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Lichen planus
1.
2. Cause
unknown, but may be mediated immunologically.
There may be a genetic susceptibility to idiopathic
lichen planus
Rarely, familial.
Lichen planus is also associated with autoimmune
disorders, such as alopecia areata, vitiligo and
ulcerative colitis
Contact allergy to mercury compounds (in dental
amalgam fillings) seems to be an important cause
of oral lichen planus
Drugs
Some patients have a hepatitis C infection.
3. Presentation
Skin lesions
Typical lesions are violaceous or lilac-coloured, intensely itchy, flat-
topped papules that usually arise on the extremities, particularly on
the volar aspects of the wrists and legs
A close look is needed to see a white streaky pattern on the surface
of these papules (Wickham’s striae).
patients rub rather than scratch, so that excoriations are
uncommon.
Köbner phenomenon may occur
Variants of lichen planus.
Annular
Atrophic
Bullous
Follicular
Hypertrophic
4. Presentation
Oral and genital skin lesions
White asymptomatic lacy lines, dots, and
occasionally small white plaques, are also found in
the mouth, particularly inside the cheeks, in about
50% of patients and oral lesions may be the sole
manifestation of the disease.
Nail
The nails are usually normal, but in about 10% of
patients show changes ranging from fine
longitudinal grooves to destruction of the entire nail
fold and bed
Scalp
lesions can cause a patchy scarring alopecia.
5.
6.
7.
8.
9. Course
Individual lesions may last for many months and the
eruption as a whole tends to last about 1 year.
the hypertrophic variant often lasts for many years.
As lesions resolve, they become darker, flatter and
leave discrete brown or grey macules.
About one in six patients will have a recurrence.
Complications
Nail and hair loss can be permanent
The ulcerative form of lichen planus in the mouth
may lead to squamous cell carcinoma.
Ulceration, usually over bony prominences, may be
disabling, especially if it is on the soles
10. Differential diagnosis
Lichenoid drug reactions
can mimic lichen planus closely.
Gold and other heavy metals, antimalarials, beta-
blockers, non-steroidal anti-inflammatory drugs, para-
aminobenzoic acid, thiazide diuretics and penicillamine.
Contact with chemicals
used to develop colour photographic film can also
produce similar lesions.
Generalized discoid lupus erythematosus
it may be hard to differentiate from lichen planus
Wickham’s striae or oral lesions favour the diagnosis of
lichen planus.
Oral candidiasis
12. Treatment
If drugs are suspected as the cause, they should be
stopped and unrelated ones substituted.
Potent topical steroids.
Systemic steroid are recommended in special situations
(e.g. unusually extensive involvement, nail destruction or
painful and erosive oral lichen planus).
PUVA or narrowband UVB
Oral ciclosporin or acitretin with stubborn lichen planus.
Antihistamines may blunt the itch.
Mucous membrane lesions, both oral and genital need no
treatment or use corticosteroid or calcineurin inhibitor.