This document provides national guidelines for sub-dermal contraceptive implants (Implanon NXT) in Oman. It discusses the introduction of implants as a new long-acting reversible contraceptive method. The guidelines cover information about the method, including effectiveness, mechanism of action, indications, benefits, risks, and medical eligibility criteria. It also provides detailed instructions for assessment of clients, insertion of implants, management of problems or side effects, and removal of implants. The aim is to expand contraceptive options and encourage use of long-acting reversible methods.
Uterus Transplantation Utx (obstetric and gynecology) D.A.B.M
Is the surgical procedure whereby a healthy uterus is transplanted into an organism of which the uterus is absent or diseased.
As part of normal mammalian sexual reproduction, a diseased or absent uterus does not allow normal embryonic implantation, effectively rendering the female infertile.
This phenomenon is known as Absolute Uterine Factor Infertility (AUFI).
Uterine transplant is a potential treatment for this form of infertility.
Uterus is a dynamic, complex organ. It is hugely blood-flow dependent.
More than 116,000 Number of men, women and children on the national transplant waiting list as of August 2017.
33,611 transplants were performed in 2016.
20 people die each day waiting for a transplant.
every 10 minutes another person is added to the waiting list.
Uterus Transplantation Utx (obstetric and gynecology) D.A.B.M
Is the surgical procedure whereby a healthy uterus is transplanted into an organism of which the uterus is absent or diseased.
As part of normal mammalian sexual reproduction, a diseased or absent uterus does not allow normal embryonic implantation, effectively rendering the female infertile.
This phenomenon is known as Absolute Uterine Factor Infertility (AUFI).
Uterine transplant is a potential treatment for this form of infertility.
Uterus is a dynamic, complex organ. It is hugely blood-flow dependent.
More than 116,000 Number of men, women and children on the national transplant waiting list as of August 2017.
33,611 transplants were performed in 2016.
20 people die each day waiting for a transplant.
every 10 minutes another person is added to the waiting list.
“Clinicians should proactively talk to their patients of reproductive age about ECPs and offer advance prescriptions for ECPs during routine gynecologic office visits….”
ESHRE Guideline on Recurrent Pregnancy Loss (RPL)Sujoy Dasgupta
Dr Sujoy Dasgupta invited to deliver a lecture on "RPL- ESHRE Guideline" in the Annual Conference of RCOG (Royal College of Obstetricians and Gynaecologists) IRC (International Representative Committee) India East held on 20-21 May, 2023
this presentation highlights the principles of uterine and ovarian transplantation. It explores the past and examines the current status for uterine and ovarian factor infertility.
“Clinicians should proactively talk to their patients of reproductive age about ECPs and offer advance prescriptions for ECPs during routine gynecologic office visits….”
ESHRE Guideline on Recurrent Pregnancy Loss (RPL)Sujoy Dasgupta
Dr Sujoy Dasgupta invited to deliver a lecture on "RPL- ESHRE Guideline" in the Annual Conference of RCOG (Royal College of Obstetricians and Gynaecologists) IRC (International Representative Committee) India East held on 20-21 May, 2023
this presentation highlights the principles of uterine and ovarian transplantation. It explores the past and examines the current status for uterine and ovarian factor infertility.
"Experiência de paíse com a IHAC = BFHI"
Baby-Friendly Hospital Initiative 2016
Experiência de 13 países são relatadas: Bolívia, Brasil, China, Gana, Irlanda, Quênia, Kuwait, Quirguistão, Nova Zelândia, Filipinas , Arábia Saudita, EUA e Vietname.
Demonstra que precisamos fortalecer e aprimorar esse programa mundial em defesa do estabelecimento da Amamentação nas Maternidades, Casas de Parto, Centros de Nascimento.
