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Cholinoblockers

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Cholinoblockers

  1. 1. CHOLINERGIC BLOCKERS www.company.com Dr Igor Khalin
  2. 2. www.company.com Parasympatholytics • Eye  inability to focus for near vision, midriasis, IOP ↑ • Saliva  xerostomia • Bronchi  bronchodilation, secretion ↓ • Heart  Rate ↑  GIT  secretion, peristalsis ↓ sphincter tone ↑ • Bladder  detrusor ↓ sphincter tone ↑
  3. 3. www.company.com Mechanism of action 1. Competitive antagonist 2. Compete with Ach 3. Block the Ach at the muscarinic receptors 4. As a result Ach is unable to bind to the receptor site and cause a cholinergic effect
  4. 4. Cholinergic Antagonists www.company.com Antimuscarinic agents Neuromuscular blockers Atropine Scopolamine Ipratropium Tropicamide Trihexyphenidyl Atracurium Pancuronium Succinylcholine Ganglionic blockers Nicotine
  5. 5. www.company.com Pharmakokinetics ATROPINE 1. Tertiary nitrogen 2. Good adsorbtion 3. Penetrate BBB Atropa belladonna
  6. 6. www.company.com Main Effects ATROPINE • Smooth muscle relaxation • Antisecretory
  7. 7. www.company.com Dose-dependent effects ATROPINE
  8. 8. www.company.com Therapeutic uses ATROPINE 1. Midriasis 2. Spasmolythic 3. Antisecretory 4. Mushroom poisoning 5. Organophosphates poisoning 6. Heart block, bradycardia 7. Resuscitation (asystole)
  9. 9. www.company.com Adverse effects ATROPINE
  10. 10. www.company.com Contraindications ATROPINE 1. Narrow-angle glaucoma 2. Pyloric stenosis 3. Prostatic hypertrophy 4. Drivers
  11. 11. www.company.com Pharmakokinetics SCOPOLAMINE Solanaceae family 1. Tertiary nitrogen 2. Good adsorbtion 3. Penetrate BBB
  12. 12. Main Effects & Adverse Effects www.company.com SCOPOLAMINE ATROPINE
  13. 13. www.company.com Therapeutic uses SCOPOLAMINE
  14. 14. www.company.com Therapeutic uses TROPICAMIDE Eye examination
  15. 15. www.company.com Therapeutic uses IPRATROPIUM 1. Bronchial asthma 2. COPD
  16. 16. www.company.com Therapeutic uses TRIHEXYPHENIDYL Parkinson’s disease
  17. 17. www.company.com Cholinergic Antagonists

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