The document provides information on nasopulmonary drug delivery systems including nasal drug delivery and pulmonary drug delivery. It discusses the anatomy and physiology of the nasal cavity and respiratory tract. It also describes various formulation approaches for nasal delivery such as nasal gels, drops, sprays and powders. The document further explains dry powder inhalers, metered dose inhalers and nebulizers as pulmonary drug delivery systems along with their advantages and disadvantages. It also discusses some marketed products for nasal sprays, dry powder inhalers and metered dose inhalers.
Microencapsulation involves coating solid, liquid, or gaseous core materials in diameters between 1-1000 μm within an inert shell. This process isolates and protects core materials while controlling drug release. Methods like single emulsion, solvent evaporation, phase separation, and spray drying are used to prepare microspheres and microcapsules for applications like oral drug delivery, vaccines, gene delivery, and targeted therapies. Microencapsulation masks tastes, separates incompatible materials, and provides environmental protection or controlled release of core substances.
Polymers are large molecules composed of repeating structural units and can be either natural or synthetic, biodegradable or non-biodegradable. They are widely used in controlled release drug delivery systems due to their ability to control drug release rates and provide advantages like improved patient compliance. Common polymers used include natural ones like collagen and alginate as well as synthetic biodegradable polymers like PLGA. Applications include ocular inserts and transdermal patches that use polymers to regulate drug diffusion out of a matrix over time.
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
This document discusses gastroretentive drug delivery systems (GRDDS), which are oral dosage forms designed to remain in the stomach for an extended period of time to prolong drug release. It covers the rationale for using GRDDS, factors controlling gastric residence time, and various approaches for prolonging gastric retention including floating systems, high-density systems, and bioadhesive or magnetic systems. Floating systems include non-effervescent and effervescent types that float due to low density or gas generation. High-density systems do not float but remain in the stomach through bioadhesion, magnetic forces, swelling to a large size, or raft formation on gastric fluids.
Gastro retentive drug delivery system (GRDDS)Shweta Nehate
This document discusses gastro-retentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs and target drug release in the upper gastrointestinal tract. It describes the physiology of the gastrointestinal tract and potential drug candidates for GRDDS. Various approaches for GRDDS are covered, including floating, high density, bioadhesive, swelling, and superporous hydrogel systems. Evaluation parameters, applications, marketed formulations, and conclusions about GRDDS are also summarized.
This document discusses methods of formulating and evaluating buccal drug delivery systems. It describes the basic structure and designs of buccal dosage forms as being matrix or reservoir types. The key components are outlined as the drug substance, bioadhesive polymers, backing membrane, and permeation enhancers. Various formulation methods are provided for solid, semi-solid and liquid buccal dosage forms including tablets, patches, films, gels and sprays. Evaluation methods are also summarized such as weight variation, thickness, friability, hardness, and in-vitro swelling studies.
The document provides information on nasopulmonary drug delivery systems including nasal drug delivery and pulmonary drug delivery. It discusses the anatomy and physiology of the nasal cavity and respiratory tract. It also describes various formulation approaches for nasal delivery such as nasal gels, drops, sprays and powders. The document further explains dry powder inhalers, metered dose inhalers and nebulizers as pulmonary drug delivery systems along with their advantages and disadvantages. It also discusses some marketed products for nasal sprays, dry powder inhalers and metered dose inhalers.
Microencapsulation involves coating solid, liquid, or gaseous core materials in diameters between 1-1000 μm within an inert shell. This process isolates and protects core materials while controlling drug release. Methods like single emulsion, solvent evaporation, phase separation, and spray drying are used to prepare microspheres and microcapsules for applications like oral drug delivery, vaccines, gene delivery, and targeted therapies. Microencapsulation masks tastes, separates incompatible materials, and provides environmental protection or controlled release of core substances.
Polymers are large molecules composed of repeating structural units and can be either natural or synthetic, biodegradable or non-biodegradable. They are widely used in controlled release drug delivery systems due to their ability to control drug release rates and provide advantages like improved patient compliance. Common polymers used include natural ones like collagen and alginate as well as synthetic biodegradable polymers like PLGA. Applications include ocular inserts and transdermal patches that use polymers to regulate drug diffusion out of a matrix over time.
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
This document discusses gastroretentive drug delivery systems (GRDDS), which are oral dosage forms designed to remain in the stomach for an extended period of time to prolong drug release. It covers the rationale for using GRDDS, factors controlling gastric residence time, and various approaches for prolonging gastric retention including floating systems, high-density systems, and bioadhesive or magnetic systems. Floating systems include non-effervescent and effervescent types that float due to low density or gas generation. High-density systems do not float but remain in the stomach through bioadhesion, magnetic forces, swelling to a large size, or raft formation on gastric fluids.
Gastro retentive drug delivery system (GRDDS)Shweta Nehate
This document discusses gastro-retentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs and target drug release in the upper gastrointestinal tract. It describes the physiology of the gastrointestinal tract and potential drug candidates for GRDDS. Various approaches for GRDDS are covered, including floating, high density, bioadhesive, swelling, and superporous hydrogel systems. Evaluation parameters, applications, marketed formulations, and conclusions about GRDDS are also summarized.
This document discusses methods of formulating and evaluating buccal drug delivery systems. It describes the basic structure and designs of buccal dosage forms as being matrix or reservoir types. The key components are outlined as the drug substance, bioadhesive polymers, backing membrane, and permeation enhancers. Various formulation methods are provided for solid, semi-solid and liquid buccal dosage forms including tablets, patches, films, gels and sprays. Evaluation methods are also summarized such as weight variation, thickness, friability, hardness, and in-vitro swelling studies.
