This document provides biographical details and career highlights of Kim Solez, including her educational background, positions held, awards received, and engagement with students over her career. It notes how early work with students in the 1970s led to an award for best research as a house officer. The document also discusses Solez's views on the future of medicine, including the possibility of eliminating all natural disease but still having social and ethical challenges, as well as new potential specialties in tissue engineering pathology and "apocalyptic pathology". Throughout, it emphasizes Solez's long-standing engagement with and mentorship of students.
Kim Solez Seizing the opportunity of technology and the future of medicine c...Kim Solez ,
Kim Solez Ishita Moghe Seizing the opportunity of technology and the future of medicine creating the possibility of a positive medical future for everyone Medical Grand Rounds Presentation Feb. 1, 2019.
Webinar 5: Designing Your Future: WHAT'S COMING NEXT?Louis Cady, MD
In this capstone webinar presentation, closing out Dr. Cady's series on dealing with COVID 19, he turns his attention to a nunmber of interesting thems:
- what's the REAL case fatality rate of COVID 19
- How is it likely that society will reopen?
- What's going to happen in education and medicine?
- What's going to happen when the robots and AI arrive?
- What's the future going to be out 500 years?
Kim Solez Mallory Chipman AHHM pathology meets faatjKim Solez ,
Kim Solez and Mallory Chipman present in the AHHM Speaker Series "Pathology Meets the Future and All That Jazz: AI, Regenerative Medicine and You" at the University of Alberta Arts and Humanities in Health and Medicine program speaker series on December 8, 2016 . Copyright (c) 2016, JustMachines Inc.
Kim Solez Seizing the opportunity of technology and the future of medicine c...Kim Solez ,
Kim Solez Ishita Moghe Seizing the opportunity of technology and the future of medicine creating the possibility of a positive medical future for everyone Medical Grand Rounds Presentation Feb. 1, 2019.
Webinar 5: Designing Your Future: WHAT'S COMING NEXT?Louis Cady, MD
In this capstone webinar presentation, closing out Dr. Cady's series on dealing with COVID 19, he turns his attention to a nunmber of interesting thems:
- what's the REAL case fatality rate of COVID 19
- How is it likely that society will reopen?
- What's going to happen in education and medicine?
- What's going to happen when the robots and AI arrive?
- What's the future going to be out 500 years?
Kim Solez Mallory Chipman AHHM pathology meets faatjKim Solez ,
Kim Solez and Mallory Chipman present in the AHHM Speaker Series "Pathology Meets the Future and All That Jazz: AI, Regenerative Medicine and You" at the University of Alberta Arts and Humanities in Health and Medicine program speaker series on December 8, 2016 . Copyright (c) 2016, JustMachines Inc.
Kim Solez Renal transplant pathology and future perspectives corefall2016Kim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives. Nephrology core lecture series Fall 2016, on October 5, 2016, at the University of Alberta, Edmonton, Alberta, Canada. Copyright (c) 2016, JustMachines Inc.
Lymphoma of the Tonsil in a Developing Communityasclepiuspdfs
The lymphoma of the tonsil is a rarity. Single case reports have appeared in countries as disparate as China, Greece, India, Japan, and Turkey. Therefore, this paper presents cases found in Nigeria among the Ibo ethnic group. The epidemiological comparisons are deemed to be worthy of documentation such as age ranges and sides of involvement.
Kiosk-Style Slide Presentation with some interactivity presented at Purdue University Teaching, Learning, and Technology Conference 2003. Must download to fully experience.
Tuskegee Tests
Provides information as to the REASONS why the FEDERAL BUREAU OF INVESTIGATION, JUDICIAL COMPLAINTS and CONGRESSIONAL COMPLAINTS Filed by Vogel Denise Newsome are being OBSTRUCTED from being PROSECUTED!
Garretson Resolution Group appears to be FRONTING Firm for United States President Barack Obama and Legal Counsel/Advisor (Baker Donelson Bearman Caldwell & Berkowitz) which has submitted a SLAPP Complaint to OneWebHosting.com in efforts of PREVENTING the PUBLIC/WORLD from knowing of its and President Barack Obama's ROLE in CONSPIRACIES leveled against Vogel Denise Newsome in EXPOSING the TRUTH behind the 911 DOMESTIC TERRORIST ATTACKS, COLLAPSE OF THE WORLD ECONOMY, EMPLOYMENT violations and other crimes of United States Government Officials. Information that United States President Barack Obama, The Garretson Resolution Group, Baker Donelson Bearman Caldwell & Berkowitz, and United States Congress, etc. do NOT want the PUBLIC/WORLD to see. Information of PUBLIC Interest!
