizing the health component and
reflecting the nutritional status of the individual or
community in question (FAO 2012).
The relationship between food security and nutri-
tion security is complex, as illustrated by the malnutri-
tion outcomes of overweight and obesity. Data reveal
that obesity is more prevalent in food insecure popula-
tions for multiple reasons. For example, a lack of ade-
quate resources for healthy foods can result in weight
gain through several channels. Low-income families
may seek to maximize their limited incomes by con-
suming low-cost, energy-dense foods, instead of more
expensive, nutrient-dense foods (Darmon et al. 2002).
Evidence shows that food insecure households sacri-
fice food quality or variety in favor of food quantity, in
order to avoid a state of absolute hunger (Radimer et al.
1992). This can result in nutrition insecurity in pres-
ence of abundance of calories, if households cannot
afford a consistent and adequate diet, and/or if food
is available or accessible only at certain times, whereby
individuals may cope by over-consuming food when
it is available or accessible, hence contributing to over-
weight and obesity (Polivy 1996; Townsend et al. 2001).
In fact, food security cannot be achieved without
nutrition security, and vice versa. Nutrition security is
an essential element of food security, as sound nutri-
tion requires more than just enough energy for every
man, woman, and child. Human needs can only be
satisfied through a diversity of macro- and micronu-
trients to ensure good health and prevention from
disease. Experts have recognized this fundamental
connection and are increasingly using the term food
and nutrition security, which merges both concepts to
emphasize both the food and health requirements for
populations (Weingartner 2005).
Food and nutrition security challenges for the
Middle East and North Africa (MENA) region
Examining the food security status of the MENA
region, it appears to be most vulnerable to food inse-
curity. Most countries of the region rely dispropor-
tionately on imports of staple foods to satisfy the
demands of a growing population. For example, the
United Nations Economic and Social Commission for
Western Asia (UN ESCWA) has calculated the ratio
of wheat imports to total merchandise exports across
different countries, and found that the average ratio
for the Arab countries (a close proxy for the MENA
region) was nearly five times higher than the world
average over the period 2000–2011 (UN ESCWA
2015). The International Food Policy Research Insti-
tute (IFPRI) combines two metrics, the ratio of food
imports to total exports plus net remittances as well as
the prevalence of child stunting, to classify all countries
in the MENA region at moderate to high risk of food
insecurity, except for the Gulf States which display a
low risk given high performance on the first metric
(Breisinger et al. 2012).
MENA countries have adopted measures to address
gaps in food security, but these efforts have gener-
ally overlooked nutrition considerations. Policies and
programs focused on the availability component of
food security and directed their efforts to increase
agricultural production and food distribution to feed
populations and prevent extreme outcomes such as
hunger and famine. Indeed, improvements in produc-
tion technology, processing, and transportation have
helped to make food more available, affordable, and
convenient, while overlooking the quality of the food
supply, or the distribution, allocation, and diversity of
the food consumed by the population (Meerman et al.
2013). Moreover, many policies, programs, and strate-
gies related to food security are skewed toward agricul-
tural production, technological approaches, and food
availability; however, the accessibility and quality of
the food consumed by the population has received less
attention, leaving initiatives to tackle nutrition security
only partially realized and hence food security com-
promised to date. As a result, diets have become less
diverse and less nutritious, with perversely negative
impacts on human health.
In parallel, MENA countries are suffering from a
nutrition transition characterized by a shift away from
a traditional, more seasonal, and more diverse diet
rich in whole grains, fruits, and vegetables; toward
a ‘Westernized’ diet high in refined cereals, animal
protein, fats, sugar, and salt (Johnston et al. 2014).
Data on changes in food availability highlight a shift
toward an increasingly energy-dense diet and high
intake of fat, coupled by a parallel decrease in com-
plex carbohydrate availability (FAOStat 2015). For
example, data for selected MENA countries includ-
ing Kuwait and Lebanon from the 1960s through
2003 show a dramatic increase in the proportion of
energy obtained from vegetable oils, and a significant
decrease in the proportion of energy from fruits and
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4. FRONTIERS IN LIFE SCIENCE 3
vegetables. Factors driving this transition include eco-
nomic growth and increased incomes, globalization
of trade and marketing, and rapid urbanization– all
which affect food production and consumption (Sibai
et al. 2010).
Concomitant with the nutrition transition, a triple
burden of malnutrition exists in the region, char-
acterized by the simultaneous occurrence of under-
nutrition, micronutrient deficiencies, and overweight
or obesity (Johnston et al. 2014), within a country,
region, household, or even individual. While the rate
of undernutrition and levels of stunting, wasting, and
underweight, particularly among under-five children,
have been on the decline in some MENA countries;
there has been a parallel, dramatic increase in the
prevalence of overweight and obesity and diet-related
non-communicable diseases (NCDs), such as diabetes,
cardiovascular disease (CVD), and cancers in the
region (Popkin 2000). For example, four MENA coun-
tries – Kuwait, Qatar, Saudi Arabia, and the United
Arab Emirates – were ranked in the top 20 for highest
obesity worldwide in 2014 (NCD Risk Factor Collab-
oration 2016); three of these countries (Saudi Ara-
bia, Kuwait, and Qatar) were also among the top 10
in diabetes prevalence worldwide in 2013, and are
expected to remain so in 2035 (International Diabetes
Federation 2013). Moreover, these relatively wealthy
Gulf States also suffer from a high prevalence of
micronutrient deficiencies (anemia, iodine, and vita-
min D deficiency), as well as stunting (Micronutrient
Initiative 2009), even though they have been classified
as low on food insecurity.
