Clonidine treats high blood pressure by reducing sympathetic tone in the brain and lowering peripheral vascular resistance. Nurses should not abruptly discontinue clonidine to avoid rebound hypertension and other complications. They monitor blood pressure and assess compliance with the medication regimen. Isosorbide nitrates treat angina by dilating blood vessels and reducing preload and afterload. Nurses educate patients about potential side effects like lightheadedness and interactions with alcohol or breastfeeding. Losartan treats hypertension by blocking angiotensin receptors, lowering blood pressure. Nurses monitor blood pressure and renal function when using losartan.