The human body contains complex control systems that maintain homeostasis. At the cellular level, organs are made of many cell types that perform specialized functions. The body contains two fluid compartments - intracellular and extracellular fluid, which together make up 60% of the body. The extracellular fluid transports nutrients and wastes between cells and organs. Homeostasis involves multiple organ systems that work together to maintain steady internal conditions through negative feedback loops, including respiratory, renal, gastrointestinal, and endocrine systems. Disruptions to these control mechanisms can lead to disease states.
Cardiac myocytes are short
branched striated muscle cells
Connected with gap junctions
gap junctions transmit
electrical activity between cells
So, cardiac myocytes act as
a single functional unit
(syncitium)1. Rhythmicity
2. Excitability
3. Conductivity
4. Contractility
Cardiac myocytes are short
branched striated muscle cells
Connected with gap junctions
gap junctions transmit
electrical activity between cells
So, cardiac myocytes act as
a single functional unit
(syncitium)1. Rhythmicity
2. Excitability
3. Conductivity
4. Contractility
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The endocrine system is composed of organs positioned throughout the body in widely separated locations. Endocrinology is the study of the structure and functioning of the endocrine system.
Senses : any of the physical processes by which stimuli are received, transduced, and conducted as impulses to be interpreted in the brain.
The special senses consist of the eyes, ears, nose, throat and skin.
Each of these organs have specialized functions that make if possible for us to experience our environment and to make that experience more pleasant
Students will be able to gain a better understanding and application of medical terminology in relation general Anatomy about:
Brief History
Medical Terminology
Anatomical Planes, Directions and Movements.
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The endocrine system is composed of organs positioned throughout the body in widely separated locations. Endocrinology is the study of the structure and functioning of the endocrine system.
Senses : any of the physical processes by which stimuli are received, transduced, and conducted as impulses to be interpreted in the brain.
The special senses consist of the eyes, ears, nose, throat and skin.
Each of these organs have specialized functions that make if possible for us to experience our environment and to make that experience more pleasant
Students will be able to gain a better understanding and application of medical terminology in relation general Anatomy about:
Brief History
Medical Terminology
Anatomical Planes, Directions and Movements.
an intro to homeostasis, its definition, significance, different types of controlling mechanisms. what is feed back mechanism, feed forward mechanism, negative feedback mechanisms. the slides give only a partial introduction to homeostasis not a detailed one. reference books used are from boron book for medical physiology, Guyton international edition on medical physiology.
this slides are for beginners to understand the Human body easier way, for Medical Reps, Sales Reps can use this for training purpose.
Authentic diagrams / pictures
Common medication used for anesthesia, there action; dosage; adverse effect; duration of action.
They Include {inhalation + Induction + Muscle relaxant + Anticholinergic + Analgesic + Resuscitation}
in this presentation lecture we gone take a hypo and hyper thyrodism that affect the human cell because both situation may increase or decrease the basal metabolic rate.
When the pituitary Gland it' s function is increased whether the cause are?
Both anterior and Posterior gland secretions are increased the most causes are ADENOMAS
in this presentation you will be learn the different drug form that all medical health workers prescribing the medication.
the medical student should have a good knowledge and keep in mind these drug forms based on medical administration the drugs are classified into invasive (injection and transdermal implantation) and non invasive (oral, inhalers, suppository)
Medical equipment and tools are crucial to saving a person's life or performing any procedure.
i presented here the most and commonly equipment used by medical student to improve their skills
This note paper is short notes of general physiology for medical students who which to understand the concept of the physiology, physiology is the mother of medicine.
A summary of skeletal muscle contraction and relaxationAyub Abdi
it consist for 4 pages and cover all the steps that occur during muscle contraction and relaxation, I does not take a time just 5 minute is enough to read. I hope it's interesting.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Lecture 1 (introduction to physiology)
1.
2.
3. INTRODUCTION:
• Human Physiology: the specific characteristics
and mechanisms the human body that make it
a living being.
• The fact that we remain alive is the result of
complex control systems.
• For example: Hunger makes us seek food,
Sensations of cold make us look for warmth.
