The document summarizes the mimetic muscles of the face, which are also called the facial expression muscles. It describes the various muscle groups - the orbicular group, nasal group, oral group, and others. It provides details on individual muscles like the orbicularis oculi, corrugator supercilii, zygomaticus major, and platysma. It also discusses the nerve supply of these muscles from the facial nerve and its branches.
Face is the most prominent part of the body
Facial muscles also known as the ‘mimetic muscles’, represent remnants of the ‘Panniculus Carnosus’ ,continuous subcutaneous muscle sheet seen in some animals.
Facial Musculature are the only somatic muscles in the body attached on one side to the bone and the other side to the skin; thus specialized for expression
Face is the most prominent part of the body
Facial muscles also known as the ‘mimetic muscles’, represent remnants of the ‘Panniculus Carnosus’ ,continuous subcutaneous muscle sheet seen in some animals.
Facial Musculature are the only somatic muscles in the body attached on one side to the bone and the other side to the skin; thus specialized for expression
Use of M-health Application to Figure Out Post-natal Depression, an Evidence-...Dr. Nasir Mustafa
Issue: 2023 - Volume 35 [Issue 24]
Use of M-health Application to Figure Out Post-natal Depression, an Evidence-based Study Dr. Nasir Mustafa * School of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey
Article Information
DOI: 10.9734/jammr/2023/v35i245326 Published: 2023-12-19
Page: 81-90
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
19. Introduction-Mimetic Muscles
• The facial muscles are a group of striated
skeletal muscles innervated by the facial
nerve (cranial nerve VII) which control
facial expression. These muscles are also
called mimetic muscles.
• Facial Expressions- movements of mimetic
musculature of the face
19
20. • The facial musculature is fairly unique. They include
the only somatic muscles in the body attached on one
side to bone and the other to skin; thus facial
movements are specialized for expression.
• The face is also one of the few places in the body
where some muscles are not attached to any bone at
all (e.g., orbicularis oculi, the muscle surrounding the
eyes; orbicularis oris, the muscle in the lips).
• They also act as sphincters and dilators of the orifices
of the face
• Facial muscles develop from second pharyngeal arch.
20
21. Groups
• For logical understanding, they are grouped
as:
1. Orbicular Group
2. Nasal Group
3. Oral Group
4. Other muscles or groups
21
23. Orbicularis Oculi:
Closes and squints the eye.
Wink, concern, perplexion.
Levator Palpebrae Superioris:
Elevates the upper eyelid.
Surprise, fear
Corrugator Supercilii:
Draws the eyebrow
inferomedially and shows
anger, concern 23
25. Nasalis:
Maxilla to the cartilage of the nose
and the oppositeside nasalis muscle.
Compresses the nares.
Procerus:
Fascia and skin medial to the
eyebrow to the fascia and skin over
the nasal bone (disdain look)
Depressor Septi Nasi:
From medial fiber of dilator naris muscle
to mobile part of nasal septum.
Depresses septum and narrows nostril 25
27. Levator labii superioris :
Infraorbital head & zygomatic head to
upper lip. Raises upper lip; helps form
naso -labial furrow. Disgust, smugness
Levator labiisuperioris alaeque nasi :
Frontal nasal process to one to ala &
other to orbicularis oris.Raises upper lip
and opens Nostril. anger, contempt
Levator anguli oris :
Maxilla below infraorbital foramen &
canine fossa to angle of mouth. Elevates
the angle of the mouth. smile, sneer,
“Dracula” expression 27
28. Zygomaticus major:
From zygomatic bone & arch to angle of
mouth. Draws the corner of the mouth
upward and laterally. Smile, laugh
Zygomaticus minor:
From zygomatic bone & medial to
zygomatic major to nasolabial groove.
Draws the upper lip upward. Smile &
Smugness.
Risorius:
From superficial fascia over parotid to
skin & mucosa on angle of lip. Retracts
corner of mouth. Grin, smile, laugh
28
29. Depressor anguli oris / triangularis:
From oblique line of mandible to angle
of mouth. Draws corner of mouth down
and laterally.
