6. *Betamethasone is a glucocorticoid receptor agonist. This leads
to control the rate of protein synthesis,depresses the magration
of polymorphonu-clear leukocytes, fibroblasts; reverses
capillary peme-abillity and lysosomal stabilization at the
cellular level to prevent or control inflammation. Clotrimazole
is antifungal agent that bind to phosphlipids in the fungal cell
membrane altering cell wall permeabillity resulting in loss of
essential intracellular elements, and it becomes active when it
is not bound to transcortin.
Mechanism of action
7. Indications
*Topical use (cream, lotion and ointment): for relief of the
inflammatory and pruritic manifestations of corticosteroid-responsive
dermatoses, such as allergic reactions, eczema, and psoriasis
*Topical use (foam): relief of the inflammatory and pruritic
manifestations of corticosteroid-responsive dermatoses of the scalp
*Systemic use: for the treatment of edocrine disorders, rheumatic
disorders, collagen diseases, dermatological diseases, allergic states,
ophthalmic diseases.
8. Pharmacokinetic
*Administratiom: taking with food (oral)
*half-life:6.5 hours.
*protein binding: 64%
*Distribution: Distributed throughout body tissues; crosses
the placenta and enters the breast milk.
*Metabolism: Hepatic(cyp3A4)
*Excretion: Via urine (<5% as unchanged drug).
*renal clearance:9.5mLmin
9. Side and adverse effect
*Topical:
Skin irritation, redness, rash, itching , or allergic
inflammation of the skin.
Spread or worsening of untreated infections.
Thinning of the skin.
Reduced skin pigmentation.
telangiectasia.
Hypertrichosis.
*oral and IM:
Abdominal pain and Muscles weakness.
insomnia,behavioural changes.
Blurred vision.
Dizziness, headache and seizures.
11. Special Considerations
*Pregnancy: Category: C
*Lactation: systemically administered corticosteroids
enter breast milk and could suppress growth.
* pediatrics: Use lowest dose (Not recommended for
children under 17).
12. Dosage Form
*Topical:base
Cream as valerate: Generic: 0.1% (15 g, 45 g) .
Gel as dipropionate augmented :Generic: 0.05% (15 g, 50 g).
Lotion as dipropionat : 0.05% (60 mL).
Ointment as dipropionate: 0.05% (15 g, 45 g).
*systamic:
Solution, Oral: Celestone: 0.6 mg/5 mL
Suspension, Injection: Celestone Soluspan: Betamethasone sodium
phosphate 3 mg and betamethasone acetate 3 mg per 1 mL (5 mL)
[contains benzalkonium chloride, edetate disodium].
13. References:
• * Saudi national formulary book
• *Lixy application.
• * http://reference.medscape.com/
• * http://www.webmd.com/
• *http://www.Uptodate.com/