Intrauterine & Intravaginal Drug Delivery SystemPRASHANT DEORE
This document discusses intrauterine and intravaginal drug delivery systems. It begins with an introduction and overview of anatomy and physiology of the female reproductive system. It then describes various types of intravaginal drug delivery systems including suppositories, bioadhesive semisolids, elastomeric rings, and solid polymeric carriers. Factors affecting vaginal drug absorption are also discussed. The document concludes by describing intrauterine drug delivery systems including non-hormonal and hormonal IUDs, and discussing advantages and disadvantages of both intravaginal and intrauterine systems.
The device which is used in the intrauterine drug delivery system is known as an Intrauterine device (IUD) (2). IUDs or intrauterine devices are small artificial objects or devices inserted into the uterus to prevent the occurrence of pregnancy by disrupting the fertilization process as a result of sexual intercourse. They have gained popularity in recent times and are one of the most effective methods of birth control in terms of long-term contraception. It can be easily installed and is flexible. These devices are usually small in size and inserted through the cervix. IUDs reduce the need for abortion with unwanted pregnancies by preventing the effective movement of eggs and sperm. However, it cannot confirm the spread of STIs or STDs such as HIV, gonorrhoea, etc
Topics covered
Introduction
Advantages
Disadvantages
Development of intra uterine devices (IUDs)
Applications
References
Evaluation of transdermal drug delivery systemSagar Savale
This document discusses the evaluation of transdermal drug delivery systems. Key aspects that are evaluated include physicochemical properties, adhesive properties, in vitro studies, in vivo studies, stability studies, and toxicological studies. These evaluations are important to ensure consistency between batches in terms of quality, performance, reproducibility and stability, and to predict factors that may influence drug delivery.
This presentation discusses implantable drug delivery systems. It begins by defining implants as solid masses of purified drug intended for implantation via minor surgery or large bore needle to provide continuous drug release over long periods. Implants are well-suited for drugs like insulin, steroids, antibiotics, and analgesics. The presentation covers advantages like controlled delivery, improved compliance and stability. It also discusses types of implant systems including rate-programmed, activation-modulated, and feedback-regulated devices. Various mechanisms for controlling drug release like diffusion, hydration and enzymatic reactions are described. The conclusion emphasizes implants can provide targeted delivery without limitations of other administration methods.
Application Of Polymer In Controlled Release FormulationAnindya Jana
Polymers are becoming increasingly important in the field of drug delivery. The pharmaceutical applications of polymers range from their use as binders in tablets to viscosity and flow controlling agents in liquids, suspensions and emulsions. Polymers can be used as film coatings to disguise the unpleasant taste of a drug, to enhance drug stability and to modify drug release characteristics.
As a consequence, increasing attention has been focused on methods of giving drugs continually for a prolonged time periods and in a controlled fashion.
This technology now spans many fields and includes pharmaceutical, food and agricultural applications, pesticides, cosmetics, and household products.
ALZET osmotic pumps are implantable devices that continuously deliver solutions over a set duration at a constant rate. They offer a simple alternative to repetitive injections by providing around-the-clock exposure to test agents without needing frequent animal handling. ALZET pumps work through osmosis, using no batteries or electronics. They have various sizes to deliver agents from 1 day to 6 weeks at controlled rates. Common applications include delivering drugs, hormones, and other compounds in animal research.
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsSuraj Choudhary
This document discusses factors affecting the design of controlled release drug delivery systems (CRDDS). It outlines several key considerations for CRDDS design including selection of the drug candidate, medical and biological rationale, and physicochemical properties. It also discusses important physicochemical factors such as solubility, partition coefficient, molecular size and diffusivity, dose size, complexation, ionization constant, drug stability, and protein binding that influence CRDDS design. Finally, it briefly describes dissolution-controlled and diffusion-controlled release approaches for developing CRDDS.
The document discusses bioadhesion and mucoadhesion. It defines bioadhesion as materials adhering to biological tissues for extended periods via interfacial forces. Mucoadhesion specifically refers to adhesion between materials and mucosal surfaces. Mucoadhesive drug delivery systems can prolong drug release at application sites, improving therapeutic outcomes. Ideal mucoadhesive polymers rapidly adhere to mucosal layers without interfering with drug release, are biodegradable and non-toxic, and enhance drug penetration at delivery sites. The mechanisms of bioadhesion involve wetting, swelling, interpenetration and entanglement of polymer chains followed by secondary bonding formations. Key factors influencing bioadhesion are discussed.
This document provides an overview of gastric retention drug delivery systems (GRDDS). It discusses the need for and advantages of GRDDS. The key approaches covered for achieving gastric retention include floating drug delivery systems, mucoadhesive systems, swellable systems, and high density systems. The document reviews gastrointestinal physiology and factors affecting gastric emptying. It also evaluates different GRDDS approaches and provides examples of commercial gastroretentive formulations. In conclusion, the document states that GRDDS are preferable for delivering drugs that need to be released in the gastric region.
Contents
Introduction
Objective
Anatomy of the Eye
Routes of drug delivery of the eye
Mechanism of ocular absorption
Factors affecting intra-ocular bioavailability
Barriers of ocular drug absorption
Methods to overcome drug barriers
Evaluation
Conclusion
Reference
Ocular administration of drug is primarily associated with the need to treat ophthalmic diseases.
Applied topically to the cornea, or instilled in the space between the eyeball and lower eyelid
Definition: Ocular DDS are designed to instilled on to topical or intra-ocular or peri-ocular to eye.
Most commonly used ocular dosage forms-
- Solutions
- Suspensions
- ointments
Ideal ophthalmic drug delivery must be able to sustain the drug release and to remain in the vicinity of front of the eye for prolong period of time.
