(Individuals With Disabilities Act Transformation Over the Years)DSilvaGraf83
(Individuals With Disabilities Act Transformation Over the Years)
Discussion Forum Instructions:
1. You must post at least three times each week.
2. Your initial post is due Tuesday of each week and the following two post are due before Sunday.
3. All post must be on separate days of the week.
4. Post must be at least 150 words and cite all of your references even it its the book.
Discussion Topic:
Describe how the lives of students with disabilities from culturally and/or linguistically diverse backgrounds have changed since the advent of IDEA. What do you feel are some things that can or should be implemented to better assist with students that have disabilities? Tell me about these ideas and how would you integrate them?
ANOVA
ANOVA
• Analysis of Variance
• Statistical method to analyzes variances to determine if the means from more than
two populations are the same
• compare the between-sample-variation to the within-sample-variation
• If the between-sample-variation is sufficiently large compared to the within-sample-
variation it is likely that the population means are statistically different
• Compares means (group differences) among levels of factors. No
assumptions are made regarding how the factors are related
• Residual related assumptions are the same as with simple regression
• Explanatory variables can be qualitative or quantitative but are categorized
for group investigations. These variables are often referred to as factors
with levels (category levels)
ANOVA Assumptions
• Assume populations , from which the response values for the groups
are drawn, are normally distributed
• Assumes populations have equal variances
• Can compare the ratio of smallest and largest sample standard deviations.
Between .05 and 2 are typically not considered evidence of a violation
assumption
• Assumes the response data are independent
• For large sample sizes, or for factor level sample sizes that are equal,
the ANOVA test is robust to assumption violations of normality and
unequal variances
ANOVA and Variance
Fixed or Random Factors
• A factor is fixed if its levels are chosen before the ANOVA investigation
begins
• Difference in groups are only investigated for the specific pre-selected factors
and levels
• A factor is random if its levels are choosen randomly from the
population before the ANOVA investigation begins
Randomization
• Assigning subjects to treatment groups or treatments to subjects
randomly reduces the chance of bias selecting results
ANOVA hypotheses statements
One-way ANOVA
One-Way ANOVA
Hypotheses statements
Test statistic
=
𝐵𝑒𝑡𝑤𝑒𝑒𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
𝑊𝑖𝑡ℎ𝑖𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
Under the null hypothesis both the between and within group variances estimate the
variance of the random error so the ratio is assumed to be close to 1.
Null Hypothesis
Alternate Hypothesis
One-Way ANOVA
One-Way ANOVA
One-Way ANOVA Excel Output
Treatme
(Individuals With Disabilities Act Transformation Over the Years)DMoseStaton39
(Individuals With Disabilities Act Transformation Over the Years)
Discussion Forum Instructions:
1. You must post at least three times each week.
2. Your initial post is due Tuesday of each week and the following two post are due before Sunday.
3. All post must be on separate days of the week.
4. Post must be at least 150 words and cite all of your references even it its the book.
Discussion Topic:
Describe how the lives of students with disabilities from culturally and/or linguistically diverse backgrounds have changed since the advent of IDEA. What do you feel are some things that can or should be implemented to better assist with students that have disabilities? Tell me about these ideas and how would you integrate them?
ANOVA
ANOVA
• Analysis of Variance
• Statistical method to analyzes variances to determine if the means from more than
two populations are the same
• compare the between-sample-variation to the within-sample-variation
• If the between-sample-variation is sufficiently large compared to the within-sample-
variation it is likely that the population means are statistically different
• Compares means (group differences) among levels of factors. No
assumptions are made regarding how the factors are related
• Residual related assumptions are the same as with simple regression
• Explanatory variables can be qualitative or quantitative but are categorized
for group investigations. These variables are often referred to as factors
with levels (category levels)
ANOVA Assumptions
• Assume populations , from which the response values for the groups
are drawn, are normally distributed
• Assumes populations have equal variances
• Can compare the ratio of smallest and largest sample standard deviations.
