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Lecture - 18 Bromometry.pptx

This document discusses bromatometry, which is a titration method using potassium bromate as the oxidizing agent. It can be used for the qualitative determination and assay of pharmaceutical substances like mephenesin, phenol sodium, and salicylate. The principle is that potassium bromate is reduced to bromide in the presence of HCl, then oxidized to produce free bromine at the endpoint, which can be detected using methyl red indicator. Some applications mentioned are the assay of isoniazid, determination of hydroxylamine, and determination of arsenic and antimony. The lecture on pharmaceutical analysis will continue this topic in the next video.

Education◦
Lecture- 18 Subject – Pharmaceutical Analysis-I Course – B. Pharm 1st Year Faculty Name – Umesh Kumar
Contents  Bromatometry  Principle  Applications
BROMATOMETRY (POTASSIUM BROMATE TITRATION):  The specific titrations with potassium bromate is referred to as Bromatometry.  It may be exploited as an effective and useful oxidizing agent in the qualitative determination (assay) of pharmaceutical substances like mephenesin, phenol sodium and salicylate.
Principle:  Potassium Bromate is a powerful oxidizing agent which is reduced smoothly to bromide in the presence of HCl and which is then oxidized to give free bromine by bromate (excess).  At the end point of titration free bromine appears.  In this type of titrations Methyl red indicator is used, which decolorises by oxidation at end point.
APPLICATIONS: 1. Assay of Isoniazid 2. Determination of Hydroxylamine 3. Determination of As/Sb
To be continued in Next video