Future of Embryology by Attuluri Vamsi KumarVamsi kumar
This comprehensive PowerPoint presentation offers a detailed exploration of the dynamic field of embryology and its significant role in medical science. Titled "Navigating the Future of Embryology: Innovations and Ethical Considerations," it delves into the history, current practices, and future prospects of embryology. It covers the evolution of embryological studies, the vital role of the Indian Council of Medical Research (ICMR) in shaping guidelines, and the impact of technological advancements on the discipline. With a focus on predictions and trends, the presentation also contemplates potential future amendments to guidelines in response to evolving technologies and ethical considerations. This resource is invaluable for medical professionals, researchers, and students keen on understanding the trajectory of embryology and its implications for future medical practices.
EMERGENCY CONTRACEPTION & RECENT ADVANCEMENT OF CONTRACEPTION.pptxTanuShekhawat6
EMERGENCY CONTRACEPTION & RECENT ADVANCEMENT IN CONTRACEPTION
Introduction
Emergency contraception (EC) is a method of contraception used as an emergency procedure before menstruation is missed, to prevent pregnancy following unprotected intercourse or expected failure of contraception.
Cont..
Emergency contraception is any method of contraception which is used after intercourse and before the potential time of implantation. This nomenclature, advocated by WHO lately and accepted by international Medical Advisory Panel and others recently.
Alternative terms: Postcoital contraception- still commonly used and 'morning after' contraception
Emergency contraception is not true contraception but rightly called interception. Interceptive - agents that do not interfere with fertilization but act on blastocyst before or soon after missing periods.
Emergency contraception is a backup plan. It cannot be used as an ongoing method of contraception because:
i) relatively high failure rates
ii) High incidence of irregular bleeding
INDIAN SCENARIO: NEED
India has the highest number of unsafe abortions in the world.
6,20,472 abortions reported in India in 2012, Two-third of them were unsafe
A woman dies every two hours due to unsafe abortion.
Widespread availability of EC can help reduce these abortions.
INDICATIONS
1. For aged couples who meet very infrequently.
2. Following single act of sexual exposure in young girls
3. When pregnancy is apprehended owing to rupture of condom, premature ejaculation in couples practising coitus interruptus etc.
4. In case of rape.
ADVANTAGES
Saves the couple from unwanted pregnancies
From unnecessary operative interferences for fear of pregnancy
From the agony of waiting for the next menstrual cycle.
Prevents adolescent pregnancies
Helps to reduce unsafe abortion
COMBINED ETHINYL ESTRADIOL AND LEVONORGESTREL (YUZPE METHOD)
Yuzpe method (Canadian Prof. Albert Yuzpe) consists of the oral administration of 2 doses of 0.1mg(100 µg) ethinyl estradiol (EE) and 0.5mg(500 µg) levonorgestrel 12 hours apart.
Failure rate- 0-2%
Ovral tablets (each containing 50 µg ethinyl estradiol and 250 µg levonorgestrel) are most commonly used to provide these doses.
Others- Noral, Ovidon
PROGESTIN-ONLY (LEVONORGESTREL)
In India- EC pill, Pill 72, unwanted
LNG-ONLY PILLS
2 doses of 0.75mg LNG pill to be taken orally 12 hours apart within 72hours of intercourse. OR Single dose of 1.5mg LNG pill to be taken within 72 hours of intercourse.
Trials have shown that a high proportion of pregnancies were averted even up to 5days (120hours). WHO recommends levonorgestrel for emergency contraceptive pill use.
Failure rate- 0-1%
Cont.
Side Effects:-
1. Nausea- in 50% using Yuzpe regimen & 20% for Levonorgestrel.
2. Vomiting - in 20% Yuzpe regimen & 5% using LNG-only pills.
If vomiting occurs within 2 hours of taking the pills - the dose should be repeated. In cases of severe vomiting - administer pills vaginally.
3. Irregular uterine bleedi
this helps the students to learn about population policy, effects of population overgrowth, family welfare program, its importance, contraceptive devices & emergency contraception
اختبار قصير: ماذا تعلم عن التغطية الصحية الشاملة؟
أَجِب على أسئلة هذا الاختبار القصير لتتأكد من صحة إجاباتك.
