SlideShare a Scribd company logo
Kikuchi-fujimoto disease:
histopathological and clinical review
of a case
http://www.medscidiscovery.com/Ar
ticlespdfs/V2N2PDF/April.2014Vol.2N
o.2p190-92.pdf
Kikuchi-Fugimoto Disease (Cervical
Subacute Necrotising
Lymphadenitis): An important
benign disease often
masquerading as lymphoma
http://www.ums.ac.uk/umj078/078(
2)134.pdf
The histopathological features of KFD are quite
distinctive : a necrotising lymphadenitis
without neutrophil infiltration,
virtually diagnostic of KFD, and the only mimic
is SLE lymphadenitis.
The lymph node changes in Kawasaki disease
(mucocutaneous lymph node disease), cat
scratch disease and atypical mycobacterial
infection are quite different, being
characterised by intravascular fibrin thrombi
and neutrophils, stellate microabscesses with
neutrophils and necrotising stellate
granulomatous inflammation respectively
Kikuchi Fujimoto Lymphadenitis:
Case Report and Literature Review
http://onlinelibrary.wiley.com/doi/10
.1002/ajh.10335/pdf
Kikuchi-Fujimoto Disease: a Rare
Differential of Lymphadenopathy
http://medind.nic.in/jac/t09/i3/jact0
9i3p145.pdf
Enigmatic Kikuchi-Fujimoto Disease
http://ajcp.ascpjournals.org/content/
122/1/141.full.pdf
Kuo17 proposed classification of the histopathologic
features of KFD into 3 evolving histologic stages: proliferative,
necrotizing, and xanthomatous. The proliferative stage
consists basically of various histiocytes, plasmacytoid
monocytes,
and a variable number of lymphoid cells with karyorrhectic
nuclear fragments and eosinophilic apoptosis debris.
If cellular aggregates in a given lymph node showed any
degree of coagulative necrosis, the case was classified as
necrotizing. If foamy histiocytes predominated in the KFD
lesions, the case was classified as xanthomatous regardless
of the presence or absence of necrosis. The most common
type was the necrotizing type, accounting for slightly more
than half of the cases. As Kuo17 pointed out, the 3 histologic
types might represent different stages of the disease or might
reflect differences in cause or host reaction. Judging from
the histologic changes, KFD perhaps begins as proliferative,
progresses to necrotizing, and finally resolves into
xanthomatous. However, sequential biopsy specimens were
not available in the study by Kuo17 to verify this postulated
concept. Also, data on the duration of the disease did not
correlate with the progression of the 3 histologic types.

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Kikuchi fujimoto disease

  • 1. Kikuchi-fujimoto disease: histopathological and clinical review of a case http://www.medscidiscovery.com/Ar ticlespdfs/V2N2PDF/April.2014Vol.2N o.2p190-92.pdf
  • 2. Kikuchi-Fugimoto Disease (Cervical Subacute Necrotising Lymphadenitis): An important benign disease often masquerading as lymphoma http://www.ums.ac.uk/umj078/078( 2)134.pdf
  • 3. The histopathological features of KFD are quite distinctive : a necrotising lymphadenitis without neutrophil infiltration, virtually diagnostic of KFD, and the only mimic is SLE lymphadenitis. The lymph node changes in Kawasaki disease (mucocutaneous lymph node disease), cat scratch disease and atypical mycobacterial infection are quite different, being characterised by intravascular fibrin thrombi and neutrophils, stellate microabscesses with neutrophils and necrotising stellate granulomatous inflammation respectively
  • 4. Kikuchi Fujimoto Lymphadenitis: Case Report and Literature Review http://onlinelibrary.wiley.com/doi/10 .1002/ajh.10335/pdf
  • 5. Kikuchi-Fujimoto Disease: a Rare Differential of Lymphadenopathy http://medind.nic.in/jac/t09/i3/jact0 9i3p145.pdf
  • 7. Kuo17 proposed classification of the histopathologic features of KFD into 3 evolving histologic stages: proliferative, necrotizing, and xanthomatous. The proliferative stage consists basically of various histiocytes, plasmacytoid monocytes, and a variable number of lymphoid cells with karyorrhectic nuclear fragments and eosinophilic apoptosis debris. If cellular aggregates in a given lymph node showed any degree of coagulative necrosis, the case was classified as necrotizing. If foamy histiocytes predominated in the KFD lesions, the case was classified as xanthomatous regardless of the presence or absence of necrosis. The most common type was the necrotizing type, accounting for slightly more than half of the cases. As Kuo17 pointed out, the 3 histologic types might represent different stages of the disease or might reflect differences in cause or host reaction. Judging from the histologic changes, KFD perhaps begins as proliferative, progresses to necrotizing, and finally resolves into xanthomatous. However, sequential biopsy specimens were not available in the study by Kuo17 to verify this postulated concept. Also, data on the duration of the disease did not correlate with the progression of the 3 histologic types.