This document contains radiographs and photomicrographs showing various bone diseases including: - Osteogenesis imperfecta showing opaque dentin and thin enamel and dentin. - Osteopetrosis showing dense bone replacing marrow in the infantile form with mandibular osteomyelitis. - Cleidocranial dysplasia with unerupted teeth and ability to approximate shoulders. - Paget's disease with cranial enlargement and dense new bone formation. - Giant cell tumor showing large giant cells in destroyed maxilla. - Massive osteolysis with extensive mandibular bone loss and pathologic fracture over 8 months.

1. Osteogenesis imperfecta.
A. Opalescent dentin in a patient with osteogenesis imperfecta.
B. Bite-wing radiograph of the same patient showing shell teeth with thin dentin
and enamel of normal thickness.

2. Blue sclera in a patient with osteogenesis imperfecta

4. Osteopetrosis. This 24 -year-old white man has the infantile form of
osteopetrosis. He has suffered from mandibular osteomyelitis And multiple
draining fistulae are present on his face.

8. Osteopetrosis. Low-power photomicrograph showing sclerotic bone that is replacing the
normal cancellous bone. The inset shows a nodular pattern of the dense bone obliterating
the marrow spaces.

9. Cleidocranial dysplasia. The patient can almost approximate
her shoulders in front of her chest.

10. Cleidocranial dysplasia. Panoramic radiograph showing
multiple unerupted teeth

11. Focal osteoporotic marrow defect. The periapical
film shows a radiolucent area containing fine trabeculatlons.

12. Focal osteoporotic marrow defect. Photornicrograph showing
normal hematopoietic bone marrow.

13. Idiopathic osteosclerosis. A. An asymptomatic area of bane sclerosis is seen
between and apical to the roots of the first and second mandibular molars. B, no
appreciable change can be seen on this radiograph taken 10 years later.

14. Condensing osteitis. Increased areas of radiodensity
surrounding the apices of the nonvital mandibular first
molar.

15. Bone scar. Residual area of increased radiodensity
in the area of extraction of the mandibular first molar.

19. Paget's disease. Lateral skull film shows marked enlargement of the cranium
with new bone formation above the outer table of the skull and a patchy, dense,
"cotton wool“ appearance.

20. Paget's disease. Periapical film showing the
"cotton wool" appearance of the bone.

22. Paget's disease. Prominent osteoblastic and osteoclastic
activity surround the bone trabeculae. Note the resting and
reversal lines.

23. Giant cell tumor. This photomicrograph shows large giant cells that are
distributed in a cellular mesenchymal tissue. This specimen was froman
aggressive lesion that had destroyed most of the maxilla.

24. Massive osteolysis. Periapical radiograph showing an ill-defined radiolucency
associated with vital mandibular teeth.
Note the loss of lamina dura.

25. Massive osteolysis. Panoramic radiograph of the same patient, showing
extensive bone loss and a pathologic fracture of the left mandible. This
destruction occurred over an 8-month period.

26. Massive osteolysis. Biopsy specimen from the same patient. The loose.
Highly vascular connective tissue shows a diffuse chronic
inflammatory cell infiltrate.