This document provides information on two herbal drugs used in Siddha medicine - Amukkara and Mancal.
[1] Amukkara is the dried root of Withania somnifera, an herb found throughout India. Its roots are collected in winter, dried, and purified before use. It has many medicinal properties and is used to treat diseases related to the immune system.
[2] Mancal is the dried rhizome of Curcuma longa (turmeric). It is cultivated across India and harvested after 9-10 months when dried and cured. It has antioxidant and anti-inflammatory properties and is used to treat various diseases related to digestion and liver function.
Regulatory requirement for setting herbal drug industryRAGHAV DOGRA
The World Health Organization (WHO) estimates that 80 percent of the population of some Asian and African countries presently use herbal medicine for some aspect of primary health care.Pharmaceuticals are prohibitively expensive for most of the world's population, half of whom lived on less than $2 U.S. per day in 2002. In comparison, herbal medicines can be grown from seed or gathered from nature for little or no cost
patent (/ˈpætənt/ or /ˈpeɪtənt/) is a set of exclusive rights granted by a sovereign state to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention. An invention is a solution to a specific technological problem and is a product or a process. Patents are a form of intellectual property.
Regulatory requirement for setting herbal drug industryRAGHAV DOGRA
The World Health Organization (WHO) estimates that 80 percent of the population of some Asian and African countries presently use herbal medicine for some aspect of primary health care.Pharmaceuticals are prohibitively expensive for most of the world's population, half of whom lived on less than $2 U.S. per day in 2002. In comparison, herbal medicines can be grown from seed or gathered from nature for little or no cost
patent (/ˈpætənt/ or /ˈpeɪtənt/) is a set of exclusive rights granted by a sovereign state to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention. An invention is a solution to a specific technological problem and is a product or a process. Patents are a form of intellectual property.
Herbal drugs are usually considered safe but when taken along with other drugs of chemical origin (allopathic drugs), they do interact with them and cause Bio-drug interaction
WHO guidelines on herbal drug monitoringKaustav Dey
This presentation points out the various guidelines laid out by World health organization for safe & effective way of monitoring of Herbal Medicine in a pharmacovigilance setting
INDIAN AND INTERNATIONAL PATENT LAW AS APPLICABLE TO HERBAL AND NATURAL PRODUCTSTejaswini Chandra
ITS A USEFUL TOPIS FOR LAW STUDNETS REGARDING THE HERBAL DRUGS AND NATURAL PRODUCTS .
ALSO USEFUL FOR THE MPHARM STUDENTS OF ALL DOMAIN TO STUDY REGARDING THE PATENT LAW
HOPE YOU ALL MAKE USE OF IT TO FULLEST AND SUCCEED.
A purified and standardized fraction with a defined minimum of four bioactive or phytochemical compounds of an extract of a medicinal plant or its part, for internal or external use of human beings or animals for diagnosis, treatment, mitigation, or prevention of any diseases but does not include administration by parenteral route.
Nutraceuticals chapter of Advance Pharmacognosy 1 of M Pharm syllabus.
This presentation involves Introduction to Nutraceuticals,
Classification of Nutraceuticals, Herbs as a food, Inorganic /mineral supplements, brief benefits of vitamin supplements, digestive enzymes and its example, use of cereals and Grains, importance of Antioxidants and Polyunsaturated fatty acids, an example of formulation and standardization of Multivitamin Tablets, what all regulatory requirement we need to manufacture Nutraceuticals and FSSAI guidelines for Nutraceuticals, sources- mediinal use - marker compound of some usually used Nutraceuticals.
In this slide contains Introductionnof Indian pharmacopeia, ayurvedic, unani pharmacopeia and monographs of herbal drugs.
Presented by: P.SUDHEER KUMAR (Department of pharmaceutical analysis ).RIPER, anantapur
In this slide contains Monographs of Herbal Drugs Study in British Herbal Pharmacopoeia and American Herbal Pharmacopoeia.
Presented by: M.SUDHEESHNA (Department of pharmaceutical analysis ).RIPER, anantapur
GMP Requirements & Drug & Cosmetic Act Provision.pptxEasy Concept
Good Manufacturing Practices (GMP) is that part of quality assurance, which ensures that products are regularly produced and controlled according to the quality standards suitable for their use.
(GMP) comes in Schedule M in D & C Act 1940 and Rules 1945.
GMPs are the requirements that the drug and methods/control /facilities used in their manufacturing, processing and packaging conforms to practice that will assure the safety and efficacy of the product.
Standardization of herbal drugs refers to “confirmation of its identity and determination of its quality, purity and detection of nature of adulterant by various parameters”.
