This document discusses electromagnetic interference (EMI) issues in automotive and aerospace applications and how simulation tools can help address them. It describes how EMI simulations were used to: 1) Identify differential cross-talk between harnesses in a car, finding that an antenna caused large coupling; 2) Determine lightning current distributions with and without shielding on aircraft; and 3) Analyze high-intensity radiated field (HIRF) effects on aircraft with shielded and unshielded cables, finding resonances that copper-coating plexiglass could address. The document emphasizes that full-vehicle/aircraft simulation is needed to adequately address EMI given complex geometries and systems.