Anxiolytics Ol 2002

SEDATIVE/HYPNOTICS ANXIOLYTICS Martha I. D ávila-García, Ph.D. Howard University Department of Pharmacology

[object Object],[object Object],Sedated Nervous Breakdown Performance Anxiety GOAL

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SEDATIVE/HYPNOTICS ANXIOLYTICS ,[object Object],[object Object],[object Object]

Manifestations of anxiety : ,[object Object],[object Object],[object Object]

Pathological Anxiety ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Causes of Anxiety ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Causes of Anxiety ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Causes of Anxiety ,[object Object],[object Object],[object Object],[object Object]

Anxiolytics ,[object Object],[object Object]

Anxiolytics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sedative/Hypnotics ,[object Object]

Sedative/Hypnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Properties of Sedative/Hypnotics in Sleep ,[object Object],[object Object],[object Object],[object Object],[object Object]

Other Properties of Sedative/Hypnotics ,[object Object],[object Object]

Sedative/Hypnotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sedative/Hypnotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sedative/Hypnotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SEDATIVE/HYPNOTICS ANXYOLITICS GABAergic SYSTEM

Sedative/Hypnotics ,[object Object],[object Object]

Benzodiazepines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Barbiturates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Respiratory Depression Coma/ Anesthesia Ataxia Sedation Anxiolytic Anticonvulsant DOSE RESPONSE BARBS BDZs ETOH

Respiratory Depression Coma/ Anesthesia Ataxia Sedation Anxiolytic Anticonvulsant DOSE RESPONSE BARBS BDZs

GABAergic SYNAPSE GABA glutamate glucose Cl - GAD

GABA-A Receptor ,[object Object],[object Object],[object Object],[object Object],GABA AGONISTS BDZs    BARBs  

Mechanisms of Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Patch-Clamp Recording of Single Channel GABA Evoked Currents From Katzung et al., 1996

Benzodiazepines ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics of Benzodiazepines ,[object Object],[object Object],[object Object]

CNS Effects (Rate of Onset) Lipid solubility

Biotransformation of Benzodiazepines From Katzung, 1998

Biotransformation of Benzodiazepines ,[object Object],[object Object],[object Object]

Properties of Benzodiazepines ,[object Object],[object Object],[object Object]

Side Effects of Benzodiazepines ,[object Object],[object Object],[object Object]

Toxicity/Overdose with Benzodiazepines ,[object Object],[object Object],[object Object]

Drug-Drug Interactions with BDZs ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics of Barbiturates ,[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics of Barbiturates ,[object Object],[object Object]

Properties of Barbiturates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Toxicity/Overdose ,[object Object],[object Object]

Toxicity/Overdose ,[object Object],[object Object],[object Object],[object Object],[object Object]

Sedative/Hypnotics ,[object Object],NREM III and IV REM 1 2 3 NIGTHS OF DRUG DOSING SLEEP PER NIGHT (%) CONTROL WITHDRAWAL

Miscellaneous Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

BUSPIRONE ,[object Object],[object Object],[object Object],[object Object],[object Object]

BUSPIRONE ,[object Object],[object Object],[object Object]

Pharmacokinetics of BUSPIRONE ,[object Object],[object Object],[object Object],[object Object],[object Object]

Zolpidem ,[object Object],[object Object],[object Object],[object Object]

Properties of Zolpidem ,[object Object],[object Object],[object Object],[object Object]

GABA ? NE DA 5-HT ACh (-) (-) (-) (-) (-) ANXIOLYTIC ? SEDATION ? ANTICONVULSANT/ MUSCLE RELAXANT ?

Properties of Other drugs . ,[object Object],[object Object],[object Object]

Properties of Other Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]

Properties of Other Drugs ,[object Object],[object Object],[object Object],[object Object]

OTHER USES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other Properties of Sedative/Hypnotics ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

References: ,[object Object],[object Object],[object Object],[object Object]

Anxiolytics Ol 2002

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Anxiolytics Ol 2002