Newton's laws of motion are three physical laws that, together, laid the foundation for classical mechanics. They describe the relationship between a body and the forces acting upon it, and its motion in response to those forces.
Unit 6, Lesson 5 - Newton's Laws of Motionjudan1970
Unit 6, Lesson 5 - Newton's Laws of Motion
Lesson Outline:
1. Law of Inertia
2. Law of Acceleration
3. Law of Interaction
4. Momentum and Impulse: An Overview
Unit 6, Lesson 5 - Newton's Laws of Motionjudan1970
Unit 6, Lesson 5 - Newton's Laws of Motion
Lesson Outline:
1. Law of Inertia
2. Law of Acceleration
3. Law of Interaction
4. Momentum and Impulse: An Overview
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
3. • Newton’s first law of motion describes how an object at
rest will stay at rest. It also describes how moving object
at constant velocity stays in motion. In both cases, force
influences an object’s motion. What characteristics of an
object makes it harder to stop?
4. • The first law of motion is the law of inertia. It states that:
• An object at rest stays at rest, and an object in
stays in motion at constant velocity unless acted
by a net external force.
5. • Inertia is the tendency of an object to resist motion. For objects at rest, inertia depends on
mass. The larger the object, the larger is the inertia.
• For moving objects, inertia depends on the object’s momentum. The greater the
of an object, the harder it is to stop from moving.
6. EXAMPLE
• Let us consider a pool ball set on the table. Before a strike from another
ball or the cue stick, the pool balls are at rest. It will remain at rest as long
as no external force will act on it. When the cue ball has been struck, the
cue ball will continue to move with constant velocity as long as no
external force acts on it.
7.
8.
9.
10.
11.
12. NEWTON'S SECOND LAW OF
MOTION
• If you are asked to push a 1kg box and a boulder, it will be easier for you to move
a 1kg box compared to the boulder at the same distance. Moving the boulder will
require greater amount of force compared to moving a 1kg box.
• How is mass, force, and the acceleration of an object related to each other?
13. LEARN ABOUT IT!
• The second law of motion is the law of acceleration. It
states that:
• The acceleration is produced when a net force acts on
mass, and that acceleration is directly proportional to
the force acting on the object and inversely proportional
to the object's mass.
14. •Newton's second law could be
mathematically written as
•F=ma
•where a is the acceleration in (m/s2), F is
the force in newton (N), m is the mass
in kilograms (kg).
•The equation is also commonly written as
•F=ma.
15.
16. EXAMPLE 1
•How much force is needed to accelerate a 75 kg
object at a rate of 5 m/s2?
17. EXAMPLE 2
•How much force is needed to accelerate a 60 kg
object at a rate of 2.5 m/s2?
18. EXAMPLE 3
•Chris wanted to move a 5 kg box across the hall. To
do this, he applied 50 N of force. What is the
acceleration of the box?
19. EXAMPLE 4
•A physics book with a mass of 1.5 kg was moved
across a table by a 45 N force. What is the
acceleration of the book?
20. EXAMPLE 5
•A 6.125 N force caused a ball to accelerate at 9.8
m/s2. What is the mass of the ball in grams?
21. EXAMPLE 6
•A 4800 N force acts on a car at rest and causes it to
accelerate at 2.4m/s2.What is the mass of the car in
grams
22. FORCE AND ACCELERATION
• The first part of the second law tells that the greater the
unbalanced force, the greater the acceleration of the body being
acted upon. If the force F1 is applied to a body at one time and a
force F2 at another time, then
• F1/a1=F2/a2
23. EXAMPLE 7
•A force of 5.0 N accelerates an object by 2.0 m/s2.
what force is needed to give the same object an
acceleration of 3.4 m/s2.
24. EXAMPLE 8
•Two forces of magnitudes 6.0 N and 4.0 N act on a
3.2 kg body. What is the acceleration produced
when these forces are acting in the same direction?
What is the acceleration produced when these
forces are oppositely directed?
26. MOMENTUM
• is a quantity that describes an object's resistance to
stopping (a kind of "moving inertia").
• is represented by the symbol p (boldface).
• is the product of an object's mass and velocity.
• p = mv
• is a vector quantity (since velocity is a vector and mass
is a scalar).
27. IMPULSE
•is a quantity that describes the effect of a net force
acting on an object (a kind of "moving force").
•is represented by the symbol J (boldface).
•is the product of the average net force acting on an
object and its duration.
•J=Ft
28. RECALL
• a=vf-vi/t
• Substituting in the equation F=ma
• Ft-mvi-mvf
• This equation tells us that a net force F acts on the
body, the impulse of the net force is equal to the
change in momentum of the body. The statement is
called the impulse-momentum theorem, which is
considered as an alternative statement of Newton’s
second law of motion.
29. EXAMPLE 9
• An air bag increases impact time to reduce the force
experienced by a driver of a car during collision. A bus hit
a car, which is parked on the road, from behind. The car
accelerates to 4.5 m/s in 0.15s. a.) What force does the
driver of the car experience is he is not wearing a seat
belt during the accident? Assume that the combined
mass of the car and driver is 2580 kg. b. If the car has an
air bag and crumple zones increase the impact time t 0.45
s, what force is experienced by the driver?
30. NEWTON'S THIRD LAW OF
MOTION
• Newton’s third law of motion explains how objects interact with each
other in terms of forces. The third law of motion is also called the law of
interaction. It states that:
• For every action, there is an equal and opposite reaction.
• When a force acts on an object, another force reacts. The two forces
that act and reacts are called action-and-reaction forces. The three
characteristics of an action-and-reaction force are:
1. equal in magnitude,
2. opposite in direction, and
3. acting on different objects.
31. EXAMPLE
• The action force is the force on the table due to the weight of the book. In return,
the table reacts by applying a force in the book that is equal in magnitude but
opposite in direction.
Momentum( p=mv)- it is a vector quantity, having the same direction as velocity.
Impulse(J=Ft)- is the product f the force and time during which the force act. It is a vector quantity with same direction as the force.
Suppose the book is now sliding across the tabletop, say to the right. The forces acting on the ball are illustrated in figure 5. The downward gravitational force is balanced by the normal force. As the book slides to the right, friction acts to slow the movement of the book. There is no force that is acting to balance friction. Hence, there is an unbalanced force acting on the book. In accordance to Newton’s first law, there is an unbalanced force acting on the book. As such, the book will change its state of motion and will slow down.
● When a car at rest or in constant velocity suddenly accelerates forward, you feel as if a force is pulling you backwards. In actuality, inertia is making your body want to stay in its state of motion as the car accelerates forward.
● A hockey puck will continue to slide across a frictionless ice until acted upon by an unbalanced external force.
● A skateboarder will fly forward off the board when hitting an obstacle or an object that stops its motion.