This document discusses kidney and urinary tract anatomy, physiology, and disease. It describes the structure and function of the kidneys and nephrons, including filtration, reabsorption, and endocrine functions. Common tests for evaluating renal and urinary tract disease are outlined, including urine analysis, imaging techniques like ultrasound and CT, and renal function tests. Specific conditions that can be investigated include kidney stones, infections, glomerular diseases, and tubular disorders.
Chronic kidney disease (CKD) consists of a spectrum of different pathophysiologic processes associated with abnormal kidney function, and a progressive decline in glomerular filtration rate (GFR).
Acute kidney failure happens when your kidneys suddenly lose the ability to eliminate excess salts, fluids, and waste materials from the blood. Acute kidney failure is also called acute kidney injury or acute renal failure. It's common in people who are already in the hospital. It may develop rapidly over a few hours.
Chronic kidney disease (CKD) means your kidneys are damaged and can't filter blood the way they should. The disease is called “chronic” because the damage to your kidneys happens slowly over a long period of time.
Chronic kidney disease (CKD) consists of a spectrum of different pathophysiologic processes associated with abnormal kidney function, and a progressive decline in glomerular filtration rate (GFR).
Acute kidney failure happens when your kidneys suddenly lose the ability to eliminate excess salts, fluids, and waste materials from the blood. Acute kidney failure is also called acute kidney injury or acute renal failure. It's common in people who are already in the hospital. It may develop rapidly over a few hours.
Chronic kidney disease (CKD) means your kidneys are damaged and can't filter blood the way they should. The disease is called “chronic” because the damage to your kidneys happens slowly over a long period of time.
This includes a comprehensive study of Renal Failure - both AKI & CKD (ESRD). It is very helpful for those who are managing the clients with renal failure.
Urinary Tract Infection with Nursing ManagementSwatilekha Das
Urinary Tract Infection introduction, definition, common microorganisms, classification, predisposing factors, clinical manifestations, pathophysiology, diagnostic studies, medical management and nursing management along with assessment, nursing diagnosis, goal, nursing interventions and expected outcome after the intervention.
Nephrotic syndrome may be caused by primary (idiopathic) renal disease or by a variety of secondary causes. Patients present with marked edema, proteinuria, hypoalbuminemia, and often hyperlipidemia.
Nephrotic syndrome is a primary glomerular disease characterized by the following:
Marked increase in protein in the urine (proteinuria)
Decrease in albumin in the blood (hypoalbuminemia)
Edema (The swelling (edema), can be most noticeable on the face, around the eyes, around the feet and ankles, and in the belly area (or the abdomen).
High serum cholesterol and low-density lipoproteins (hyperlipidemia)
Nephrotic syndrome is a clinical disorder characterized by marked increase of protein in the urine ( proteinuria ), decrease in albumin in the blood (hypoalbuminemia ),edema, & excess lipids in the blood ( hyperlipidemia )
Pathophysiology
Nephrotic syndrome can occur with almost any intrinsic renal disease or systemic disease that affects the glomerulus.
Although generally considered a disorder of childhood, nephrotic syndrome does occur in adults, including the elderly. Causes include:
Chronic glomerulonephritis
Diabetes mellitus with intercapillary glomerulosclerosis
Amyloidosis of the kidney
Systemic lupus erythematosus
Multiple myeloma and renal vein thrombosis.
NSAIDs
Pre eclampsia
Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood.
This presentation comprises of congenital anomalies of kidney and urinary tract made concise and in depth for PG preparation. It contains all important topics of the regarding subject covered in detail.
kindly check this slide for nephrotic syndrome. in this slide i covered all the points regarding this topic.
if any suggestion give comment on this topic
Pyelonephritis
It is the inflammation of the kidney & upper urinary tract that usually results from the bacterial infection of the bladder.
Pyelonephritis can be classified in several different catagories:
-acute pyelonephritis
-chronic pyelonephritis
-xanthogranulomatous pyelonephritis
Hepatic encephalopathy is one of the deadly complication of liver diseases, occurs due to profound liver failure and from accumulation of ammonia and other toxic metabolites in blood.