The Doctor and the Good Life - Introduction to Bioethics and Natural LawAmiel Villanueva
Second version of my lecture on medical ethics / bioethics to the Learning Unit II class of the UP College of Medicine as part of IDC 201: History of Medicine. This was presented last May 9, 2018.
Slide design by SlidesCarnival (slidescarnival.com)
“We hope our first edition newsletter, aids in the recovery and cure of MS” Dr Moore
About the Author
Founded by LDM Inc.,
Love and Divinity In Motion, Organization includes a Campus Directory of Projects, Schools, and Studio Ventures. Love and Divinity is also Accredited in Holistic Health and Healing. Accredited School Director: Dr Leslie M. Moore. Our Mission involves Mind, Body, and Soul Agenda, Events,
Publications, and Campus Activities Online. We host Free and Tuition/Fee Based Services and Programs Online. Now, Mia Jonita Resorts; is a Branch of our Business Development of 5 Years, Education Building, Field Experience online and off, and 12 years Work Field experience total. Dr Moore also Yogi Goddess, has grown as a Virtual Entrepreneurs, during the past 2 years, of our 5 year development.
http://miajresort3d.yolasite.com
Kim Solez A renaissance in renal pathology brought about by regenerative medi...Kim Solez ,
Dr. Kim Solez presents A renaissance in renal pathology, nephrology and transplantation brought about by regenerative medicine: How to jump start the process.
Kim Solez Renal transplant pathology and future perspectives corefall2016Kim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives. Nephrology core lecture series Fall 2016, on October 5, 2016, at the University of Alberta, Edmonton, Alberta, Canada. Copyright (c) 2016, JustMachines Inc.
Lymphoma of the Tonsil in a Developing Communityasclepiuspdfs
The lymphoma of the tonsil is a rarity. Single case reports have appeared in countries as disparate as China, Greece, India, Japan, and Turkey. Therefore, this paper presents cases found in Nigeria among the Ibo ethnic group. The epidemiological comparisons are deemed to be worthy of documentation such as age ranges and sides of involvement.
Kiosk-Style Slide Presentation with some interactivity presented at Purdue University Teaching, Learning, and Technology Conference 2003. Must download to fully experience.
Tuskegee Tests
Provides information as to the REASONS why the FEDERAL BUREAU OF INVESTIGATION, JUDICIAL COMPLAINTS and CONGRESSIONAL COMPLAINTS Filed by Vogel Denise Newsome are being OBSTRUCTED from being PROSECUTED!
Garretson Resolution Group appears to be FRONTING Firm for United States President Barack Obama and Legal Counsel/Advisor (Baker Donelson Bearman Caldwell & Berkowitz) which has submitted a SLAPP Complaint to OneWebHosting.com in efforts of PREVENTING the PUBLIC/WORLD from knowing of its and President Barack Obama's ROLE in CONSPIRACIES leveled against Vogel Denise Newsome in EXPOSING the TRUTH behind the 911 DOMESTIC TERRORIST ATTACKS, COLLAPSE OF THE WORLD ECONOMY, EMPLOYMENT violations and other crimes of United States Government Officials. Information that United States President Barack Obama, The Garretson Resolution Group, Baker Donelson Bearman Caldwell & Berkowitz, and United States Congress, etc. do NOT want the PUBLIC/WORLD to see. Information of PUBLIC Interest!
The Doctor and the Good Life - Introduction to Bioethics and Natural LawAmiel Villanueva
Second version of my lecture on medical ethics / bioethics to the Learning Unit II class of the UP College of Medicine as part of IDC 201: History of Medicine. This was presented last May 9, 2018.
Slide design by SlidesCarnival (slidescarnival.com)
“We hope our first edition newsletter, aids in the recovery and cure of MS” Dr Moore
About the Author
Founded by LDM Inc.,
Love and Divinity In Motion, Organization includes a Campus Directory of Projects, Schools, and Studio Ventures. Love and Divinity is also Accredited in Holistic Health and Healing. Accredited School Director: Dr Leslie M. Moore. Our Mission involves Mind, Body, and Soul Agenda, Events,
Publications, and Campus Activities Online. We host Free and Tuition/Fee Based Services and Programs Online. Now, Mia Jonita Resorts; is a Branch of our Business Development of 5 Years, Education Building, Field Experience online and off, and 12 years Work Field experience total. Dr Moore also Yogi Goddess, has grown as a Virtual Entrepreneurs, during the past 2 years, of our 5 year development.
http://miajresort3d.yolasite.com
Similar to Kim Solez Seizing the opportunity of technology and the future of medicine creating the possibility of a positive medical future for everyone1
Kim Solez A renaissance in renal pathology brought about by regenerative medi...Kim Solez ,
Dr. Kim Solez presents A renaissance in renal pathology, nephrology and transplantation brought about by regenerative medicine: How to jump start the process.