1 تحتفل منظمة الصحة العالمية (المنظمة) في يوم 7 نيسان/ أبريل من كل عام بذكرى إنشائها، باليوم الذي دخل فيه دستورها حيز النفاذ. فكم ستبلغ المنظمة من العمر هذا العام (2018)؟
30 عاماً
50 عاماً
70 عاماً
90 عاماً
2 ما المقصود بالتغطية الصحية الشاملة؟
يُقصد بالتغطية الصحية الشاملة حصول جميع الأفراد والمجتمعات المحلية على الخدمات الصحية اللازمة لهم متى وحيثما لزمتهم.
التغطية الصحية الشاملة تحمي الناس من الوقوع في دائرة الفقر حينما يُسددون تكاليف الخدمات الصحية اللازمة لهم من أموالهم الخاصة.
التغطية الصحية الشاملة تُمكّن جميع الأشخاص من الحصول على الخدمات التي تعالج أهم أسباب الإصابة بالمرض والوفاة.
التغطية الصحية الشاملة تعني تقديم خدمات صحية للأفراد ومختلف فئات السكان كالقضاء على مواقع تكاثر البعوض.
جميع ما سبق.
3 ما نسبة سكان العالم غير القادرين على الحصول على الخدمات الصحية اللازمة لهم؟
ما لا يقل عن 30% من سكان العالم
ما لا يقل عن 50% من سكان العالم
ما لا يقل عن 70% من سكان العالم
ما لا يقل عن 90% من سكان العالم
4 يُدفع نحو 100 مليون شخص في العالم إلى دائرة ’الفقر المدقع‘ (أي يعيشون بدخل لا يتجاوز 1.90 دولاراً أمريكياً في اليوم) بسبب اضطرارهم إلى سداد تكاليف خدمات الرعاية الصحية اللازمة لهم.
صحيح
خطأ
5 من له دور يؤديه في الدعوة إلى تحقيق التغطية الصحية الشاملة؟
أنت
الجماعات غير الهادفة إلى الربح
العاملون في مجال الصحة
وسائط الإعلام
جميع ما سبق
Session 6 se and complications [repaired]
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
5. 3
INTRODUCTION
The birth spacing program has started in October 1994 with the provision of
four contraceptive methods. In 1996 intrauterine contraceptive device
(IUCD) has been added as a fifth method. In the current five- year plan
(2011-2015) for health development, Ministry of Health has planned to
expand birth spacing program, through adding a new contraceptive method
to currently provided birth spacing methods and encourage women to use
long-acting methods. That new method is sub-dermal contraceptive
implant.
Sub dermal contraceptive implant research and development began at the
Population Council laboratories in New York in 1966. The development of
contraceptive implants was made possible by the discovery of silicone and
its bio-compatibility in the human body. Silastic tubes with sealed ends and
filled with steroids provided a sustained release of the steroids in vitro over
months; these models were the precursors of today’s contraceptive
implants. This technology has resulted in the development and patenting of
Norplant and Norplant-2 (Jadelle) by the Population Council.
These guidelines cover many subjects relevant to the Implanon NXT birth
spacing method. They include information about the method itself, such as
definition, mechanism of action, shelf life, indications, health benefits,
advantages, disadvantages and side effects. Assessment of the client is also
included and a detailed description of Implanon NXT insertion and removal.
In addition, Management of problems that may arise is included. Medical
eligibility criteria for Implant adopted by WHO in 2015, are included in the
last section of the guidelines.
Dr. Fatima Ibrahim Al Hanai
Director of Woman & Child Health Department
11. 9
DEFINITION
Implanon NXT is a hormone-releasing contraceptive method for women used to prevent
pregnancy for up to 3 years. The implant is a radio-opaque, flexible plastic rod about the
size of a matchstick that contains a progestin hormone called etonogestrel, preloaded in
a sterile disposable applicator. The implant is inserted subdermal just under the skin of
the inner side of the upper arm. Implanon NXT does not contain estrogen.
