This document discusses the challenges of keeping up with the vast amount of new medical literature being published each year. It notes that PubMed alone indexes over 5,000 journals and that thousands of new citations are added each week. It then estimates that it would take over 600 hours per month to read all new entries. The rest of the document provides recommendations on tools and resources that can help researchers and medical professionals keep current, including table of contents alerts, saved search alerts in PubMed, Google alerts, blogs, Twitter, podcasts, and synthesized literature from sources like the Cochrane Library.