Between .05 and 2 are typically not considered evidence of a violation
assumption
• Assumes the response data are independent
• For large sample sizes, or for factor level sample sizes that are equal,
the ANOVA test is robust to assumption violations of normality and
unequal variances
ANOVA and Variance
Fixed or Random Factors
• A factor is fixed if its levels are chosen before the ANOVA investigation
begins
• Difference in groups are only investigated for the specific pre-selected factors
and levels
• A factor is random if its levels are choosen randomly from the
population before the ANOVA investigation begins
Randomization
• Assigning subjects to treatment groups or treatments to subjects
randomly reduces the chance of bias selecting results
ANOVA hypotheses statements
One-way ANOVA
One-Way ANOVA
Hypotheses statements
Test statistic
=
𝐵𝑒𝑡𝑤𝑒𝑒𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
𝑊𝑖𝑡ℎ𝑖𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
Under the null hypothesis both the between and within group variances estimate the
variance of the random error so the ratio is assumed to be close to 1.
Null Hypothesis
Alternate Hypothesis
One-Way ANOVA
One-Way ANOVA
One-Way ANOVA Excel Output
Treatme
This Slides presents different types of Parametric Test- like
T-test,
Parametric Test,
Assumption of Parametric Test,
Paired T Test,
One Sample T Test,
ANOVA,
ANCOVA,
Regression,
Two Way ANOVA,
Repeated Measure ANOVA,
Multiple Regression
(Individuals With Disabilities Act Transformation Over the Years)DSilvaGraf83
(Individuals With Disabilities Act Transformation Over the Years)
Discussion Forum Instructions:
1. You must post at least three times each week.
2. Your initial post is due Tuesday of each week and the following two post are due before Sunday.
3. All post must be on separate days of the week.
4. Post must be at least 150 words and cite all of your references even it its the book.
Discussion Topic:
Describe how the lives of students with disabilities from culturally and/or linguistically diverse backgrounds have changed since the advent of IDEA. What do you feel are some things that can or should be implemented to better assist with students that have disabilities? Tell me about these ideas and how would you integrate them?
ANOVA
ANOVA
• Analysis of Variance
• Statistical method to analyzes variances to determine if the means from more than
two populations are the same
• compare the between-sample-variation to the within-sample-variation
• If the between-sample-variation is sufficiently large compared to the within-sample-
variation it is likely that the population means are statistically different
• Compares means (group differences) among levels of factors. No
assumptions are made regarding how the factors are related
• Residual related assumptions are the same as with simple regression
• Explanatory variables can be qualitative or quantitative but are categorized
for group investigations. These variables are often referred to as factors
with levels (category levels)
ANOVA Assumptions
• Assume populations , from which the response values for the groups
are drawn, are normally distributed
• Assumes populations have equal variances
• Can compare the ratio of smallest and largest sample standard deviations.
Between .05 and 2 are typically not considered evidence of a violation
assumption
• Assumes the response data are independent
• For large sample sizes, or for factor level sample sizes that are equal,
the ANOVA test is robust to assumption violations of normality and
unequal variances
ANOVA and Variance
Fixed or Random Factors
• A factor is fixed if its levels are chosen before the ANOVA investigation
begins
• Difference in groups are only investigated for the specific pre-selected factors
and levels
• A factor is random if its levels are choosen randomly from the
population before the ANOVA investigation begins
Randomization
• Assigning subjects to treatment groups or treatments to subjects
randomly reduces the chance of bias selecting results
ANOVA hypotheses statements
One-way ANOVA
One-Way ANOVA
Hypotheses statements
Test statistic
=
𝐵𝑒𝑡𝑤𝑒𝑒𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
𝑊𝑖𝑡ℎ𝑖𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
Under the null hypothesis both the between and within group variances estimate the
variance of the random error so the ratio is assumed to be close to 1.