More recently, national intakes of harmful and
protective foods in countries of the MENA region
were evaluated using 2010 consumption data (Afshin
et al. 2015). A strong association has been reported
between high consumption of harmful food compo-
nents (processed meat, red meat, trans fatty acids,
sugar-sweetened beverages, and sodium), low con-
sumption of other protective foods (fruits, vegetables
and beans, nuts and seeds, whole grains, and seafood
omega-3 fatty acid), and increased mortality from
cardio-metabolic diseases (diabetes, systolic blood
pressure, body mass index, fasting plasma glucose, and
total cholesterol) across all countries of the region,
thus making such food consumption patterns strong
predictors of these diseases. In addition, the dietary
energy supply from the different food groups (harm-
ful and protective) shows that the traditional diet has
been modified, such that all MENA countries experi-
ence higher than recommended per capita consump-
tion of harmful food components; and most, if not
all, MENA countries experience insufficient per capita
consumption of protective foods (Afshin et al. 2015).
In sum, excess caloric intake manifested by high
rates of overweight and obesity does not guarantee and
should not be considered as an indicator of food and
nutrition security. On the contrary, both rich and poor
countries in the MENA region exhibit evidence of the
triple burden of malnutrition, and therefore food and
nutrition insecurity.
How is food and nutrition security measured?
Food security is typically measured at the national level
or at the household/individual level, with a range of
measures existing at each level.
At the national level, national indicators of food
security include (a) the Global Food Security Index
(GFSI) developed by the Economist Intelligence Unit,
which incorporates 28 unique indicators related to
affordability, availability, as well as quality and safety
of food (GFSI date unknown); and (b) the Maplecroft
Food Security Risk Index developed by the Maplecroft
firm, which assesses food security on the basis of 18
indicators related to health status, as well as availability,
stability, and access to food (Maplecroft Food Security
Index and interactive global map date unknown).
At the household/individual level, measures of food
security include (a) the Global Hunger Index (GHI)
developed by IFPRI, which is a composite measure
of three indicators: the proportion of undernourished
population, the prevalence of underweight and mor-
tality rate in under-five children (IFPRI 2014); (b)
the Arab Family Food Security Scale (AFFSS) and (c)
the Household Food Insecurity Access Scale (HFIAS).
Both (a) and (b) were adapted by researchers at the
American University of Beirut (AUB) from tools orig-
inally developed by the United States Agency for
International Development (USAID). The AFFSS and
HFIAS rely on survey responses, anthropomorphic
measurements, and dietary intake information (Naja
et al. 2014; Sayhoun et al. 2014).
The example of Lebanon: varying food and nutrition
security status according to different indices
Due to the complexity and diversity of food security
assessments, there is no single consensus as to food and
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5. 4 N. HWALLA ET AL.
nutrition security status in many parts of the MENA
region. The example of Lebanon reflects this lack of
consensus. Three different national assessments con-
ducted by IFPRI have found that Lebanon, as a whole,
is subject to moderate food and nutrition insecurity
(Breisinger et al. 2010; Yu et al. 2010; Ahmed et al.
2013). It is worth noting, however, that these assess-
ments were conducted at the national level, and were
performed before the onset of the Syrian Crisis and
resulting inflows of significant Syrian refugee popu-
lations into Lebanon. On the other hand, Lebanon
was classified as scoring well on the 2014 GHI, with
a reported index of <5 indicating a low-hunger status
(IFPRI 2014).
With regard to assessment tools and food and
nutrition security measures that have been tested and
applied in the field, these have provided a range of
estimates of food and nutrition (in)security, and have
shown to be largely consistent. In Lebanon, for exam-
ple, the AFFSS determined that 42% of Lebanese citi-
zens living in the south of the country were food and
nutrition insecure, and 62% of Palestinian refugees
living in Lebanon were food and nutrition insecure
(Sayhoun et al. 2014). Such elevated levels are rela-
tively consistent with findings from the HFIAS, which
showed that nearly 52% of Lebanese households in
the Bekaa Valley are food and nutrition insecure (Naja
et al. 2014) (Table 1).
Table 1. Food security prevalence among Lebanese sub-
populations.
