This document discusses organ donation shortages in the US and emerging technologies like 3D bioprinting of organs and head transplants as potential solutions. It notes that over 120,000 people are on organ transplant waitlists in the US despite only 2.5 million annual deaths. 3D bioprinting of tissues and organs could help by producing customized organs without rejection risks. The document also discusses a planned first human head transplant by Dr. Sergio Canavero to treat a 30-year-old man's rare genetic disorder that cannot be addressed by gene editing alone. The head transplant would be an attempt to treat the man's condition which currently has a life expectancy of around 20 years.
Lukas P, Organ Cloning, period 3, 11 slides (first slide blank) - Please disregard my previous upload. I uploaded wrong version. The correct version is called Organ Cloning Project Revised.
Lukas P, Organ Cloning, period 3, 11 slides (first slide blank) - Please disregard my previous upload. I uploaded wrong version. The correct version is called Organ Cloning Project Revised.
Kim Solez Introduction to regenerative medicine Fall 2015Kim Solez ,
Dr. Kim Solez presents "Introduction to Regenerative Medicine" on September 10, 2015 in the Technology and Future of Medicine course LABMP 590 http://www.singularitycourse.com at the University of Alberta in Edmonton, Canada. Copyright (c) 2015, JustMachines Inc.
The Potential Impact of Preimplantation Genetic Diagnosis on Discrimination o...blaine_5
The argument that selection against specific genetic traits will lead to increased discrimination is both compelling and troubling. Indeed, it is reasonable to conclude that if a large number of people use PGD to select against traits they consider to be disabilities then the probability of increased discrimination and marginalization would be greatly increased. However, as this Note argues, most participants in the PGD disability debate overlook important limitations of both trait selection and large-scale PGD adoption that will likely mitigate the negative potentially negative impact of PGD technology.
Solez Update on the Technology and Future of Medicine Course: Space, Regenera...Kim Solez ,
Dr. Kim Solez presents Update on the "Technology and Future of Medicine Course: Space, Regenerative Medicine, Large Touch Screens, and Leonard Cohen" on September 25, 2014 at Lab Medicine Pathology Grand Rounds at the University of Alberta in Edmonton, Canada.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Kim Solez Tissue Engineering Pathology Meets Human Cell Atlas a Glimpse into ...Kim Solez ,
Dr. Kim Solez presents "Tissue Engineering Pathology Meets Aviv Regev's Human Cell Atlas: A Glimpse Into the Future of Pathology" on March 8th, 2017 at the University of Alberta in Edmonton, Alberta, Canada Copyright (c) 2017, JustMachines Inc.
Kim Solez Introduction to regenerative medicine Fall 2015Kim Solez ,
Dr. Kim Solez presents "Introduction to Regenerative Medicine" on September 10, 2015 in the Technology and Future of Medicine course LABMP 590 http://www.singularitycourse.com at the University of Alberta in Edmonton, Canada. Copyright (c) 2015, JustMachines Inc.
The Potential Impact of Preimplantation Genetic Diagnosis on Discrimination o...blaine_5
The argument that selection against specific genetic traits will lead to increased discrimination is both compelling and troubling. Indeed, it is reasonable to conclude that if a large number of people use PGD to select against traits they consider to be disabilities then the probability of increased discrimination and marginalization would be greatly increased. However, as this Note argues, most participants in the PGD disability debate overlook important limitations of both trait selection and large-scale PGD adoption that will likely mitigate the negative potentially negative impact of PGD technology.
Solez Update on the Technology and Future of Medicine Course: Space, Regenera...Kim Solez ,
Dr. Kim Solez presents Update on the "Technology and Future of Medicine Course: Space, Regenerative Medicine, Large Touch Screens, and Leonard Cohen" on September 25, 2014 at Lab Medicine Pathology Grand Rounds at the University of Alberta in Edmonton, Canada.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Kim Solez Tissue Engineering Pathology Meets Human Cell Atlas a Glimpse into ...Kim Solez ,
Dr. Kim Solez presents "Tissue Engineering Pathology Meets Aviv Regev's Human Cell Atlas: A Glimpse Into the Future of Pathology" on March 8th, 2017 at the University of Alberta in Edmonton, Alberta, Canada Copyright (c) 2017, JustMachines Inc.