Buccal drug delivery systems provide a promising route for drug administration. They allow drugs to bypass first-pass metabolism by absorbing through the buccal mucosa into the systemic circulation via the facial veins. This presentation discusses buccal tablets, patches, films, gels and ointments as potential dosage forms. Key advantages are ease of administration, termination of therapy, and localization of drug in the oral cavity. However, drugs must not irritate oral tissues and must be stable at buccal pH levels. Evaluation parameters for these systems include residence time, permeation, swelling, release rate and toxicity studies. Some commercial buccal products are used to treat nausea, angina and oral infections.
Osmotic drug delivery systems use osmotic pressure to provide controlled release of drugs over extended periods of time. They consist of a drug core surrounded by a semipermeable membrane with a delivery orifice. When exposed to fluids, osmotic pressure causes water to enter the system, dissolving the drug and pushing it out through the orifice at a controlled rate. The three main types are Rose-Nelson pumps, elementary osmotic pumps, and controlled porosity osmotic pumps. These systems offer advantages over traditional methods for conditions requiring prolonged, consistent drug levels.
This document summarizes a seminar on gastroretentive drug delivery systems (GRDDS). GRDDS are designed to retain drugs in the stomach for prolonged periods of time to allow for sustained drug release. The seminar outlines various GRDDS technologies including floating, swelling, mucoadhesive, and high density systems. It also discusses candidate drugs for GRDDS, advantages like improved bioavailability, and evaluation methods like dissolution testing, floating time, and mucoadhesive strength testing. Limitations include instability at gastric pH and requirement of high fluid levels for floating systems.
ODDS (Ocular Drug Delivery Systems) provide novel approaches for instilling drugs onto the eye's surface or inside the eye. Common ODDS include gels, ointments, microspheres, and nanoparticles, and they offer benefits like increased dosing accuracy, sustained drug release, and improved ocular bioavailability. However, they also present disadvantages such as inability to stop treatment during emergencies and potential interference with vision. The eye has multiple barriers that limit drug penetration, including the tear film, cornea, conjunctiva, sclera, and blood-retinal barrier. Physical methods like iontophoresis, sonophoresis, and microneedles can enhance drug transport across these barriers. A
ocular barriers and methods to overcome barriersTarun Gollapudi
This document summarizes barriers to ocular drug delivery and methods to overcome them. The major barriers include ocular surface barriers like the cornea, ocular wall barriers like the sclera, retinal barriers, the vitreous body, lachrymal fluid, and properties of the drug itself like solubility and molecular weight. Methods to enhance delivery include microneedles, ultrasound, iontophoresis, periocular routes, and intravitreal injections. Various ophthalmic formulations are also discussed like eye drops, gels, ointments, and inserts that utilize approaches like prodrugs, penetration enhancers, and nanoparticle carriers to improve ocular bioavailability.
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
The document provides information on nasal and pulmonary drug delivery systems. It discusses the anatomy of the nose and lungs, as well as various delivery methods. The nasal cavity has a lining that is highly vascular and rich in mucus glands, providing a large surface area for drug absorption. Pulmonary delivery uses aerosols to deposit drugs in the lungs. Some key advantages of these routes include rapid onset of action, avoidance of first-pass metabolism, and improved bioavailability over oral delivery. Delivery methods include liquid formulations, metered-dose pumps, dry powder inhalers, and nebulizers. Overall, the document outlines the anatomical features and absorption pathways in the nose and lungs, and reviews different systems for delivering drugs via these
This document provides an overview of intrauterine and intravaginal drug delivery systems. It discusses the anatomy and physiology of the female reproductive system and factors that affect vaginal drug absorption. Various types of intravaginal drug delivery systems are classified and described, including suppositories, bioadhesive semisolids, elastomeric rings, and solid polymeric carriers. Advantages include avoiding first-pass metabolism and providing controlled drug release over extended periods. Intrauterine systems can deliver drugs locally via non-hormonal or hormonal IUDs. Animal models for studying vaginal drug absorption are also mentioned.
This document discusses various contraceptive types and their mechanisms of action. It describes the characteristics of ideal contraceptives and defines contraception. The main types discussed are hormonal methods like oral pills, patches, rings and IUDs; barrier methods like condoms and diaphragms; fertility awareness methods; emergency contraception; and surgical sterilization. Hormonal contraceptives work mainly by preventing ovulation while barrier methods block sperm from entering the uterus. Natural methods avoid sex during the fertile window but have a higher typical use failure rate than other methods.
Intrauterine & Intravaginal Drug Delivery SystemPRASHANT DEORE
This document discusses intrauterine and intravaginal drug delivery systems. It begins with an introduction and overview of anatomy and physiology of the female reproductive system. It then describes various types of intravaginal drug delivery systems including suppositories, bioadhesive semisolids, elastomeric rings, and solid polymeric carriers. Factors affecting vaginal drug absorption are also discussed. The document concludes by describing intrauterine drug delivery systems including non-hormonal and hormonal IUDs, and discussing advantages and disadvantages of both intravaginal and intrauterine systems.
