IBC Life Sciences "Stem Cell Research Challenges" Conference Presentation
In Vivo Differentiation of Stem Cell and Their ProgenyRobert Lanza, MDVP Medical & Scientific DevelopmentAdvanced Cell TechnologyAdjunct ProfessorInstitute of Regenerative MedicineWake Forest University School of Medicine
CAUTIONARY STATEMENTCONCERNING FORWARD-LOOKING STATEMENTSThis presentation contains “forward-looking statements” as defined under thefederal securities laws. Actual results could vary materially. Factors thatcould cause actual results to vary materially are described in our filings withthe Securities and Exchange Commission. You should pay particular attentionto the “risk factors” contained in documents we file from time to time with theSecurities and Exchange Commission. The risks identified therein, as well asothers not identified by the Company, could cause the Company’s actualresults to differ materially from those expressed in any forward-lookingstatements.
Stem cells are smart• In vitro: Without the right environmental clues they don’t know whatwe want them to do. Left to their own devices in vitro, theydifferentiate into a hodgepodge of cell types – neurons, heating heartcells, ciliated epithelium, and even miniature “eyeballs”• In vivo: Stem cells home towards damaged tissue where they caninitiate tissue regeneration. We need a better grasp of the roles playedby such chemical signals as insulinlike growth factor (IGF-1), whichmay also take part in causing local cells to revert to a multipotent stateand begin differentiating into the required tissue types. Thisphenomena (epimorphic regeneration) underlies the ability of newts &zebrafish to regrow limbs and organs.
End-stage renal disease will cost US $1 trillion during the comingdecade
A few last thoughts• Moving into the clinic – perhaps the damaged tissue area can do partof the work for us• More basic research – we need to better understand the in vivo factorsthat control stem cell fate and repair• Regenerative medicine’s ideal – to find a means to cause controlledde- and trans- differentiation of cells in adult tissue. Will it ever bepossible to generate an environment that replicates the ability of newtsand zebra fish to regenerate tissue, to regrow entire limbs and organs?•