Native Client is an open source technology that allows native compiled code to run safely and securely in web browsers. It expands web programming beyond JavaScript by allowing code written in C and C++ to run at near-native speed, while maintaining OS portability and safety. The Native Client SDK includes tools and libraries like Pepper that provide a bridge between native code modules and JavaScript, enabling two-way asynchronous communication. Developing a Native Client application involves creating HTML, native module, and manifest files, then compiling and loading the module via the manifest.