The device which is used in the intrauterine drug delivery system is known as an Intrauterine device (IUD) (2). IUDs or intrauterine devices are small artificial objects or devices inserted into the uterus to prevent the occurrence of pregnancy by disrupting the fertilization process as a result of sexual intercourse. They have gained popularity in recent times and are one of the most effective methods of birth control in terms of long-term contraception. It can be easily installed and is flexible. These devices are usually small in size and inserted through the cervix. IUDs reduce the need for abortion with unwanted pregnancies by preventing the effective movement of eggs and sperm. However, it cannot confirm the spread of STIs or STDs such as HIV, gonorrhoea, etc
Topics covered
Introduction
Advantages
Disadvantages
Development of intra uterine devices (IUDs)
Applications
References
Evaluation of transdermal drug delivery systemSagar Savale
This document discusses the evaluation of transdermal drug delivery systems. Key aspects that are evaluated include physicochemical properties, adhesive properties, in vitro studies, in vivo studies, stability studies, and toxicological studies. These evaluations are important to ensure consistency between batches in terms of quality, performance, reproducibility and stability, and to predict factors that may influence drug delivery.
This presentation discusses implantable drug delivery systems. It begins by defining implants as solid masses of purified drug intended for implantation via minor surgery or large bore needle to provide continuous drug release over long periods. Implants are well-suited for drugs like insulin, steroids, antibiotics, and analgesics. The presentation covers advantages like controlled delivery, improved compliance and stability. It also discusses types of implant systems including rate-programmed, activation-modulated, and feedback-regulated devices. Various mechanisms for controlling drug release like diffusion, hydration and enzymatic reactions are described. The conclusion emphasizes implants can provide targeted delivery without limitations of other administration methods.
Application Of Polymer In Controlled Release FormulationAnindya Jana
Polymers are becoming increasingly important in the field of drug delivery. The pharmaceutical applications of polymers range from their use as binders in tablets to viscosity and flow controlling agents in liquids, suspensions and emulsions. Polymers can be used as film coatings to disguise the unpleasant taste of a drug, to enhance drug stability and to modify drug release characteristics.
As a consequence, increasing attention has been focused on methods of giving drugs continually for a prolonged time periods and in a controlled fashion.
This technology now spans many fields and includes pharmaceutical, food and agricultural applications, pesticides, cosmetics, and household products.
ALZET osmotic pumps are implantable devices that continuously deliver solutions over a set duration at a constant rate. They offer a simple alternative to repetitive injections by providing around-the-clock exposure to test agents without needing frequent animal handling. ALZET pumps work through osmosis, using no batteries or electronics. They have various sizes to deliver agents from 1 day to 6 weeks at controlled rates. Common applications include delivering drugs, hormones, and other compounds in animal research.
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsSuraj Choudhary
This document discusses factors affecting the design of controlled release drug delivery systems (CRDDS). It outlines several key considerations for CRDDS design including selection of the drug candidate, medical and biological rationale, and physicochemical properties. It also discusses important physicochemical factors such as solubility, partition coefficient, molecular size and diffusivity, dose size, complexation, ionization constant, drug stability, and protein binding that influence CRDDS design. Finally, it briefly describes dissolution-controlled and diffusion-controlled release approaches for developing CRDDS.
The document discusses bioadhesion and mucoadhesion. It defines bioadhesion as materials adhering to biological tissues for extended periods via interfacial forces. Mucoadhesion specifically refers to adhesion between materials and mucosal surfaces. Mucoadhesive drug delivery systems can prolong drug release at application sites, improving therapeutic outcomes. Ideal mucoadhesive polymers rapidly adhere to mucosal layers without interfering with drug release, are biodegradable and non-toxic, and enhance drug penetration at delivery sites. The mechanisms of bioadhesion involve wetting, swelling, interpenetration and entanglement of polymer chains followed by secondary bonding formations. Key factors influencing bioadhesion are discussed.
This document provides an overview of gastric retention drug delivery systems (GRDDS). It discusses the need for and advantages of GRDDS. The key approaches covered for achieving gastric retention include floating drug delivery systems, mucoadhesive systems, swellable systems, and high density systems. The document reviews gastrointestinal physiology and factors affecting gastric emptying. It also evaluates different GRDDS approaches and provides examples of commercial gastroretentive formulations. In conclusion, the document states that GRDDS are preferable for delivering drugs that need to be released in the gastric region.
Contents
Introduction
Objective
Anatomy of the Eye
Routes of drug delivery of the eye
Mechanism of ocular absorption
Factors affecting intra-ocular bioavailability
Barriers of ocular drug absorption
Methods to overcome drug barriers
Evaluation
Conclusion
Reference
Ocular administration of drug is primarily associated with the need to treat ophthalmic diseases.
Applied topically to the cornea, or instilled in the space between the eyeball and lower eyelid
Definition: Ocular DDS are designed to instilled on to topical or intra-ocular or peri-ocular to eye.
Most commonly used ocular dosage forms-
- Solutions
- Suspensions
- ointments
Ideal ophthalmic drug delivery must be able to sustain the drug release and to remain in the vicinity of front of the eye for prolong period of time.
Buccal drug delivery systems provide a promising route for drug administration. They allow drugs to bypass first-pass metabolism by absorbing through the buccal mucosa into the systemic circulation via the facial veins. This presentation discusses buccal tablets, patches, films, gels and ointments as potential dosage forms. Key advantages are ease of administration, termination of therapy, and localization of drug in the oral cavity. However, drugs must not irritate oral tissues and must be stable at buccal pH levels. Evaluation parameters for these systems include residence time, permeation, swelling, release rate and toxicity studies. Some commercial buccal products are used to treat nausea, angina and oral infections.
Osmotic drug delivery systems use osmotic pressure to provide controlled release of drugs over extended periods of time. They consist of a drug core surrounded by a semipermeable membrane with a delivery orifice. When exposed to fluids, osmotic pressure causes water to enter the system, dissolving the drug and pushing it out through the orifice at a controlled rate. The three main types are Rose-Nelson pumps, elementary osmotic pumps, and controlled porosity osmotic pumps. These systems offer advantages over traditional methods for conditions requiring prolonged, consistent drug levels.