Depressor labii inferioris :
From base of mandible to skin n mucosa
of lower lip. Draws lower lip downward
and laterally. Sadness, uncertainty, dislike
Mentalis :
From mandible below lower incisors to
skin of chin. Raises and protrudes lower
lip as it wrinkles skin on chin. doubt,
pout, disdain 29
30. Orbicularis Oris:
From buccinator muscle to angle of
mouth (upper lip) and mandible
(lower lip). Closes lips; protrudes lips.
puckering, whistling
Buccinator :
From alveolar process f max. and mand. In
region of molars & pterygomandibular
ligament. Presses the cheek against teeth;
Compresses distended cheeks. pucker,
exertion, sigh
Platysma :
From skin and superficial fascia of pectoral
and deltoid region to lower border of
mandible. Draws up the skin of the superior
chest and neck. Creature from Black Lagoon”
expression 30
32. Occipitofrontalis :
Frontal Belly:
From ant. Part of
Galea aponeurotica to
Skin on lower part
of forehead.
Wrinkles forehead;
Raises eyebrows
Anterior auricular: Draws ear
upward and forward
Occipital belly:
From lateral 2/3rd of
Superior nuchal line
To post. Part of
galea Aponeurotica.
Draws scalp
backward
Superior auricular : Elevates ear
Posterior Auricular: Draws ear
upward and backward
32
Cannot
consciously
move.
Temperoparietali
s has to be
checked.
34. Facial N. (VII)
• LMNs in facial nucleus is in inferior pons
• It emerges from the brainstem between the pons and the medulla, and
controls the muscles of facial expression
• The facial nerve is developmentally derived from the hyoid arch (second
pharyngeal branchial arch). The motor division of the facial nerve is
derived from the basal plate of the embryonic pons, while the sensory
division originates from the cranial neural crest.
Course:
• Fibres course around abducens nucleus - internal genu Exits
brainstem at cerebellopontine angle with CN VIII Through the
petrous part of the temporal bone Through internal acoustic meatus
with CN VIII Into facial canal, along walls of the tympanic cavity
(external genu of facial nerve, geniculate ganglion)
34
35. Exits skull via stylomastoid foramen, most branches go
through parotid gland
• Temporal
• Zygomatic
• Buccal
• Marginal mandibular
• Cervical
• Posterior auricular
• The oculomotor nerve [III], which innervates the
levator palpebrae superioris; sympathetic fibers,
which innervate the superior tarsal muscle.
35
37. The muscles of facial expression arise
from the second branchial arch,
are innervated by the seventh cranial
nerve (i.e. the facial nerve, cranial
nerve VII),
Fluidity of facial movements is
orchestrated by their interaction with
the SMAS
38. The epicranius or occipitofrontalis muscle of the scalp
has an anterior and posterior region connected by the
galea aponeurotica . Contraction of these muscles
allows the skin to slide over the scalp.
The frontalis muscle is a member of the epicranius
complex that begins at the anterior hairline and inserts
into the forehead and eyebrow skin.
39. Midline vertical forehead skin tension
lines occur due to variation in distance
between the left and right frontalis bellies.
Horizontal skin tension lines occur
perpendicular to the frontalis contractile
orientation.
Loss of frontalis function results in
flattening of forehead skin tension lines
and a drooping eyebrow. This occurs when
the temporal branch of the facial nerve is
disrupted.
Patients with compromised frontalis
function may be unable to open their eyes
widely, due to the synergistic effect this
muscle has with the orbicularis oculi
muscle.
40. The small periauricular muscles or the
temporoparietalis group arise from the
superficial temporalis SMAS and the
lateral galea.
They help draw back the temporal skin
and are innervated by the posterior
ramus of the temporal branch of the
facial nerve.
