This document summarizes neurohumoral transmission in the central nervous system. It discusses the various neurotransmitters and chemical mediators involved, including amino acids (glutamate, GABA, glycine), biogenic amines (dopamine, serotonin), and neuropeptides. The pathways, receptors, and functions of these neurotransmitters are described. Neurodegenerative diseases associated with deficits in these neurotransmitters are mentioned, such as Parkinson's disease, Alzheimer's, and Huntington's disease. The conclusion states that further understanding of neurotransmitter receptor subtypes may lead to improved treatments for neurological disorders.