1. PIGEMENTED
CELLULAR NEVUS
SUMMAIRA SARWAR
ROLL NO:11

2. NEVUS:
A benign, exophytic, usually pigmented,
congenital lesion of the skin or mucosa
composed of focal collections of rounded
melanocytes (nevus cells).
• The term nevus commonly used for
mole.
• Nevi mostly occur on skin, occasionally
occur on mucous membrane.
• Its also called birthmark.

3. Classification:
• Intradermal (mucosal)
• Junctional
• Compound
• Macular form also called Blue
nevus
• Epithelioid or Spitz

5. INTRAMUCOSL NEVUS:
• It is also known as INTRADERMAL
nevus.

6. CLINICAL FEATURES:
• The lesion grows slowly.
• It is generally less then 1 cm in
diameter.
• Intradermal nevus occurs in young
patients and is one of common skin
lesions.
 On skin it is raised or flat.
 It is tan or dark brown.
 It will often contain more hair than
surrounding normal skin.

7. • Intramucosal nevus occurs in oral
cavity mostly on the Hard palate or
Gingiva.
 Its an asymptomatic.
 Pigmented.
 Brown to black.
 Slighted elevated papule or flat
macule.

8. HISTOPATHOLOGY:
• It is characterized by nests, cords or
sheets of nevus cell confined to
connective tissue.
• Cells of nevus may be epithelioid,
lymphocyte like, spindle or
multinucleated types.
• Mitotic figures are usually absent.
• One of features of nevus is
presence of fibrous connective
tissue zone which separates it from
overlying epithelium.

10. TREATMENT:
As a general rule all solitary
pigmented papules or nodules of
the oral cavity should be excised.
Once excised nevi do not tend to
recur.

11. JUNCTIONAL NEVUS:

12. CLINICAL FEATURES:
• It is benign.
• Brown to black lesion.
• Occurs primarily on the skin and
occasionally on oral mucosa.
• Within oral cavity it usually
appears as a pigmented macular
lesion on the hard palate or
gingiva.

13. HISTOPATHOLOGY:
• It is characterized by the presence of
nevus cell nests in the basilar region of
epithelium.
• No nevus cells found in surround
connective tissue.
• Careful examination is required
because similar type of focal
proliferation of melanocytes
(junctional cavity) occurs in melanoma.
• It is important to note it can transform
to malignant melanoma.

15. TREATMENT:
It should be excised and submitted to
histopathological examination. Once
excised, a junctional nevus does not
tend to recur.

16. COMPOUND NEVUS:

17. • It has the combined
characteristics of the
intramucosal nevus and
junctional nevus.
• Exhibiting nevus cells in the
basal region of the epithelium
and the adjacent connective
tissue.

18. CLINICAL FEATURES:
• Compound nevus is far more
common then other nevi.
• In oral cavity it tends to occur as
pigmented papule or macule.
• It occurs on hard palate or
gingiva.
TREATMENT:
The nevus is treated by an
excisional biopsy that serves as a
diagnostic and therapeutic
procedure.

19. BLUE NEVUS:

20. CLINICAL FEATURES:
• The blue nevus in benign pigmented
lesion that presents as a dark blue
dome-shaped papule or as a flat
macule on the skin or mucosa.
• It occurs most commonly on the hard
palate.

21. HISTOPATHOLOGY:
• In blue nevus pigment-producing
cells are spindled and fusiform
dendritic cells.
• Cells are confined to the connective
tissue.
• They are separated and parallel to
the normal overlying epithelium.
• Macrophages often present among
dendritic cells.
• They have no tendency to transform
into malignant lesion.

23. TREATMENT:
Excisional biopsy is performed,
which is also serves as the
definitive treatment for this
lesion.

24. EPITHELIOID NEVUS:

25. • It is also called Spitz nevus and
formerly called a “benign juvenile
melanoma.
CLINICAL FEATURES:
• It presents as a solitary small pink to
reddish-brown papule.
• It occurs on skin of face and
extremities of children.

26. HISTOPATHOLOGY:
• It is usually composed of spindle
shaped and large epithelioid nevus
cells with abundant cytoplasm.
• It is relatively circumscribed nests
located at or near dermal and
epidermal interface.
• It is multinucleated.
• Its size is 5 to 6 mm in diameter.

28. TREATMENT:
Conservative excision of the entire
lesion is curative.

29. QUESTIONS??