All health care providers should receive instruction and training prior to performing
insertions and/or removal of Implanon NXT.
EFFECTIVENESS
Implanon NXT is one of the most effective and long lasting methods. Over 3 years of
Implanon NXT use there is chance of less than 1 pregnancy per 100 women (1 per 1,000
women).
MECHANISM OF ACTION
The contraceptive effect of Implanon NXT is achieved by:
1. Preventing ovulation.
2. Preventing sperm penetration by altering the cervical mucus.
3. Possibly preventing implantation by thinning the endometrium.
SHELF LIFE
Store Implanon NXT at 25°C; short outing permitted to 15°-30°C. Protect from light.
Avoid storing Implanon NXT in direct sunlight or at temperatures above 30°C .Use before
expiry date printed on its plaster.
INDICATIONS
Nearly all women can use implants safely and effectively. It can be even used for the
followings:
• Multiparous or Nulliparous.
• Clients of any age, including adolescents and women over 40 years old.
• Have just had an abortion, miscarriage, or ectopic pregnancy.
• Women who smoke cigarettes, regardless of their age or a number of cigarettes
smoked.
• Breastfeeding mothers (starting as soon as 6 weeks after childbirth).
• Have history of anemia or current anemia.
• Have varicose veins.
• Are infected with HIV, whether or not on antiretroviral therapy.
HEALTH BENEFITS
Helps to protect against: • Risks of pregnancy.
• Symptomatic pelvic inflammatory disease.
• Iron-deficiency anemia
12. 10
ADVANTAGES
• Do not require the user to do anything once after insertion.
• Prevent pregnancy very effectively.
• Are long-lasting (up to 3 years). (In case of obese women with BMI >30 up to 2.5
years)
• Complete return of fertility on removal.
• Do not interfere with sex.
• Women can begin using implants without:
o Pelvic examination.
o Blood tests or other routine laboratory tests.
o Cervical cancer screening.
o Breast examination (unless there is a positive history that necessitates examination).
However, as per the national guidelines, clinical breast examination should be
done to all birth spacing clients.
DISADVANTAGES
• Require specifically trained provider to insert and remove. It is considered a minor
surgical procedure.
• A woman cannot start or stop the method by herself.
• Changes in bleeding pattern are common, but not harmful. Typically, prolonged
irregular bleeding over the first year, and then lighter, infrequent bleeding.
• Relatively expensive method.
SIDE EFFECTS:
Implanon NXT users are more likely to have oligomenorrhea or Amenorrhea than
irregular bleeding.
Changes in bleeding patterns, includes:
Ø First several months: Spotting, oligomenorrhea, amenorrhea, or menometrorrhagia.
v After about one year: More regular menses or Infrequent changes in bleeding pattern.
Other side effects
• Headaches, Abdominal pain.
• Mood changes, Nausea.
• Breast tenderness, dizziness.
• Acne (can improve or worsen)
• Weight change
• Other possible physical changes: Enlarged ovarian follicle
13. 11
ASSESSMENT OF CLIENT FOR CONTRACEPTIVE IMPLANTS USE
History
After asking the client about the standard birth spacing history taking questions as personal
history, obstetric history, and menstrual history, ask her the questions below about known
medical conditions. If she answers “no” to all of the questions, then she can have implants
inserted if she wants. If she answers “yes” to a question, follow the instructions. In some
cases, she can still start using implants.
1. Are you breastfeeding a baby less than 6 weeks old?
❏NO ❏YES
She can start using implants as soon as 6 weeks after childbirth (see if she is fully or nearly
fully breastfeeding or Partially breastfeeding).