1Organ Transplants [Type the company name]Assignment 1Com.docxhyacinthshackley2629
1
Organ Transplants
[Type the company name]
Assignment 1:Commercialization of Organ Transplants
Commercialization of Organ Transplants
Commercializing the sale of transplant organs has become a popular topic of discussion within the last few years. I was surprised that in my beginning research I found that a lot of people are for the commercial sale of organs to patients who need them and actually believe that it has the potential to become something that could change the way we look at organ transplants. R R Kishore wrote in his paper, Human organs, scarcities, and sale: morality revisited,To many the process may sound iniquitous and even sinful but, in fact, it is fair and natural and is consistent with normal human behaviour. The back and forth argument about whether or not the sale of human organs is a moral issue has many positions and points of view, however seems to be split between those who feel it is a natural solution that goes along with human nature and those who feel it is degrading and unethical and goes against equality for the human race.
From my research I have been able to find out about the different practices of organ sales. Most of the times when people think about organ sales they most often associate it with the cases of a person who is in need of money and sells a kidney to another person who needs it. However I have learned through research that there are many other scenarios. One (in countries where the prior consent of the deceased is required for cadaveric organ donation) is to pay people living now for rights over their body after death. Another (in countries where the consent of relatives is required for cadaveric organ donation) is to pay relatives for transplant rights over their recently deceased loved ones' bodies(Garzon, 2012).
Going into this assignment I didn’t really have a set side that I was on when it came to this topic. However after reading many articles on the subject I was able to better form a solid opinion. After gaining a better understanding of the subject overall I have come to the belief that selling organs is not morally wrong; at least not in most ways.
A great deal of good could come out of the commercialization of organ sales. There are also many issues with patients waiting on transplants that could be remedied if organs could be freely sold. Annually, 300,000 people receive organtransplantsworldwide.Noteveryone who needs a transplant receivesone, and there remains a surplus ofpatients waiting to receive an organ. Every year this number increases (Wilkinson, 1998). Some of the increasing number of people dying during the wait for an organ could be improved with this simple change. However, even though the death rate of patients waiting on an organ keeps increasing and is a very big problem it is not the only problem that needs to be fixed. Physicians mustchoosebetweenpatientswhenallocating organs-some get organs and some are refused. As a result, patients who feelthe.
HE 485W Bioethics for Public Health
please answers each of the following in a brief paragraph.
l. Please explain why we should have cause for concern regarding
the Bioethical issues facing us in today's modern contemporary
Society
2. When does an individuals' right to choose begin to threaten the
autonomy of others? Likewise, when does the quest for
autonomy begin to threaten individual rights?
3. Please explain how genetic engineering and testing along with
Bio-technology has the potential to promote discrimination.
4. Please describe the inherent social challenges in cloning human
beings as we have discussed them in class or otherwise.
5. In your opinion, would it ever be appropriate for employers to
screen for predetermined genetic disorders. Why and Why not?
6. Would it ever be ethical to withhold information from a dying
patient? Why and Why not?
Organ Transplants
Ethical Issues
What are Organ Transplants?Cadaveric organ donation: Involves removing organs from a recently deceased donor.Living organ donation: Involves the donation of one of a paired organ (ex: kidneys) or a portion of an organ (such as a lobe of the liver or lung). The donor's organ system is still able to function after the donation. Living donors are often related to the patient, but that is not always the case.
HistoryIn 1954, the first successful kidney transplant was performed in the United States. It was a kidney from a living identical twin donor.
History cont.More than a half of a century after the very first transplant, more than 80,000 people whose death without a donor is certain are on waitlists in the United States waiting for a new lung, kidney, heart, or liver. The United Network for Organ Sharing reports that about half of these people will die without receiving the necessary organs. Human organs are a scarce medical resource and have many ethical issues concerning organ transplantation.
ConsentA donor card is the main signal for permission to collect an organ from a potential donor. Also there is an attempt to gain approval from a next of kin or other family members. If a family member isn’t present for that decision then recovery agencies would act solely on the donor card.