Kim Solez The bridge between transplant and regenerative med Tissue engineeri...Kim Solez ,
Dr. Kim Solez presents "The Bridge Between Transplantation & Regenerative Medicine: The Beginning of Tissue Engineering Pathology" at the ATI Fellows Lecture Series on August 18, 2015.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Dr. Kim Solez presents the "Chair's Introduction" and "Medicine Writ Large: The Ultimate in Translational Medicine" at BIT's 4th Annual World Congress of Molecular and Cell Biology, Big Challenges, Huge Opportunities, in Dalian, China on April 26, 2014.
Foresight in medicine: research induced society changes in the next decadeCaroline McClain
The 2013 symposium hosts a debate among scientists, doctors, policy makers and epistemologists aimed at identifying forthcoming medical research developments likely to impact on society in the next ten years.
Personalized (or precision) medicine is the changing paradigm and will reshape service contents and delivery modalities. The main clinical areas where major progress is expected are cancer, neurodegenerative disorders, chronic obstructive pulmonary diseases, rare diseases, dysmetabolic and endocrine system related diseases.
Progress in imaging, the application of nanotechnologies, the use of robotics, wired environments and telematics, portable devices, stem cells and new materials will make personalized medicine feasible and affordable. At the same time, epigenetics, pharmacogenomics, synthetic biology will contribute extensively to change further
medicine and its social aspects, and will need to be regulated by a new bioethical approach.
In collaboration with Georgetown University Italian Research Institute and ISSNAF.
As part of "Anno Della Cultura Italiana" or Year of Italian Culture in the U.S.
Steph The Fore people began to die of a disease, and the diseas.docxwhitneyleman54422
Steph:
The Fore people began to die of a disease, and the disease seemed to target women and children specifically. (Bichell, 2016) The Fore people called the disease kuru in their native language, which meant trembling or shivering. (Bichell, 2016) During this time in the 1950s, researchers came in and were trying to discern what was happening to the Fore people of Papua New Guinea. They continued to research and test the people, and while doing so they kept eliminating disease after disease. During this time they tested for diseases, infections, viruses, etc. All of this just eliminated the various issues and taking them out of the equation. (Bichell, 2016) Many locals believed it was the result of sorcery, but they were insistent on finding out what was happening because with all the women dying, they were running out of bloodline. Around 1961, a researcher began to map out bloodlines trying to find a genetic link to the disease, but was unsuccessful. Then, there was a discovery. The Fore people believed that the bodies of their dead would be better served by being eaten by the women who loved them. This was because the bodies would have been eaten by worms or insects, and the Fore believed it was better if they ate their loved ones themselves. (Bichell, 2016) Typically the women would eat the loved ones, but the women would also feed the children “snacks” sometimes until they were old enough to live with the men. (Bichell, 2016) This was the cause of the disease. This disease was unique because it was nothing like anything scientists had seen before. It was not a virus or infection and it was later found that the illness caused was a protein that made the body eat away at the brain, making holes in it, and eventually killing the host of the illness. (Bichell, 2016) This story is a good example of anthropology’s holistic approach because it used testing that did not disrupt or hurt any additional people. It used genetic bloodlines and blood tests to find the right illness, instead of disrupting the people or causing more problems. This was great because the Fore were wanting help in understanding what was happening, but if people had come in and started causing problems among the people, they may have been forced out. This could have led to the complete extinction of the Fore.
++++++++++++++++++++++++++++++++++++++++++++++++++++++
Gary:
The people of Papua New Guinea were a hidden species, until the 1930's and some twenty years from that, they began being studied and researched. It was estimated that some 200 people, per year died of a condition called " kuru" which meant shivering and trembling. When an individual, primarily a woman or young child ( under the age of 8) contracted the disease, they would lose control of their body functions and emotions. For this reason, some researchers called it the " laughing death". When 'kuru' was first studied, it was believed that sorcery was the culprit, and then furt.
Introduction to Robert F. Kennedy Jr. book available on Amazon. https://amzn.to/365aF8V
I created this PDF file of the intro to his book to give people a good idea what the book is about. I had no idea what I was getting into when I got the book. No people or person should be given as much power as Fauci, big pharma and big tech has.
Many thanks to Robert F Kennedy Jr for the time and effort he spent putting this together for the world to read.
20 significantly Brave Leaders who contributed to Medicine | CIO Women MagazineCIOWomenMagazine
Many human pursuits depend on leadership to succeed. Sports, education, the arts, journalism, law, the military, and medicine may all attribute their success to the kind of leadership supplied.
Special video and in-person presentations awaited guests at
the February 10 dinner for the Friends of the National Library of
Medicine (FNLM) Board of Directors and the National Library of
Medicine (NLM) Board of Regents in the Lister Hill building lobby.