2. Do you have severe cirrhosis of the liver, a liver infection, or liver tumor?
❏NO ❏YES
If she reports serious active liver disease(jaundice, severe cirrhosis, liver Tumor), do not
provide implants. Help her choose a method without hormones.
3. Do you have a serious problem now with a blood clot in your legs or lungs?
❏NO ❏YES
If she reports a current blood clot (not superficial clots), and she is not on
Anticoagulant therapy, do not provide implants. Help her choose a method without
Hormones.
4. Do you have vaginal bleeding that is unusual for you?
❏NO ❏YES
If she has unexplained vaginal bleeding that suggests pregnancy or an underlying
medical condition, implants could make diagnosis and monitoring of any treatment more
difficult. help her choose a method to use while being evaluated and treated (not
progestin-only injectable, or a copper-bearing or hormonal IUD).
After treatment, re-evaluate for the use of implants.
5. Do you have or have you ever had breast cancer?
❏NO ❏YES
Do not provide implants. Help her choose a method without hormones. Be
sure to explain the health benefits and risks and the side effects of the method that the
client will use. Also, point out any conditions that would make the method inadvisable,
when relevant to the client.
Examination
General examination
Pulse - Blood pressure - Weight
Pallor and signs of SLE
Jaundice
Breast examination
Systemic examination
Cardiovascular (legs for DVT)
Abdominal (liver enlargement
&tenderness)
Pelvic examination (only if indicated)
Laboratory Investigations
Urine test, if pregnancy suspected
CBC if anemic
Pap smear, if indicated
Breast & liver ultrasonography, if indicated
Antiphospholipid antibodies if she is
suspected
14. 12
USING CLINICAL JUDGMENT IN SPECIAL CASES
Usually, a woman with any of the conditions listed below should NOT use implants. In
special circumstances, however, when other more appropriate methods are not
available or acceptable to her, a qualified provider who can carefully assess a specific
woman’s condition and the situation may decide that she can use implants. The provider
needs to consider the severity of her condition and, for most conditions, whether she
will have access to follow-up.
• Breastfeeding less than 6 weeks since giving birth (considering the risks of another
pregnancy and that a woman may have limited further access to implants)
• An acute blood clot in deep veins of legs or lungs.
• Unexplained vaginal bleeding before evaluation for possible serious underlying
condition.
• Had breast cancer more than 5 years ago, and it has not returned.
• Severe liver disease, infection, or tumor.
• Systemic lupus erythematous with positive (or unknown) antiphospholipid
antibodies.
CONTRAINDICATIONS
Implanon NXT should not be used in women who have:
• Known or suspected pregnancy.
• Current or past history of thrombosis or thromboembolic disorders.
• Liver tumors, benign or malignant, or active liver disease.
• Undiagnosed abnormal uterine bleeding.
• Known, suspected or personal history of breast cancer, or other current or past
history of progestin-sensitive tumors.
• Allergic reaction to any of the components of Implanon NXT.
15. 13
METHOD PROVISION AND INSTRUCTIONS FOR METHOD USE
A. INITIATING CONTRACEPTION WITH IMPLANON NXT
IMPORTANT:
Rule out pregnancy before inserting the implant.
Timing of insertion depends on the woman’s recent contraceptive history, as follows:
v No preceding hormonal contraceptive use in the past month
Implanon NXT should be inserted between Day 1 (first day of menstrual cycle) and
Day 5 of the menstrual cycle, even if the woman is still bleeding. If inserted as
recommended, back-up contraception is not necessary. If deviating from the
recommended timing of insertion, the woman should be advised to use a barrier
method until 7 days after insertion. If intercourse has already occurred, pregnancy
should be excluded
v Switching contraceptive method to Implanon NXT
a. From Combined hormonal contraceptives:
Implanon NXT should preferably be inserted on the day after the last active tablet of
the previous combined oral contraceptive. At the latest, Implanon NXT should be
inserted on the day following the usual tablet-free or placebo tablet interval of the
previous combined hormonal contraceptive. If inserted as recommended, back-up
contraception is not necessary. If deviating from the recommended timing of
insertion, the woman should be advised to use a barrier method until 7 days after
insertion. If intercourse has already occurred, pregnancy should be excluded.