Hepatic coma is advanced stage of hepatic encephalopathy.
This includes a comprehensive study of Renal Failure - both AKI & CKD (ESRD). It is very helpful for those who are managing the clients with renal failure.
Urinary Tract Infection with Nursing ManagementSwatilekha Das
Urinary Tract Infection introduction, definition, common microorganisms, classification, predisposing factors, clinical manifestations, pathophysiology, diagnostic studies, medical management and nursing management along with assessment, nursing diagnosis, goal, nursing interventions and expected outcome after the intervention.
Nephrotic syndrome may be caused by primary (idiopathic) renal disease or by a variety of secondary causes. Patients present with marked edema, proteinuria, hypoalbuminemia, and often hyperlipidemia.
Nephrotic syndrome is a primary glomerular disease characterized by the following:
Marked increase in protein in the urine (proteinuria)
Decrease in albumin in the blood (hypoalbuminemia)
Edema (The swelling (edema), can be most noticeable on the face, around the eyes, around the feet and ankles, and in the belly area (or the abdomen).
High serum cholesterol and low-density lipoproteins (hyperlipidemia)
Nephrotic syndrome is a clinical disorder characterized by marked increase of protein in the urine ( proteinuria ), decrease in albumin in the blood (hypoalbuminemia ),edema, & excess lipids in the blood ( hyperlipidemia )
Pathophysiology
Nephrotic syndrome can occur with almost any intrinsic renal disease or systemic disease that affects the glomerulus.
Although generally considered a disorder of childhood, nephrotic syndrome does occur in adults, including the elderly. Causes include:
Chronic glomerulonephritis
Diabetes mellitus with intercapillary glomerulosclerosis
Amyloidosis of the kidney
Systemic lupus erythematosus
Multiple myeloma and renal vein thrombosis.
NSAIDs
Pre eclampsia
Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood.
This presentation comprises of congenital anomalies of kidney and urinary tract made concise and in depth for PG preparation. It contains all important topics of the regarding subject covered in detail.
kindly check this slide for nephrotic syndrome. in this slide i covered all the points regarding this topic.
if any suggestion give comment on this topic
Pyelonephritis
It is the inflammation of the kidney & upper urinary tract that usually results from the bacterial infection of the bladder.
Pyelonephritis can be classified in several different catagories:
-acute pyelonephritis
-chronic pyelonephritis
-xanthogranulomatous pyelonephritis
Hepatic encephalopathy is one of the deadly complication of liver diseases, occurs due to profound liver failure and from accumulation of ammonia and other toxic metabolites in blood.
Hepatic coma is advanced stage of hepatic encephalopathy.
Each kidney contains over 1 million tiny structures called nephrons. Each nephron has a glomerulus, the site of blood filtration. The glomerulus is a network of capillaries surrounded by a cuplike structure, the glomerular capsule (or Bowman’s capsule). As blood flows through the glomerulus, blood pressure pushes water and solutes from the capillaries into the capsule through a filtration membrane. This glomerular filtration begins the urine formation process.Inside the glomerulus, blood pressure pushes fluid from capillaries into the glomerular capsule through a specialized layer of cells. This layer, the filtration membrane, allows water and small solutes to pass but blocks blood cells and large proteins. Those components remain in the bloodstream. The filtrate (the fluid that has passed through the membrane) flows from the glomerular capsule further into the nephron.The glomerulus filters water and small solutes out of the bloodstream. The resulting filtrate contains waste, but also other substances the body needs: essential ions, glucose, amino acids, and smaller proteins. When the filtrate exits the glomerulus, it flows into a duct in the nephron called the renal tubule. As it moves, the needed substances and some water are reabsorbed through the tube wall into adjacent capillaries. This reabsorption of vital nutrients from the filtrate is the second step in urine creation.The filtrate absorbed in the glomerulus flows through the renal tubule, where nutrients and water are reabsorbed into capillaries. At the same time, waste ions and hydrogen ions pass from the capillaries into the renal tubule. This process is called secretion. The secreted ions combine with the remaining filtrate and become urine. The urine flows out of the nephron tubule into a collecting duct. It passes out of the kidney through the renal pelvis, into the ureter, and down to the bladder.The nephrons of the kidneys process blood and create urine through a process of filtration, reabsorption, and secretion. Urine is about 95% water and 5% waste products. Nitrogenous wastes excreted in urine include urea, creatinine, ammonia, and uric acid. Ions such as sodium, potassium, hydrogen, and calcium are also excreted
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Role of Mukta Pishti in the Management of Hyperthyroidism
medicine.Kidney lecture 1.(dr.ala)
1. KIDNEY AND URINARY TRACT DISEASE
DR. ALAA HUSSAIN A. AWN
KIDNEY TRANSPLANT NEPHROLOGIST AND
SPECIALIST OF INTERNAL MEDICINE
2. HEADLINES
- ANATOMY AND PHYSIOLOGY (kidneys and UT)
-Ix.