AFFSS (South
Lebanon) (%)
AFFSS
(Palestinian
refugees) (%)
HFIAS (The
Bekaa Valley)
(%)
Food secure 58 38 48.3
Mildly food insecure – – 17.7
Moderately food insecure 32 42 12.9
Severely food insecure 10 20 21.1
Total 100 100 100.0
Recommendations and conclusions
Nutrition at the core of all four dimensions of food
security
In face of the challenges that shape the high level of
food and nutrition insecurity in the region, and the
triple burden of malnutrition which is aggravating the
situation, the MENA region has failed to develop effec-
tive policies to achieve food and nutrition security,
mainly because current programs and strategies have
been skewed toward agricultural production and food
production, while disregarding more crucial elements
such as the accessibility and quality of food consumed
by the population.
In this paper, we propose that nutrition should con-
stitute an integral part of all four dimensions of food
security. Accordingly, the availability, accessibility, uti-
lization, and stability of both macro- and micronutri-
ents should be incorporated into all four dimensions
of food security as applied to analysis, policy, and
programming in the MENA region.
With regard to food availability, enhancements can
be made to improve the quality and quantity of
nutrients within foods. For example, bio-fortified rice
which contains beta-carotene has been developed and
promoted as one means to improve the nutritional
status of populations with vitamin A deficiency (Inter-
national Rice Research Institute date unknown). Gov-
ernment policies can be structured to support such
fortification programs.
Food accessibility can similarly be improved by
explicitly focusing on access to nutritious food.
Improvements to a farmer’s own production, to the
purchase of food, or to food received through assis-
tance programs should focus on the provision of safe
and nutritious food. For example, subsidy reforms
that improve both energy consumption and nutrient
diversity constitute an important step toward food and
nutrition security.
Food utilization is clearly tied to the issue of
nutrition and, accordingly, food security policies and
programs should ensure that every individual can con-
sume safe and nutritious foods. For example, nutrition
education programs like community-based interven-
tions targeting school-aged children and adults can
emphasize the selection of safe and nutrient-dense
foods and help individuals make optimal, healthy food
choices. Programs targeting infants and young chil-
dren should promote good nutrition practices for opti-
mal growth and development, such as breastfeeding
with timely, nutritionally adequate and safe comple-
mentary feeding, which offer protection from under-
and over-nutrition that can progress into adult-onset
chronic diseases. Promoting nutritious food to con-
sumers can thereby inform agriculture by demanding
increased production of nutritious foods.
Moving forward, it will be important not only to
place greater emphasis on the nutrition components
of food security, but also to shift focus to include an
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6. FRONTIERS IN LIFE SCIENCE 5
element of sustainability in providing dietary recom-
mendations. This includes viewing food consumption
patterns through a sustainability lens; considering sus-
tainable food consumption and production simultane-
ously; adopting public policies to support sustainable
consumption and discourage food waste; and revising
food-based dietary guidelines to promote sustainable
consumption (Hwalla et al. 2015).
Finally, with regard to food stability, nutrition
considerations including the macro- and micronu-
trient content of food must be taken into account.
For example, emergency feeding programs should
work to provide needy individuals with food bas-
kets and/or voucher-based assistance that can deliver
essential macro- and micronutrients that are vital for
human health and well-being. Providing refugees or
the underprivileged with staple foods such as oil, sugar,
and flour may help meet energy needs but does not
directly deliver protein and micronutrient diversity
needed for adequate growth and maintenance, and
could potentially contribute to nutrient deficiencies
that impact growth of children and health of adults.
Questions over which nutrients to provide are clearly
related to the wider questions of how to achieve a bal-
ance between delivering food choices to beneficiaries
that meet their preferences as well as ensuring dietary
diversity for optimal health.
Capacity building in food and nutrition security
Food and nutrition security is an ongoing challenge for
the MENA region. There is a clear need for expanded
and updated data covering the multiple dimensions
of food and nutrition security, to support evidence-
based policies and programs. The region also demands
experts who are equipped to gather, assess, and apply
such data and thereby address this challenge, now and
into the future. However, the region generally lacks
appropriately qualified specialists. For example, agri-
cultural experts often lack basic knowledge of nutri-
tion concepts and so are unprepared to work within
interdisciplinary teams to address food and nutri-
tion security. To move forward, capacity building in
food and nutrition security should focus attention
on research to explore technical challenges from an
interdisciplinary perspective; endorse academic pro-
grams and degrees to help leaders build capacity in the
region; foster community-based initiatives to ensure
food security at national levels; and sponsor/support
conferences on a regular basis to address the urgency of
the regional food and nutrition security situation and
facilitate partnerships.
Food and nutrition insecurity is considered one of
the main drivers of the Arab uprisings, and will con-
tinue to be a problem for countries in the MENA
region for years to come. ‘Comprehensive, country-
specific food security strategies and their implemen-
tation are key for development and peace’ (Breisinger
2013). Therefore, generating reliable and comprehen-
sive data and information around food and nutrition
security and building capacity will be essential to pro-
vide the right abilities and processes for evidence-
based decisions to address this challenge now and into
the future.
Disclosure statement
No potential conflict of interest was reported by the
authors.
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