IBC Life Sciences "Stem Cell Research Challenges" Conference Presentation
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11/8/2005
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IBC Life Sciences "Stem Cell Research Challenges" Conference Presentation
- 1. In Vivo Differentiation of Stem Cell and Their Progeny Robert Lanza, MD VP Medical & Scientific Development Advanced Cell Technology Adjunct Professor Institute of Regenerative Medicine Wake Forest University School of Medicine
- 2. CAUTIONARY STATEMENT CONCERNING FORWARD-LOOKING STATEMENTS This presentation contains “forward-looking statements” as defined under the federal securities laws. Actual results could vary materially. Factors that could cause actual results to vary materially are described in our filings with the Securities and Exchange Commission. You should pay particular attention to the “risk factors” contained in documents we file from time to time with the Securities and Exchange Commission. The risks identified therein, as well as others not identified by the Company, could cause the Company’s actual results to differ materially from those expressed in any forward-looking statements.
- 3. Alzheimer’s Dwarfism Parkinson’s Strokes Epilepsy Hemophilia Kidney failure Chronic pain Cancer Infertility Burns AIDS Muscular dystrophy ALS Affective disorders Macular degeneration Hypoparathyroidism Heart disease Liver failure Enzymatic defects Diabetes Osteoarthritis Multiple sclerosis Huntington’s Hypocholesterolemia Rheumatoid arthritis Atherosclerosis Ulcers Spinal cord injuries
- 5. Stem cells are smart • In vitro: Without the right environmental clues they don’t know what we want them to do. Left to their own devices in vitro, they differentiate into a hodgepodge of cell types – neurons, heating heart cells, ciliated epithelium, and even miniature “eyeballs” • In vivo: Stem cells home towards damaged tissue where they can initiate tissue regeneration. We need a better grasp of the roles played by such chemical signals as insulinlike growth factor (IGF-1), which may also take part in causing local cells to revert to a multipotent state and begin differentiating into the required tissue types. This phenomena (epimorphic regeneration) underlies the ability of newts & zebrafish to regrow limbs and organs.
- 6. •Parkinson’s ($6 billion/yr) •Stroke ($45 billion/yr) •Spinal cord injury ($10 billion/yr) •Epilepsy ($3 billion/yr) •Alzheimer’s ($100 billion/yr) •Multiple sclerosis ($10 billion/yr)
- 11. Generation of ES cells using parthenogenesis
- 16. WBC colony from cloned stem cells
- 17. •Cardiovascular disease costs the US $329 billion annually
- 18. ~ Biodegradable scaffolds ~ Self-assembly
- 21. End-stage renal disease will cost US $1 trillion during the coming decade
- 23. A few last thoughts • Moving into the clinic – perhaps the damaged tissue area can do part of the work for us • More basic research – we need to better understand the in vivo factors that control stem cell fate and repair • Regenerative medicine’s ideal – to find a means to cause controlled de- and trans- differentiation of cells in adult tissue. Will it ever be possible to generate an environment that replicates the ability of newts and zebra fish to regenerate tissue, to regrow entire limbs and organs? •