Donor Card ConcernsThere is fear and distrust that if you are a organ donor then less effort would be placed into saving your life if your death meant organs for others.Coercion takes place when signing up for a license, because everyone’s license is marked with the decision to be a organ donor or not.
Allocation ConcernsOrgan recipients are chosen from a long waiting list after they have been medically determined to be a eligible candidate. The criteria for these lists are weighed upon factors such as age range, causes of failure, and stage of organ failure.
An attempt to balance justice...The United Network for Organ Sharing policy tries to make the decision of organ donating fair by placing criteria on the donatin ...
1. Chris Baker
Bio-Medical Ethics
“We Can Rebuild Him…”
Allow me to present to you two startling medical facts: Fact One: Despite 2.5 million
deaths per year in the United States according to the CDC, there are over 120,000 people waiting
for organ transplants across America.i The extreme dichotomy of these numbers emphasizes the
primary point – there is a massive shortage of donated organs in the United States. Fact 2: Germ-
line editing (GLE) is ripe with controversy – some deserved, some not. Congruent to this idea,
there are some disorders, such as Werdnig-Hoffman disease, that somatic cell editing, or even
Germ-line editing may not be able to fix. This is because the body simply does not have a highly
detectable amount of SMN, a protein found in high amounts in motor neurons, which is
responsible for muscle growth, sitting upright, and proper breathing.iiiii And spinal muscular
atrophy, of which Werdnig-Hoffman is the most severe type, is the leading hereditary cause of
infant mortality in the world.iv What do these medical facts have in common? Nothing, aside
from their philosophical and increasingly empirical solution – the ideas and applied principles
found within the philosophy of Trans-Humanism. That is, the idea that tool-making and tool-
using is a fundamental core of what it means to be human - individually, societally, and
medically. This means that as human nature continues to produce shades of gray and nuance, so
too must our tools. Although this essay is not designed to be critical of GLE, it will show how
the philosophy and applied principles of Trans-Humanism absolutely play a vital role in
answering questions regarding GLE, and organ demand and procurement in the United States.
2. What Are The Issues?
According to a November report by the United Network for Organ Sharing (UNOS), a
group dedicated to advancing “organ availability and transplantation by uniting and supporting
our communities for the benefit of patients through education, technology and policy
development,” there are over 120,000 thousand people on organ transplant waitlists from all
around the United States.vvi Of those 120,000, close to 81% are waiting for kidneys, an organ
which the human body has two of, and of which the human body can survive with only one. This
is followed by the liver, of which a person can live with a smaller, donated portion.
Unfortunately, despite the fact that the two biggest organ shortages are related to organs which,
theoretically, are easier to donate because the pool for those organs is bigger (potential donors
are alive, as well as deceased), and you only need one or only a portion, the fact remains that
they constitute over 90% of the total amount of people on the waitlist.
In addition, raising the supply of viable organs is not a simple process, as it is not easy to
convince people to donate. In America, there is an opt-in approach. This is where people who
decide they want to be donors are able to register “in” at the website “organdonor.gov” and can
do so by state.vii Despite the ease, however, there are many ethical considerations that both the
doctor and potential donor, as well as the general public must be able to answer. It is unlikely
that a significantly large amount of people are against donations, philosophically. However, with
the lack of supply, philosophical questions must be asked and answered. For instance, should the
United States adopt an opt-out approach, like many countries in Europe have? An opt-out
system works with the idea that everyone is a potential donor, and upon your death, your organs
are harvested for use in patients on organ donation waitlists, unless you have previously
specified that you do not want to be a donor. On November 30, 2015, Wales became the first
3. nation in the UK to start what they call “presumed consent,” meaning that if one does not want to
donate, they have to specifically state so.viii Like the issue of organ donation by itself, this
decision is not without controversy. For instance, what of people whose religion forbids them
from donating used, personal, organs? Even without a religious component, what of
conscientious objectors, people wary of a system that they believe sees people as a means to an
end, who would rather harvest their organs than save their life? Or, perhaps more simply and
more poignant to the discussion, what of paternalism vs autonomy? If there are truly such things
as individuals, and individuals own their own bodies, should they not have the final say,
regardless of any positive or negative outcomes?