Null Hypothesis
Alternate Hypothesis
One-Way ANOVA
One-Way ANOVA
One-Way ANOVA Excel Output
Treatme
(Individuals With Disabilities Act Transformation Over the Years)DMoseStaton39
(Individuals With Disabilities Act Transformation Over the Years)
Discussion Forum Instructions:
1. You must post at least three times each week.
2. Your initial post is due Tuesday of each week and the following two post are due before Sunday.
3. All post must be on separate days of the week.
4. Post must be at least 150 words and cite all of your references even it its the book.
Discussion Topic:
Describe how the lives of students with disabilities from culturally and/or linguistically diverse backgrounds have changed since the advent of IDEA. What do you feel are some things that can or should be implemented to better assist with students that have disabilities? Tell me about these ideas and how would you integrate them?
ANOVA
ANOVA
• Analysis of Variance
• Statistical method to analyzes variances to determine if the means from more than
two populations are the same
• compare the between-sample-variation to the within-sample-variation
• If the between-sample-variation is sufficiently large compared to the within-sample-
variation it is likely that the population means are statistically different
• Compares means (group differences) among levels of factors. No
assumptions are made regarding how the factors are related
• Residual related assumptions are the same as with simple regression
• Explanatory variables can be qualitative or quantitative but are categorized
for group investigations. These variables are often referred to as factors
with levels (category levels)
ANOVA Assumptions
• Assume populations , from which the response values for the groups
are drawn, are normally distributed
• Assumes populations have equal variances
• Can compare the ratio of smallest and largest sample standard deviations.
Between .05 and 2 are typically not considered evidence of a violation
assumption
• Assumes the response data are independent
• For large sample sizes, or for factor level sample sizes that are equal,
the ANOVA test is robust to assumption violations of normality and
unequal variances
ANOVA and Variance
Fixed or Random Factors
• A factor is fixed if its levels are chosen before the ANOVA investigation
begins
• Difference in groups are only investigated for the specific pre-selected factors
and levels
• A factor is random if its levels are choosen randomly from the
population before the ANOVA investigation begins
Randomization
• Assigning subjects to treatment groups or treatments to subjects
randomly reduces the chance of bias selecting results
ANOVA hypotheses statements
One-way ANOVA
One-Way ANOVA
Hypotheses statements
Test statistic
=
𝐵𝑒𝑡𝑤𝑒𝑒𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
𝑊𝑖𝑡ℎ𝑖𝑛 𝐺𝑟𝑜𝑢𝑝 𝑉𝑎𝑟𝑖𝑎𝑛𝑐𝑒
Under the null hypothesis both the between and within group variances estimate the
variance of the random error so the ratio is assumed to be close to 1.
Null Hypothesis
Alternate Hypothesis
One-Way ANOVA
One-Way ANOVA
One-Way ANOVA Excel Output
Treatme
This Slides presents different types of Parametric Test- like
T-test,
Parametric Test,
Assumption of Parametric Test,
Paired T Test,
One Sample T Test,
ANOVA,
ANCOVA,
Regression,
Two Way ANOVA,
Repeated Measure ANOVA,
Multiple Regression
Statistics for Anaesthesiologists covers basic to intermediate level statistics for researchers especially commonly used study designs or tests in Anaesthesiology research.
Calculating Analysis of Variance (ANOVA) and Post Hoc Analyses Follo.docxaman341480
Calculating Analysis of Variance (ANOVA) and Post Hoc Analyses Following ANOVA
Analysis of variance (ANOVA)
is a statistical procedure that compares data between two or more groups or conditions to investigate the presence of differences between those groups on some continuous dependent variable (see
Exercise 18
). In this exercise, we will focus on the
one-way ANOVA
, which involves testing one independent variable and one dependent variable (as opposed to other types of ANOVAs, such as factorial ANOVAs that incorporate multiple independent variables).
Why ANOVA and not a
t
-test? Remember that a
t
-test is formulated to compare two sets of data or two groups at one time (see
Exercise 23
for guidance on selecting appropriate statistics). Thus, data generated from a clinical trial that involves four experimental groups, Treatment 1, Treatment 2, Treatments 1 and 2 combined, and a Control, would require 6
t
-tests. Consequently, the chance of making a Type I error (alpha error) increases substantially (or is inflated) because so many computations are being performed. Specifically, the chance of making a Type I error is the number of comparisons multiplied by the alpha level. Thus, ANOVA is the recommended statistical technique for examining differences between more than two groups (
Zar, 2010
).