4. CELLS ARE THE LIVING UNITS OF THE
BODY:
• Each organ is an aggregate of many different
cells held together by intercellular supporting
structures.
• Each type of cell is specially adapted to perform
one or a few particular functions.
• The entire body, contains about 100 trillion cells.
• Almost all cells also have the ability to reproduce
additional cells of their own kind.
7. • About 60 percent of the adult human body is
fluid, mainly a water solution of ions and
other substances.
1. Intracellular fluid: fluid is inside the cells,
28L, 2/3 of total body fluid.
2. Extracellular fluid: fluid in the spaces outside
the cells, 14L, 1/3 of total body fluid.
8. EXTRACELLULAR FLUID—THE
“INTERNAL ENVIRONMENT”
• Extracellular fluid is in constant motion
throughout the body.
• In the extracellular fluid are the (1) ions and (2)
nutrients needed by the cells to maintain life
(internal environment or milieu intérieur).
• The aviability and proper concentration of ECF
components (glucose, oxy, amino acid and so on)
gives the cell capable of living and performing
their special functions.
9. Differences Between Extracellular and
Intracellular Fluids:
• The extracellular fluid contains large amounts:
1. sodium, chloride, and bicarbonate ions plus
nutrients for the cells, such as oxygen,
glucose, fatty acids, and amino acids.
2. carbon dioxide.
3. Other cellular waste products that are being
transported to the kidneys for excretion
(ammonia).
10. • intracellular fluid differs significantly from the
extracellular fluid and contains large amounts:
1. potassium, magnesium, and phosphate ions.
11.
12. HOMEOSTASIS or (Steady State):
• maintenance of nearly constant conditions in the
internal environment.
• American physiologist Walter Cannon (1871–1945)
• all organs and tissues of the body, for exam:
1. Lungs provide oxygen to the extracellular fluid to
replenish the oxygen used by the cells,
2. The kidneys maintain constant ion concentrations,
3. And the gastrointestinal system provides nutrients.
• Powerful control systems exist for maintaining the
concentrations of sodium and hydrogen ions, as well
as for most of the other.
13. • Normal body functions require the integrated
actions of cells, tissues, organs, and the multiple
nervous, hormonal, and local control systems
that together contribute to homeostasis and
good health.
• Disease is often considered to be a state of
disrupted homeostasis.
• pathophysiology seeks to explain how the
various physiological processes are altered in
diseases or injury.
14. • Extracellular fluid is transported through the
body in two stages:
1. is movement of blood through the body in the
blood vessels.
2. movement of fluid between the blood
capillaries and the intercellular spaces between
the tissue cells.
15.
16. ORIGIN OF NUTRIENTS IN THE
EXTRACELLULAR FLUID:
• Respiratory System:
• The blood picks up oxygen in the alveoli, thus
acquiring the oxygen needed by the cells.
• Gastrointestinal Tract:
• dissolved nutrients, including carbohydrates,
fatty acids, and amino acids, are absorbed from
the ingested food into the extracellular fluid of
the blood.
17. • Liver and other organs that perform primarily
metabolic functions:
• The liver changes the chemical compositions of
many substances.
• The liver also eliminates certain waste products
produced in the body and toxic substances that
are ingested.
• Musculoskeletal system:
• The body could not move to obtain the foods
required for nutrition.
• The musculoskeletal system also provides
motility for protection against adverse
surroundings.
18. REMOVAL OF METABOLIC END
PRODUCTS:
1. Removal of Carbon Dioxide by the Lungs.
2. Urea, uric acid and excesses of ions and
water are excreted by the kidneys.
3. Undigested material and some waste
products are excreted as feces by the
Gastrointestinal tract.
4. The detoxification or removal of many drugs
and chemicals through feces is done by liver.
19. REGULATION OF BODY FUNCTIONS:
• By means of:
1. Nervous system.
2. Hormonal system.
20. 1- Nervous System:
• composed of three major parts:
1. The sensory input portion.
2. The central nervous system (or integrative
portion).
3. The motor output portion.
• An important segment of the nervous system is
autonomic system, It operates at a subconscious
level and controls many functions of the internal
organs. Like (pumping heart), (gastrointestinal
motility), (hormonal secretion).
