Dr. Kim Solez presents "Regenerative Medicine Part II: When Will the Current "Wild West" Period End and What Should We Do in the Meantime? on March 2nd, 2017 in the Technology and Future of Medicine course LABMP 590 at the University of Alberta in Edmonton, Alberta, Canada. Copyright (c) 2017, JustMachines Inc.

1. Kim Solez, MD

2. Analogy between the start of clinical
transplantation and the start of
clinical regenerative medicine.

3. In transplantation a “wild west “ period
between the first transplant in 1954
and advent of cyclosporine in 1983.

4. One might image with exponential
change 30 years might become 3!

5. Moore’s Law Muted in Medicine! Might
Take Longer for “Wild West” to End.

6.  Regulatory oversight that is completely focused
on compliance. Discourages risk-taking and
innovation.
 Health care doesn't have the same financial
reward system. Facebook isn't about to pay $1
billion for the latest hot-ticket item in imaging
and informatics.
 Security always trumps information sharing, and
so better, faster linkages are constrained
because of security concerns, most of which are
bogus.
Moore’s Law Muted in Medicine!

7. Difficult to Know Where to Draw
Line in Sand. Twenty Cell Types in
Kidney, Including Cells Making
Renin and Renal Erythropoietic
Factor. How Many Do We Need to
Get Right and To What Extent?

8. We Do Not Need To Feel Embarrassed If
Classification Reflects “Wild West”.
Current Transplantation Classification
Contains Old Entities Like Hyperacute
Rejection and Perfusion Injury.
n

9. Hyperacute Rejection is Similar to
Regenerative Medicine Attempts with
Vessels Lacking Endothelium, Both
Types of Organs “Clot Like Crazy”
n

10. I Wrote a Poem About All This,
Or Rather A Poem Wrote Itself

11. The Discovery of Papilla As Likely
Stem Cell Niche in Kidney Also
Harkens Back to Older Times!

12. Papillary Necrosis Due To Analgesic
Abuse was a Big Deal in the 60s and
70s but Now Has Disappeared.

13. High Point from Latest Cell Therapy
Regenerative Medicine Society
(CTRMS) Meeting

14. Khouloud Saliba and I Presented at TERMIS
(Regenerative Medicine) Meeting in San
Diego Dec. 11-14, 2016.

15. Met Astgik Petrosyan Who Has Written About
the Many Additional Variables Which Will
Add Complexity to New Banff Classification
 Decellularized Renal Matrix and Regenerative
Medicine of the Kidney: A Different Point of
View Petrosyan Astgik, … and Perin Laura. Tissue
Engineering Part B: Reviews. May 2016, 22(3): 183-
192.
 A Step Towards Clinical Application
of Acellular Matrix: A Clue from Macrophage
Polarization. Petrosyan A, …Perin L. Matrix Biol. 2016
Aug 26. pii: S0945-053X(16)30133-0.

16. Astgik Petrosyan Variables Will Necessitate
AI Approaches to New Banff Classification!