Presenting problems in renal and urinary tract disease.
3. ANATOMY AND PHYSIOLOGY
Adult kidneys are 11-14 cm in
length, located in the
retroperitoneal area on either
side of aorta and IVC.
The right kidney is usually a
few centimeters lower
(because the liver lies above
it) ,,
Each kidney contain
approximately one million
nephrons, which receive rich
blood supply ( 20-25% of
cardiac out put)..
4. NEPHRONS
Which involve;
The glomerulus
(afferent arteriole,
efferent arteriole ,
bowman's capsule)
Proximal convoluted
tubule
Loop of henle
Distal convoluted
tubule
Collecting tubule
5. FUNCTIONS OF THE KIDNEYS
Excretion of nitrogenous waste products and toxins.
Body fluid control.
Electrolyte balance.
Acid – base balance
Endocrine function:
1- erythropoietin production
2- activation of vitamin D
3- renin-angiotensin production
6.
7. large volumes of an ultrafiltrate of plasma (120 ml/min, 170
litres/day) at the glomerulus, and selectively reabsorbing
components of this ultrafiltrate at points along the nephron.
The rates of filtration and reabsorption are under the control of
many hormonal and haemodynamic signals.
8. The kidney is the main source of erythropoietin, which is
produced by interstitial peritubular cells in response to hypoxia.
Replacement of erythropoietin reverses the anaemia of chronic
renal failure .
The kidney is essential for vitamin D metabolism; it hydroxylates
25-hydroxycholecalciferol to the active form, 1,25-
dihydroxycholecalciferol. Failure of this process contributes to
the hypocalcaemia and bone disease of chronic renal failure .
9. Renin is secreted from the juxtaglomerular apparatus in
response to
1- reduced afferent arteriolar pressure,
2-stimulation of sympathetic nerves, and
3- changes in sodium content of fluid in the distal convoluted
tubule at the macula densa.
Renin generates angiotensin II , which causes:
1- aldosterone release from the adrenal cortex,
2- constricts the efferent arteriole of the glomerulus and thereby
increases glomerular filtration pressure .
3- induces systemic vasoconstriction.
By these mechanisms, the kidneys 'defend' circulating blood
volume, blood pressure and glomerular filtration during
circulatory shock. However, the same mechanisms lead to
systemic hypertension in renal ischaemia.
10. MECHANISMS OF MICTURITION AND URINARY CONTINENCE
Continence is dependent on anatomical structures, and on
neurological and muscle (sphincter and detrusor) function.
Parasympathetic nerves arising from S2-4 stimulate detrusor
contraction, resulting in micturition.
Sympathetic nerves arising from T10-L2 relay in the pelvic
ganglia and produce detrusor relaxation and contraction of the
bladder neck (both via α-adrenoceptors).
11.
12. The distal sphincter mechanism is innervated by
somatic motor fibres from sacral segments S2-4 which
reach the sphincter either by the pelvic plexus or via
the pudendal nerves.
Afferent sensory impulses pass to the cerebral cortex,
from where reflex-increased sphincter tone and
associated suppression of detrusor contraction inhibits
micturition until it is appropriate.
