Isabel I of Castile was born in 1451 in Madrigal de las Altas Torres, Spain. She married Ferdinand II of Aragon in 1469, though they needed a papal dispensation due to their status as second cousins. The pope initially refused to grant the dispensation, but issued the Bull of Simancas in 1471 that legitimized their marriage. Isabel was queen of Castile from 1474 until her death in 1504, and also queen consort of Sicily and Aragon through her marriage to Ferdinand. They had four daughters and one son together.