Needle-less injection technology (NLIT), developed in the 1940s, offers a method to administer medications without conventional needles, primarily benefiting patients with chronic conditions requiring frequent injections. This technology utilizes high-pressure fluid to penetrate the skin, with various commercial devices like PharmaJet and Bioject adopting different power sources for drug delivery. The advantages of needle-less systems include improved patient compliance due to painlessness, reduced risks of needle-related injuries, and better administration of precise dosages.

1. Presented By
S.Shiva Shivani
12y71so330
M.Pharm(Pharmaceutics)
Samskruthi College Of Pharmacy

2.  Since 150 years needle based injections have ruled the parenterals .
Even now they form the major part of parenteral dosage form.
 To overcome the problem related to needle based injections there is
one technology that has received constant attention during the past
few years that has all of the sought after benefits..Needle less injection
technology (NLIT) was discovered in 1940’s in FRANCE.
 Needle-less injection systems are novel ways to introduce various
medicines into patients without piercing the skin with a conventional
needle.
 This is mainly useful for the patients who are suffering from chronic
diseases who requires injectable products 2-3 a day.
For Ex:-Diabetes patient

3. Needle free injection
demonstration
Recent development in drug
release

4.  Needle free injection technology works by forcing liquid medications
at high speed through a tiny orifice that is held against the skin .
 This creates an ultra stream of high pressure fluid that penetrates the
skin without the use of needle.
 The design of this device has a major influence on the accuracy of
subcutaneous delivery and the stresses improved on the product to be
delivered.
 The design must ensure that a sufficient high pressure is generated to
puncture the skin, while the subsequent pressure is reduced to ensure
that the molecule is deposited at a level that doe’s not reach the
muscle tissue

5.  High pressure delivery could potentially damage fragile molecules ,
such as monoclonal antibodies.
 Successful delivery of such molecules, therefore requires a device with
carefully controlled power nuances.
Working of needle less
injection

6. Every commercial device has in common three main components they
are:-
 The injection Device
 The needle less syringe
 The power source
 The injection device is the one which is operated in order to propel the
power source to inturn move the drug.
 The needle less syringe is the one containing the drug substance and
the nozzle through which the drug moves into the skin.
 In between the propeller of the injection device and the drug reservoir
of the syringe lies the power source.

8.  There are many different types of power sources available in the
market each having its own PROS and CONS.
 The common power sources include:
Compressed gas cartridges
Spring system
Piezoelectric crystals
Lorentz force actuator using current
 Since a few decades gas powder systems and spring systems have been
used but they had their own disadvantages of improper control over
the velocity of the drug.
 These are now replaced by the newer technologies like Lorentz force
actuators that can control the velocity and pressure of the drug
released .

9.  Pharma Jet ®(Spring system)
 BioJect B2000 ®(Gas Chamber)
 Iject ®(Gas Chamber)
 MIT Jet ®(Lorentz force actuator)
 Pen Jet ®(Gas Chamber)
 MicroJect Injections(Piezo electric current)

10.  Uses a spring system to move the drug reservoir through the nozzle.
 Pharma Jet’s innovative needle-free injection technology delivers drugs
and vaccines to intramuscular, subcutaneous and intradermal tissue
depths.

11.  This injection technology works by forcing liquid medication at high
speed through a tiny orifice that is held against the skin.
 The diameter of the orifice is smaller than the diameter of human hair.
 This creates an ultra fine stream of high pressure fluid that penetrates
the skin without single needle.
 This is unique because it delivers injections to a number of injection
depth.

12. Bioject needle device
Medicament passing through the
skin

13.  It is prefilled single used disposable device configured to administered
0.5-1ml subcutaneous or intramuscular injections.

14.  Utilizes current and magnetism Lorentz force to propel the liquid
forward and so it is adjustable by fluctuating the currents.

15.  A gas powered system similar to Bioject but uses Nitrogen as Gas.

16.  Uses Piezo electric current from the crystals present in the system

17.  Patient compliance, as there is no pain.
 Easy administration. Often favouring self administration and
administration by untrained people.
 Worker safety, as it prevents accidental pricking with used needles
 Re-usability of major portion of the needle less injections, rather than
complete removal of the syringe.
 Cost effective.
 Administration of drug at required rate for required time to required
region below the skin, thus favouring administration of proper dosage
regimen.

18.  One main advantage of needle less injections over the conventional
systems is that they release the drug as a fine jet which when enters the
body dissipates as a “web” in between the cells and so easily gets
absorbed rather than the conventional forms which form a globule like
structure in between the cells and take time to diffuse and act

19.  If a needle syringe is not sterilized, reusing it can lead to the spread of
diseases.
 Risk of cross-contamination from needle-stick injury
 Under or overdosing resulting in poor injection technique of patients
 Costs of sharps disposal
 Needle phobia
 Injection site pain
 Poor compliance leading to long term worsening of conditions.

20.  Needle free technology offers the very obvious benefits of reducing
patient concern about conventional needles and no needle disposable
issues.
 Not only it can benefit pharmaceutical industry in increasing product
sales, it has the added potential to increase compliance with dosage
regimens and improved outcomes
 In the developing world, there are major challenges of disease
transmission through re use of needles.
 Organizations such as WHO and CDC(center for disease control) and
groups like gate foundation have supported the development of needle
free alternatives for drug delivery.