To be clear, this portion of the essay is not intended to discourage organ donation, but
rather to illustrate briefly controversial issues that stem from it. That said, the question must still
be “How can we increase the supply of organs, while respecting people’s right to not donate if
they wish?” This is where the rapidly advancing technology of 3D printed organs comes into
play.
What Does This Look Like?
Dr. Gabor Forgacs is a scientist with the University of Missouri-Columbia, and a
researcher for Organovo, a research institute dedicated to “changing the shape of medical
research and practice.” And he - along with the general scientific community - believes that the
time is close at hand where technology will literally be able to print organs, a process called
“bio-printing.” Using a printer, they are able to release certain cells into an outgoing atmospheric
gelatin. The cells then begin the replication process naturally, just as they would when the body
forms. The cells divide, fuse, and divide again, creating more complex forms of tissue.ix A
4. significant advantage to this method is the fact that the tissue that is grown is collected from your
own organ’s cells, meaning there is no donation needed, and there is very little chance of
rejection. “I think that what was science fiction fifty years ago is becoming a reality today,” says
Dr. Forgacs. To be fair, printing a viable organ is still some years away. “This work is an
important step in that direction by enabling us to use biological materials that we believe are
necessary to do this. However, years of research are still required,” said Adam Feinberg, a
biomedical engineer at Carnegie Mellon University, who has been working on similar
technologyx. One thing that makes Feinberg’s work especially important is the cost associated
with the actual printing process. While the majority of such printers cost around $100,000
dollars, Feinberg’s printer costs less than $1,000.xi “Our vision is that other research groups can
take this technology and apply it broadly to other tissue-engineering and soft-materials 3D-
printing challenges," Feinberg said.xii
What Does This Mean?
First and foremost, this means a direct, positive impact on the availability of organs for
those in need, in the near future. To be clear, bio-printing is still a few years away, at the earliest.
Despite this, there is much to be hopeful for, given the speed at which technological innovations
appear. But more than that, bio-printing avoids some of the ethical issues surrounding organ
donation, such as creating a viable and sustainable method of increasing supply, while allowing
people and donors to retain their autonomy.
What Are The Issues?
Germ-line editing and somatic cell editing are processes in which the DNA of stem-cells
are modified. These modifications repair or replace entirely damaged portions of DNA. The
5. primary difference between the two is the duration of the effect – Somatic cell editing affects
only the person being treated with that form of gene therapy. Germ-line editing, however, is a
kind of modification that can be passed on. The advantage to this form of genetic modification is,
it is argued, the eventual eradication of genetic diseases – diseases like sickle cell anemia, cystic
fibrosis, or down-syndrome. The argument appeals to a sense of finality in that a disease can be
completely “erased,” literally, from our genetic code. Notwithstanding, there are many who
believe in a future dominated by “Gattaca” like people – genetically modified, and “perfect,”
while those unable to afford such procedures given the lowliest of jobs and lifestyles. “Should
germ-line editing become a more common practice, moving from the realm of medicine to
desire,” they say, “what’s to stop people from genetically altering away any perceived
‘imperfection,’ leaving the rest of poorer humanity in the dust?” While this critique subscribes to
a social justice perspective of germ-line editing, there are other genetic diseases that simply
cannot be treated with somatic cell editing, or even germ-line editing. Illnesses such as these
require a different approach.
What Does It Look Like?
