ATOSIBAN Update In Preterm Labor Dr. Sharda Jain Lifecare Centre
PRETERM BIRTH
As defined by the WHO,
Preterm is defined as babies born alive before 37 weeks of
pregnancy are completed.
Sub-categories of preterm birth:
Extremely preterm (<28><32><34><37 weeks).
ESHRE Guideline on Recurrent Pregnancy Loss (RPL)Sujoy Dasgupta
Dr Sujoy Dasgupta invited to deliver a lecture on "RPL- ESHRE Guideline" in the Annual Conference of RCOG (Royal College of Obstetricians and Gynaecologists) IRC (International Representative Committee) India East held on 20-21 May, 2023
Thromboprophylaxis in pregnancy and puerperiumManju Puri
This presentation is about thromboprophylaxis in pregnancy and puerperium and describes the risk assessment , indications, drugs to be used, when to start, for how long to continue.
prostaglandin, labour, pregnancy, obstetrics, delivery, normal labour, normal delivery, first stage of labour, induction of labour, pph, post partum haemorrhage, bleeding in pregnancy, abortion
Eclampsia is conclusive and convulsive phase of a wide spectrum disease pre eclampsia. More conclusive RCT are required to assert the efficacy of biomarkers as a sensitive predictability of eclampsia.
ATOSIBAN Update In Preterm Labor Dr. Sharda Jain Lifecare Centre
PRETERM BIRTH
As defined by the WHO,
Preterm is defined as babies born alive before 37 weeks of
pregnancy are completed.
Sub-categories of preterm birth:
Extremely preterm (<28><32><34><37 weeks).
ESHRE Guideline on Recurrent Pregnancy Loss (RPL)Sujoy Dasgupta
Dr Sujoy Dasgupta invited to deliver a lecture on "RPL- ESHRE Guideline" in the Annual Conference of RCOG (Royal College of Obstetricians and Gynaecologists) IRC (International Representative Committee) India East held on 20-21 May, 2023
Thromboprophylaxis in pregnancy and puerperiumManju Puri
This presentation is about thromboprophylaxis in pregnancy and puerperium and describes the risk assessment , indications, drugs to be used, when to start, for how long to continue.
prostaglandin, labour, pregnancy, obstetrics, delivery, normal labour, normal delivery, first stage of labour, induction of labour, pph, post partum haemorrhage, bleeding in pregnancy, abortion
Eclampsia is conclusive and convulsive phase of a wide spectrum disease pre eclampsia. More conclusive RCT are required to assert the efficacy of biomarkers as a sensitive predictability of eclampsia.
The use of algorithms & emergency boxes in obstetric emergencyWafaa Benjamin
obstetric hemorrhage Is the major cause of maternal mortality globally.
Substandard management identified as a contributor for maternal mortality in UK in 80% of the cases.
Is the major cause of mortality in Egypt ,according to the last Egyptian Maternal Mortality Report in 2001.
So we need to Work in a team, Do all needed steps, In the proper sequence of the steps,
competent emergency team should have Knowledge ,Skills , Attitude & exposed to regular Labor Ward drills.
Ready available Algorithms & Emergency Boxes are found to be helpful in emergency situations.
Obstetric emergency which can kill instantly !! - PPH presenting to ED, so what is the role of Emergency Dept ? The most basic presentation of Obstetric emergency and how to tackle it? Being an emergency physician, obstetrics is always challenging! Keep yourself updated with Obstetric emergency.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
The Importance of Community Nursing Care.pdfAD Healthcare
NDIS and Community 24/7 Nursing Care is a specific type of support that may be provided under the NDIS for individuals with complex medical needs who require ongoing nursing care in a community setting, such as their home or a supported accommodation facility.
ICH Guidelines for Pharmacovigilance.pdfNEHA GUPTA
The "ICH Guidelines for Pharmacovigilance" PDF provides a comprehensive overview of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines related to pharmacovigilance. These guidelines aim to ensure that drugs are safe and effective for patients by monitoring and assessing adverse effects, ensuring proper reporting systems, and improving risk management practices. The document is essential for professionals in the pharmaceutical industry, regulatory authorities, and healthcare providers, offering detailed procedures and standards for pharmacovigilance activities to enhance drug safety and protect public health.
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
As we watch Dr. Greene's continued efforts and research in Arizona, it's clear that stem cell therapy holds a promising key to unlocking new doors in the treatment of kidney disease. With each study and trial, we step closer to a world where kidney disease is no longer a life sentence but a treatable condition, thanks to pioneers like Dr. David Greene.