ANOVA is a procedure that culminates in a statistic called the
F
statistic. It is this value that is compared against an
F
distribution (see
Appendix C
) in order to determine whether the groups significantly differ from one another on the dependent variable. The formulas for ANOVA actually compute two estimates of variance: One estimate represents differences between the groups/conditions, and the other estimate represents differences among (within) the data.
Research Designs Appropriate for the One-Way ANOVA
Research designs that may utilize the one-way ANOVA include the randomized experimental, quasi-experimental, and comparative designs (
Gliner, Morgan, & Leech, 2009
). The independent variable (the “grouping” variable for the ANOVA) may be active or attributional. An active independent variable refers to an intervention, treatment, or program. An attributional independent variable refers to a characteristic of the participant, such as gender, diagnosis, or ethnicity. The ANOVA can compare two groups or more. In the case of a two-group design, the researcher can either select an independent samples
t
-test or a one-way ANOVA to answer the research question. The results will always yield the same conclusion, regardless of which test is computed; however, when examining differences between more than two groups, the one-way ANOVA is the preferred statistical test.
Example 1: A researcher conducts a randomized experimental study wherein she randomizes participants to receive a high-dosage weight loss pill, a low-dosage weight loss pill, or a placebo. She assesses the number of pounds lost from baseline to post-treatment
378
for the thre ...
This powerpoint presentation gives a brief explanation about the biostatic data .this is quite helpful to individuals to understand the basic research methodology terminologys
Inferential statistics are techniques that allow us to use these samples to make generalizations about the populations from which the samples were drawn. ... The methods of inferential statistics are (1) the estimation of parameter(s) and (2) testing of statistical hypotheses.
Statistics for Anaesthesiologists covers basic to intermediate level statistics for researchers especially commonly used study designs or tests in Anaesthesiology research.
Calculating Analysis of Variance (ANOVA) and Post Hoc Analyses Follo.docxaman341480
Calculating Analysis of Variance (ANOVA) and Post Hoc Analyses Following ANOVA
Analysis of variance (ANOVA)
is a statistical procedure that compares data between two or more groups or conditions to investigate the presence of differences between those groups on some continuous dependent variable (see
Exercise 18
). In this exercise, we will focus on the
one-way ANOVA
, which involves testing one independent variable and one dependent variable (as opposed to other types of ANOVAs, such as factorial ANOVAs that incorporate multiple independent variables).
Why ANOVA and not a
t
-test? Remember that a
t
-test is formulated to compare two sets of data or two groups at one time (see
Exercise 23
for guidance on selecting appropriate statistics). Thus, data generated from a clinical trial that involves four experimental groups, Treatment 1, Treatment 2, Treatments 1 and 2 combined, and a Control, would require 6
t
-tests. Consequently, the chance of making a Type I error (alpha error) increases substantially (or is inflated) because so many computations are being performed. Specifically, the chance of making a Type I error is the number of comparisons multiplied by the alpha level. Thus, ANOVA is the recommended statistical technique for examining differences between more than two groups (
Zar, 2010
).
ANOVA is a procedure that culminates in a statistic called the
F
statistic. It is this value that is compared against an
F
distribution (see
Appendix C
) in order to determine whether the groups significantly differ from one another on the dependent variable. The formulas for ANOVA actually compute two estimates of variance: One estimate represents differences between the groups/conditions, and the other estimate represents differences among (within) the data.