Guests attended a preview of a new video chronicling
the remarkable life and career of Michael E. DeBakey, M.D.,
pioneering cardiac surgeon, mentor to students young and
old, and tireless champion of the National Library of Medicine.
Dr. DeBakey died in 2008 at the age of 99.
Special video and in-person presentations awaited guests at
the February 10 dinner for the Friends of the National Library of
Medicine (FNLM) Board of Directors and the National Library of
Medicine (NLM) Board of Regents in the Lister Hill building lobby.
Guests attended a preview of a new video chronicling
the remarkable life and career of Michael E. DeBakey, M.D.,
pioneering cardiac surgeon, mentor to students young and
old, and tireless champion of the National Library of Medicine.
Dr. DeBakey died in 2008 at the age of 99.
Doctors, Scientists and Nutritionists on Kangen WaterChristopher Allen
Similar to Kim Solez Seizing the opportunity of technology and the future of medicine creating the possibility of a positive medical future for everyone1 (17)
Slide deck for annual meeting of Transplant Regenerative medicine Community of Practice of American Society of Transplantation at noon in Room 204 in John B. Hynes Convention Center. Everyone welcome! Many exciting initiatives to discuss!
Kim Solez Xenotransplantation- The Rest of the Story April 8 2022 6.pptxKim Solez ,
Nephrology Grand Rounds Presentation at the University of Alberta discussing the big picture issues surrounding xenotransplantation and its relation to stem cell generated organs and bioengineered organs in the future
Kim Solez Hooking-Up Physical Forces Optimism and Dark Energy Presentation Se...Kim Solez ,
Kim Solez Banff New Media Institute Presentation, "Smart, Sexy, Healthy" ThinkTank, Sept 6 2001
Hooking-Up, Physical Forces, Optimism and Dark Energy: Imagery, Hope, and Health.
Kim Solez 384 years of banff spirit new june 26 2019Kim Solez ,
Kim Solez 384 years of Banff spirit new June 26 2019 The most remarkable slide is number 137. "By Spring of 2019 every erroneous statement we complained about had been reversed. We celebrated by creating a new video trailer on our YouTube channel on June 25 2019." How about that!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Humble Herbalist Invites Country Pathologist
to Present at Medical Grand Rounds
Robert H. Heptinstall - Kim Solez Mentor
Referred to himself at “Country Pathologist”
Will be 99 on July 22, 2019.
3. Heptinstall Was Born and Raised in Keswick in the
UK Lake District population 4,821. Solez grew up in
Avoca, New York, population 1,099. Even More
“Country” Than Heptinstall! Both towns have had
stable populations for 80+ years.
4. Keswick has a Pencil Museum. Avoca (near
Bath) has a Bombardier Repair Facility that
repairs Edmonton LRT cars (among others).
5. Ishita Moghe BSc, Graduate
Student in Renal
Pathology/Nephrology
Immersion. Training in
Kidney Pathology in the Year
before Medical School.
Her Dog is Toto from Wizard of Oz
Reincarnated! Same Kind of Dog.
6. On my YouTube Channel
https://www.youtube.com/user/kimsolez
subscription rate went up six fold when
Ishita Moghe began co-presenting with me!
7. Previously I Only Knew Students’ Thoughts About
Tech&Future of Medicine Course Through Feedback
Questionnaire, but in Dec. 2018 Spontaneous
Positive Outpouring. Ishita Moghe Lectures Seemed
Like Only New Element to Account for This .
Bertalan Mesko - The
8. She described how the words we dealt with in
meeting programs and other cyberNephrology
work came much easier to her than other
medical words in medical school.
It occurred to me that she could have
benefitted if I had taught her nephrology and
renal pathology when she was working with
me before medical school.
Akshatha Raghuveer worked with me on
Banff meetings 2009-2013. Is now an
Internal Medicine Resident. Gave me
idea for Nephrology Immersion.
9. Ishita Moghe incorporates experience
from sport, dance, and piano
performance as she prepares for
presenting renal biopsy pathology alone
in the conference room the hour before
the conference.
11. The challenge of friendly AI becomes just a small part of
a much larger challenge of creating a friendly world in
which humans still have lives of significance, human
history is retained and extended.
We all need to be engaged in ensuring a positive
outcome for humanity. The future is ours
to shape. We need to get busy doing that!
Part of the imagined future could be
one where all disease was eliminated
but life was intolerable. Another where the only diseases
are from bioterrorism.
We Could Eliminate All Disease and Still
Have A Terrible World!
12. All natural disease may be eliminated, leaving
only man-made diseases. But that may leave
as much for physicians to do as there is today!
Challenging responses to bioterrorism and
stem cell technologies.
