This document discusses dietary therapies for LGS, specifically the ketogenic diet. It provides a history of the ketogenic diet and how it works. The classic ketogenic diet typically uses a 4:1 or 3:1 fat to carbohydrate+protein ratio. Variations include the Modified Atkins Diet and Low Glycemic Index Treatment. Research shows the classic ketogenic diet reduces seizures in 47% of LGS patients. Factors in choosing the right diet include a child's safety, family commitment, and individual considerations like food preferences and daily schedule. Future research may explore the ketogenic diet's effects on cognition and behavior for LGS.
Make your body fit by developing some good healthy habits which includes having nutritious diet. So lets look at some nutritious naturally available products.
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The Science of Weight Loss: Why Most Diets Fail & How to SucceedJohn Mauremootoo
In this presentation, I review weight management approaches that have shown success in high quality peer reviewed publications. I begin by listing the evidence filters I use to assess the science, briefly summarise the rising obesity epidemic, reveal the (underwhelming) secret of weight loss - spoiler alert: its calories in vs. calories out! However, the devil is in the detail and the remainder of the presentation unpacks this detail to provide information on the components of weight loss and how to manipulate these components to maximise success and long term well-being.
The problem of most individual health wise is simply eating disorder.
The idea is for you to get more calories from protein and fat and less from carbohydrates. You cut back most on the carbs that are easy to digest, like sugar, soda, pastries, and white bread.
This is a great way to start and track a sustainable diet. The foods are listed for you, all you have to do is select weight loss or maintain and follow the easy to read chart!
Make your body fit by developing some good healthy habits which includes having nutritious diet. So lets look at some nutritious naturally available products.
Grab Your Free E book Of CARB CYCLING AND WEIGHT LOSS Here:
In this book you know all the secret and incredible things about Weight loss. Like,
• How to lose 54lbs in a month without exercise and dieting?
• Lose 20lbs In A Week By Drinking Smoothies ,How?
• These 5 Keto Recipes Helps You To Lose 20lbs In A week, How?
• Get Up To 100% Free bonuses Inside This Secret Book.
The Science of Weight Loss: Why Most Diets Fail & How to SucceedJohn Mauremootoo
In this presentation, I review weight management approaches that have shown success in high quality peer reviewed publications. I begin by listing the evidence filters I use to assess the science, briefly summarise the rising obesity epidemic, reveal the (underwhelming) secret of weight loss - spoiler alert: its calories in vs. calories out! However, the devil is in the detail and the remainder of the presentation unpacks this detail to provide information on the components of weight loss and how to manipulate these components to maximise success and long term well-being.
The problem of most individual health wise is simply eating disorder.
The idea is for you to get more calories from protein and fat and less from carbohydrates. You cut back most on the carbs that are easy to digest, like sugar, soda, pastries, and white bread.
This is a great way to start and track a sustainable diet. The foods are listed for you, all you have to do is select weight loss or maintain and follow the easy to read chart!
Keto advanced weight loss is a fat burning pill or supplement which shed fat quickly. Well, it's natural as well as works as a fast working fat heater. This is among the most effective supplements which works wonder to gain that slim looking shape.
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The lecturer content is based on the Kathmandu University course syllabus. But, can be used for any undergraduate medical course for MBBS, BDS and Nursing.
Keto advanced weight loss is a fat burning pill or supplement which shed fat quickly. Well, it's natural as well as works as a fast working fat heater. This is among the most effective supplements which works wonder to gain that slim looking shape.
Have you been fighting the weight loss battle and miserably losing at it? This is all too common. And, despite the truth, magazines and celebrities blame an inability to shed the extra weight on your motivation levels. Meticore weight loss supplement provides a great solution to lose weight rapidly but sometimes you have to exercise patience.
The lecturer content is based on the Kathmandu University course syllabus. But, can be used for any undergraduate medical course for MBBS, BDS and Nursing.
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Our aim is to alleviate human suffering related to diabetes and its complications among those least able to withstand the burden of the disease. From 2002 to March 2017, the World Diabetes Foundation provided USD 130 million in funding to 511 projects in 115 countries.
For every dollar spent, the Foundation raises approximately 2 dollars in cash or as in-kind donations from other sources.
The total value of the WDF project portfolio reached USD 377 million, excluding WDF’s own advocacy and strategic platforms.
