Skeletal system
Divisions of skeletal system,
types of bone,
salient features and functions
of bones of axial and appendicular skeletal system Organization of skeletal muscle,
physiology of muscle contraction,
neuromuscular junction.
Skeletal system
Divisions of skeletal system,
types of bone,
salient features and functions
of bones of axial and appendicular skeletal system Organization of skeletal muscle,
physiology of muscle contraction,
neuromuscular junction.
Bones of lower limb (Human Anatomy)
by DR RAI M. AMMAR
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Bones of lower limb (Human Anatomy)
by DR RAI M. AMMAR
www.facebook.com/drraiammar
www.twitter.com/drraiammar
www.instagram.com/drraiammar
www.linkedin.com/in/drraiammar
www.themedicall.com/blog/auther/drraiammar/
For Any Book or Notes Visit Our Website:
www.allmedicaldata.wordpress.com
www.drraiammar.blogspot.com
YOUTUBE CHANNEL :
https://www.youtube.com/channel/UCu-oR9V3OdFNTJW5yqXWXxA
ANY QUESTION ??
Get in touch with us at Any of the Above Social Media or Email at
drraiammar@gmail.com
allmedicaldata@gmail.com
The branch of science concerned with the bodily structure of humans, animals, and other living organisms, especially as revealed by dissection and the separation of parts.
The muscular system is a complex network of tissues and organs responsible for movement, stability, and heat generation in the human body. Comprising more than 600 individual muscles, it enables various functions, including locomotion, posture maintenance, breathing, and circulation assistance. Muscles are composed of muscle fibers, which are elongated cells capable of contracting and relaxing to generate force. Skeletal muscles, attached to bones via tendons, facilitate voluntary movements, such as walking and lifting objects, under conscious control. Smooth muscles, found in organs like the digestive tract and blood vessels, perform involuntary functions like peristalsis and regulating blood flow. Cardiac muscle, exclusively present in the heart, sustains its rhythmic contractions to pump blood throughout the body. The muscular system works in coordination with the skeletal, nervous, and circulatory systems to ensure efficient movement and overall bodily function. Regular exercise and proper nutrition are essential for maintaining muscular health and strength throughout life.
skeletal, cardiac & smooth Muscles by Thiru Murugan.pptxthiru murugan
Unit III – The Muscular System - Anatomy
Types and structure of muscles
Muscle groups
Alterations in disease
Applications and implications in nursing
Muscle:
Muscle is a soft tissue and it is one of the 4 basic tissues, along with nervous tissue, epithelium, and connective tissue.
Muscles helps in movement, support and protection of internal organs.
Muscles can perform variety of functions
Muscles tissue is made up of cells called “MYOCYTES” or muscle fibers.
There are more than 600 muscles in the human body. A kind of elastic tissue makes up each muscle, which consists of thousands, or tens of thousands, of small muscle fibers.
Types of Muscles: There are 3 main types of muscles
Skeletal muscle
Cardiac muscle
Smooth muscle
Skeletal muscle:
These are having close relationship to the bone or skeleton, so called Skeletal muscles
It present in limbs and related body parts & It form about 40% of body weight.
Under microscope the skeletal muscles fibers shows prominent striations, so called “Striated Muscles” & It is also known as “Voluntary Muscles” (movements are under our control)
Structure of Skeletal muscle:
Muscle fibers shows transverse striations under light microscope so it is called “striated muscles”
The nucleus is located peripherally.
Each skeletal muscle is an organ that consists of numerous cells called muscle fibers.
Each muscle fibers surrounded by “ Endomysium”
Inside each skeletal muscle, muscle fibers are organized into bundles, called fascicles, each fascicle surrounded by perimysium.
The whole muscle is covered by “epimysium”
Each skeletal muscle has three layers: endomysium, perimysium and epimysium
Muscle fibers:
Muscle is composed of many long cylindrical-shaped elongated fibres called muscle fibers
Length varies according to the size and shape of the muscles.
