This document summarizes work using high-throughput computing on the Open Science Grid to generate large materials databases. Key points: - The researchers used over 2.6 million CPU hours on the Open Science Grid to run thousands of ab initio calculations for materials properties like diffusion coefficients. - This enabled the creation of the world's largest database of diffusion data from a single research group, with properties for over 350 material systems. - The databases are publicly available online and help discover new scientific insights not possible from smaller datasets. - The researchers are now using the same high-throughput approach on the Open Science Grid to calculate other materials properties at scale, like excess formation volumes in alloys.