b. From Progestin-only contraceptives:
There are several types of progestin-only methods Implanon NXTshould be inserted as
follows:
a. Injectable Contraceptives: Insert Implanon NXT on the day the next injection is due.
b. Minipill: a woman may switch to Implanon NXT on any day of the month , Implanon
NXTshould be inserted within 24 hours after taking the last tablet.
If Implanon NXT inserted as recommended, back-up contraception is not necessary. If
deviating from the recommended timing of insertion, the woman should be advised
to use a barrier method until 7 days after insertion. If intercourse has already
occurred, pregnancy should be excluded.
v Following abortion or miscarriage
a. First trimester: Implanon NXTshould be inserted within 5 days following a first-
trimester abortion or miscarriage.
b. Second trimester: Insert Implanon NXT between 21 to 28 days following second-
trimester abortion or miscarriage.
If inserted as recommended, back-up contraception is not necessary. If deviating
from the recommended timing of insertion, the woman should be advised to use a
barrier method until 7 days after insertion. If intercourse has already occurred,
pregnancy should be excluded.
17. 15
B. INSERTION OF IMPLANON NXT
The basis for successful use and subsequent removal of Implanon NXT is a correct and
careful performance sub-dermal insertion of the implant in accordance with the
instructions. Both the health care provider and the woman should be able to feel the
implant under the skin after placement.
All healthcare providers performing insertions and/or removals of Implanon NXT
should receive instructions and training prior to insertion or removal of the implant.
PREPARATION
Before insertion of Implanon NXT, the healthcare provider should confirm that:
a. The woman is neither pregnant nor has any other contraindication for the use of
Implanon NXT.
b. The woman has performed a medical history and physical examination.
c. The woman counseled about the benefits and risks of Implanon NXT.
d. The woman has reviewed and completed a verbal consent to be maintained with
the woman’s chart.
e. The woman does not have allergies to the antiseptic and anesthetic to be used
during insertion.
INSERTION OF IMPLANON NXT UNDER ASEPTIC CONDITIONS
The following equipments are needed for the implant insertion:
1. An examination table for the woman to lie on
2. Sterile surgical drapes, sterile gloves, antiseptic solution (preferred Betadine
solution), permanent marker
3. Local anesthetic, needles, and syringe
4. Sterile gauze, adhesive bandage, pressure bandage
Figure 1: An applicator and its parts are shown below
20. 18
Step (7):
Hold the applicator just above the needle, at the textured surface area. Remove the
transparent protection cap by sliding it horizontally in the direction of the arrow away
from the needle (Figure 5). If the cap does not come off easily, the applicator should not
be used. You can see the white colored implant by looking into the tip of the needle. Do
not touch the grey slider until you fully inserted the needle subdermally, as it will retract
the needle and prematurely release the implant from the applicator.
Figure (5)
Step (8):
With your free hand, stretch the skin around the insertion site with thumb and index
finger, (figure 6).
Step (9):
Puncture the skin with the tip of the needle angled about 30° (Figure 7).
Figure (7)
22. 20
Step (12):
Always verify the presence of the implant in the woman’s arm immediately after
insertion by palpation. By palpating both ends of the implant, you should be able to
confirm the presence of the 4 cm rod (Figure 10).
Figure (10)
If you cannot feel the implant or are in doubt of its presence;
• Check the applicator. The needle should be fully retracted and only the grey tip of the
obturator should be visible.
• Use other methods to confirm the presence of the implant.
Suitable methods are:
o Two-dimensional X-ray,
o X-ray computerized tomography (CT scan),
o Ultrasound scanning (USS) with a high-frequency linear array transducer(≥10
MHz)
o Magnetic Resonance Imaging (MRI).