Dr. Sergio Canavero, of the Turin Advanced Neuromodulation Group (TANG) in Italy,
will attempt within the next two years the world’s first, complete, head transplant. One of the
first obstacles has already been overcome – a willing participant. Valery Spiridonov, a 30-year-
old computer scientist from Vladimir, Russia has volunteered for the procedure. Valery suffers
from a genetic disorder called Werdnig-Hoffman disease, a disease which affects his ability to sit
up, causes significant breathing problems, and is a type of spinal muscular atrophy – the leading
cause of infant mortality in the world. It is also the most severe type of this disorder, and
diagnosed patients typically do not live past twenty years of age. Despite this, Valery has lived to
6. thirty, but understands that his condition gets worse every year. “I can hardly control my body
now," he said. "I need help every day, every minute. I am now 30 years old, although people
rarely live to more than 20 with this disease."xiii What makes this a rather interesting case is the
fact that germ-line editing or somatic cell editing cannot be used to treat the disease. The primary
effect of this disorder is that the motor neurons do not produce detectable amounts of the protein
SMN, which is vital for muscle growth in the spine. As a result, these kinds of gene therapy are
not appropriate forms of treatment. “It will be about curing incurable neurological disorders for
which other treatments have failed big time, so gene therapy, stem cells - they all just came to
nothing. We have failed despite billions of dollars being poured into this sort of research,” says
Dr. Canavero. xiv The process involves an immensely sharp cutting tool cutting the spinal cord at
the base of the head. Then, using a technique known as “spinal cord fusion,” the head will be
reattached on a donor body. “The key to SCF is a sharp severance of the cords themselves," Dr.
Canavero explains in a paper published earlier this year, ‘with its attendant minimal damage to
both the axons in the white matter and the neurons in the gray laminae. This is a key point. The
spinal cord of the donor body will then be fused with the spinal cord of the recipient's head.
Chemicals called polyethylene glycol or chitosan can be used to encourage SCF, according to
Dr. Canavero. The muscles and blood supply will then be sutured.’” xv It is expected that the
entire healing process will take around a year, with a mandatory 3-4 week medically induced
coma immediately following completion of the surgery. Despite the risk and associated cost, Dr.
Canavero is confident that the surgery can and will succeed. “It will be a success. There is a step-
by-step, no-risk approach to all this. If step one doesn't pan out, we will work more on that step
until it works, move on and so on. There is a detailed plan - we are not just concocting this in
7. some secret Frankenstein lab. We are way ahead now into the project, everything is moving - it
is no longer science fiction.”xvixvii
Anticipated Criticisms
When it comes to discussing and supporting new technologies and procedures in the
medical profession, one of the first kinds of criticisms that come deal with issues of social
justice. Generally speaking, these are indeed valid concerns and should be addressed when and if
possible. With issues involving the successful tackling of a lack of supply of organs for donors,
or being able to perform an experimental procedure, the medical industry and doctors should not
be concerning themselves with potential abuses of technology. Nor should they be concerning
themselves with worries over who will be first to have access to care, or if it will be distributed
“fairly.” Again, those are typically valid concerns – ordinarily. However, when dealing with
organ shortages, or deadly and debilitating genetic diseases, medical ethicists must be careful not
to hinder treatment options for people who are suffering right now. If an issue is a shortage of
organs, the solution must be to increase supply. Despite that, autonomy must be respected, and
the ability to choose protected. This being the case, it is a moral imperative for doctors and
ethicists alike to support efforts to increase supplies with new and emerging technologies. If bio-
printing plays a role in that process, then so be it. And the greater support it receives, the greater
chance it has at helping the most amount of people possible.
Likewise, when it comes to commonly occurring genetic diseases (especially those which
somatic cell and germ-line editing cannot treat), the goal should be to either lesson instances, or
combat it appropriately once it has been diagnosed. If this procedure has even a slight chance at
8. working (and it has much more), it is ethically imperative that medical professionals and ethicists
alike show support for it. Sufferers of this disease are rare – few and far between. Yet despite
medical professionals’ best efforts, these people have little options for living a relatively normal
life. It becomes crucial then that people who suffer with similar diseases not be left behind or
forgotten because we are worried about accessibility for some in the future, or potentials for
abuse. If those are to be primary concerns, then very few of the medical breakthroughs society
experiences today would not exist. Allow the technologies and procedures to come into
existence, and then look for just ways of access and available. Nonetheless, the goal for doctors
is to treat people right now. And there are people right now who could be benefitting from these
emerging technologies and procedures.