The WDF mission:
The ketogenic diet, often referred to as keto, is a low-carbohydrate, high-fat diet that has been shown to help some people lose weight. The ketogenic diet has been studied for its potential benefits in weight loss, managing diabetes, and even some neurological disorders like epilepsy. However, it's essential to note that the ketogenic diet may not be suitable for everyone. Before starting any drastic diet change like keto, it's advisable to consult with a healthcare provider or a registered dietitian, especially if you have any underlying health conditions.
This is a follow-up to our "Everything you always wanted to know about Nutrition but were afraid to ask" webinar. We received many questions about the role of macronutrients (carbs, proteins, and fats) in our diet--how much, what kind, what balance, etc. So we're dedicating an entire webinar to this subject! With Cristin Stokes, RD, LN of MUS Wellness.
The ketogenic diet (or keto diet, for short) is a low carb, high fat diet that offers many health benefits.
In fact, many studies show that this type of diet can help you lose weight and improve your health.
Ketogenic diets may even have benefits against diabetes, cancer, epilepsy, and Alzheimer’s disease.
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****Note: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Topics Include; Emerging Therapies and The Clinical Trial Process presented by Dennis Dlugos, MD, MSCE, Involvement Opportunities for LGS Families presented by John Currier, MBA and Christina SanInocencio, MS, Cannabis for LGS: Overview, Experiences and Clinical Practice presented by Heather Barnes Jackson and Jeremy Toler, MD
LGS Foundation 2016 Conference - Saturday AfternoonLGS Foundation
Topics Include: Expecting to Transition - Reframing the Journey presented by Amy Miller, MSN, MA, PCNS-BC, ACHPN, Individual Education Program (IEPs) presented by Dena Hook, Telling Your Story presented by Patricia Moore and Dietary Therapies: Creative Strategies presented by Stephanie Criteser, RD, CSP and Natalie Cummings, RD
LGS Foundation 2016 Conference - Friday MorningLGS Foundation
Topics Include: Therapies for LGS (Part One) - Pharmacological, presented by Angus A WIlfong, MD and Therapies for LGS (Part 2) - Non-Pharmacological presented by Scott Demarest, MD
LGS Foundation 2016 Conference - Friday AfternoonLGS Foundation
Topics include: Understanding Cognitive Problems in LGS presented by Michael Chez, MD, Effective Communication presented by Patricia Moore and, National Resources for Individuals with LGS presented by Jennifer Wolfenbarger, MPH
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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2 Case Reports of Gastric Ultrasound
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
4. Agenda/Objectives
Defining & Comparing Diets
• Initiation Protocol Differences
• Home strategies
• Resources
Choosing the Right Diet:
• What does the research say?
• What is best for my child and my family?
6. Diet History: Ancient Medicine
“Let food be thy
medicine and medicine
be thy food”
– Hippocrates.
•Fasting to achieve seizure control
7.
8. Diet History: Modern Medicine
• Wilder (1921): KD reproduces fasting and
decreases seizures in children with
epilepsy
• Between 1941 and 1980, all child epilepsy
text books reported on the ketogenic diet.
• Discovery of phenytoin (1938)– focus
shifted to developing new AEDs.
• Livingston (1972) : treated > 1000 children
with KD
• With increasing AEDs developed and
available, the use of the KD decreased.
Ketones
12. How does it work?
• Stimulates starvation.
• Body burns carbohydrate (glycogen) supply and burns
fat as the primary energy source.
• Ketones are made when fat is broken down.
• Ketones circulating in the body and brain can result in
improved seizure control although we still do not know
how.
• Blood sugar levels are also decreased. Lower blood
sugar may also help decrease seizures.
13. Types of Dietary Therapy
• Classic Ketogenic Diet
• Modified Atkins Diet (MAD)
• Medium Chain Triglyceride Oil Diet (MCT diet)
• Low Glycemic Index Treatment (LGIT)
14. 60%
30%
10%
How do these diets compare?
Classic Low Glycemic Modified Atkins
Fat Protein Carbs
90%
6%4%
77%
17%
6%
Kossoff, EH, et al (2011). | Pfeifer, HH. (2012)
~4-8 g net* carb 45-60 g total carb 10 g net carb
15. Initiation Protocols
• Classic Ketogenic diet
– hospitalization from 2-5 days
– Some with 24 hr fasting start
– Some with decreased calories to start
– Some gradually increase diet ratio (dose)
• MAD, MCT, LGIT
– Home diet start after 1-2 hour+ clinic education
16. MCT Oil: Medium Chain Triglycerides
• Derived from coconut oil
(~50-60% MCT oil)
• Absorbed directly from
the gut into the liver
• Makes more ketones per
gram than LCT
• Does not contain
essential fatty acids
• Has gut side effects if
intake is too high too fast
17. The KD Ratio Prescription
Fat
grams
Protein
grams
Carb
grams
Amount for growthTypically 1-4 x more Calculated to meet ratio
4:1, 3:1, 2:1, 1:1
18. General Medication Principles
• Tablets – YES!