Till the presence of the implant has been verified, the woman should be advised to use
a non-hormonal contraceptive method, such as condoms.
Step (13):
Place a small adhesive waterproof bandage over the insertion site. Request that the
woman palpates the implant.
23. 21
Step (14):
Apply a pressure bandage with sterile gauze to minimize bruising. The woman may
remove the pressure bandage in 24 hours and the small bandage over the insertion site
after 3 to 5 days.
Figure (10)
Step (15):
Complete the USER CARD and give it to the woman to keep. Also, complete the PATIENT
CHART LABEL and affix it to the woman's medical record.
Step (16):
The applicator is for single use only and should be disposed of in accordance with the
Center for Disease Control and Prevention guidelines for handling of hazardous waste.
24. 22
PRACTICAL COMPLICATIONS OF INSERTION
Non-insertion
Implanon NXT has inbuilt safety features to reduce the risk of non-insertion, but it is still
important to check for the presence of the implant in the applicator and to palpate the
skin after insertion. The applicator should be checked immediately at the end of the
insertion procedure. The needle should be fully retracted and only the grey tip of the
obturator should be visible.
Deep insertion
The correct way of insertion of implant should be situated subdermally
(subcutaneously), just under the skin. Significant migration of the implant is not thought
to occur when an implant has been correctly inserted; therefore, deep implant
insertions are more likely a result of the insertion technique. If an implant is inserted too
deeply, it may be difficult to remove and/or locate, and there is greater potential for
neurovascular injury, infection, and scar formation.
Nerve or vascular injury
Implanon NXT states that the implant should be inserted at the inner side of the upper
arm to avoid the large blood vessels and nerves that lie deeper in the connective tissue
between the Biceps and triceps muscles.
25. 23
REMOVAL OF IMPLANON NXT
A. PREPARATION
Before initiating the removal procedure, the healthcare provider should carefully read
the instructions for removal and consult the USER CARD and/or the PATIENT CHART
LABEL for the location of the implant. The exact location of the implant in the arm
should be verified by palpation. If the implant is not palpable, ultrasound with a high-
frequency linear array transducer (10 MHz or greater) or magnetic resonance Imaging
(MRI) can be performed to verify its presence. A non-palpable implant should always be
first located prior to removal. Suitable methods for localization include ultrasound with a
high-frequency linear array transducer (10 MHz or greater) or magnetic resonance
Imaging (MRI). If these imaging methods fail to locate the implant, an etonogestrel
blood level determination can be used for verification of the presence of the implant.
After localization of a non-palpable implant, consider conducting removal with
ultrasound guidance. There have been occasional reports of migration of the implant;
usually this involves a minor movement relative to the original position. This may
complicate localization of the implant by palpation, ultrasound or magnetic resonance
imaging, and removal may require a larger incision and more time.
Exploratory surgery without knowledge of the exact location of the implant is strongly
discouraged.
Removal of deeply inserted implants should be conducted with caution in order to
prevent injury to deeper neural or vascular structures in the arm and be performed by
healthcare providers familiar with the anatomy of the arm.
Before removal of the implant, the health care provider should confirm that:
• The woman does not have allergies to the antiseptic or anesthetic to be used.
• Remove the implant under aseptic conditions.
The following equipments are needed for removal of the implant:
o An examination table for the woman to lie on
o Sterile surgical drapes, sterile gloves, antiseptic solution, permanent marker
(optional)
o Local anesthetic, needles, and syringe
o Sterile scalpel, forceps (straight and curved mosquito)
o Skin closure(steri strips), sterile gauze, an adhesive bandage, and pressure
bandages.
26. 24
B. REMOVAL PROCEDURE
Step (1):
Clean the site where the incision will be made and apply an antiseptic. Locate the
implant by palpation and mark the distal end (end closest to the elbow), for example,
with a permanent marker (Figure 11).
