Atropine drug important

1. Atropa billadonna

2. Sidra
MP-CHEM-4
Organic Chemistry
Session : 2020-2022
Department of Chemistry
The Women University Multan.

3. Atropine is
solanaceous alkaloid.
It occurs in deadly
night shade plant
Atropa belladonna.
Specific
rotation of
atropine is -
22 degree.
Atropine is ester
of tropic acid.
It is hydrolyzed to
tropine and tropic
acid.
It is an
important
class of drug.

4. Eyes:
 Topical atropine is used in treatment of eyes.
 It is used as mydriatic to dilate pupils.
 While atropine eye drops have been shown to be
effective in slowing the progression of myopia in
children in several studies.
 All doses are effective. Low dose is thus
generally recommended due to less side effects.

5. Atropine eye drops

6. Heart :
 Atropine injection is used in the treatment of
bradycardia ( heart disease).
 Atropine is useful in second and third degree
heart block.
 Atropine has also been used in an effort to
prevent a low heart rate during intubation of
children.

7. Secretions:
 It actions on the parasympathetic nervous
system inhibit salivary and mucus gland.
 This drug may also used in inhibiting sweating
via sympathetic nervous system.
 This can be useful in treating hyperhidrosis and
can prevent the death rate of dying patients.
.

8. Poisoning:
 Atropine serves as a treatment for poisoning by
organophosphate insecticides and nerve agents by
injection such as:
I. Tubun (GA)
II. Serin (GB)
III. Soman (GD)
 Atropine used to reduce the effects of poisoning by
blocking muscarinic acetylcholine receptors.

9. Dose of atropine are needed
for organophosphate
pesticide poisoning .
Optimizing oxygenation
prior to the use of atropine to
minimize the potential for
dyrhythmias.

11. Atropine play
role to
reduce :
Muscle
spasms
Stomach
spasms
Intestine
spasms
Bladder or
other organs