The actual arrangement of the fibres depending on the function of the muscle.
Each muscle fibers covered by a membrane is called the sarcolemma.
The cytoplasm of a muscle fiber is called Sarcoplasm
In sarcoplasm there are many mitochondria and bundles of fine longitudinal thread like part is called “myofibrils”
Microscopic structure of myofibrils:
A myofibril (also known as a muscle fibril or sarcostyle) is a basic rod-like part of a muscle cell.
Muscles are composed of tubular cells called myocytes, known as muscle fibres in striated muscle, and these cells in turn contain many chains of myofibrils.
They are created during embryonic development in a process known as myogenesis.
Under light microscope each myofibril consist of 2 bands:
Light band or “I” Band and Dark band or “A” Band
The alternating pattern of these bands results in the striated appearance of skeletal muscle.
Light band or “I” Band:
The I-bands (isotropic in polarized light) appear light in color.
I band divided into 2 portions by a narrow dark line called “Z” line or “Z” Disc.
This “Z” line is formed by protein which does not permit the light.
The part in between 2 “Z” lines called “sarc
2. Unit - 7-Muscles Anatomy, Thiru Murugan, Msc Professorthiru murugan
The Muscular System
By Thiru murugan. M
The Muscular system:
Types and structure of muscles
Muscle groups: muscles of the head, neck, thorax, abdomen, pelvis, upper limb and lower limbs
Principal muscles: deltoid, biceps, triceps, respiratory, abdominal, pelvic floor, pelvic floor muscles, gluteal muscles and vastus lateralis
Major muscles involved in nursing procedures
Muscle:
Muscle is a soft tissue and it is one of the 4 basic tissues, along with nervous tissue, epithelium, and connective tissue.
Muscles helps in movement, support and protection of internal organs.
Muscles can perform variety of functions
Muscles tissue is made up of cells called “MYOCYTES” or muscle fibers.
There are more than 600 muscles in the human body. A kind of elastic tissue makes up each muscle, which consists of thousands, or tens of thousands, of small muscle fibers.
Types of Muscles: There are 3 main types of muscles
Skeletal muscle
Cardiac muscle
Smooth muscle
Skeletal muscle:
These are having close relationship to the bone or skeleton, so called Skeletal muscles
It present in limbs and related body parts & It form about 40% of body weight.
Under microscope the skeletal muscles fibers shows prominent striations, so called “Striated Muscles” & It is also known as “Voluntary Muscles” (movements are under our control)
Structure of Skeletal muscle:
Muscle fibers shows transverse striations under light microscope so it is called “striated muscles”
The nucleus is located peripherally.
Each skeletal muscle is an organ that consists of numerous cells called muscle fibers.
Each muscle fibers surrounded by “ Endomysium”
Inside each skeletal muscle, muscle fibers are organized into bundles, called fascicles, each fascicle surrounded by perimysium.
The whole muscle is covered by “epimysium”
Each skeletal muscle has three layers: endomysium, perimysium and epimysium
Muscle fibers:
Muscle is composed of many long cylindrical-shaped elongated fibres called muscle fibers
Length varies according to the size and shape of the muscles.
The actual arrangement of the fibres depending on the function of the muscle.
Each muscle fibers covered by a membrane is called the sarcolemma.
The cytoplasm of a muscle fiber is called Sarcoplasm
In sarcoplasm there are many mitochondria and bundles of fine longitudinal thread like part is called “myofibrils”
Microscopic structure of myofibrils:
A myofibril (also known as a muscle fibril or sarcostyle) is a basic rod-like part of a muscle cell.
Muscles are composed of tubular cells called myocytes, known as muscle fibres in striated muscle, and these cells in turn contain many chains of myofibrils.
They are created during embryonic development in a process known as myogenesis.
