Lennox-Gastaut syndrome is a severe childhood epilepsy syndrome characterized by multiple seizure types, cognitive impairment, and a specific EEG pattern of slow spike-and-wave discharges. It commonly causes seizures, especially during sleep, and is associated with high mortality. Polysomnography can identify comorbid sleep disorders like sleep apnea and assess seizure activity during sleep. Treatment involves antiepileptic drugs and management of sleep issues and comorbidities.
Not epileptic
•Wrong seizure type (semiology)
•Wrong epileptic syndrome
•Wrong interpretation of EEG and imaging
When to start a drug?
•Which drug and in what dose?
•When to change the drug?
•When (and how) to add a second drug (and which one)?
•When to stop the drug(s)?
•When to consider alternative therapies, including surgery?
Not epileptic
•Wrong seizure type (semiology)
•Wrong epileptic syndrome
•Wrong interpretation of EEG and imaging
When to start a drug?
•Which drug and in what dose?
•When to change the drug?
•When (and how) to add a second drug (and which one)?
•When to stop the drug(s)?
•When to consider alternative therapies, including surgery?
Hello readers.................!!!!!!!!!!!!!!
This is my 32nd powerpoint.....its regarding a form of childhood epilepsy, known as "LENNOX-GASTAUT SYNDROME".
It has been dealt with in the Therapeutics way, and in precise format.
Do look into it and give your reviews!!!!
Thank you!!!!
@rxvichu-alwz4uh!!!!
:) :)
Hello readers.................!!!!!!!!!!!!!!
This is my 32nd powerpoint.....its regarding a form of childhood epilepsy, known as "LENNOX-GASTAUT SYNDROME".
It has been dealt with in the Therapeutics way, and in precise format.
Do look into it and give your reviews!!!!
Thank you!!!!
@rxvichu-alwz4uh!!!!
:) :)
A review of epilepsy in the elderly, the etiopathogenesis, clinical challenges, diagnosis, use of antiseizure drugs and outcomes. Also the various special considerations in managing elderly patients with epilepsy.
We've all heard the term 'fat-burning', but how does it really happen in the body? Fat cells in the body release a hormone that signals to the brain that there is enough energy stored. This triggers your body to burn energy stored as fat
How is insomnia managed?
Cognitive behavioral therapy for insomnia (CBT-I) can help you control or eliminate negative thoughts and actions that keep you awake and is generally recommended as the first line of treatment for people with insomnia. Typically, CBT-I is equally or more effective than sleep medications.
Topics Include; Emerging Therapies and The Clinical Trial Process presented by Dennis Dlugos, MD, MSCE, Involvement Opportunities for LGS Families presented by John Currier, MBA and Christina SanInocencio, MS, Cannabis for LGS: Overview, Experiences and Clinical Practice presented by Heather Barnes Jackson and Jeremy Toler, MD
LGS Foundation 2016 Conference - Saturday AfternoonLGS Foundation
Topics Include: Expecting to Transition - Reframing the Journey presented by Amy Miller, MSN, MA, PCNS-BC, ACHPN, Individual Education Program (IEPs) presented by Dena Hook, Telling Your Story presented by Patricia Moore and Dietary Therapies: Creative Strategies presented by Stephanie Criteser, RD, CSP and Natalie Cummings, RD
LGS Foundation 2016 Conference - Friday MorningLGS Foundation
Topics Include: Therapies for LGS (Part One) - Pharmacological, presented by Angus A WIlfong, MD and Therapies for LGS (Part 2) - Non-Pharmacological presented by Scott Demarest, MD
LGS Foundation 2016 Conference - Friday AfternoonLGS Foundation
Topics include: Understanding Cognitive Problems in LGS presented by Michael Chez, MD, Effective Communication presented by Patricia Moore and, National Resources for Individuals with LGS presented by Jennifer Wolfenbarger, MPH
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
LGS and Sleep
1. Lennox-Gastaut
syndrome (LGS) and
Sleep
Sagarika Nallu, M.D.