41. The orbicularis oculi muscle
complex is the major group that
acts on the eyelid and periorbital
skin. It inserts into the medial
and lateral canthal tendons and
encircles the eye region.
Its palpebral portion has a
preseptal component overlying
the orbital septum and a
pretarsal portion overlying the
tarsal plate of the eyelid. The
palpebral orbicularis oculi
muscle aids in tear excretion.
•Upper pretarsal and preseptal muscles depress the
upper lid. The orbital component of this muscle
group allows voluntary tight closure of the eye. The
palpebral portion allows gentle eye closure and
blinking.
42. The corrugator supercilii muscle is located over the
medial upper orbital rim.
It contributes to a 'scowling' facial expression by drawing
the eyebrows medially and downward.
It interdigitates with and is covered by the frontalis and
orbicularis oculi muscles.
The vertical and oblique skin tension lines of the
glabella are caused by contraction of this muscle, which
is innervated by the temporal branch of the facial nerve
43. The procerus muscle
overlies the nasal bone
and attaches to the
nasal root skin.
It causes
foreshortening of the
nose and 'rabbit lines‘
(i.e. skin tension lines
exaggerated by
wrinkling up the nose).
44. The nasalis muscle courses
across the nasal dorsum and
facilitates alar 'flaring‘ and
compression. These muscles
are innervated by the
zygomatic and buccal
branches of the facial nerve.
The depressor septi nasi
muscle lies deep to the
orbicularis oris and can form
a transverse skin tension line
across the philtrum. It plays
a minor role in facial
expression by pulling the
columella down toward the
lip
45. The orbicularis oris muscle allows pursing and puckering
of the lips, apposition of the corners of the mouth, and
pulling of the lips up against the teeth and gingivae.
It has no bony or cartilaginous attachment and is
innervated by the buccal or marginal mandibular branches
of the facial nerve.
This circumferential muscle is necessary for correct speech
and allows enunciation of the letters M, V, F,P and O.
The facial arteries and veins are covered and protected
from damage by the lip elevator muscles.
46. The quadratus labii superioris muscle group is
comprised of several lip elevators.
The levator anguli oris and risorius muscles
are mouth angle retractors and elevators.
The zygomaticus major muscle travels from
the zygoma downward and diagonally to the
upper corner of the mouth, where it
contributes to the nasolabial fold.
Zygomaticus major and minor muscles are the
main contributors to smile formation.
The risorius muscle also contributes to a
smiling facial expression by drawing back the
corners of the mouth.
The modiolus platform is formed by the
convergence of fibers from the orbicularis oris
and lip elevators and depressors.
It is located 1cm lateral to the mouth angle
and accounts for cheek 'dimples' in some
patients. It works in synergy with the perioral
muscles to facilitate speech enunciation.
47. The buccinator muscle constitutes a large area of the
cheek as it courses from the posterior maxillary area to
the upper medial surface of the mandible, where it
interdigitates with the orbicularis oris.
The buccinator is innervated by the
buccal branch of the facial nerve and
contracts synergistically with the
orbicularis oris muscle. Together, these
muscles allow whistling of the lips.
The buccinator also keeps the cheek flat
against the teeth, which prevents food
accumulation during chewing.
It also prevents overextension of the
cheek when high intraoral pressures are
generated.
48. The depressor anguli oris (triangularis), depressor labii
inferioris (quadratus) and the mentalis muscles are lip
depressors and retractors that antagonize the superior
perioral muscle groups.
They are innervated by the marginal mandibular branch of
the facial nerve.
The deep mentalis muscle permits chin elevation and
depression and protrusion of the lower lip. The bellies of
the mentalis muscles have variable proximities to each
other.
A patient with a chin 'dimple' or 'cleft chin‘ has a larger
distance between mentalis muscles. This is a normal anatomic
variant.
49. The platysma muscle runs from
the superficial fascia of the chest
across the anterior and lateral
neck over the mandible to
intercalate with the lower lip
depressors and retractors.
It is innervated by the cervical
branch of the facial nerve.