• Gel Caps – YES!
• Liquids – NO!
• Chewables – NO!
• Suspensions – NO!
Disclaimer – sometimes we do prescribe liquids, chewables, and suspensions…if there are no
other options (only 2/50 children are currently on “sugar free” suspensions currently in my
practice – not low carb!)
Key Keto Point
19.
20.
21. Home Strategies & Side Effect Management
• Picky eating / Feeding difficulties
– Meal schedule, division of responsibility around
feeding – Ellyn Satter www.ellynsatterinstitute.org
– Formulas, modulars, pre-prepared keto food products
– “all in one meals”
– Feeding therapy referral
22. KD Products
• Formulas that may be utilized for the ketogenic diet include:
• KetoCal (Nutricia)
– KetoCal 3:1 Powder (unflavored)
– KetoCal 4:1 Powder (vanilla)
– KetoCal 4:1 LQ Liquid (vanilla & unflavored)
• RCF (Abbott) – Ross carbohydrate free formula – soy based carbohydrate
free formula
– Used in milk protein allergy
– Used when carbohydrates must be very limited due to low caloric needs
• KetoVolve (Nutr-e-volution)
– Mild flavored powder; also chocolate flavor
• KetoVie 4:1 (Cambrooke) & KetoVie Peptide
– Chocolate & Vanilla –
– Peptide not on market yet
Also baking products and pre-made food available from Cambrooke. Baking flour from Solace.
23. Modular Products
• A variety of modular products may need to be added to
ensure nutrient needs are met and ketogenic ratios are
correct
• Lipid
– Microlipid (Nestle) – safflower oil emulsion at 4.5 kcal/mL
– MCT oil (Nestle) – fractionated coconut oil at 7.7 kcal/mL
– Liquigen (Nutricia)- MCT emulsion at 4.5 kcal/mL
– Betaquik (Vitaflo) – MCT emulsion at 1.89 kcal/mL
– Carbzero (Vitaflo) – LCT emulsion at 1.8 kcal/mL
– Retail Oils (Olive Oil, coconut oil) – variable caloric density
24. Modular Products
• Carbohydrate
– Solcarb (solace) – carbohydrate powder – maltodextrin – 3.75 kcal/g
– Polycal (nutricia) – carbohydrate powder – maltodextrin – 3.84 kcal/g
• Protein
– Beneprotein (Nestle) – whey protein powder – 6 g/7 g powder
– Complete AA mix (Nutricia) – 100% AA – 8.2 g/10 g powder
• Combination
– Super Soluble DuoCal (nutricia) – Fat + Carbohydrate - hydrolyzed
cornstarch, refined vegetables including coconut oil
25. Home Strategies & Side Effect Management
• Constipation
– Increase fluid
– Increase fiber & probiotic foods
– Medications: miralax, milk of magnesia, senna tablets
– GI referral
26. Home Strategies & Side Effect Management
• Sick Days (e.g dehydration from vomiting, diarrhea,
inadequate fluids)
– TABLET MEDICATIONS for pain and fever
– # 1 HYDRATION
• Electrolyte beverage
• fluids 2-4 oz every hour
– Broth + 1-2 saltines
– Meals with half added fat
– Close communication with ketogenic diet team and
pediatrician
27. Long Term Side Effect Management
• Decreased bone density
– Weight bearing activity
– Vitamin D, Calcium & Phosphorus
• Kidney stone risk
– Drink a lot of fluids
– May need alkalizing agent e.g. cytra k crystals, baking soda
• Vitamin & Mineral deficiency
– Multivitamin & mineral, calcium, vitamin D, carnitine
• High blood lipids (cholesterol, triglycerides)
– Fat type adjusted – increase MCT, decrease sat fats, increase
unsat fats, add omega 3 rx
– Fiber increased and ratio decreased
28. Resources to Learn More
Websites
Support
Groups
Books
www.thecharliefoundation.org
www.mathewsfriends.com
www.myketocal.com
www.epilepsy.org
Keto Hope Foundation
29. Choosing the Child
for the Diet and the
Diet for the Child
• What does the research say about KD and
LGS?