Stability testing of natural products.docxKipaPape
Stability is defined as the capacity of drug to remain within established specification limits to maintain its identity, strength, quality and purity throughout the retest or expiration dating period.
It is the ability of formulations to retain its physical, chemical, microbiological and toxicological parameters same that time of manufacturer.
Herbal drugs are usually considered safe but when taken along with other drugs of chemical origin (allopathic drugs), they do interact with them and cause Bio-drug interaction
WHO guidelines on herbal drug monitoringKaustav Dey
This presentation points out the various guidelines laid out by World health organization for safe & effective way of monitoring of Herbal Medicine in a pharmacovigilance setting
INDIAN AND INTERNATIONAL PATENT LAW AS APPLICABLE TO HERBAL AND NATURAL PRODUCTSTejaswini Chandra
ITS A USEFUL TOPIS FOR LAW STUDNETS REGARDING THE HERBAL DRUGS AND NATURAL PRODUCTS .
ALSO USEFUL FOR THE MPHARM STUDENTS OF ALL DOMAIN TO STUDY REGARDING THE PATENT LAW
HOPE YOU ALL MAKE USE OF IT TO FULLEST AND SUCCEED.
A purified and standardized fraction with a defined minimum of four bioactive or phytochemical compounds of an extract of a medicinal plant or its part, for internal or external use of human beings or animals for diagnosis, treatment, mitigation, or prevention of any diseases but does not include administration by parenteral route.
Nutraceuticals chapter of Advance Pharmacognosy 1 of M Pharm syllabus.
This presentation involves Introduction to Nutraceuticals,
Classification of Nutraceuticals, Herbs as a food, Inorganic /mineral supplements, brief benefits of vitamin supplements, digestive enzymes and its example, use of cereals and Grains, importance of Antioxidants and Polyunsaturated fatty acids, an example of formulation and standardization of Multivitamin Tablets, what all regulatory requirement we need to manufacture Nutraceuticals and FSSAI guidelines for Nutraceuticals, sources- mediinal use - marker compound of some usually used Nutraceuticals.
In this slide contains Introductionnof Indian pharmacopeia, ayurvedic, unani pharmacopeia and monographs of herbal drugs.
Presented by: P.SUDHEER KUMAR (Department of pharmaceutical analysis ).RIPER, anantapur
In this slide contains Monographs of Herbal Drugs Study in British Herbal Pharmacopoeia and American Herbal Pharmacopoeia.
Presented by: M.SUDHEESHNA (Department of pharmaceutical analysis ).RIPER, anantapur
GMP Requirements & Drug & Cosmetic Act Provision.pptxEasy Concept
Good Manufacturing Practices (GMP) is that part of quality assurance, which ensures that products are regularly produced and controlled according to the quality standards suitable for their use.
(GMP) comes in Schedule M in D & C Act 1940 and Rules 1945.
GMPs are the requirements that the drug and methods/control /facilities used in their manufacturing, processing and packaging conforms to practice that will assure the safety and efficacy of the product.
Standardization of herbal drugs refers to “confirmation of its identity and determination of its quality, purity and detection of nature of adulterant by various parameters”.
Stability testing of natural products.docxKipaPape
Stability is defined as the capacity of drug to remain within established specification limits to maintain its identity, strength, quality and purity throughout the retest or expiration dating period.
It is the ability of formulations to retain its physical, chemical, microbiological and toxicological parameters same that time of manufacturer.
some Monograph of herbal drugs according to siddha and unani pharmacopoeiaRAGHAV DOGRA
Yunani or Unani medicine (Urdu: طب یونانی tibb yūnānī[1]) is the term for Perso-Arabic traditional medicine as practiced in Mughal India and in Muslim culture in South Asia and modern day Central Asia. The term is derived from Arabic Yūnānī "Greek",[2] as the Perso-Arabic system of medicine was in turn based on the teachings of the Greek physicians Hippocrates and Galen.[3]
The Hellenistic origin of Unani medicine is still visible in its being based on the classical four humours: Phlegm (Balgham), Blood (Dam), Yellow bile (Ṣafrā') and Black bile (Saudā'), but it has also been influenced by Indian and Chinese traditional systems
Siddha Medicine (Tamil:சித்த வைத்தியம் Citta- or Tamiḻ-maruttuvam) is a system of traditional medicine originating in ancient Tamilakam in South India.[1][2]
Traditionally, it is taught that the siddhars laid the foundation for this system of medication. Siddhars were spiritual adepts who possessed the ashta siddhis, or the eight supernatural powers. Agastya is considered the first siddha and the guru of all siddhars; the siddha system is believed to have been handed over to him by Murugan, son of Shiva and Parvati.
The Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy of the Government of India coordinates and promotes research in the fields of ayurveda and Siddha medicine.[4] The Central Council of Indian Medicine (CCIM), a statutory body established in 1971 under AYUSH, monitors higher education in areas of Indian medicine, including siddha medicine
Coriander is a spice produced from the round, tan-colored seeds of the coriander plant (Coriandrum sativum), which is a member of the parsley family. The word coriander can be used to describe the entire plant: leaves, stems, seeds, and all.
PHARMACOGNOSTIC STUDIES OF CORIANDRUM SATIVUM LINN.
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Origin: Dried roots or roots and rhizomes of Cephaelis ipecacuanha, known as Rio or Brazilian Ipecacuanha, or of C. acuminata, known as Cartagena, Nicaragua or Panama Ipecacuanha (Fam. Rubiaceae).
Ipecacuanha contains not more than 2% of foreign organic matters and yields not less than 2% of total alkaloids, calculated as emetine.
Medicinal value of plant Rheum australe including its nomenclature, habit and habitat, cultivation and collection, Macro and Microscopic characteristics, phytochemical constituents and its pharmacological action.
Synonyms: Rhizoma Hydrastis, GoldenSeal, Yellow root, Gelbwurzel.
Origin: Dried rhizomes and roots of Hydrastis Canadensis (Fam. Ranunculaceae).
Ph. Eur. 6.2 Hydrastis Canadensis containing not less than 2.5% of hydrastine and not less than 3.0% of berberine, calculated on the dried basis. .
The alkaloids are defined as ‘basic nitrogenous plant products, mostly optically active and possessing nitrogen heterocyclic as their structural unit, with a pronounced physiological action.
The term alkaloid was coined by W. Meissner, a Germon Pharmacist. The first alkaloid to be synthesised was Coniine in1886.It was isolated in 1827.
These are organic product of natural and synthetic origin which are basic in nature and contain one or more nitrogen atom, normally of heterocyclic nature and posses specific pharmacological action on human or animal body.
The true alkaloids are toxic in nature.contain hetrocyclic nitrogen which is derided from amino acids and always basic in nature.
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
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Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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1. MONOGRAPHS OF HERBAL DRUGS
ACCORDING TO SIDDHA
PHARMACOPOEIA
Presented by – Komal Gupta
M. Pharm Analysis
ISFCP
2. INTRODUCTION:-
Siddha system is one of the oldest systems of medicines
in India.
The term Siddha means Achievements.
Siddha medicines is a system of Traditional medicines
originating in ancient Tamilakam in South India.
Siddha focused to ‘ Ashtamahasiddhi ’ the eight
supernatural powers.
3. AMUKKARA
Amukkara is the dried root of Withania somnifera
(L.) Dunal Syn. Physalis somnifera L., P.
flexuous L., P. arborescense DC. (Fam.
Solanaceae).
Is a perennial shrub, found in waste land, cultivated
fields and open grounds throughout India. It is also
cultivated in certain areas of Madhya Pradesh and
Rajasthan.
Roots are collected in winter, washed and cut into
small pieces. The dried root is subjected to
purification process before use. It grows in Mullai
and Marutham thinai.
5. DESCRIPTION
a) Macroscopic:
Roots straight, unbranched, thickness varying with age,
roots bear fiber like secondary roots, outer surface buff to
grey-yellow with longitudinal wrinkles; crown consists of
remains of variously thickened stem bases; fracture short
and uneven odour characteristic , taste bitter and acrid.
b) Microscopic:
Transverse section of root shows cork exfoliated or crushed;
when present rectangular, radially flattened and non-
lignified; cork cambium 2 to 4 diffused rows of cells;
secondary cortex about twenty layers of compact
parenchymatous cells mostly filled with starch grains;
phloem consists of sieve tubes, companion cells, phloem
parenchyma; cambium 4 or 5 rows of tangentially 2
elongated cells; xylem hard forming a closed vascular ring
separated by multiseriate medullary rays.
6. Powder:
Yellowish grey; shows cork cells, parenchyma cells,
tracheids,vessels, fibres and starch.
Identity, Purity and Strength:-
Foreign matter Not more than 2 percent
Total Ash Not more than 7 percent
Acid Insoluble ash Not more than 1 percent
Alcohol soluble extractive Not less than 15 percent
Water soluble extractive Not less than 27 percent
7. ASSAY:-
HPLC conditions for the separation of withaferin A in
Alcohol extract.
Mobile phase : n- Hexane: Isopropanol (9:1)
Flow rate : 0.2 ml/min.
Column : Porasil A coiled column (1.2ft. x 1/8 inch)
Detector : UV at 225 nm.