Summary
Given the length of this essay, it is understood that a truly comprehensive presentation
with significantly more time and data needs to be offered. If this paper can initiate the
conversation, and start people thinking about how Trans-Humanist philosophy might provide the
basis for some of the answers, then this essay will have been a success. The philosophies and
principles of Trans-Humanism have been presented in a way that hopefully gives the reader a
more precise understanding of what that means, through concrete examples of those beliefs in
action. Trans-Humanism recognizes the fundamental aspect of tool making and tool using in
human nature, and does not seek to shy away from that, even if the potential for abuse is there.
That critique is misguided, especially when considered in light of the immediate need of such
tools. That is not to say that it is always misguided. Rather, a doctor’s first priority is to the
patient in their office. There is an immediate and serious need for these emerging technologies,
and it is the responsibility of medical ethicists and medical professionals to unite in solidarity
9. over them – especially considering their impact and usefulness. Many of these technologies are
some time away, while at the same time, not all that far off. The confidence in them by the
medical community continues to grow steadily, and their potential cannot be overstated.
Specifically, somatic cell and germ-line editing, although supported generally by the author, are
not appropriate forms of therapy in all cases. Some disorders need something else; something
more. In other cases, organ procurement is a complicated and difficult process and issue. If there
existed a technology that would allow scientists and doctors to literally print healthy, functioning
organs – grown using a patient’s own cells – then it is imperative that such technologies be
supported.
i http://www.cdc.gov/nchs/fastats/deaths.htm
ii “The SMN protein is expressed in all tissues of mammalian organisms,butparticularly high levels areexpressed in
motor neurons (Coovert et al.1997;Lefebvre et al.1997). In contrast,individualsaffected by the most severe form
of SMA, Werdnig-Hoffman syndrome or SMA type I, have barely detectable levels of SMN in motor neurons.
(Coovert et al.1997; Lefebvre et al.1997).” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168095/
iii “Spinal muscular atrophy (SMA) is an autosomal recessiveneurodegenerative disorder,leadingto progressive
muscleweakness, atrophy, and sometimes premature death. SMA is caused by mutation or deletion of the survival
motor neuron-1 (SMN1) gene. An effective treatment does not presently exist.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369530/
iv “SPINAL muscular atrophy (SMA) is a common autosomal recessivediseasethatis the leadinghereditary causeof
infantmortality.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168095/
v “Our mission is to advanceorgan availability and transplantation by unitingand supportingour communities for
the benefit of patients through education, technology and policy development.”
https://www.unos.org/about/mission-values/
vi See Graph: https://www.unos.org/data/transplant-trends/#waitlists_by_organ
vii http://www.organdonor.gov/index.html
viii “The system, known as presumed consent, will mean that people who do not want to donate their organs will
have to formally optout. It comes into force on Tuesday (Nov 31,2015) and supporters say itwill savelives with
organs availableto patients across the UK.” http://www.bbc.com/news/health-34968491
ix https://www.youtube.com/watch?v=yLwEFQnHSiY
x http://www.livescience.com/52571-3d-printers-could-build-organs.html
xi http://www.livescience.com/52571-3d-printers-could-build-organs.html
xii “It also uses open-sourcesoftware that the researchers say they inviteothers to hack and improve.”
http://www.livescience.com/52571-3d-printers-could-build-organs.html
10. xiii http://www.medicalnewstoday.com/articles/292306.php
xiv “So actually,head transplantor body transplant,whatever your angleis,is actually a failureof medicine. It is not
a brilliantsuccess,a brilliantadvancementto medical science.When you justhaven't tackled biology,you don't
know how to treat genes, you don't really understand,and you real ly need to resort to a body transplant,itmeans
that you've failed.So this must not be construed as a success of medical research."
http://www.medicalnewstoday.com/articles/301073.php?trendmd-shared=0
xv The recipientwill be kept in a coma for around 3-4 weeks, says Dr.Canavero, duringwhich time the spinal cord
will besubject to electrical stimulation viaimplanted electrodes in order to boost the new nerve connections.”
http://www.medicalnewstoday.com/articles/292306.php
xvi This is “a procedure he claims will takearound 150 surgeons and nurses approximately 36 hours to complete
and will costaround $11 million.”http://www.medicalnewstoday.com/articles/292306.php
xvii http://www.medicalnewstoday.com/articles/301073.php?page=2