Focus of medicine no longer disease but
enhancement, which will extend beyond the
physical to the moral and spiritual.
Social responsibility an important aspect of
medicine and one of the focuses of the course.
2045 is only 26 years from now. Many of you
will still be working then. What will medical
careers be like then?
13. “It is the curse of humanity that it learns to tolerate even
the most horrible situations by habituation. Physicians
are the natural attorneys of the poor, and the social
problems should largely be solved by them.”
-Rudolf Virchow
Rudolf Virchow on the Social
Responsibility of Medicine
14. At the age of 27 I was an intern in Pathology at Johns
Hopkins. I read in the Oberlin Alumni Magazine about
the Oberlin Winter Term program and decided to offer
an experience in January 1973 when I was on my
cytology rotation. This involvement with students
continued 46 years to the present day. Dr. Heptinstall
called the students “the children” but benignly tolerated
them.
Most Quotes by Rudolf Virchow were
made in 1848 when he was 27 years of
age. What was I doing at the age of 27?
First engagement of undergraduate
students in my research.
15. Kim Solez Career Timeline
• MD With Honour and With Distinction in Research,
University of Rochester, Borden Award for Best Medical
Research done by a member of the Graduating Class
(Medical School) 1972
• Francis F. Schwentker Award for Best Research done by
a Johns Hopkins Hospital House Officer, 1974
• Assistant/Associate Professor of Pathology and Medicine
JHU 1977-87
• Chair of Department of Pathology, University of Alberta,
1987-92.
• First Banff Conference on Transplant Pathology 1991 (still
continues with future conferences planned to 2025!)
• National Kidney Foundation (U.S.) support of
cyberNephrology Center 1997- 2007
16. Kim Solez Career Timeline
• International Society of Nephrology support of Informatics
Commission 1997-2007
• William Boyd Lectureship 2002, Canadian Association of
Pathologists.
• Researcher of the Year, Capital Health Authority, 2005.
• National Kidney Foundation (US) Distinguished
International Medal, 2009
• Technology and Future of Medicine course begins 2011
• Tier 1 Clinical Mentoring Award, University of Alberta
Faculty of Medicine and Dentistry, 2016
https://www.youtube.com/watch?v=j03j1JMlYg0
• Teaching technology and the future of medicine to entire
first year medical student class directly begins in 2016.
• Eight publications in 2017-18 year. Career high.
• Medical Grand Rounds February 1, 2019 Age 72
17. Students Key to 1974 Award!
Francis F. Schwentker Award for Best Research done by a
Johns Hopkins Hospital House Officer, 1974 In presenting the
award Chair of Medicine Victor McKusick read the full names of
all coauthors saying “Since Dr. Solez was a busy house officer I
am sure the other authors did considerable work.”
Solez, K., Kramer, E.C., and Heptinstall, R.H.: The pathology of
acute renal failure: Leukocyte accumulation in the vasa
recta. Am. J. Pathol. 74:31a, 1974
“Solezocytes”
in vasa recta
in acute tubular
injury
18. Students Key to 1974 Award cont.!
Solez, K., Kramer, E.C., Fox, J.A., and Heptinstall, R.H.:
Medullary plasma flow and intravascular leukocyte accumulation
in acute renal failure. Kidney Int. 6:24-37, 1974.
Solez, K., Miller, M., Quarles, P.A., Finer, P.M., and Heptinstall,
R.H.: Experimental papillary necrosis of the kidney. IV.
Medullary plasma flow. Am. J. Pathol. 76:521-528, 1974.
Solez, K., Fox, J.A., Miller, M., and Heptinstall, R.H.: Effects of
indomethacin on renal inner medullary plasma flow.
Prostaglandins 7:91-97, 1974.
“Solezocytes”
in vasa recta
in acute tubular
injury
19. Full Professorship a Great Honor!
In 1977 Chair of Medicine Victor McKusick was happy to give me
joint appointment in Medicine and predicted it would keep pace
with my primary appointment in Pathology at the Assistant and
Associate Professor level but said “Being a Professor of Medicine
at Johns Hopkins is a great honour. It is unlikely that a pathologist
could achieve that honour.”
Full Professorship in
Medicine probably
unattainable for a
pathologist Victor
McKusick said.
20. Full Professorship a Great Honor!
That statement stuck with me, and I was very proud of my joint
appointment in Medicine. When I became Chair of Pathology at
the University of Alberta in 1987 I asked Chair of Medicine
Garner King about the joint appointment in Medicine. He just
looked at me in amazement. He had worked quite hard to recruit
me but did not anticipate this! The joint appointment did not
happen. Ah well. What might have been!
Full Professorship in
Medicine probably
unattainable for a
pathologist Victor
McKusick said.
