liposomal-gene-delivery-system.pptx

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Liposomal gene therapy is a promising new approach for treating disease. It works by using liposomes, which are spherical vesicles made of phospholipids, to deliver therapeutic genes directly to cells. The liposomes protect the DNA from degradation and promote cellular uptake of the genes, allowing for expression of therapeutic proteins and potential correction of genetic defects.

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The pharmaceutical Quantity by Design (QbD) is a systemic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quantity risk management. QbD has been adopted by U.S Food and Drug Administration (FDA) for the discovery, development and manufacture of drugs. Quality- by- design (QbD) is a concept introduces by the International Conference on Harmonization (ICH) Q8 guidelines.

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Niosomes, Aquasomes, Phytosomes,Electrosomes Molecular pharmaceutics (MPH 201T) PRESENTATION BY- NARAYAN R KOTE M PHARM [PHARMACEUTICS] ROLL NO. 8 GUIDANCE BY :- Dr . TIWARI S. S CONTENTS NIOSOMES AQUASOMES PHYTOSOMES ELECTROSOMES NIOSOMES Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. The vesicle is composed of a bilayer of non-ionic surface active agents and hence the name niosomes. The niosomes are very small, and microscopic in size. Their size lies in the nanometric scale. Although structurally similar to liposomes, they offer several advantages over them. Niosomes have recently been shown to greatly increase transdermal drug delivery and also can be used in targeted drug delivery, and thus increased study in these structures can provide new methods for drug delivery. STRUCTURE OF NIOSOMES Structurally, niosomes are similar to liposomes, in that they are also made up of a bilayer. However, the bilayer in the case of niosomes is made up of non-ionic surface active agents rather than phospholipids as seen in the case of liposomes. Most surface active agents when immersed in water yield micellar structures however some surfactants can yield bilayer vesicles which are niosomes. STRUCTURE OF NIOSOMES Structurally, niosomes are similar to liposomes, in that they are also made up of a bilayer. However, the bilayer in the case of niosomes is made up of non-ionic surface active agents rather than phospholipids as seen in the case of liposomes. Most surface active agents when immersed in water yield micellar structures however some surfactants can yield bilayer vesicles which are niosomes. APPLICATION OF NIOSOMES Drug Targetting One of the most useful aspects of niosomes is their ability to target drugs. Niosomes can be used to target drugs to the reticuloendothelial system.It can be achieved by coating with polymer e.g. PEG. In Diagnosis Niosomes have also been used as carriers for iobitridol, a diagnostic agent used for X-ray imaging. Anti-neoplastic Treatment Most antineoplastic drugs cause severe side effects. Niosomes can alter the metabolism; prolong circulation and half life of the drug, thus decreasing the side effects of the drugs. Niosomes, is decreased rate of proliferation of tumor and higher plasma levels accompanied by slower elimination.Leishmaniasis :- Leishmaniasis is a disease in which a parasite of the genus Leishmania invades the cells of the liver and spleen. Use of niosomes in tests conducted showed that it was possible to administer higher levels of the drug without the triggering of the side effects, and thus allowed greater efficacy in treatment. Delivery of Peptide Drugs:- Oral peptide drug delivery has long been faced with a challenge of bypassing the enzymes which would breakdown the peptide. Use of niosomes to successfully protect the peptides from gastrointestinal peptide breakdown is being investigated. In an in-vitro study conducted by ODDS.

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