Research Designs Appropriate for the One-Way ANOVA
Research designs that may utilize the one-way ANOVA include the randomized experimental, quasi-experimental, and comparative designs (
Gliner, Morgan, & Leech, 2009
). The independent variable (the “grouping” variable for the ANOVA) may be active or attributional. An active independent variable refers to an intervention, treatment, or program. An attributional independent variable refers to a characteristic of the participant, such as gender, diagnosis, or ethnicity. The ANOVA can compare two groups or more. In the case of a two-group design, the researcher can either select an independent samples
t
-test or a one-way ANOVA to answer the research question. The results will always yield the same conclusion, regardless of which test is computed; however, when examining differences between more than two groups, the one-way ANOVA is the preferred statistical test.
Example 1: A researcher conducts a randomized experimental study wherein she randomizes participants to receive a high-dosage weight loss pill, a low-dosage weight loss pill, or a placebo. She assesses the number of pounds lost from baseline to post-treatment
378
for the thre ...
This powerpoint presentation gives a brief explanation about the biostatic data .this is quite helpful to individuals to understand the basic research methodology terminologys
Inferential statistics are techniques that allow us to use these samples to make generalizations about the populations from which the samples were drawn. ... The methods of inferential statistics are (1) the estimation of parameter(s) and (2) testing of statistical hypotheses.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. •Compare magnitude of a
problem between groups
• Identify risk factors
•Evaluate efficacy of interventions
(test hypothesis)
– Experiments
• Programs evaluation
3. • Levels of comparison
– Two independent groups (parameters)
– Two related parameters
– Several independent groups
(parameters)
4. Comparison of means (using
t-test)
• There are different types of t-tests:
a) One sample t-test:
a)Used to test hypothesis about
single population mean
b)Independent samples t-
test(independent means t-test):
•used to compare the mean scores of two
different populations, for example experiment
and control groups in experimental studies
•different participants are assigned to
each condition
(this is sometimes called the
independent- measures
5. c) Paired sample t-test (dependent means t-tes
–Used to compare the mean scores
for the same group of people on two
different occasions.
–the test is used when there are
two experimental conditions
–the same participants take part in
both conditions of the experiment
– the test is sometimes referred to as
the
matched pairs
6. • Assumptions of t-test:
– The data are normally distributed.
–In the dependent t-test this, means
that the sampling distribution of the
differences between scores should be
normal, not the scores themselves.
–Data are measured at least on an
interval scale.
– The independent samples t-test also
assumes:
•Variances in these populations are roughly
equal (homogeneity of variance).
•Scores are independent (because they come
from different people).
7. Performing t-tests using SPSS
(Examples) a)Testing the
hypothesized mean for a single
population (t-test):
Example
a) Researchers collected birth weight
data from a randomly selected sample
of 50 newborns. The mean birth weight
and standard were deviations were 3.1
and 0.57 kg respectively. Test the
hypothesis that the population birth
weight is not different from
3.5 kg at α=0.05
– Perform the test manually (do your
self)
b) Using SPSS software and a data file
“data for exercise 50”, test this same
hypothesis at the same level of
confidence.
8. Analyze →compare means →one sample T- tes
quantitative variable into the ‘test variables’ field →Ty
hypothesized mean in the ‘test value’
field
→Ok
The output from this
analysis are given below:
9. b)Two independent groups (two independent
samples t- test):
Example: Using a data file “CREG”,
test the hypothesis that the mean birth weight of male and femal
not different at α=0.05. Analyze → compare means →indep
samples T-test →drag the quantitative variable into th
variables’ field → move the qualitative variable into th
‘grouping variable’ field →Ok
The dialog sample box and outputs are
provided in the tables below
10. Reporting the result of Independent t-
test
• Mean birth weight of male and female
newborns were compared using two
independent samples t-test. We found
that the mean(±SD) birth weight of
male,[3.070 (±0.560) kg] and
female,[3.142 (±581)kg] was not
significant different at α=0.05
t(df) = -0.442(48), p =0.66.
11. c) Paired sample T-
Test:
• Is a type of t-test applied in condition of :
– Self-paired (before and after)
– Matching alike groups ( by age or sex for
instance)
–Measurements are taken at two distinct points
in time
–The difference between two observations
are used rather
than individual observations.