22. Dr. Pamela Quarles
Became a psychiatrist in Alexandria, Virginia. Was the
daughter of legendary black historian Benjamin Quarles
(center of 1992 image)
https://en.wikipedia.org/wiki/Benjamin_Arthur_Quarles .
23. Elizabeth (Beth) Kramer “Are
you still doing that old stuff?”
Became a nursing leader. Five years later she
came back to see me. I told her what I was up to,
and she said “Are you still doing that old stuff?”
This embarrassing remark motivated me to
become an innovator, to step out of the box, to do
unexpected things.
24. Elizabeth (Beth) Kramer “Are
you still doing that old stuff?”
This drive to innovate led me to found and
direct a course on Technology and the
Future of Medicine, which talks about a
future world in which:
1) machines become smarter than we are
and take over the future agenda of the
world (The Technological Singularity),
and
2) stem cell generated organs and organ
repair offers a cure for most diseases.
25. Think Different – Sharing
cyberNephrology 5B3.09 WCM
HSC with Students & Fellows
since May 15 2015
Annette Shaff / Shutterstock.com
26. Here are the current students
from 2019. In many ways they are
a direct lineage from those
Oberlin college Winter Term
students 46 years ago in 1973!
27. If cyberNephrology were my whole
life there would be something out of
balance. Tuesday night poetry at
the Nook brings balance back. Many
at risk youth there. I provide video,
lighting and infrastructure.
28.
29.
30. New aspects of the future taught
in the LABMP 590 course suggest
two new disciplines of pathology:
1) Tissue Engineering Pathology, study of the
abnormalities in stem cell generated organs, a
discipline which helps to perfect regenerative
medicine therapies (Good!)
2) Apocalyptic Pathology, study of the pathology of the
elimination of the human species by sentient
machines who found us a nuisance (Bad! Theoretical
only (we hope!), the human remains/artifacts left
behind for robots to study after we meet our demise!)
31. Technology Run Amuck Scenarios,
Unfriendly AI & Nanotechnology Gone Wrong
- Grey Goo – Not Appealing Lecture Subjects!
32. You Know Something About the Apocalypse
The End of the World Through One of Robert
Frost’s Best Known Poems.
33. In an anecdote he recounted in 1960, prominent
astronomer Harlow Shapley claims to have inspired "Fire
and Ice”. Shapley describes an encounter he had with
Robert Frost in 1922 a year before the poem was
published in which Frost, noting that Shapley was the
astronomer of his day, asks him how the world will end.
Shapley responded that either the sun will explode and
incinerate the Earth, or the Earth will somehow escape
this fate only to end up slowly freezing in deep space.
Shapley was surprised at seeing "Fire and Ice" in print a
year later, and referred to it as an example of how
science can influence the creation of art, or clarify its
meaning. (From Wikipedia)
Science Influences Art: Robert Frost’s
“Fire and Ice” Inspired by a conversation
with prominent astronomer Harlow Shapley
34. Acceptance. Share power. The AIs will not all be under our
control. They will compete and cooperate with us just like
other people, except with greater diversity and
asymmetries
We need to set up mechanisms (social, legal, political,
cultural) to ensure that this works out well
Inevitably, conventional humans will be less important
Step 1: Lose your sense of entitlement
Step 2: Include AIs in your circle of empathy
The Future and All That Jazz: Art Helps
Convey Important Messages of Science.
36. In 2019 We Have Agency, But Proof Is Lacking
Who Influenced What. As Instances Accumulate
Evidence Becomes Convincing. Timeline 2 days
to 6 months. Much Faster than Before! Formal
Documentation Lacking. Like Internal Medicine
My father Dr. Chester Solez now 95 and well,
is an internist whose first paper was
nephrologic, but who then concentrated on
cardiology working in the VA hospital system
in the US and finally rising to Chief of
Medicine and Chief of Staff. He emphasized
to me repeatedly that unless you were
performing procedures most of your day to
day patient encounters you could not be sure
you were helping the individual patient. You
only knew that in aggregate. That is very like
modern life today in general. Internal
medicine is the model!
37. Do We Have Agency? Can We Make
Change? In Previous Eras It Took Years to
Decades to Effect Change Via Journal
Articles and Books.
In Banff Classification, we are still
struggling with borderline changes after
27 years. Discussed with Leonard
Cohen in 2005, became the song
“Treaty” 11 years later. Isolated v
lesions discussed as evidence for
rejection for 6 years. Interaction stylized
documented, and formal. Slow, but you
knew who influenced what.
38. In 2019 We Have Agency, But Proof Is Lacking
Who Influenced What. As Instances Accumulate
Evidence Becomes Convincing. Timeline 2 days
to 6 months. Much Faster than Before! Formal
Documentation Lacking. Three Examples. #1
Instance #1 Human Cell Atlas Project
(HCAP) at ASN Meeting.