Assistant professor
Pediatric Neurology, Epilepsy & Sleep Medicine
Chief of Pediatric Neurology
Director of Pediatric Sleep Medicine
University of South Florida
Morsani College of Medicine
2. Lennox-Gastaut
syndrome (LGS)
Severe form of childhood-onset epilepsy associated with
high morbidity and mortality
Peak period between ages 3 and 5 years
More common in males
Annual prevalence of 0.26 per 1000 at age 10 years
Comprises ~4% of childhood epilepsy cases
High mortality rates-Sudden unexpected death in epilepsy
(SUDEP) is the most frequent cause of death among
patients with Lennox-Gastaut syndrome
Status epilepticus
7. EEG in LGS
Paroxysmal Fast 10Hz Activity -This is
associated with tonic seizures- mainly
in sleep.
or can occur with minimal clinical
manifestations, such as apnea or
perhaps truncal rigidity.
Can be seen mainly during non-REM
sleep.
11/19/2017
8. EEG in LGS
Since a diagnosis relies so heavily on finding that classic EEG
feature and since tonic seizures tend to occur mostly during
sleep, a sleep EEG is essential.
These fast rhythms that are essential for diagnosis and are
essential in differentiating Lennox-Gastaut Syndrome from
other epilepsy syndromes in which slow spike in wave
discharges can be seen.
Misdiagnosis or over diagnosis of LGS
11/19/2017
9. Features of Several Epileptic
Disorders
Resnick T. Journal of Child Neurology, 2017.
10. Seizure Triggers
11/19/2017
Missed dose of medication
Sleep deprivation
Illness
Stress, anxiety, overstimulation
Hormonal changes
Alcohol and drugs of abuse
Hyperventilation
Flashing lights
Temperature extremes
Dehydration
11. Common Sleep
Comorbidities
Sleep provides an opportunity to examine and potentially
improve epilepsy
Insomnia
Excessive daytime somnolence
Sleep apnea - both Central and Obstructive events
Epilepsy and obstructive sleep apnea (OSA) frequently
coexist, and treating OSA in epilepsy patients may reduce
seizure frequency and improve daytime sleepiness
11/19/2017
13. Medications and sleep
Benzodiazepines are generally safe in low doses but in
higher doses and in select patients they may be associated
with respiratory depression, hypoventilation,
hypoxemia, and obstructive sleep apnea (OSA).
Narcotics can be associated with apneas and
hypoventilation with increased risk with higher doses and
use of other central nervous system depressants.
Antidepressants may partially improve OSA by suppressing
stage rapid eye movement and increasing upper airway
tone but do not completely treat OSA.
11/19/2017
Medication Effects on Sleep and Breathing clinics in Chest Medicine 2014
GilbertSedaMD, PhDaSheilaTsaiMDbTeofiloLee-ChiongMDc
14. Common Sleep
Comorbidities
Nocturnal seizures lead to disturbed quality of sleep at
night and leads to excessive daytime somnolence
Medications
Polysomnogram or sleep study to rule out sleep apnea.
Obstructive sleep apnea treatment- CPAP/BiPAP, ENT
surgery.
Evaluating for Central sleep apnea
11/19/2017
15. LGS and Sleep
Thorough Sleep history
Evaluating for sleep disorders
Treatment strategies-
Eliminating/ minimizing the
contributing factors
11/19/2017
17. References
Resnick T, Sheth RT. Early Diagnosis and Treatment of
Lennox-Gastaut Syndrome. Journal of Child Neurology
2017;32(11):947-955.
Sforza E, Mahdi R, Roche F, et al. Nocturnal interictal
epileptic discharges in adult Lennox-Gastaut syndrome: the
effect of sleep stage and time of night. Epileptic Disord
2016;18(1):44-50.
Eisensehr I, Parrino L, Noachtar S, et al. Sleep in Lennox–
Gastaut syndrome: the role of the cyclic alternating pattern
(CAP) in the gate control of clinical seizures and generalized
polyspikes. Epilepsy Research 2001;46:241–250.
