Ceftriaxone sodium is a third generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis, promoting instability and killing bacteria. It is indicated for UTIs, respiratory infections, gynecologic infections, bone/joint infections, intra-abdominal infections, skin infections, and meningitis. Adverse reactions include headache, fever, diarrhea and allergic reactions like rash. Nurses should check for penicillin allergies and monitor patients with impaired vitamin K synthesis or low stores as the drug may affect clotting. Nalbuphine hydrochloride is an opioid agonist-antagonist used for moderate to severe pain as an adjunct to anesthesia

1. XVI. Drug Study
NAME OF THE
MACHANISM
DRUG
Generic Name:
OF ACTION
Inhibit cell wall
Ceftriaxone
sodium
INDICATIONS
CONTRA-
ADVERSE
NURSING ALERT
-UTI, lower
INDICATIONS
-Contra-indicated to
REACTION
Adverse effect:
-Before giving drug ask
synthesis,
respiratory tract,
patient with
headache, fever,
patient if he allergy to
promoting
gynecologic, bone hypersensitivity to
dizziness, phlebitis,
penicillin or
instability,
or joint, intra-
drug or other
diarrhea, genital
cephalosporin.
Brand Name:
usually
abdominal, skin
cephalosporin.
pruritus, candidiasis,
-obtain c/s test
Rocephin
bactericidal.
structure
-use cautiously in
eosinophilia,
-monitor PT and INR in
infection,
patients
thrombocytopenia,
patient with impaired Vit
Dosage:
septicemia
hypersensitivity to
pain, tenderness at
K synthesis or low Vit K
1g
-meningitis,
penicillin because of
injection site, rash,
stores. Vit K may be
Classification:
perioperative
possibility of cross-
pruritus, chills,
needed.
3rd generation
prevention, acute
sensitivity with other
anaphylaxis
-Drug is commonly used
cephalosporin
bacterial otitis
beta lactam drug
in home antibiotic
media, neurologic
-use cautiously with
program for outpatient
disorder, carditis
breast feeding
treatment of serious
and
women, patient with
infection such as
uncomplicated
history of colitis and
osteomyelitis and
gonoccocal
renal insufficiency.
community- acquired
vulvovaginitis
pneumonia

2. NAME OF THE
MACHANISM
DRUG
Generic Name:
OF ACTION
Unkown. Binds
-moderate to
INDICATIONS
-contraindicated
REACTION
Adeverse effect:
Reassess patient’s level of pain
Nalbuphine
with opiate
severe pain
in patients
Dizziness,
at least 15-30 min. after
hydrochloride
receptors in the
hypersensitivity
headache, sedation,
parenteral administration
drug
vertigo, confusion,
CNS, altering
Brand Name:
perception of
Nubain
and emotional
response to pain.
Dosage:
5mg
Classification:
Opioid agonistantagonist,
opioid partial
agonist
INDICATIONS
-adjunct to
balanced
anesthesia
CONTRA-
-use cautiously
in patient with
history of drug
abuse and in
those with
emotional
instability, head
injury, impaired
ventilation, MI
with nausea and
vomiting, hepatic
or renal disease.
ADVERSE
crying, delusion,
depression,
nervousness,
NURSING ALERT
-drug act as opioid antagonist
and may cause withdrawal, watch
for signs of it,
hallucination,
-Drug causes respiratory
hypertension or
depression 10mg is equal to
hypotension, blurred
respiratory depression produced
vision, dry mouth,
by 10mg morphine
constipation, urinary
urgency, respiratory
depression,
dyspnea, pulmonary
edema
-monitor circulatory, respiratory,
bladder and bowel function. If
breath is <12 cpm withhold drug
-psychological and physical
dependence may occur with
prolonged use.

3. NAME OF
MACHANISM
THE DRUG
OF ACTION
INDICATIONS
CONTRA-
ADVERSE
INDICATIONS
REACTION
NURSING ALERT