This document summarizes a seminar on gastroretentive drug delivery systems (GRDDS). GRDDS are designed to retain drugs in the stomach for prolonged periods of time to allow for sustained drug release. The seminar outlines various GRDDS technologies including floating, swelling, mucoadhesive, and high density systems. It also discusses candidate drugs for GRDDS, advantages like improved bioavailability, and evaluation methods like dissolution testing, floating time, and mucoadhesive strength testing. Limitations include instability at gastric pH and requirement of high fluid levels for floating systems.
ODDS (Ocular Drug Delivery Systems) provide novel approaches for instilling drugs onto the eye's surface or inside the eye. Common ODDS include gels, ointments, microspheres, and nanoparticles, and they offer benefits like increased dosing accuracy, sustained drug release, and improved ocular bioavailability. However, they also present disadvantages such as inability to stop treatment during emergencies and potential interference with vision. The eye has multiple barriers that limit drug penetration, including the tear film, cornea, conjunctiva, sclera, and blood-retinal barrier. Physical methods like iontophoresis, sonophoresis, and microneedles can enhance drug transport across these barriers. A
ocular barriers and methods to overcome barriersTarun Gollapudi
This document summarizes barriers to ocular drug delivery and methods to overcome them. The major barriers include ocular surface barriers like the cornea, ocular wall barriers like the sclera, retinal barriers, the vitreous body, lachrymal fluid, and properties of the drug itself like solubility and molecular weight. Methods to enhance delivery include microneedles, ultrasound, iontophoresis, periocular routes, and intravitreal injections. Various ophthalmic formulations are also discussed like eye drops, gels, ointments, and inserts that utilize approaches like prodrugs, penetration enhancers, and nanoparticle carriers to improve ocular bioavailability.
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
The document provides information on nasal and pulmonary drug delivery systems. It discusses the anatomy of the nose and lungs, as well as various delivery methods. The nasal cavity has a lining that is highly vascular and rich in mucus glands, providing a large surface area for drug absorption. Pulmonary delivery uses aerosols to deposit drugs in the lungs. Some key advantages of these routes include rapid onset of action, avoidance of first-pass metabolism, and improved bioavailability over oral delivery. Delivery methods include liquid formulations, metered-dose pumps, dry powder inhalers, and nebulizers. Overall, the document outlines the anatomical features and absorption pathways in the nose and lungs, and reviews different systems for delivering drugs via these
This document provides an overview of intrauterine and intravaginal drug delivery systems. It discusses the anatomy and physiology of the female reproductive system and factors that affect vaginal drug absorption. Various types of intravaginal drug delivery systems are classified and described, including suppositories, bioadhesive semisolids, elastomeric rings, and solid polymeric carriers. Advantages include avoiding first-pass metabolism and providing controlled drug release over extended periods. Intrauterine systems can deliver drugs locally via non-hormonal or hormonal IUDs. Animal models for studying vaginal drug absorption are also mentioned.
This document discusses various contraceptive types and their mechanisms of action. It describes the characteristics of ideal contraceptives and defines contraception. The main types discussed are hormonal methods like oral pills, patches, rings and IUDs; barrier methods like condoms and diaphragms; fertility awareness methods; emergency contraception; and surgical sterilization. Hormonal contraceptives work mainly by preventing ovulation while barrier methods block sperm from entering the uterus. Natural methods avoid sex during the fertile window but have a higher typical use failure rate than other methods.
The document provides information on various contraceptive methods. It discusses:
1. Temporary contraceptive methods including barrier methods (condoms, diaphragms), intrauterine devices, and hormonal contraception (oral contraceptives, injections, patches, rings).
2. Permanent contraceptive methods include sterilization.
3. Oral contraceptives contain estrogen and progestin or just progestin. They prevent pregnancy primarily by suppressing ovulation and thickening cervical mucus. Side effects may include nausea, breast tenderness, and mood changes.
This document provides an overview of various contraceptive methods. It discusses temporary contraceptive methods including barrier methods like condoms and diaphragms, hormonal methods like oral contraceptive pills and emergency contraception, and intrauterine devices. It also covers permanent sterilization methods like vasectomy and tubectomy. For each method, it describes the mechanism of action, effectiveness, advantages, and disadvantages.
Intrauterine devices (IUDs) are small devices placed in the uterus to prevent pregnancy. There are two main types - non-medicated and medicated. Non-medicated IUDs use mechanics to prevent pregnancy while medicated IUDs release drugs like copper or hormones. Copper IUDs release copper which has spermicidal and spermatocidal effects. Hormone releasing IUDs prevent implantation and thickening of cervical mucus through local progesterone release. Common examples include the Copper T IUD and the Progestasert progesterone releasing IUD. IUDs are highly effective, reversible contraceptives that are placed by a healthcare provider and can remain in place for
This document provides information about intrauterine drug delivery systems (IUDs). It discusses the anatomy and physiology of the female reproductive system. It describes the types of IUDs including non-hormonal copper IUDs and hormonal IUDs like Progestasert that release progesterone. The advantages of IUDs include avoiding first-pass metabolism and providing localized drug delivery. Applications of IUDs include emergency contraception, treatment for heavy menstrual bleeding and menopausal hormone therapy.
This document discusses various methods of contraception, including their mechanisms of action, advantages, and disadvantages. It describes temporary contraceptive methods like barrier methods (condoms), hormonal methods (oral contraceptive pill, injectables, implants), intrauterine devices, and emergency contraception. It also discusses permanent sterilization methods like vasectomy and tubal ligation. The ideal contraceptive is described as widely acceptable, inexpensive, simple to use, safe, highly effective, and requiring minimal effort. Failure rates for different contraceptive methods during the first year of use are also provided for comparison.