R3 Stem Cells and Kidney Repair A New Horizon in Nephrology.pptxR3 Stem Cell
R3 Stem Cells and Kidney Repair: A New Horizon in Nephrology" explores groundbreaking advancements in the use of R3 stem cells for kidney disease treatment. This insightful piece delves into the potential of these cells to regenerate damaged kidney tissue, offering new hope for patients and reshaping the future of nephrology.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
1. PROFESSOR, UNIT HEAD, MGIMS, SEVAGRAM
Master Trainer, National Nodal center, Emergency
Obstetrics Care
Master Trainer, National Nodal center, Critical Care in
bstetrics
Master Trainer, National Nodal center, Maternal Near Miss
Co- Leader, Maternal Death Audit, Quality Assurance at
National & State
Co leader , Maternal Near Miss, National & State Roll Over
Member Global Women’s Health Task Force
Member Global Women’s Towards Unity for Health
Expert Committee Member, National Guidelines for
Obstetrics HDU/ICU
Expert Committee Member, National Guidelines for
Maternal Near Miss
Violence Against Women – Work in Community
Through Global Health through Training , Education
and Service (GHETS)
Board Of Studies Member, PIMS, Deemed
University
2. Near Miss Situations in
Labor Room
P R O F . S U R E K H A T A Y A D E
M B B S , M D , D N B , M N A M S , F I C O G ,
F I M E , A M R C O G , F A I M E R F E L L O W , P H D
M G I M S , S E V A G R A M
3. है तेरी मेहरबानी के अंधेरों से
हम मुकर गए
है तेरी मेहरबानी के बबन जाने
ही हम संवर गए
9. Near Miss is
• “A woman who nearly died but
survived a complication that
occurred during pregnancy,
childbirth or within 42 days of
termination of pregnancy”
• In practical terms, a very ill
woman who would have died
had it not been that luck and
good care was on her side
10. EnumerateHypertensive Crisis
Eclampsia
Placenta Previa
Placental Abruption
Postpartum
hemorrhage
Postpartum Collapse
Obstructed Labor
Rupture Uterus
Amniotic Fluid
Embolism
Retained Placenta
Inversion of uterus
Anemia with CCF
Ectopic with Shock
Medical disorder
complicating
Pregnancy
Thromboembolism
Toxicity
Acute Pulmonary
Edema
11. 1.Case Scenario
Let’s start with the first one
Sheela 22 year old,
Primigravida unbooked ,
inadequate antenatal care, 36
weeks,
Referred from district hospital
with persistent (lasting 15 min
or more), acute-onset,
severe hypertension, BP
170/120 mm hg
What is the condition?
What is the drug of choice for management?
12. “
PRINCIPLES
• Avoid drastic and sudden lowering of BP.
• Maintain DBP : 90-100 mm Hg
• Systolic BP > 110 mm Hg
LABETALOL
• Inj Labetalol : (ACOG 2016 – 1ST LINE)
• 20 mg IV, if no response then 40-80mg every 20-30 min,
max of 220 mg
• for infusion: 1-2 mg/min
HYDRALAZINE
• Hydralazine (5 mg IV bolus then if needed, 5–10 mg IV
every 10-20 min to a maximum of 45 mg) (FIGO 2016)
NIFEDIPINE
• Nifedipine tablet (10 mg orally every 20-30 min to a
maximum of 30 mg)
• (FIGO 2016) (RCOG 2011 -1ST LINE)
17. Check airway and intubate, if required
Rapidly evaluate vital sign
(pulse,BP,temperature).
If pulse not palpable then CPR, intubate and
resuscitate.
If breathing then give Oxygen (4-6l) by mask
or nasal canula.
Investigation: Blood group, CBC with
platelets, LFT, KFT
Magnesium sulfate loading dose: 4 g IV
as 8 ml of 50% solution diluted in 12 mL
saline over 5 minutes. 10 gm of 50%
solution, 5 g in each buttock as deep IM
injection (can add 1 mL of lignocaine in
same syringe. Maintenance dose of 5
gms IM 4 hourly in alternate buttock
Labetolol -10-20 mg IV, then 20-80 mg
every 20-30 min, max of 220 mg: for
infusion: 1-2 mg/min
Nifedipine 10-30 mg PO, repeat in 45
min if needed
Hydralazine Inj. 5 mg IV or IM, later 5-10
mg every 30 min once BP is controlled
repeat every 3 hours to a max 5 doses
Monitor vital sign (pulse, BP & respiration > 16/min), patellar reflexes and urinary output > 30ml/hr
Maintain strict fluid balance chart to prevent fluid overload.
Provide maintenance dose of anti-convulsive and anti- hypertensive drugs
Auscultate lung base hourly for rales ( indication of pulmonary edema)
Plan delivery, Monitor progress of labour, LSCS for obstetric indication
18. What antihypertensive
to provide with
Magnesium sulphate?
Can we give
Magnesium sulphate
& Nifedipine
together?
Nifedipine and Magnesium sulphate given together can cause
acute fall in BP, gap should be there between these two drugs,
and antihypertensive to be given after measuring BP
19. 3.Case
Scenario
Telephonic Call received from outreach
hospital at Utavali Melghat.
