Basics regarding indomethacin drug. Indomethacin class,chemical or pharmacological name. Indications and contraindications of indomethacin. Side effects of indomethacin. Pediatric dosage for indomethacin. Nurses responsibility.

1. INDOMETHACIN
Shivnetri Chauhan
B.sc(N) 3rd yr.
Rama college of
nursing.
BY:

2. INTRODUCTION
• Indomethacin is indole -3-acetic
acid derivative classified as
NSAIDs.
• Primarily it is an anti-inflammatory
drug.

3. DRUG AND IT'S GROUP
Non Steroidal anti- inflammatory
drugs.

4. TRADE NAME
Indocin
PHARMACOLOGICAL NAME
4- chlorobenzoyl-5-methoxy-2-methyl-1-
indole-3-acetic acid

5. DOSAGE
The dose of indomethacin varies as per
different body problems :
 For Rheumatoid Arthiritis
 Initial dose is 1-2 mg/kg/day orally in
divided doses.
 Maximum dose is 3-4 mg/kg/day .

6.  For ankylosing spondylitis
 Initial dose is 25 mg orally 2-3 times a day.
 Maintenance dose is as per the patients
toleration with increment of 25-50 mg weekly
until satisfactory response or maximum dose is
achieved.
 The maximum dose is 100mg in single dose
and 200mg in daily dose.

7.  For osteoarthritis
 25 mg orally 2-3 times per day .
 Maintenance dose is increment of
25-50 mg weekly until get
satisfactory response.
 Maximum single dose is 100 mg.
 Maximum daily dose is 200 mg

8.  For Bursitis and Tendinitis
 75-150 mg orally per day in
3-4 divided doses.

9.  For Patent ductus arteriosus
Age at first dose :Less than 48 hrs :
 First dose :0.2 mg/kg IV
 Second dose: 0.1 mg/kg IV
 Third dose: 0.1 mg/kg IV

10. Age at first dose: 2-7 days :
 First dose: 0.2 mg/kg IV
 Second dose: 0.2mg/kg IV
 Third dose:0.2 mg/kg IV
Age at first dose:Over 7 days
 First dose:0.2 mg/kg IV
 Second dose:0.25 mg/kg IV
 Third dose:0.25 mg/kg IV

11. STRENGTH
Indomethacin oral suspension is of
25 mg per 5ml is an off white
suspension.

12. Route Of Administration
 ORAL
 IV
 SUPPOSITORY

13. PHARMACOKINETICS
 Half life is about 5-10 hrs.
 Metabolised in liver.
 Excreted via kidney.
 Undergoes appreciable
enterohepatic circulation.

14. Mechanism Of Action
Indomethacin produces potent analgesic and
anti inflammatory effects by inhibiting the
synthesis of prostaglandins via inhibiting the
cyclooxygenase enzyme or COX enzyme.

15. INDICATIONS
 Pain
 Rheumatoid
Arthritis
 PDA
 Osteoarthritis
 Spondylitis
 Gouty arthritis

16. CONTRAINDICATIONS
 Hypersensitivity
 Peptic ulcers
 Asthma
 Urticaria
 Suppositories are contraindicated
in patients with history of
proctitis or rectal bleeding.

17. SIDE EFFECTS
 Headache
 Dizziness
 Dyspepsia
 Hyponatremia
 Nausea
 Heartburn
 Indigestion
 Vomiting

18. NURSE'S RESPONSIBILITIES
 Question patient carefully regardi aspirin
sensitivity before initiation of therapy.
 Observe patients carefully , instruct to
report adverse reactions promptly to
prevent serious and sometimes
irreversible or fatal effects.

19.  Give drug with food or after meals.
 Discontinue drug if eye changes or
symptoms of hepatic or renal
impairment occur.
 Test RFT between doses.
 Use the drug only as suggested and
avoid overdose.

21. THANK U...