The document describes various methods of contraception, including temporary and permanent options. Temporary methods discussed include barrier methods like condoms, vaginal methods like spermicides and diaphragms, intrauterine devices (IUDs), and hormonal methods like oral contraceptive pills and injectables. Permanent methods discussed are male and female sterilization. The advantages, disadvantages, effectiveness, and other details are provided for many of the discussed contraception methods.
The document summarizes intrauterine devices (IUDs) which are small T-shaped devices inserted into the uterus to prevent pregnancy for 1-10 years. There are two main types - hormonal IUDs which release progestogen and prevent pregnancy through thickening cervical mucus and altering the uterus, and non-hormonal or copper IUDs which release copper ions that are toxic to sperm. IUDs have high effectiveness rates of 99.2-99.9% and can be used as long-term or emergency contraception. Risks include pelvic inflammatory disease and potential infertility if not properly inserted.
An IntraUterine System (IUS) or IntraUterine Drug Delivery System (IUDDS) is a small object that is placed inside the uterus above the endometrium and is active or medicated when it contains a therapeutic agent. It is a small string that is inserted through the cervix and placed in the uterus to prevent pregnancy.
It is a small string that hangs down from the IUD into the upper part of the vagina.
IUD is not noticeable during intercourse.
This document provides an overview of contraception including hormonal and non-hormonal methods. It discusses the embryology of the reproductive system and the effects of hormones like estrogen and progesterone. Various contraceptive methods are described such as oral contraceptive pills containing estrogen and progesterone, progestogen-only pills, injections, implants, IUDs, barriers, fertility awareness methods, and sterilization. Emergency contraception options like the emergency contraceptive pill and copper IUD are also summarized. Traditional natural family planning techniques and their limitations are reviewed.
This document provides information about family planning and contraceptive methods. It discusses that family planning refers to limiting the number of children through contraception, and half of pregnancies in the US are unintended. Contraceptive methods are classified as modern or traditional. Modern methods have lower failure rates and include IUDs, implants, injections, pills, condoms, etc. The document then discusses various contraceptive methods in detail, including their mechanisms of action, effectiveness tiers, and contraindications. Top-tier highly effective methods include IUDs, implants and sterilization. Second-tier include hormonal methods like pills, injections, patch and ring.
This document provides information on various family planning methods including temporary/spacing methods (barrier methods, intrauterine devices, hormonal methods, post-conceptional methods, and miscellaneous methods) and permanent/terminal methods (vasectomy and tubectomy). It describes each method in detail, covering their purpose, how they work, merits and demerits. The temporary methods discussed help prevent pregnancy as long as they are used correctly, while permanent methods provide lifelong protection from pregnancy.
The document discusses the anatomy of the human uterus and provides details on intrauterine devices (IUDs). It describes the historical background of IUDs, their mechanisms of action including morphological and biochemical changes in the endometrium, as well as potential complications. The summary is as follows:
[1] The document discusses the anatomy of the human uterus and historical background of intrauterine devices (IUDs) for birth control.
[2] IUDs prevent pregnancy primarily by interfering with sperm viability and mobility through morphological and biochemical changes in the endometrium as well as copper ion release.
[3] Potential complications of IUDs include pelvic inflammatory disease risk with
This document discusses various methods of fertility control, including natural methods like the rhythm method, barrier methods using condoms, spermicides, and IUDs. It also covers hormonal contraception using oral contraceptive pills, implants, and sterilization surgeries like tubectomy and vasectomy. The main mechanisms, advantages, and disadvantages of each method are described. Permanent sterilization involves surgical procedures to cut and tie off the fallopian tubes or vas deferens.
The document discusses intrauterine devices (IUDs). It describes the anatomy of the uterus and explains that IUDs are small objects inserted through the cervix into the uterus to prevent pregnancy. There are two main types - non-medicated IUDs made of plastic or stainless steel, and medicated IUDs that deliver drugs like copper or progesterone. IUDs are highly effective birth control but can increase bleeding or cramping.
Similar to Intrauterine and Intravaginal drug delivery system (20)
Unit I Historical background and development of pharmacy profession.pdfGaurav Patil
Discover the evolution of pharmacy from ancient times to modern practice, tracing the development of pharmaceuticals, drug regulation, and the role of pharmacists in healthcare. Gain a deeper understanding of the profession's origins and its impact on society. Whether you're a student or a practitioner, this presentation offers a rich exploration of pharmacy's rich heritage.
his presentation delves into the formulation, advantages, and applications of semisolid dosage forms, including creams, ointments, and gels. Learn about their unique properties, manufacturing processes, and considerations for drug delivery. Whether you're a student or a pharmaceutical professional, this presentation offers valuable insights into this essential aspect of medication delivery.
Poster presentation on Digitalization of Pharma.pdfGaurav Patil
This poster deals with the Digitalization of the Pharma field. It covers the history, current happenings, and future trends of digitalization in the pharma field. Overall it give a brief and concise information about the Pharma 4.0 concpet. That how the digitalization shape the pharmaceutical industry.
Essay on Pharmacovigilance safety Challenges and Perspectives.pdfGaurav Patil
This presentation include the brief information regarding the Pharmacovigilance safety :Challenges and Perspectives. I had took part in one competition wherein I submitted this short essay on PV.