TLC:-
T.L.C. of Petroleum ether soluble fraction of Alcohol extract
on an aluminum plate precoated with silica gel 60 F254
(E.Merck) 0.2 mm. thickness using Petroleum ether (80 -
100° C).Chloroform (1:1) spraying with 10% Methanolic
Sulphuric acid reagent and heating the plate for ten
minutes at 105oC shows two spots at Rf. 0.17 (violet) and
0.92 (grayish brown).
8. CONSTITUENTS:-
Withanolides- withaferin A, withanone, withanolides I, II, III,
III A, C, D, E, F, G, H, I, J,K, L, M, WS-I, P and S
,withasomidienone, cuscohygrine, anahygrine, tropine,
pseudotropine,anaferine,isopellatierine, 3- tropyltigloate.
PROPERTIES AND ACTIONS:-
Cuvai (taste) : Kaippu (bitter)
Gunam (quality) : Ilaku (glittery,soft,moist)
Virium (sensation) : Veppam (heat)
Pirivu (section) : Karppu(noir)
Ceykai (ability) : Anamaiperukki, Kayakarpamakki,
Urakkamundakki, Uramakki, Udalveppakarri, Udarterri,
Vikkamurukki.
10. MANCAL
Mancal is the dried and cured rhizome of Curcuma longa
L. Syn. C. domestica Valeton(Fam. Zingiberaceae).
Isa perennial herb, extensively cultivated in all parts of the
country; crop is harvested after 9 to 10 months when lower
leaves turn yellow; rhizomes carefully dug up withhand-
picks between October-April and cured by boiling in its own
decoction and dried.
It grows in Kurinci and Marutham thinai.
12. DESCRIPTION:-
a) Macroscopic
Rhizomes ovate, oblong or pyriform (round turmeric) or
cylindrical, often short branched (long turmeric), former
about half as broad as long, latter 2 to 5 cm. long and about
1 to 1.8 cm. thick, externally yellowish to yellowish-brown
with root scars and annulations of leaf bases; fracture
horny, fractured surface orange to reddish brown;central
cylinder twice as broad as cortex; odour and taste
characteristic.
b) Microscopic:
Transverse section of rhizome shows epidermis with thick-
walled, cubical cells of various dimensions; a few layers of
cork developed under epidermis and oleo-resin cells with
brownish contents scattered; cork generally composed of 4
to 6 layers of thin-walled, brick-shaped parenchyma; cortex
characterised by the presence of
13. Cont..
mostly thinwalled rounded parenchyma cells and scattered
collateral vascular bundles; cells of ground tissue contain
starch grains of 4 to 15 μm in diameter; oil cell with
suberised walls containing either orange-yellow globules of
volatile oil or amorphous resinous matter; vessels mainly
spirally thickened, a few reticulate and annular.
Powder:-
Yellow; shows fragments of cork cells; parenchyma cells
with gelatinised starch grains; oleo-resin cells with brownish
content; vessels with spiral thickening; a few oil globules;
starch grains simple, rounded, measuring 4 to 15 μm in
diameter.
14. IDENTIFICATION:-
On the addition of concentrated Sulphuric acid or a mixture
of concentrated Sulphuric acid and alcohol to the powdered
drug, a deep crimson colour is produced.
A piece of filter paper is impregnated with an alcoholic
extract of the powder, dried, and then moistened with a
solution of Boric acid slightly acidified with Hydrochloric acid,
dried again, the filter paper assumes a pink or brownish red
colour which becomes deep blue or greenish-black on the
additςion of alkali.
15. IDENTITY, PURITY AND STRENGTH:-
Foreign matter Not more than 2 percent
Total Ash Not more than 9 percent
Acid insoluble ash Not more than 1 percent
Alcohol soluble extractive Not less than 8 percent
Water soluble extractive Not less than 12 percent
Volatile oil Not less than 4 percent
16. TLC:-
T.L.C. of Alcoholic extract of the drug on aluminium plate
precoated with silica gel 60 F254 (E. Merck) 0.2 mm.
thickness using Toluene: Ethyl acetate (9:1) shows five
spots under UV (366nm) at Rf. 0.10 (yellow), 0.15 (greenish
yellow), 0.38, 0.48 and 0.94 (all skyblue). With
Anisaldehyde- Sulphuric acid reagent and heating the plate
for five minutes at 105oC ten spots appear at Rf. 0.10
(blackish yellow), 0.15 (dull yellow), 0.28, 0.35, 0.43, 0.51
(all violet), 0.58 (light pink), 0.64 (violet), 0.82 (red) and
0.94 (pink).
Constituents:-
Curcumin, desmethoxy curcumin, bisdemethoxy curcumin,
dihydrocurcumin, β-turmerone,bisabolane derivatives,
ukonan A, B, C & D phytosterols and fatty acids.