The Department of Human Biology & Toxicology at UMONS provides expertise in predictive toxicology, metabonomics, QSAR approaches, and conventional toxicity studies in rodents to support risk assessment. It works with pharmaceutical, biomedical, food, and chemical companies, as well as academic labs. The department conducts applied research projects and offers services like toxicity profiling, biomarker identification, and training in predictive toxicology and risk assessment. It has specialized equipment for metabonomics studies in rodents and cell cultures.

1. Toxicological Risk Assessment
An initiative of
24 October 2013 - UCL - Brussels (Woluwe)
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2. Department of Human Biology & Toxicology
UMONS
Pr Jean-Marie Colet
Head of Department
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3. Fields of expertise and industrial targets
Fields of expertise
• Tools in predictive toxicology
• NMR-based Metabonomics (in vitro and in vivo)
• QSAR approaches (Percepta, DEREK, METEOR, …)
• Conventional tox studies in rodents
• Risk assessment (RTD determination)
Industrial applications fields
• Pharma – Biomedical – Clinical Research Groups
• Food and chemistry industry
• Academic labs involved in early development of new
molecules
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4. Applied research projects
FIRST Spin-off OPTA
Sciwan Consult
TAXUD
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5. Special equipments
Examples
All equipments to conduct Metabonomics studies in rodents and
on cell cultures
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Animal facility with refrigerated metabolic cages
Menarini Spotchem EZ (clinical chemistry)
Cell culture Lab / isolated mitochondria
NMR spectrometers
Softwares for NMR data handling & multivariate data
analysis
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6. Services provided to companies
Examples
• First characterization of potential drug adverse effects
(Liver, kidney, cardiac)
• Metabonomic profiling (in vivo and in vitro models)
• Biomarkers identification
• Invertebrates models for environmental risk assessment
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7. Training proposals to companies
• Metabonomics training (theory + practice)
• Methods in predictive toxicology (QSAR, in vitro testing, …)
• Risk assessment (RfD determination / HIA)
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8. Contact
UMONS - Faculty of Medicine & Pharmacy
Department of Human Biology & Toxicology
"Le Pentagone" Aile 2A
Avenue du champ Mars, 6
7000 Mons
www.umons.ac.be/toxico
Prof. Jean-Marie Colet
Head of Department
jean-marie.colet@umons.ac.be  +32 65 37 35 06
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