This essay will give you a brief information about the PV process and it outcome, it will also reflect a light on the safety point of view
This presentation deals with the brief study of functionalized graphene oxide nanoparticles for the delivery of model anticancer drug. It represents benefits of targeted drug delivery over the conventional drug delivery,
It is one of the remingtons journal club seminar which is part of masters degree progam in pharmacy.
Intranasal delivery of drug loaded thiolated co-polymeric microparticles for...Gaurav Patil
E-Presentation at Two days 15th Indo-US virtual International Conference
on “Global advances in Pharmaceutical and Allied Science”
In collaboration with
APP Gujarat State branch, AAP American International branch,
AAP Pharmedu Healthcare Manag Division
This is a seminar of my M Pharm Sem-II. It consist of nearly all information about the dosage form called Aerosol in briefly. It will be helpful for the students to get insights about this topic in very simple manner.
This presentation deals with they proposal of my M Pharm research project topic briefly. It consist of various areas which needs to answer during the course of project.
This presentation includes the detail information about the physics of tablet compression and compaction, Compression, Effect of friction, distribution of forces, compaction profiles,solubility.
Covid-19 Standard operating procedure for HomeGaurav Patil
This document provides standard operating procedures (SOP) for preventing the spread of COVID-19 within the home. It outlines responsibilities for household members and procedures for safely shopping, handling currency, using public areas, and disinfecting surfaces, clothing, food, and other items. It also recommends improving immunity through yoga, meditation, herbal teas, and waiting 72 hours before using unwashed items. The goal is to lay down guidelines for home prevention of COVID-19 transmission.
Prevention and spread on corona posterGaurav Patil
This is a poster presentation on a topic name Covid-19: Spread and prevention. It includes a brief information about novel coronavirus spread and prevention in simple form.
This presentation includes an brief idea about the pharmacy act 1948 in India and also deals with its the chapter that included in the act.(Education Regulations, PCI, State PCI, Registration of Pharmacist , Approval of Institutions, Offences penalties etc.)
Case presentation [on Swine Flu (H1 N1 Flu)].Gaurav Patil
This document presents information about Swine Flu (H1N1 Flu) through a case study presentation. It discusses:
- The causes, symptoms, and risk factors of Swine Flu, including that it is transmitted from pigs to humans and first recognized in 2009.
- A case study of a 60-year-old farmer diagnosed with Swine Flu, including results of medical tests showing elevated temperature and signs of infection.
- The treatments used including the antiviral drug Tamiflu and antibiotics, along with their mechanisms of action and potential side effects.
- Lifestyle recommendations to prevent and limit the spread of Swine Flu such as staying home when sick, hand washing, coughing/s
India has a long history of utilizing aromatic plants and is a major producer and exporter of aromatic plants and essential oils. The document discusses several important aromatic plants grown in India including sandalwood, mentha, lemongrass, vetiver, geranium, and eucalyptus. It provides details on the source of each plant, the chemical constituents in the essential oils extracted from them, and their various traditional and commercial uses.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
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Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
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Intrauterine and Intravaginal drug delivery system
1. INTRAUTERINE AND INTRAVAGINAL
DRUG DELIVERY SYSTEM
By
Gaurav Shriram Patil.
Final Year B.Bharm.
Kvps, Institute of Pharmaceutical Education, Boradi.
Gaurav Patil
1
2. Contents
Introduction
Anatomy and Physiology of female reproductive system
Advantages
Disadvantages
Classification of Intrauterine devices
Intrauterine and Intravaginal drug delivery System
References
Gaurav Patil
2
3. Introduction
Vagina and Uterus are the route for administration of contraceptives , antifungals
and antimicrobials.
These are used for local or systemic absorption.
Because of vast network of blood vessels, vaginal wall is suitable for drug
absorption.
The rate and extent of drug absorption may vary depends upon:
1) Formulation factors
2) Physiology
3) Age of patient
4) Menstrual cycle
Gaurav Patil
3
4. An Intra Uterine Device(IUD) is a small plastic contraceptive
device that is gently inserted into the uterus (womb) by the
physician or nurse practitioner.
IUDs are about 98-98% effective in preventing pregnancy and one
type of IUDs can stay in place for up to 10 years before needing to
be replaced.
The IUD is most effective choice for the women who had her
children and now want long term , but not permanent contraception.
The IUD may also a good choice for women who cannot take birth
control pills.
Gaurav Patil
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5. Anatomy and Physiology of Female Reproductive System
Female Reproductive System
Gaurav Patil
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6. The Female Reproductive system mainly consist of Following organs:
1. Vagina- Muscular canal about 3 inches long. Muscular canal about 3 inches long. Vaginal
wall surface is covered with epithelium cells. Size: in premenopausal female 7.8 cm in
length & 2 cm wide, in postmenopausal female 4.5 cm in length & 1-1.5 cm in width.
2. Uterus- Non pregnant uterus is around 7.5cm long, 5cm wide and 2.5cm thick.
Endometrium is highly vascular made up of simple columnar epithelium and highly
sensitive to hormonal secretions of ovary. During complete cycle endometrium goes
thickening with hormonal impact
3. Fallopian Tubes- Also called as Oviducts or Uterine tubes around cm long. The internal
surface is of ciliated columnar epithelium cells.
4. Ovaries- Two in number each on either side of uterus. These having shape and size like
of unehllled almond. Ovaries produced hormone called Progesterone, Estrogen.
5. Vulva- Its has basic five parts namely Labia Majora , Labia Minora, Vestibules, Cliotoris,
Mons Pubis
Gaurav Patil
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7. Advantages
Reversible
Highly effective contraceptive method
Method is private
Less expensive over a time
It can be use by a women who is breastfeed
Avoid first pass effect
Minimal side effects compare to others
Increase bioavailabity.
