The Mannich reaction involves the condensation of formaldehyde with ammonia (or its salts) and a compound containing active hydrogen, leading to the formation of beta-amino ketones. This reaction can also utilize salts of primary or secondary amines or amides instead of ammonia. A specific example is provided where a ketone, formaldehyde, and diethylamine react under microwave irradiation to produce the Mannich product.

1. MANNICH REACTION
CHE-MYSTERY
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NAVEEN K
II-M.Sc CHEMISTRY,
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2. Mannich reaction
• In mannich reaction, formaldehyde is condensed with ammonia, in the form of its
salt and a compound containing an active hydrogen.
• This can formally be considered as an addition of ammonia to give H2NCH2OH,
followed by a nucleophilic substitution.
• Instead of ammonia, the reaction can be carried out with salts of primary or
secondary amines, or with amides.
• The reaction of a ketone, formaldehyde, and diethylamine with microwave
irradiation gave the Mannich product, a beta-amino ketone.

3. Mechanism

4. Example

5. Example

6. Thank You
CHE-MYSTERY
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