This study assessed job satisfaction among 97 pharmacy professionals in Southwest Ethiopia. Over half (60.8%) reported being satisfied with their job due to helping patients and professional gratification. However, more than one third (39.2%) were dissatisfied mainly due to inadequate salary, poor interaction with healthcare teams, lack of motivation and training, and poor infrastructure. The study aimed to evaluate job satisfaction and factors influencing it among pharmacy workers in the region, which is important for improving healthcare quality and outcomes. A survey was administered from June to July 2011 across multiple towns.