24 year old Primigravida with 33 weeks
gestation with Twins, referred from Dharni
Govt hospital
With Eclampsia
Loading dose given, 2 gram additional given
Patient continuously convulsing
Status eclampticus
How to manage?
20. Questions I asked the
Senior Resident
Is there a
competent
anesthesist
Do You have
arrangement for
Blood and
Components
Availability of
Oxygen
Ventilator
Available
Oxytocics
Advice- Go
ahead, Take
consent, Explain
situation to
relatives
Give GA, Do
Cesarean section
Outcome -Survival
Team effort
Preterm babies with
team effort survived
Patient on ventilator
for two days,
recovered with no
residual morbidity
21. 4.Case
Scenario
Radha , 20 year old , 35 weeks of
pregnancy ,G2 P1L1A0 has Bleeding
Per vaginum and her uterus appears
tense and tender , BP 130/90 mmHg
Could it be abruption ?
Or do you need to rule out Placenta
Previa?
Is it possible to do this clinically?
What is the algorithm to manage Placental
Abruption?
27. 4.Case
Scenario
G2P1L1, Prev LSCS ( 4 yr old male child), nurse by profession, wife of
anesthetist, shifted from private hospital ( doctor accompanied), in a
state of shock. History of 28 weeks IUD terminated with misoprostol,
post delivery excessive bleeding, oxytocics, bimanual massage and 1
unit blood transfusion given. Pulse /BP unrecordable , pt shifted
directly to OT. On exploration bucket handle tear of Cervix, sutured ,
still bleeding continued, laparotomy done, vertical posterior wall tear of
lower segment extending from below, hysterectomy done, Bilateral
internal iliac ligation done. After closure we could still find oozing from
vagina , hence vagina packed with adrenaline soaked pack. Patient
managed in critical care unit. Received total 22 transfusions, including
blood, FFP, Platelets. 3 days patient on ventilator. Vaginal packing
done twice. Outcome – survival , no residual morbidity
What are learnings from this case?
What are guidelines to manage Postpartum hemorrhage?
30. Uterine Massage
Bimanual Uterine Compression
Drugs
Oxytocin 10 IM- 20-40 U IV in 500
-1000ml at 125 ml/hr
Ergometrine 0.2-0.4 mg IV repeat
after 15 mins, 8 hourly max 5
doses
Misoprostol 400-800 mcg per
rectal
Carboprost 250 ug Im every 15
mins max 8 doses
Tranexamic acid 1 gm IV
Surgical Intervention
Removal of Retained placenta
Repair of tears
Uterine packing
Ballon Tamponade
Brace Sutures
Step vise devascularisation
Arterial embolisation
Hysterectomy
32. “ ▪ Documentation is very
important
▪ Protocols followed,
▪ Team approach all need
documentation
33. Kanta had atonic PPH during her second delivery,
managed with massive blood transfusion,
uterotonics and noninvasive bimanual compression
Bleeding stops
She is now managed in
critical care Unit and is
under level two care
During next two hours
of monitoring
We find her respiration is
becoming laboured and
SPO2 falls , blood
pressure falls
Anesthetist and
Physician team
available
Patient intubated
Echo done – shows left
ventricular failure
Acute pulmonary Odema
and TRALI is suspectedWHAT IS TRALI?
How do you
manage?
35. TRALI
Stop transfusion
Support patient
Intubate
Edema fluid
investigated for
protein
CBC, DC, chest X-ray
Hypoxemia
Hypotension
Acute Respiratory
distress
Pulmonary edema
With 6 hours of
transfusion
Adequate
Respiratory and
hemodynamic
Supportive
management
36. 30 year old Dulari,
unbooked, Primigravida
was brought to Utavali
Hospital , Melghat at 38
weeks with labor
pains,4-5 cm dilated
liquor was on higher
side , she progressed
normally during the next
few hours.
During second stage ,
patient collapsed. What
could be the cause?
Business
Finance
Leader Economy
Risk
Profit
Rise
Idea
37.
38. Second Gravida primigravida, booked case, gave history that her mother had PPH
when she was born and due to intractable bleeding , her mother died when giving
birth to her.
Patient apprehensive throughout pregnancy, reassured, all possible high risk
factors ruled out. Red Alert written on patient’s case sheet.
At term, patient came in labour. Progressed well. Middle of night telephonic call
received, patient delivered ,but while removing placenta she has gone in shock.
Acute uterine inversion suspected.
Prompt management. Immediate reposition advised, done. Patient
attended immediately by senior consultant, reposition, resuscitation, Blood
transfusion, Oxytocics, critical care management
Never ignore any symptom, any
apprehension of patient
Be Alert
39. Survival of acute severe
morbidly ill patient
Team effort
Multidisciplinary
approach
Infrastructure
of HDU/ICU
Skilled Health
personnel with
dedication