These factors operate in a coordinated fashion in the
micturition cycle, which has a 'storage' (or 'filling')
phase and a 'voiding' (or 'micturition') phase .
At approximately 75% bladder capacity there is a
desire to void. Voluntary control is now exerted over
the desire to void, which disappears temporarily.
13. The act of micturition is initiated first by voluntary and then by
reflex relaxation of the pelvic floor and distal sphincter
mechanism, followed by reflex detrusor contraction.
These actions are coordinated by the pontine micturition centre.
14. INVESTIGATION OF RENAL AND URINARY
TRACT DISEASE
TESTS OF FUNCTION
IMAGING TECHNIQUES
OTHER TESTS (Radionuclide studies, renal Bx.)
15. Renal excretory function can be assessed by measuring serum
levels of compounds excreted by the kidney, commonly the
products of protein catabolism (urea and creatinine).
Blood urea is a poor guide to renal excretory function as it
varies with protein intake, liver metabolic capacity and renal
perfusion .
16.
17. Serum creatinine is more reliable as it is produced from muscle
at a constant rate and almost completely filtered at the
glomerulus.
If muscle mass remains constant, changes in creatinine
concentration reflect changes in GFR.
However, an increase outside the normal range is typically not
seen until GFR is reduced by about 50% , and isolated
measurements of serum creatinine may give a misleading
impression of renal function, particularly if muscle mass is
unusually small (or large).
18. Urine measurements to derive creatinine clearance provide a
reasonable approximation of the GFR .
More accurate measurement of GFR is now most easily
undertaken by ascertaining the clearance of 51Cr-labelled
ethylene diamine-tetra acetic acid (EDTA).
19. The blood filtered through the glomerulus in a rate of
90-120 cc/min.( 170 L / day)
We use the creatinine clearance as approximation of
glomerular filtration rate.
Creatinine clearance= ( 140-age) wt / (s. creatinine )(
72)
Creatinine clearance in Female=___________* 0.85
Cr cl =U Cr * v / S Cr * Time ( min)
21. URINALYSIS
Dipsticks may be used to screen for blood and protein semi-
quantitatively .
Urine microscopy can detect
red cells of glomerular origin and red cell casts, indicative of
intrinsic renal disease,
white blood cells and bacteria seen in urine infections.
Crystals (e.g. of calcium oxalate, cysteine or urate) may be
seen in renal calculus disease, although calcium oxalate and
urate crystals are also sometimes found in normal urine that has
been left to stand.
Urine pH can provide diagnostic information in the assessment
of renal tubular acidosis
persistently low specific gravity will be found in diabetes
insipidus .
22. SHOWING ON THE RIGHT GLOMERULAR BLEEDING WITH MANY
DYSMORPHIC FORMS INCLUDING ACANTHOCYTES (TEARDROP
FORMS), AND ON THE LEFT BLEEDING FROM LOWER IN THE
URINARY TRACT
23. ,ON THE LEFT, PHASE CONTRAST IMAGES SHOW HYALINE
CASTS, A NORMAL FEATURE OF URINE (× 160). ON THE RIGHT,
NUMEROUS RED CELLS AND A LARGE RED CELL CAST IN ACUTE
GLOMERULAR INFLAMMATION (× 100, NOT PHASE CONTRAST
24. Timed urine collections can be used;( 24 h)
To measure creatinine clearance as a surrogate for GFR
can provide a quantitative measure of urinary protein loss.
measure the urinary excretion rates of compounds such as
calcium, oxalate and urate that can form renal calculi .
25. Simple measurement of tubular excretory function can be made
by comparison of blood and urine ratios of electrolytes to
creatinine.
Fractional excretion of sodium (= urinary Na/plasma Na ×
plasma creatinine/urine creatinine).
It is reduced in volume depletion when the tubules are avidly
conserving sodium, and increased in the tubular damage
associated with acute tubular necrosis.
26. IMAGING TECHNIQUES
Plain X-rays ( KUB)
may show the renal outlines ,
opaque calculi and calcification within the renal
tract.