Dr. Kim Solez presents the "Chair's Introduction" and "Medicine Writ Large: The Ultimate in Translational Medicine" at BIT's 4th Annual World Congress of Molecular and Cell Biology, Big Challenges, Huge Opportunities, in Dalian, China on April 26, 2014.

1. CMCB-2014, “Big Challenges,
Huge Opportunities”
Panel G1 Role of Molecular and
Cell Biology in Translational
Medicine
Chair’s Introduction
Kim Solez, M.D.

2. “A specialist is a barbarian whose ignorance is
not well-rounded.” - Stanislaw Lem At age 26, just
after graduation from medical school, I was a
specialist interested in acute tubular injury:
Solez, K., et al: Medullary plasma flow and
intravascular leukocyte accumulation in acute
renal failure. Kidney Int. 6:24-37, 1974.

3. This specialist interest shared by only to a few led
eventually decades later to something very
general and widely accessible, the concept of
“Medicine Writ Large”, medicine as something
much larger than you ever imagined!

4. Medicine Writ Large:
The Ultimate in
Translational Medicine
Kim Solez, M.D.

5. Five years later I published the definitive
description of the pathology of acute tubular
injury. Solez et al. Morphology of "acute tubular
necrosis" in man: Analysis of 57 renal biopsies
and comparison with the glycerol model.
Medicine 58:362-376, 1979.

6. The Banff Classification of Kidney Transplant Pathology
Histologic criteria for the diagnosis of rejection and other
conditions in the transplanted kidney, began in 1991, updated
and expanded every two years in consensus meeting.

7. Banff Transplant Pathology Meetings Began in the
Transcanada Pipelines Pavilion at the Banff Centre in
1991, Future Meetings Are Planned through 2021.

8. Slide 8
Banff Classification: Milestones
• 1991 First Conference
• 1993 First Kidney International publication
• 1995 Integration with CADI
• 1997 Integration with CCTT classification
• 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies,
microwave.
• 2001 Classification of antibody-mediated rejection
– Regulatory agencies participating
• 2003 Genomics focus, ptc cell accumulation scoring
• 2005 Gene chip analysis. Elimination of CAN, identification of chronic
antibody-mediated rejection.
• 2007 First meeting far from a town called “Banff” – La Coruna, Spain.
- 2013 Banff Foundation for Allograft Pathology created, Swiss non-profit
foundation, provides infrastructure, succession planning.

9. Global consensus generation while
maintaining intellectual freedom.

10. Like the mosh pit at a great rock concert.
No partner, the ultimate in individuality,
dangerous, but
when the music is
good everyone
dances in sync
and life is good.

11. Unique Multidisciplinary Course on Technology and
the Future of Medicine LABMP 590 Created in 2011

12. The Technological Singularity
The technological singularity occurs as artificial intelligences
surpass human beings as the smartest and most capable life
forms on the Earth. Technological development is taken over by
the machines, who can think, act and communicate so quickly
that normal humans cannot even comprehend what is going on.
The machines enter into a "runaway reaction" of self-
improvement cycles, with each new generation of A.I.s
appearing faster and faster. From this point onwards,
technological advancement is explosive, under the control of the
machines, and thus cannot be accurately predicted (hence the
term "Singularity"). – Ray Kurzweil

13. Moore’s Law Predicts Singularity

14. Evidence for the Coming
Primacy of Machines
• Evidence for the Coming
Technological Singularity
1. Time Magazine cover Feb. 2011
“2045: The Year Man Becomes
Immortal”
2. IBM’s Watson computer beats top
human contenders on Jeopardy!
3. Foxconn announces plans to
replace one milion workers with
one million robots Nov. 2012
4. The Technological Singularity
appears in Dilbert March 2013

15. • The technological Singularity. Existential risks,
AI, genomics, and nanotech.
• Ways to optimize a positive outcome for
humanity in the co-evolution of humans and
machines . The influence of these
considerations on medicine of the future.
• Balanced view provided by incorporating both
tech skeptics and tech advocates.
• Dean of Science speaking, prominent people
internationally. Most lectures not very
“medical”. Easily understood.
• We could eliminate all diseases as we know
them today and still have a terrible world. Need
attention to the social responsibility of
medicine, Medicine Writ Large.
Course Content

16. Medicine Writ Large
“Medicine is a social science, and politics is nothing else than
medicine writ large. Medicine as a social science, as the science of
human beings, has the obligations to point out problems and to
attempt their theoretical solution: the politician, the practical
anthropologist, must find the means for their practical solution.”
– Rudolf Virchow

17. Medicine Writ Large
“It is the curse of humanity that it learns to tolerate even the most
horrible situations by habituation. Physicians are the natural
attorneys of the poor, and the social problems should largely be
solved by them.”
– Rudolf Virchow

18. Medicine Writ Large
Kim Solez, M.D.