The document discusses various mediation efforts of the Israeli-Palestinian conflict over time. It outlines UN and US-led mediation attempts from 1948 to 1967 that largely failed. The Camp David Accords of 1978 saw success when US President Carter mediated direct talks between Egyptian President Sadat and Israeli Prime Minister Begin, resulting in the 1979 Egypt-Israel Peace Treaty. More recent mediation attempts by the US, UN and Quartet since 2000 have faced greater challenges and obstacles. The document analyzes factors that contributed to the success of the 1978 Camp David Accords and challenges facing current US envoy George Mitchell.