• Advantages:
– Controls erroneous factors
– Biological variability is illuminated
– Makes comparison more precisely
12. Example: Using a data file “CREG”,
test the hypothesis that the mean
Fasting blood sugar (FBS) before and
after exercising in Gym for one month
among office holding
workers is not different at α=0.05.
Calculate the effect size.
Solution:
•Check assumptions (normality of
the differences)
•To do so, first compute the
differences between
base line FBS and the value after Gym
exercise of one month
•Then, visualize the data and test
using Shapiro
13. Analyze → compare means →paired
samples Ttest →move the two
quantitative variable that you are
interested in comparing for each
subject into the box
‘paired variables’→ then, click Ok.
The output generated from this
procedure is shown in the following two
tables
14. Reporting the result of paired
t- test
The mean difference of FBS before and
after exercise, mean(±SD) was [ =
=11.14 (±10.86). This difference was
significant with t(df) = 7.25(49) , p
<0.001. The effect of exercise on the
FBS, Effect size=0.62% was observed,
which is very high.
15. Analysis of Variance
(ANOVA)
Introduction
A method of testing the hypothesis of
unequal means for more than two groups
without increasing the Type-I error rate of
the groups or
• Statistical technique for comparing means
for multiple (usually 2) independent
populations without increasing their Type-I
error rate
16. Purpose of
ANOVA
The purpose of ANOVA is to test
whether an independent variable has an
effect on a dependent variable without
increasing the Type-I error rate,
where…
the dependent variable is
Interval/ratio level (continuous), and
the independent variable is
nominal,ordinal, or interval level
17. One Way
ANOVA
–Takes into account only one sources
of variation/factor while comparing
means or variances.
–ANOVA is used to test statistical hypotheses
that propose differences between group
means.
–to test whether an independent variable has
an effect on a dependent variable without
increasing the type-I error rate, where…
–the dependent variable is Interval/ratio
level (continuous), and
–the independent variable is nominal,
ordinal, or interval level
18. Why One Way
ANOVA?
•When the group to be compared are
more than two, using ‘t’ test is
unreliable:
– tedious (kC2 comparisons) .
–Greater probability of making a type 1
error rejecting H0 when it is true.
– When a single ‘t’ test is performed at a
confidence level of 95%, we are willing to
accept type 1 error of 5% = 1 in 20
–If we do 20 ‘t’ tests on random data - expect
that 1 will be significantly different.
Example:
–Comparing three groups using t-test might
cause a type 1 error of at least 14.3%.
20. i)The sum of squares due to differences
between the group means (SSB).
ii)The sum of squares due to differences
between the observations within each group
(SSW). This is also called the residual sum of
squares.
SST = SSB + SSW
SST = Total sum of squared deviations of
each observation about grand mean
SSB = Total sum of squared deviations of
group means about grand mean
SSW = Total sum of squared deviations of
each observation about group mean
21. • Properties of F test:
–If F is close to 1, the two variances are likely
to be equal
–The larger the value of ‘F’ the greater the
chance that the two variances are not the
same
– Does not identify the group or groups that
differ.
–Is robust (provides dependable results even
when there are violations of the assumptions).
–Violations are more critical when sample sizes
are small or ‘n’s are not equal
–If there are real differences, the between
groups variation will be larger.
– If violations can’t be controlled or you think
that
there may be an increased chance of a type 1
error use p = 0.01
22. Relationship Between t
and F
• F = t2
•‘F’ and ‘t’ are based on the same
mathematical
model and t is just a special case of
ANOVA.
•It is ok to use F test when comparing
2 means
23. Assumptions in
ANOVA
•All populations from which the samples were drawn
are normally distributed. One of the following tests is
used to check for normality:
–Kolmogorov–Smirnov test,
–QQ plot
–Shapiro-Wilk test
•Each of the populations has the same variance (all
variances are equal). Check one the following tests to
confirm homogeneity of the variances:
–Rule of thumb: ratio of largest to smallest sample SD
must be less than 2:1
–Levene's test
–Bartlett's test
24. •The set of observations of data are independent
and
drawn randomly from population.