Under light microscope each myofibril consist of 2 bands:
Light band or “I” Band & Dark band or “A” Band
The alternating pattern of these bands results in the striated appearance of skeletal muscle.
Light band or “I” Band:
The I-bands (isotropic in polarize
1 GNM anatomy Unit _ 14 Muscular System.pptxthiru murugan
By:M. Thiru murugan
Unit XIV
Type, structure and functions of muscle
Origin, Insertion, and action of muscles
Muscle:
Muscle is a soft tissue and it is one of the 4 basic tissues, along with nervous tissue, epithelium, and connective tissue.
Muscles helps in movement, support and protection of internal organs.
Muscle cells or myocytes contain protein filaments called myofilaments actin & myosin that producing a contraction that changes both the length and the shape of the cell.
Types of Muscles:
There are 3 types of muscles: skeletal, cardiac & smooth muscle
Skeletal muscle or “voluntary muscle” or striated Muscles is attached to bone, helps in movement & in maintaining posture.
Smooth muscle or “involuntary muscle” or non striated muscles is found within the walls of organs and structures
Cardiac muscle is also an "involuntary muscle" found only in the heart.
Structure of Skeletal muscle:
Skeletal muscle consist plasma membrane is called sarcolemma, the cytoplasm is called sarcoplasm & specialized sarcoplasmic reticulum that play important role in regulation of Calcium.
Cells contain many nucleus peripherally
It consist of number of elongated cells called muscle fibers or muscle cell , that consist of myofibrils (elongated protein molecules).
These Muscle fibers are arranged in bundle called fasciculi
Each muscle fibers covered by endomysium, each fasciculi covered by perimysium & the whole muscle is covered by epimysium.
Neuromuscular junction (NMJ) or myoneural junction is a chemical synapse between a motor neuron and a muscle fiber.
It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction.
Properties of skeletal muscle:
Excitability: this refers to muscle tissue being able to react to nervous stimulation.
Extensibility: this refers to the ability of muscle tissue to lengthen when contracting
Elasticity: this refers to the ability of muscle tissue to return to its normal resting length once it has been stretched.
Contractility: this refers to the capacity of a muscle to contract or shorten forcibly when stimulated by nerves and hormones
Muscle contraction:
Muscle use the movement of actin against myosin to create contraction.
In skeletal muscle, contraction is stimulated by electrical impulses transmitted by the nerves
Cardiac and smooth muscle contractions are stimulated by internal pacemaker cells which regularly contract, and propagate contractions to other muscle cells they are in contact with.
All skeletal muscle and many smooth muscle contractions are facilitated by the neurotransmitter acetylcholine.
Types of muscle contraction:
Isotonic contractions maintain constant force or tone in the muscle as the muscle length changes
Isometric contractions changes in force without changing the length of the muscle
Muscle tone is defined as the tension in a muscle at rest.
Function of skeletal muscles
Body movement (Locomotion)
Maintenance of posture
Respiration
Constriction of organs and vess
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Toxic effects of heavy metals : Lead and Arsenicsanjana502982
Heavy metals are naturally occuring metallic chemical elements that have relatively high density, and are toxic at even low concentrations. All toxic metals are termed as heavy metals irrespective of their atomic mass and density, eg. arsenic, lead, mercury, cadmium, thallium, chromium, etc.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Salas, V. (2024) "John of St. Thomas (Poinsot) on the Science of Sacred Theol...Studia Poinsotiana
I Introduction
II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
2. MUSCLE
•Muscle is a contractile tissue which brings about body
movements by contraction and relaxation of its fibers.
• PARTS OF A MUSCLE:-
i. Two ends:
Origin – the end of the muscle which remains fixed
during its contraction.
Insertion – the end which moves during its
contraction.
ii. Two parts:
Fleshy part - contractile, and is called the 'belly'.
Fibrous part - non-contractile and inelastic. It is
called TENDON.