23. Non-Pharmacologic Therapy
Ketogenic Diet
Surgery
Focal, lobar, or multilobal resection vs hemispherectomy
Vagus nerve stimulation
Corpus callosotomy
Editor's Notes
Approximately 10% of children who experience epilepsy before the age of 5 years will be diagnosed with Lennox-Gastaut syndrome
Deaths often related to accidents or status epilepticus; limited data suggest that 20 years after diagnosis, approxi- mately one-quarter of Lennox-Gastaut syndrome patients are likely to have died
~ 20 years after diagnosis, approximately one-quarter of Lennox-Gastaut syndrome patients are likely to have died
Initial EEG with both awake and sleep is important.
Some people consider the presence of 10-hertz fast activity as an essential for diagnosis.
Among antiepileptic drugs, valproic acid is generally con- sidered first-line therapy, and has demonstrated efficacy in the treatment of myoclonic, atypical absence, and atonic seizures. Its use is limited, however, by the rare but serious risk of liver toxicity, and by its potential to interact with other antiepileptic drugs.3 Valproic acid–induced liver toxicity is associated with the neurometabolic disorder Alpers-Huttenlocher syndrome, which is caused by rare mutations in the gene for mitochondrial DNA polymerase g (POLG).
Various benzodiazepines (diazepam, clo- nazepam, and nitrazepam, in addition to clobazam) have also been used in the treatment of Lennox-Gastaut syndrome; how- ever, association with sedation, drooling, and exacerbation of the frequency of seizures in children with Lennox-Gastaut syn- drome, in particular tonic seizures, make them less desirable as first-line therapy
Early treatment of Lennox-Gastaut syndrome could potentially alter the course of the disease, as a result of slowing or limiting structural changes, reducing cognitive decline, and reducing drop attack– associated injuries.
When there is failure to suppress seizures, particularly in patients with intractable frequent daily seizures, the likelihood of a variety of serious risks associated with seizures, such as anoxia, status epilepticus, falls and accidents, and death, is high
These characteristics are frequently seen in pediatric patients with Lennox-Gastaut syndrome. Drug treatment of Lennox-Gastaut syndrome can have a direct exacerbating impact on these comorbidities, and also an indirect impact via drug-drug interactions.
It is important to note that early treatment should not be confined to antiepileptic drug use, but should also include consideration of a ketogenic diet, vagus nerve stimulation, and epilepsy surgery, as well as various combinations of these therapies to both optimize seizure control and improve quality of life in patients with Lennox-Gastaut syndrome.
A ketogenic diet is a high-fat, moderate protein, and low-carbohydrate diet that has long been in use for seizure treatment, and emerged from the observed reduction in seizures among patients with epilepsy during fasting periods when ketone levels are elevated.37 A Johns Hopkins study of 71 pediatric patients with Lennox-Gastaut syndrome given a keto- genic diet found that after 1 year, 44% of patients had a >50% reduction in seizures, and 18% had a 90% to 99% seizure reduction. Notably, the rate of seizure reduction diminished over the 1-year period, with better efficacy being seen at 3 months and 6 months compared to 1 year.
Vagus nerve stimulation is used in cases of refractory epilepsy and involves the implantation in the chest of a generator of intermittent electrical stimuli to an electrode wrapped around the left vagus nerve in the neck.37 In the overall Lennox-Gastaut syndrome patient pop- ulation, more than half experience a >50% reduction in sei- zures after initiation of vagus nerve stimulation.37 With regard to specific Lennox-Gastaut syndrome subtypes, vagus nerve stimulation has been found to be effective for children who experience myoclonic seizures, but has shown limited efficacy in tonic seizures, and has been less effective than corpus callosotomy for atonic seizures.
Corpus callosotomy is usually employed in refractory epilepsy, when all other options have failed. Vagus nerve stimulation is typically tried first in these patients, because it is reversible and is not associated with the risks inherent with craniotomy.41 Corpus callosotomy has been shown to reduce seizure frequency among patients with Lennox-Gastaut syn- drome, particularly in those with atonic seizures, although in other types of seizures associated with Lennox-Gastaut syn- drome, the efficacy of corpus callosotomy is approximately equivalent to that of vagus nerve stimulation