•Results of ANOVA are approximates rather than
exact.
•Data are parametric.
•Variables required for one way ANOVA:
– Two variables:
•One categorical independent variable with three or
more distinct categories. This could be continuous
variable categorized into three or more groups
•One continuous dependent variable
25. Running One way AOVA using
SPSS
i)In the MENU, click on
‘Analyze=> Compare Means =>One Way
ANOVA=>drag the quantitative
variable into ‘dependent list’ and the factor
into ‘Factor’=> Option=> descriptive, fixed and
random effects => homogeneity of
variances=> continue=>
Ok.
ii)Examine the output and do the post hoc
test if ANOVA test is significant to identify which
group is different.
26. Exampl
e
Assume that that 25 patients with blisters were randomly assigned into 2
treatments and a placebo group. Treatments: Treatment A, Treatment B,
Placebo
Average number of days until blisters was healed after starting the
treatment was measured and compared
Data
• A: 5,6,6,7,7,8,9,10
• B: 7,7,8,9,9,10,10,11
• P: 7,9,9,10,10,10,11,12,13
[means]:
[7.25]
[8.875]
[10.11]
1)Compare the three groups using appropriate
graphs
2)Describe the data using numerical
summaries
3)Is there a significant difference among
these
means at α=0.05? Test the hypothesis
using:
a)manual methods
b) SPSS Software
27. Solutions:
1) First show graphical displays to
visualize the comparison
• Side-by-side box plots (Graph>Legacy>Box
plots)
Box and whisker comparing average days
required for the three groups to remove
blisters
28. 2)Numerical Summary of the
result
3) Test the Hypothesis
a)Manual Methods
1)Describe the data:
– Done in the previous table
2) Check Assumption
• Each group is approximately normal
–check this by looking at histograms and/or
normal quantile plots, or use assumptions
– can handle some non-normality, but not
severe
outliers
29. •Standard deviations of each group
are approximately equal
–Rule of thumb: ratio of largest to smallest
sample standard deviation must be less than
2:1, or
– Twice the smallest SD is greater than the
largest
SD.
3) State the hypotheses:
• H0: The mean # of the three treatment are
equal.
•Ha: Not all the treatment mean # of days
are equal.
4) Calculate the test statistic
30. DF (numerator)= K-1= 3-
1= 2
MSb= 34.72/2 =17.36
Fc = MSb/MSw= 17.36/2.69 = 6.45
5)Decision and conclusion:
– Since Fc= 6.45 > FT =3.44, we reject
the Ho
–At least one of the means is
significantly different.
See the summary in the following
table
31. 3 (b) Use the SPSS to test the same
hypothesis done manually
Standard Deviation
Check
Compare largest and smallest standard
deviations:
• largest: 1.764
• smallest: 1.458
• 1.458 x 2 = 2.916 > 1.764
One way ANOVA Output
32. • Interpretation of the output
– The mean number of days blister was
remove was removed from the three
group was statistically significant
difference, F(2,22)=6.45, P.Value =
0.006.
33. 3.2.4. Multiple Comparison
• ANOVA does not provide any information on which
population or populations differed from the other.
• Multiple-comparison procedures are used to provide
information on this point.
• All are essentially based on the t-test but include appropriate
corrections for the fact that we are comparing more than
one
pair of means.
• There are long list of multiple comparison: but the most
frequently used ones are:
– Bonferroni’s t-method
– Tukey’s HSD (Honestly Significant Difference)
– Cheffe’s Procedure;
34.
35.
36. Application of ANOVA (Summary)
• Applicable to quantitative variables
• Number of groups to be compared is more than two.
• More appropriate when randomized experimental design is
employed.
• But, can also be used for observational designs and surveys.
• When ANOVA is significant and Ho is rejected, then it is
important to do a post hoc test( pair-wise comparison).
It divides ‘α’ by the number of comparisons, k (α/k,).
• When assumptions required for ANOVA are not met, a nonparametric
test equivalent to ANOVA (Kruskal Wallis test) is performed.