• What is best for my child and my family?
30. Research/Evidence
Expert Opinion on the Management of Lennox–Gastaut
Syndrome: Treatment Algorithms and Practical
Considerations
Authors: J. Helen Cross,1,* Stéphane Auvin,2 Mercè Falip,3 Pasquale Striano,4 & Alexis Arzimanoglou5,6
Reviewed 18 studies that included data on LGS patients
and found 47% experienced >50% reduction in seizure
frequency for 3-36 months on the classic KD (1 MAD)
31. Treatment Algorithm
The VNS may
be synergistic
with KD
TPM may be synergistic
with KD, but acidosis
and risk for kidney stones
VPA
LGT
RUF
CLBTPM FLB
Keto Diet
VNS
Resective Surg
Callosotomy
KD can
amplify
side
effects
of VPA
Cross et al 2017
32. Selection Criteria
• Patient is safe for the diet
– can use fat for energy
• Family is committed to a trial of the diet for 3
months.
• Family can attend follow up appointments and
obtain lab tests when requested.
35. What Diet is Best for Us?
• Child’s food preferences
• Child’s willingness to participate with diet
restrictions
• Oral feeding skills/safety
• Food Allergies/intolerances
• Daily schedule
• Caregiver availability to prepare meals & cooking
skill set
• Hospital vs Home Start
36. Future Research in KDs
• The future of KD research is in
cognitive and behavior
development.
• Unknown if the KD in any
form could have an effect
cognitively or behaviorally
even if seizures do not change
for children with LGS.
Editor's Notes
Thank Christine for the honor of allowing me to speak here at this conference.
Ask the audience:
How many here are MDs, RNs or NPs?
How many here are RDs that work with the ketogenic diet? Work with children? Adults?
How many are parents? How many are parents of a keto kid/families on the keto diet?
How many have tried the keto diet in the past?
How many were at the last conference in Denver and attended the presentation of ketogenic diets?
Disclaimer: although there are consensus guidelines regarding ketogenic dietary treatment, implementation and management varies slightly among center and child given the uniqueness of each individual and their response to the diet and treatment. Please discuss any dietary changes or treatments with your medical team prior to initiating them.
Photo from Epilepsy kids cartoon.
Not so much food, as the lack of food.
The Transfiguration is the last painting by the Italian High Renaissance master Raphael. Here the apostles cannot stop the boy’s seizures (demon possesion narrative at the time) until Jesus comes and tells them
Scene of Jesus saying that this type of fits come out with prayer and fasting.
Livingston (1972) : treated > 1000 children on the ketogenic diet: 52% had complete control of seizures, 27% had improved control.
At the discovery of phyenytoin in 1938, the attention of the physicians and researchers shifted focus from the MOA and efficacy of the KD to new AEDs.
In a new era
A type of ketogenic diet therapy even is used for our pets!
***Ketonix
? What ketone does urine check.
Glucose monitor
Beta-hydroxybutyrate stays in blood if it is not used as energy. Acetone (which Ketonix indicates) is processed in the liver and expelled in the breath, e.g the concentration decreases over time. The beta-hydroxybutyrate level can be rapidly decreased by ingesting sugar, the acetone level will not react as quick. Example, eating a high protein meal can produce a result of low beta-hydroxybutyrate while still having acetone.
When glycogen stores are used up, body loses water storage. Hydration is very important.
A net carb is your total carb grams – fiber grams (do NOT subtract sugar alcohols).
Some centers use net carbs in calculating the classic ketogenic diet others use total carb.
Classic Ketogenic
4:1 ratio or 3:1 ratio
Older children, tend to respond at a lower ratio
About 4-8 g of carbohydrate per 1000 calories
Weigh with food scale.
Modified Atkins
~1:1 ratio; 10 g carbohydrate per 1000 calories; but NO limit on protein.
Use measuring cups & spoons
Option to use scale
Low glycemic index
~1:1 ratio; 40-60 g of carbohydrate per day.
Use exchange lists for low glycemic load/index foods
Food does not need to be weighed on a scale
MCT diet
Use MCT oil for 40-60% of fat intake; consume carbohydrates per list exchanges; weigh out food on scale.