3. PROPERTIES OF MUSCLE FIBRES
•CONTRACTABILITY: the muscle fibers contract
lengthwise, to bring body movements when stimulated.
•EXCITABILITY: the muscle fibers are sensitive and
respond to stimulus.
• EXTENSIBILITY: the muscle fibers return to their original
length on removing the stimulus.
• ELASTICITY: the muscle fibers are elastic and can be
stretched.
4. Types of Muscles
• There are three types
of muscles:
i. Skeletal/Striated
Muscle – the
muscles attached to
skeleton
ii. Smooth/Non-
striated Muscle –
the muscles attaches
to viscera (abdominal
organs)
iii. Cardiac Muscle – the
muscle of the heart
5. SKELETAL MUSCLE
• The most abundant
muscle in our body.
• They are voluntary, that is
under our control and
striated.
• Located superficially and
mostly attached to the
skeleton.
• They are unbranched,
cylindrical, multinucleated
muscle fibers.
6. Functions
i. Body Movement – contraction of these muscle fibers cause
body movement.
ii. Heat Production – metabolism within the muscle cells
releases heat as end product, which increases during
strenuous exercises.
iii. Posture and Body support – These muscles maintain body
posture by providing support around flexible joints.
Types of skeletal muscle fibres
Red Fibres White Fibres
Their speed of contraction is
less but more sustained. They
are fatigue resistant hence
present in postural muscles
and long muscles of the back.
Their speed of contraction is
fast but less sustained. They
are easily fatigued hence
present in the muscles of the
eyeball, etc.
7. SARCOMERE
• The structural and functional unit
of a striated muscle fibre, and it is
due to the presence of this the
muscle appears striated.
• It is the basic unit of contraction,
that is it is the contraction of this,
which brings about the
contraction of a muscle fibre.
• it comprises of two types of
filaments, called myofilaments:-
i. Thick filaments: it is
composed of a protein called
myosin
ii. Thin filaments: it is
composed of protein called
actin
• The sliding of thin filament
over the thick filament brings
about the contraction of
sarcomere, and hence the
contraction of muscle fibre.
8. Smooth Muscle
• They are present in the walls
of the hollow organs, blood
vessels, glands and skin.
• They are involuntary,
unstriated muscle fibres.
• They have unbranched,
spindle shaped muscle fibres.
• Functions:
i. Movement of organs to
facilitate proper mixing of
food
ii. Regulation of blood flow.
iii. Propulsion of urine
9. Cardiac Muscle
• It is also called myocardium.
• It is present only in the walls
of the heart.
• Its major function is pumping
of blood from the heart
• It is involuntary and striated
muscle.
• It has branched, cylindrical
fibres with intercalated discs
and they are uninucleated.
• It is auto-rhythmic, that is it
generates its own contractions
and does not require an
external stimulus for its activity.