21. Sensory receptors detect the state of the body or
the state of the surroundings.
• For instance, receptors in the skin alert us whenever
an object touches the skin at any point.
• The eyes are sensory organs that give us a visual
image of the surrounding area.
• The ears are also sensory organs.
The central nervous system is composed of the
brain and spinal cord.
• The brain can store information, generate thoughts,
create ambition, and determine reactions that the
body performs in response to the sensations.
Appropriate signals are then transmitted through
the motor output portion of the nervous system to
carry out one’s desires.
22.
23. 2- Hormone Systems:
• Located in the body are eight major endocrine
glands and several organs and tissues that secrete
chemical substances called hormones.
• For instance, thyroid hormone increases the rates
of most chemical reactions in all cells.
• The hormones provide a system for regulation that
complements the nervous system.
• The nervous system regulates many muscular and
secretory activities of the body.
• Hormonal system regulates many metabolic
functions.
24.
25. 1- immune system:
• The immune system consists of the white blood cells,
tissue cells derived from white blood cells, the thymus,
lymph nodes, and lymph vessels that protect the body
from pathogens such as bacteria, viruses, parasites, and
fungi.
• The immune system provides a mechanism for the body to
(1) distinguish its own cells from foreign cells and substances.
(2) destroy the invader by phagocytosis or by producing
sensitized lymphocytes or specialized proteins (e.G.,
Antibodies) that either destroy or neutralize the invader.
26. 2- integumentary system:
• The skin and its various appendages (including the
hair, nails, glands, and other structures) cover,
cushion, and protect the deeper tissues and organs
of the body.
• Generally provide a boundary between the body’s
internal environment and the outside world.
• The integumentary system is also important for
temperature regulation and excretion of wastes.
• It provides a sensory interface between the body
and the external environment.
• The skin generally comprises about 12 to 15 percent
of body weight.
27.
28.
29. REPRODUCTION
• Sometimes reproduction is not considered a
homeostatic function.
• It does, however, help maintain homeostasis by
generating new beings to take the place of those
that are dying.
• This may sound like a permissive usage of the term
homeostasis, but it illustrates that, in the final
analysis, essentially all body structures are organized
such that they help maintain the automaticity and
continuity of life.
31. • The human body has thousands of control
systems,
1. Genetic control systems (help control
intracellular and extracellular functions).
2. Control systems operate within the organs.
3. Throughout the entire body.
32. EXAMPLES OF CONTROL
MECHANISMS:
• Regulation of Oxygen and Carbon Dioxide
Concentrations in the Extracellular Fluid.
• Regulation of Arterial Blood Pressure.
33. Normal Ranges and Physical Characteristics of Important
Extracellular Fluid Constituents
35. Negative Feedback Nature of Most
Control Systems:
• A way as to arrest the change or reverse the direction
of change.
• Also known as balancing feedback
• Example:
• A high concentration of carbon dioxide in the
extracellular fluid increases pulmonary ventilation.
• This, in turn, decreases the extracellular fluid carbon
dioxide concentration because the lungs expire
greater amounts of carbon dioxide from the body.
• In general, if some factor becomes excessive or
deficient, a control system initiates negative
feedback
36.
37.
38. Positive Feedback:
• A way as to increase the intensity of the change
in the same direction.
• Positive feedback can sometimes be useful.
• Blood clotting is an example of a valuable use of
positive feedback. This mechanism can get out
of hand and cause formation of unwanted
clots.{Heart attack}.
• Childbirth is another instance in which positive
feedback is valuable.
• Generation of nerve signals.
39.
40. • Positive feedback can sometimes cause vicious
cycles and death:
• Positive feedback leads to instability rather than
stability and, in some cases, can cause death (Loss
of 2 L of blood).
• Mild degree of positive feedback can be overcome
by the negative feedback control mechanisms of
the body (Loss of 1 L of blood).
41. More Complex Types of Control
Systems—Adaptive Control:
• Feed forward.
• The nervous system, contains great numbers
of interconnected control mechanisms.
• Temperature-sensitive neurons located in the
body and skin.