*Coconut oil is mostly C-12
MCT oil is mostly C-10
C-8 chain in mouse models has been found to be anti-epileptic
-There is an OTC designer MCT oil that is higher in C-8 …
Ed point about coconut oil - ~ 60% is MCT oil and of that it is C-12 chain.
MCT oil is mostly C-10 chain but can be designed/manufactured to be high in c-8, which in some mouse models has been found to be particularly anti-epileptic.
There are multiple mechanisms of the ketogenic diet – not just anti seizure, but also can somehow change the natural history of the progression of epilepsy and prevent further
This tells us the dose of the classic ketogenic diet.
Does the KD look like this? Or
What is on the market – A LOT – prescribed by your keto team. A medical food. Must be approved and monitored by MD and RD. Though can get them for $$ on the “grey” amazon and craig’s list market. (no gaurentee of quality or exp. Date!)
Keto is popular now.
GT feeders, oral eaters.
Each formula option has it’s +/-
You need to know your formulas, know what medi-cal covers, what insurance covers, the cost, the ingredients, the tolerance of the patient, and the ability to mix of the family.
Powder vs liquid (GT = liquid)
Still use a scale for liquid for exact measurements – or provide a graduated cylinder – but difficult to clean. 1 mL = 1 g
Duocal – not commonly used by RDs, but I like to use it in RCF because it provides fat and carb – so I can use more than just the solcarb or polycal. Also it decreases the products that we have on our formulary, so that is easier for everyone.
Fiber foods: avocado, flax seeds/flax ground/flax oil, chia seeds, psyllium husk powder, slipper elm bark powder hemp seeds, winter squash, spinach, chard, greens, broccoli, brussel sprouts, cauliflower, kale sauerkraut, okra, asparagus, red onions, garlic MCT oil
Probiotic foods: dill pickles, plain whole fat greek yogurt, sauerkraut, keifer, kimchi, miso, natto
Recommend not giving senna tea (do not have a dose), caution with magnesium Calm drink for young children. We need to know doses.
4 cups water, ½ tsp baking soda, ½ tsp morton lite salt, flavoring w crystal lite or lemon/citrus zest.
Diluted pedialyte
Need the bicarb, need the sodium, in some cases need the dextrose that is in pedialyte.
Confer with your keto team about the specifics of your sick plan.
But don’t be scared!! This is why you are followed closely!! And why the RD and MD make all those crazy recommendations. Bone density: yearly bone density (DEXA scans). Referral to endocrinologist for bisphosphonate treatment
Kidney stones: yearly ultra sounds. Referral to urologist or nephrologist.
Photos of other books on here.
ketovie
Find photo of Cross Et Al
Success of the ketogenic may allow AEDs to be tapered and some discontinued.
Response rate occures within 3 months of goal diet dose but for evaluating how long the child is to be on the diet – look at the risk/benefit
We do not have evidence for the MCT but the MCT makes ketones like the CKD and the MAD, so it will likely work as well. The LGIT may be a place to start the diet for families that have a highly processed diet, and then gradually adjust to a classic or MAD diet.
Half respond with 50% reduction of seizures to KD or MAD.
Diet can be started along with 1st or 2nd AED.
Possible that LGIT and MCT diet will have same response rate.
Compliance depends on management of adverse effects and seizure response.
VPA – valproic acid – first line therapy
LGT – lamotrigine –us as an adjunct
RUF – second line adjunctive – try to discontinue VPA or LGT
There are some positive and troublesome but not contraindicatory indications between medications.
Weight gain with VPA – a lower sugar diet can be beneficial, even if not a keto, LGIT, MAD
~50% of children with LGS respond to the classic or modified ketogenic diet therapy within 3 months with a decrease of 50% frequency in seizures.
Recent recommendations are to implement the diet as early as the first AED is started if desired and especially if two AEDs are not providing benefit.
It is possible that the LGIT and MCT diets may provide similar treatment responses, though the studies have not been done.
Compliance to the diet depends on management of adverse effects and seizure response.
How do we get from here to
Here…for carb choices?
Sometimes we have to take time to get ready for these changes.
Sometimes we have the child and parents on board but we have to get the grandparents! You know, the kid comes home and had grahm crackers, a bag of gold fish, extra juice, cookies, cake, suddenly they are bouncing off walls and won’t eat dinner?
Wait a minute, when did this change, when grandma was mom, there was no sugar in the house?
Food as love – trips, time together, games,
Are there any modifications that need to be implemented first?
Pros/Cons for each diet?