10. Muscles of the Upper Limb
Muscles of Arm:-
Anterior: (Flexion of Arm) Posterior: (Extension of Arm)
• Biceps Brachii Triceps Brachii
• Coraco-brachialis
• Brachialis
Muscles of Forearm:-
Anterior: (Flexion of Forearm) Posterior: (Extension of Forearm)
• Pronator Teres Anconeus
• Flexor carpi radialis Brachio-radialis
• Palmaris longus superficial Extensor carpi radialis longus
• Flexor digitorum superficialis Extensor carpi radialis brevis
• Flexor carpi ulnaris Extensor digitorum
• Flexor digitorum profundus Extensor digiti minimi
• Flexor pollicis longus deep Extensor carpi ulnaris
• Pronator quadrus Supinator
Abductor pollicis longus
Extensor pollicis brevis deep
Extensor pollicis longus
Extensor indices
Superficial
13. Muscles of the hand
• Abductor pollicis brevis
• Flexor pollicis brevis
•Opponens pollicis
• Adductor pollicis
• Palmaris brevis
• Abductor digiti minimi
• Flexor digiti minimi
• Opponens digiti minimi
• Lumbricals(4)
• Palmar interossei(4)
• Dorsal Interossei(4)
F
14. Muscles of lower limb
Muscles of thigh:-
Anterior: (Extension of thigh)
• Sartorius
• Quadriceps Femoris- it has,
Rectus Femoris
Vastus lateralis
Vastus intermedius
Vastus medialis
• Articularis genu
• Tensor fascia lata
Medial: (Adduction of thigh)
• Adductor brevis
• Adductor longus
• Adductor magnus
15. Muscles of thigh(cont’d)
Posterior:- (Flexion of thigh)
HAMSRTING MUSCLES:
• Semi-tendinosus
• Semi-membranosus
• Short head of biceps
femoris
• Ischial fibres of Adductor
magnus
NON-HAMSTRING
MUSCLES:
• Long head of biceps
femoris
16. MUSCLES OF FRONT OF TRUNK
•Pectoralis Major
• Pectoralis minor Pectoral Region
• Subclavius
• Deltoid
• External Intercostal
• Internal intercostal
• Transversus thoracis
Subcostalis Thorax
Intercostalis intimi
Sternocostalis
deltoid
17. MUSCLES OF BACK OF TRUNK
• Trapezius
• Lattisimus dorsi
• Levator scapulae Back
• Rhombois major
• Rhomboid minor
• Supraspinatous
• Infraspinatus
• Subscapularis Scapular
• Teres minor Muscles
• Teres major
18. Nerve-Muscle Junction (NMJ)
• Neuromuscular junction (NMJ)
refers to the intimate contact of
the nerve endings with the muscle
fibre to which they innervate.
• It is a microstructure through
which the process of contraction is
initiated or halted in the muscles
by the neurons.
• Components of a NMJ are:-
i) Pre - synaptic terminal (Axon
terminal)
ii) Synaptic Cleft
iii) Post - synaptic terminal
19. COMPONENTS OF NMJ
Presynaptic Terminal: The presynaptic terminal is an axonal
terminal of a motor neuron. The axonal terminal contains a
number of synaptic vesicles. These vesicles contain the
neurotransmitters that are released upon receiving a nerve
impulse.
Synaptic Cleft: It is the space between the presynaptic terminal
and the postsynaptic cell. It is roughly the size of 30 nm. The
synaptic cleft allows the neurotransmitters to diffuse and reach
the other side of the synapse or the neuromuscular junction. It
also contains enzymes for the degradation of the excess or extra
neurotransmitters.
Post Synaptic Cell: The postsynaptic cell is the skeletal muscle
fiber. The motor neurons make synapse on the membrane of the
skeletal muscle fibers, whose membrane has receptors for
binding to the released neurotransmitters.
20. Mechanism of Contraction
• When a nerve impulse reaches the presynaptic
axonal terminal, it causes depolarization. As a result,
the voltage-gated calcium channels open. The
calcium ions from the surrounding environment
diffuse into the presynaptic axon.
• These calcium ions activate the membrane proteins.
These proteins mediate the fusion of synaptic
vesicles to the cell membrane of the neuron,
resulting in the release of neurotransmitters into the
synaptic cleft.
• They diffuses across the synaptic cleft and binds to
the receptors. This results in the opening of the
cation channels. These channels are open to both
sodium and potassium ions.
21. • As the concentration of sodium ions is
higher in the extracellular space, the sodium
ions enter through these open cation
channels. As a result, depolarization of the
skeletal muscle increases..
The depolarization of post – synaptic
membrane results in the opening of
voltage-gated calcium channels locate on
the membrane as well as the membrane of
the smooth endoplasmic reticulum.
• As the calcium ions enter the cell, it
initiates the cycle of skeletal muscle
contraction. The actin-myosin bridges of the
sarcomere are formed, and the result in
contraction of the skeletal muscles.
Mechanism of Contraction CONT’D