Gaurav Patil
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8. Disadvantages
Possible irregular bleeding or increased cramping
Possible expulsion of device
Does not protect against STDs or HIV
Patient Incompliance
Only few drugs can be administered
Influence with sexual intercourse.
Gender specificity.
Gaurav Patil
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10. Classification of Intravaginal DDS
Vaginal
Drug
Delivery
System
Vaginal
Rings
Onitment
Supposito
ries
Vaginal
Capsules
and
Tablets
Gels and
Creams
Powders
Gaurav Patil
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11. Intrauterine Drug Delivery System
Definition : The IUDs are the small objects that are inserted through the cervix
and placed in the uterus to prevent the pregnancy.
Types of IUDs for controlled drug delivery:-
1) Non-hormonal IUDs. (Ex. copper-T, copper-7)
2) Hormonal IUDs. ( Ex. Progestasert)
1) Non-hormonal IUDs/ copper medicated IUDs.
• It is consists of polyethylene or polypropylene plastic support of number-7 or
letter-T with certain amount of pure electrolytic copper wire wound around them.
• Copper is cytotoxic and enhance spermicidal & spermatodepressive action of
IUD.
Gaurav Patil
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12. • The Non-hormonal IUDs does not contain any therapeutic agent.
• This kind of IUDs are available in the forms of rings. Eg. Lippe’s
loop, Copper-.
• The exposed surface area of copper is 380 mm².
• This kind of IUDs having no hormonal side effects.
• They are easy to insert.
• Types- Cu T-200--------200 mm².
Cu T-30---------30 mm².
Copper-T
Gaurav Patil
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13. 2) Hormonal IUDs/ Medicated IUDs
• These are the T-shaped devices made up of polyethylene frame measures 32mm both
vertical and horizontal directions
• There is a silicone reservoir containing either progesterone or levonogestral on a vertical
stem and further enclosed in a sleeve of rate controlling membrane of ethylenevinyl-
copolymer.
• It prevents the pregnancy up to 5 years by steadily realizing small amount of Progesterone
directly into the uterus.
• For some womens it may also prevent the ovulation from occurring.
• The hormonal IUD is available in Australia and USA under a brand name Mirena.
• This kind of IUD is also used in a condition of Breast cancer.
• Example: Mirena IUD.
Gaurav Patil
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14. Intravaginal Drug Delivery System
Ideality of Intravaginal DDS
1) Component should melt at vaginal temperature i.e. at 37oC.
2) Device should be nontoxic and nonirritating.
3) Formulation should be nonsensitive on vaginal pH.
4) Formulation should have wetting and emulsifying properties.
5) It should be stable on storage.
6) Formulation should have proper viscosity to avoid leakage of drug
from vagina.
Gaurav Patil
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15. Classification of Intravaginal drug delivery system
A. Localized :
1) Barrier contraception
(Diaphragm, Cervical cap, Sponge)
2) Prevention/Treatment of infection
( Gels, Cream, Ointment)
B. Systemic :
A. Suppositories or pessaries.
B. Bio(muco)adhesive semisolids.
• These are emulsion bases formulation to deliver antifungal agents such asimidazole. Give
controlled delivery for 3 or more hrs.
Gaurav Patil
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16. C. Solid polymeric carriers.
a. Solid hydrogels:
Having swelling property which enables the drug to diffuse out of the macromolecular
network. eg. Nu-gel ( Johnson & Johnson)
b. Elastomeric intravaginal rings( IVR):
1) Matrix (homogeneous dispersion)
2) Reservoir (core)
3) Sandwich (shell)
Elastomer exert slight tension on vaginal wall, more suitable for hydrophobic drugs.
Normally designed to contain steroidal hormones.
Gaurav Patil
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17. Other novel approaches :
1) Medicated Vaginal Tampons- A medicated vaginal tampon, approved as a medical
device by the Food and Drug Administration (FDA) .
• This bifunctional tampon contains a polymeric delivery system (strips) that absorb menstrual
fluid while gradually releasing lactic acid and citric acid.
• eg. Brilliant pH tampons.
Gaurav Patil
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18. 2) Vaginal Films-
• Vaginal films are polymeric drug delivery systems shaped as thin sheets, usually ranging
from 220 to 240 μ m in thickness.
• These systems are often square (approximately 5cm × 5cm), colorless, and soft, presenting
a homogenous surface.
• Vaginal films are produced with polymers such as polyacrylates, polyethylene glycol,
polyvinyl alcohol, and cellulose derivatives.
• Eg.VCF (vaginal contraceptive films)
Gaurav Patil
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19. # ADVANTAGES
• Minimal side effects
• Rapid drug absorption
• Avoid first pass effect
• Increases the bioavailability.
# DISADVANTAGES
• Only few drugs are administered
• Patient Incomplianace
• Gender Specificity
• Some drugs are sensitive at
vaginal pH. May causes irritation.
Gaurav Patil
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20. References
1. Chatterjee Arkendu & Kumar Lalit (2009), On overview of Intra-vaginal Drug
deliverysystem, Journal of Pharmacy research, 2 (4) 698-700.
2. Chien Y. W. (2007), Novel Drug Delivery Systems, Revised and Expanded, Marcel
Dekker, Inc., New York, Second Indian Reprint , Vol.-50, p. 529-629.
3. Baviskar D.T & Jain D.K , Novel Drug Delivery Systems, Nirali Prakashan,
p. 10.1-10.8
4. Brahmankar D. M. & Jaiswal S. B. (2009), Biopharmaceutics and
PharmacokineticsA Treatise, 2nd edition, Vallabh Prakashan, p. 502-508.
Gaurav Patil
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