Oct. 29, 2017 “Blind-sided by the future”
message posted to Facebook complaining
about exclusion of HCAP from mainstream
meetings. Oct. 31, 2017 HCAP scientist and
nephrologist Benjamin Humphries appointed
Chair of Program Committee for 2018 ASN
Meeting. March 31, 2018 YouTube video
describing Moghe-Solez paradox of exclusion
of such subjects from mainstream meetings,
https://www.youtube.com/watch?v=dAb6Epw
pEkM
August 2018 Aviv Regev plenary
presentation on HCAP at 2018 ASN meeting
announced, in Kidney News received in Sept.
39. What a moment it was to hear Aviv Regev’s
ASN Plenary talk Oct. 26 2018 after all the
anticipation and talk with her afterward!
40. In 2019 We Have Agency, But Proof Is Lacking
Who Influenced What. As Instances Accumulate
Evidence Becomes Convincing. Timeline 2 days
to 6 months. Much Faster than Before! Formal
Documentation Lacking. Three Examples. #2
Instance #2 Sept 15th, 2018 Yuval Noah Harari Claims
humans will be stuck, all plot lines wrecked when machines
do all crucial decision making.
https://www.theatlantic.com/magazine/archive/2018/10/yuval
-noah-harari-technology-
tyranny/568330/?fbclid=IwAR2WjyHq_srFD4Zg_Wop-
3emHbWLpQRvtrgr5qW04cqRm_X8f1GpEzzYFw0
Sept 21, 2018 Our multithreading video points out humans
will adapt, culture could be many-fold better than today with
multithreading.
https://www.youtube.com/watch?v=wL2rL8LPfQM
Oct. 4, 2018 In his Wired interview Harari now says human
reaction to machine decision making is work in progress, no
predictions can be made!
https://video.wired.com/watch/yuval-harari-tristan-harris-
humans-get-
hacked?fbclid=IwAR1soHWIpmVz8P9HITPzd5Bdl2mYOy-
nXOe272x-6Eh5ufKVet5XXp_RmQU
41. In 2019 We Have Agency, But Proof Is Lacking
Who Influenced What. As Instances Accumulate
Evidence Becomes Convincing. Timeline 2 days
to 6 months. Much Faster than Before! Formal
Documentation Lacking. Three Examples. #2
Multithreading - Kim Solez, M.D.
Multithreading
Is where we're heading.
Obviously
Can't you see?
That's what in the future we will use extra intellect
for
So that instead of one life we can have four or more!
All concurrent
In the moment.
42. In 2019 We Have Agency, But Proof Is Lacking
Who Influenced What. As Instances Accumulate
Evidence Becomes Convincing. Timeline 2 days
to 6 months. Much Faster than Before! Formal
Documentation Lacking. Three Examples. #2
So everything fun and interesting you want to do you can
Even if events are in different places in the same short time
span!
Multiboxing in video games is just a small instance
Of something that in real life will allow us to pounce
On every desirable opportunity
With characters that are still us you see
And at the end of the day all our diverse facets of personality
Can compare notes on the day’s accomplishments endlessly.
Boy/Girl won't my multiple instances of self have fun
Swapping yarns about all the things they've done.
43. In 2019 We Have Agency, But Proof Is Lacking
Who Influenced What. As Instances Accumulate
Evidence Becomes Convincing. Timeline 2 days
to 6 months. Much Faster than Before! Formal
Documentation Lacking. Three Examples. #2
And imagine how compatible they will be
Since in the end they are all really me!
Every day lived with glorious concurrent adventures
And every night with grand stories told by raconteurs,
Multiple instances of ourselves
And gleeful as Santa's elves!
44. In 2019 We Have Agency, But Proof Is Lacking
Who Influenced What. As Instances Accumulate
Evidence Becomes Convincing. Timeline 2 days
to 6 months. Much Faster than Before! Formal
Documentation Lacking. Three Examples. #2
In his wired video interview Harari advises that individuals can
accomplish very little by themselves. They should join groups,
causes, he says. That is the opposite of our experience doing
videos together where we seem to be accomplishing a lot
without joining groups. More recent interviews do not have this.
45. All Five Reasons in this May 24, 2018
Article are Unsupported & Incorrect:
Bertalan Mesko - The
46. All Five Reasons in this May 24, 2018
Article are Unsupported & Incorrect:
Bertalan Mesko – The Medical
Futurist incorrectly states that:
1. AI cannot be empathetic.
2. AI cannot do nonlinear thinking.
3. Machines cannot interpret data.
“No robot or algorithm could clearly interpret complex,
multi-layered challenges – involving the psyche. While
they will provide the data, interpretation will always
remain human territory.”
https://medicalfuturist.com/5-reasons-artificial-intelligence-wont-replace-physicians
4. There will always be tasks like the Heimlich maneuver
algorithms and robots can never complete.
