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Management of VT/VF Storm in
Advanced Heart Failure:
What to Think About,
What Works?
What Doesn’t Work?
Owen Obel, MD
VA North Texas Healthcare System, UT
Southwestern Medical Center
Dallas, Texas
Disclosures
Speaker: Medtronic, Biotronik, Boston Scientific
Advisory: Medtronic, Biotronik
Definition of VT/VF Storm
• Diverse arrhythmic
mechanisms, broad
definition
• Frequent episodes of
VT/VF requiring
cardioversion
• Management guidelines
rely on anecdotal evidence
• Most trials define >2
episodes/24h. Episodes
usually more frequent
6 minute recording
SUBSTRATE
 Scar
 Myopathy
 Hypertrophy
 Valve/congenital
 Ischemia
 Channelopathy
Monomorphic VT
Polymorphic VT
Ventricular Fibrillation
VT/VF Storm
Mechanisms
TRIGGER
 Unknown / 1st shock
 Sympathetic hyperactivation
 HF decompensation
 Ischemia/infarction
 Electrolyte (K+ and Mg++)
 Ectopy
 Special situations
VS
ACLS
Guidelines
Group 2Group 1
OR
VT/VF Storm in Advanced Heart Failure
Beta-Blockade
12 patients received all 3
Lidocaine (22)
Procainamide (16)
Bretylium (18)
1 week mortality: 22% group 1 vs. 82% group 2
1 year mortality: 33% group 1 vs. 95% group 2 Nadamanee Circulation 2000
IV beta-
blockers
(21)
Left stellate
ganglion
block (6)
• 342 patients with recurrent
VT/VF (BP<80, shock)
• Refractory to/intolerant of:
lidocaine/procainamide/bretylium
• IV Amiodarone:
 125mg/24 hr
 500mg/24 hr
 1000mg/24 hr
• Supplemental infusions for
breakthrough VT
IV Amio Multicenter Trial Group Circulation 1995
VT/VF Storm in Advanced Heart Failure
Amiodarone
P=0.067
Amiodarone and beta-blockade
are synergistic
Beta-blockers should always be
co-administered at maximum
tolerated doses
Beta-blockade
Amiodarone
Dofetilide
Lidocaine/Mexilitene
✔ Procainamide
Sotalol
Dronedarone
Flecainide
Propafenone
Verapamil/Diltiazem
✗
VT/VF Storm in Advanced
Heart Failure
• IV Sedation is used very early in treatment path
• General anesthesia is a highly effective measure
• Propofol reduces sympathetic tone by inhibiting
central sympathetic discharge
• Patients may require >48 hours of full anesthesia
Sedation / General Anesthesia
VT/VF Storm in Advanced Heart Failure
When AADs Fail
LV Assist Devices
Cardiac Sympathetic Denervation
VT/VF Storm in Advanced Heart Failure
LV Assist Devices
IV inotropes for hemodynamic support
are proarrhythmic
LVADs should be used instead
LVADs have a powerful independent
anti-arrhythmic effect (even in DCM)
VT/VF Storm in Advanced Heart Failure
Cardiac Sympathetic Denervation
Thoracic epidural
anesthesia
Stellate ganglion block/
ganglionectomy
• Both TEA and CSD have been used with success in
VT/VF storm
• Patients with advanced heart failure have been included
in case series
• TEA has more of an immediate effect
• Neither procedure is reported to cause hemodynamic
compromise Vashegi HRJ 2014
VT/VF Storm in Advanced Heart Failure
CRT-induced Proarrhythmia
Conclusions
• VT/VF storm is not uncommon in patients with advanced
heart failure, precipitant often not known
• Beta-blockade and amiodarone are the cornerstone AADs
• Sedation (often) or general anesthesia (sometimes)
required
• IV inotropes exacerbate ventricular arrhythmias
• LV assist devices can be of great benefit
• Cardiac sympathetic denervation has been successfully
used

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Management of vt vf storm in advanced heart failure

  • 1. Management of VT/VF Storm in Advanced Heart Failure: What to Think About, What Works? What Doesn’t Work? Owen Obel, MD VA North Texas Healthcare System, UT Southwestern Medical Center Dallas, Texas
  • 2. Disclosures Speaker: Medtronic, Biotronik, Boston Scientific Advisory: Medtronic, Biotronik
  • 3. Definition of VT/VF Storm • Diverse arrhythmic mechanisms, broad definition • Frequent episodes of VT/VF requiring cardioversion • Management guidelines rely on anecdotal evidence • Most trials define >2 episodes/24h. Episodes usually more frequent 6 minute recording
  • 4. SUBSTRATE  Scar  Myopathy  Hypertrophy  Valve/congenital  Ischemia  Channelopathy Monomorphic VT Polymorphic VT Ventricular Fibrillation VT/VF Storm Mechanisms TRIGGER  Unknown / 1st shock  Sympathetic hyperactivation  HF decompensation  Ischemia/infarction  Electrolyte (K+ and Mg++)  Ectopy  Special situations
  • 5. VS ACLS Guidelines Group 2Group 1 OR VT/VF Storm in Advanced Heart Failure Beta-Blockade 12 patients received all 3 Lidocaine (22) Procainamide (16) Bretylium (18) 1 week mortality: 22% group 1 vs. 82% group 2 1 year mortality: 33% group 1 vs. 95% group 2 Nadamanee Circulation 2000 IV beta- blockers (21) Left stellate ganglion block (6)
  • 6. • 342 patients with recurrent VT/VF (BP<80, shock) • Refractory to/intolerant of: lidocaine/procainamide/bretylium • IV Amiodarone:  125mg/24 hr  500mg/24 hr  1000mg/24 hr • Supplemental infusions for breakthrough VT IV Amio Multicenter Trial Group Circulation 1995 VT/VF Storm in Advanced Heart Failure Amiodarone P=0.067 Amiodarone and beta-blockade are synergistic Beta-blockers should always be co-administered at maximum tolerated doses
  • 8. • IV Sedation is used very early in treatment path • General anesthesia is a highly effective measure • Propofol reduces sympathetic tone by inhibiting central sympathetic discharge • Patients may require >48 hours of full anesthesia Sedation / General Anesthesia VT/VF Storm in Advanced Heart Failure When AADs Fail LV Assist Devices Cardiac Sympathetic Denervation
  • 9. VT/VF Storm in Advanced Heart Failure LV Assist Devices IV inotropes for hemodynamic support are proarrhythmic LVADs should be used instead LVADs have a powerful independent anti-arrhythmic effect (even in DCM)
  • 10. VT/VF Storm in Advanced Heart Failure Cardiac Sympathetic Denervation Thoracic epidural anesthesia Stellate ganglion block/ ganglionectomy • Both TEA and CSD have been used with success in VT/VF storm • Patients with advanced heart failure have been included in case series • TEA has more of an immediate effect • Neither procedure is reported to cause hemodynamic compromise Vashegi HRJ 2014
  • 11. VT/VF Storm in Advanced Heart Failure CRT-induced Proarrhythmia
  • 12. Conclusions • VT/VF storm is not uncommon in patients with advanced heart failure, precipitant often not known • Beta-blockade and amiodarone are the cornerstone AADs • Sedation (often) or general anesthesia (sometimes) required • IV inotropes exacerbate ventricular arrhythmias • LV assist devices can be of great benefit • Cardiac sympathetic denervation has been successfully used