5. Human machine cooperation is the ultimate solution. There is
nothing better.
47. Directly contradicts author’s own
book from October 2017 about
physicians being replaced:
Bertalan Mesko - The Medical Futurist
states it correctly:
“AI will not replace physicians, but
physicians using AI will replace
physicians not using AI.”
48. We Directly Contradicted the May 24
July 20th 2018 posts in series of
videos from Aug. 20 to Oct 11th.
Bertalan Mesko - The
49. October 22 Bertalan Mesko video that
agrees with us does not mention us!
https://www.youtube.com/watch?v=h
T0ly4pDSoY.
50. Taken together these three examples
suggest our videos are accomplishing
major things, have agency.
Bertalan Mesko - The
51. Short time frame, days to weeks, in
these effects suggests a new model
of science communication.
Bertalan Mesko - The
52. Pathology and AI Came Together in
April 2017 FDA Approval of Digital
Pathology for Primary Diagnosis
Cytology,
Frozen Sections,
and
Hematopathology
were excluded
from approval.
53. In 2018 the First Ever Digital Pathology
and AI Congress in New York City
54. I recruited Digital Pathology expert
Yukako Yagi to joint UAlberta/Univ.
Pittsburgh position in early 1990s!
Now at Memorial Sloan Kettering, she was one of keynote
speakers at 2018 Digital Pathology and AI Congress.
55. Almost Overnight Pathology Went
From Having the Worst Promotion
of Any Specialty to the Best. We
became the Hollywood of Medicine!
56. Gone Are The Blood And Guts. Now
Every Page is Visually Appealing
and Seductive!
57. Every Effort Is Made to be Reassuring
and Comforting.
“AI pathology is never going to
replace pathologists.”
“Nobody should feel threatened by
advances in computational pathology.”
“The integrative aspects of pathology,
the cognitive abilities of pathologists,
and the collective wisdom generated
over many years as a community
cannot be replaced by a machine.”
58. These statements are only true near term,
not forever:
“AI will really help enrich your ability to
practice pathology and improve your
ability to serve your patients.”
“AI is not here to remove pathologists
from the decision-making process.”
“(AI is) an exciting step forward in
the discipline of pathology – one that
puts pathologists at the very center
of clinical care and precision
therapeutics.”
59. I direct a course on Technology and
the Future of Medicine which
considers many of these issues
Ishita took the course in Fall 2017.
Five AI faculty also teach in the
course.
Bertalan Mezko , Daniel Kraft, and
Gerd Leonhard teach similar courses
but as a professional keynote
speakers, not a full time academics.
The government of Finland has
recently started a free AI course which
it encourages all its citizens to take. It
teaches some special government
fictions.
www.singularitycourse.com
http://www.elementsofai.com/
60. New Finnish Government AI course
www.elementsofai.com Says We Do Not
Need to Fear AI because Self
Improvement Requires Human Help.
“… even if a system could optimize its own workings, it would keep
facing more and more difficult problems that would slow down its
progress, quite like the progress of human scientists requires ever
greater efforts and resources by the whole research community and
indeed the whole society, which the … entity wouldn’t have access
to. … human society still has the power to decide what we use AI
technology for. (With progress in AI we become)…better at
controlling any potential risks due to it.”
61. New Finnish Government AI course
www.elementsofai.com President of
Finland spoke at graduation ceremony
for course on Thursday Sept. 6th 2018!
62. Machines Will Be Able to Create Their
Own Models of the World but Humans
Will Want to Get a Word in Edgewise!
https://www.theguardian.com/books/2018/jun/15/rise-of-the-machines-has-
technology-evolved-beyond-our-control-
63. Machines Will Be Able to Create Their
Own Models of the World but Humans
Will Want to Get a Word in Edgewise!
"Google Translate was known for its humorous errors, but in
2016, the system started using a neural network developed
by Google Brain, and its abilities improved exponentially.
Rather than simply cross-referencing heaps of texts, the
network builds its own model of the world, and the result is
not a set of two-dimensional connections between words, but
a map of the entire territory. In this new architecture, words
are encoded by their distance from one another in a mesh of
meaning – a mesh only a computer could comprehend."
https://www.theguardian.com/books/2018/jun/15/rise-of-the-machines-
has-technology-evolved-beyond-our-control-
64. Fictional Worlds Presented to Sentient
AI As Fact Threaten Humanity’s Survival
AI Will be Sensitive to Lies About Itself
65. Fictional Worlds As Models of the Real
World Exist Already in 2018 and Will
Increase in Number and Influence