Figure (11)
Step (2):
Anesthetize the arm, for example, with 0.5 to 1 ml 1% lidocaine at the marked site
where the incision will be made (Figure 12). Be sure to inject the local anesthetic under
the implant to keep it close to the skin surface.
Figure (12)
Step (3):
Push down the proximal end of the implant (Figure 13) to stabilize it; a bulge may
appear indicating the distal end of the implant. Starting at the distal tip of the implant,
make a longitudinal incision of 2 mm towards the elbow.
Figure (13)
27. 25
Step (4):
Gently push the implant towards the incision until the tip is visible. Grasp the implant
with forceps (preferably curved mosquito forceps) and gently remove the implant
(Figure 14).
Figure (14)
Step (5):
If the tip of the implant does not become visible in the incision, gently insert a forceps
into the incision (Figure 15). Flip the forceps over into your other hand (Figure 16).
Figure (15) Figure (16)
Step (6):
If the implant is encapsulated, make an incision into the tissue sheath and then remove
the implant with the forceps (Figures 16and 17).
Figure (17) Figure (18)
29. 27
Step (10):
Apply a pressure bandage with sterile gauze to minimize bruising. The woman may
remove the pressure bandage in 24 hours and the small bandage in 3 to 5 days (Figure
22).
Figure (22)
REPLACING IMPLANON NXT
Immediate replacement can be done after removal of the previous implant and is similar
to the insertion procedure described in the section of the Insertion of Implanon NXT
The new implant may be inserted in the same arm, and through the same incision from
which the previous implant was removed. If the same incision is being used to insert a
new implant, anesthetize the insertion site [for example, 2 ml lidocaine (1%)] just under
the skin along the ‘insertion canal.’ Follow the subsequent steps in the insertion
instructions.
RESUSCITATION
As with all procedures, there is a risk of collapse due to a vasovagal reaction or
anaphylaxis.so it recommends to keep essential drugs and equipment for resuscitation
beside the procedure.
WHEN TO RETURN
Assure every client that she is welcome to come back anytime—for example, if she has
problems, questions, or wants another method; she has a major change in health status,
or she thinks she might be pregnant.
Also, if:
• She has pain, heat, pus, or redness at the insertion site that becomes worse or does
not go away, or she sees a rod coming out.
33. 31
• To help prevent anemia, suggest she take iron tablets and tell her it is important to
eat foods containing iron, such as meat and poultry (especially beef and chicken
liver), fish, green leafy vegetables, and legumes (beans, bean curd, lentils, and peas).
• If heavy or prolonged bleeding continues or starts after several months of normal
menses or amenorrhea, or you suspect that something may be wrong for other
reasons, consider underlying conditions unrelated to method use.
4. Ordinary headaches (non-migrainous)
• Paracetamol (500–1000 mg), or another pain reliever.
• Any headache that gets worse or occurs more often during use of implants should be
evaluated.
5. Mild abdominal pain
• Ibuprofen (200–400 mg), paracetamol (500–1000 mg), or other pain reliever.
• Consider locally available remedies.
6. Acne or Chloasma
• If the client wants to stop using implants because of acne, she can consider switching
to COCs. Many women’s acne improves with COC use.
• Chloasma may develop in women with history of choasma gravidarum advise to
avoid exposure to the sun or ultraviolet radiation.
7. Weight change
Review diet and counsel as needed.
8. Breast tenderness
• Recommend that she wears a supportive bra (including during strenuous activity and
sleep).
• Try hot or cold compresses.
• Suggest ibuprofen (200–400 mg), paracetamol (500–1000 mg), or other pain
reliever.
• Consider locally available remedies.
9. Mood changes or changes in sex drive
• Ask about changes in her life that could affect her mood or sex drive, including
changes in her relationship with her partner. Give her support as appropriate.
• Clients who have serious mood changes such as major depression should be referred
for care.
10.Nausea or dizziness
Reassure
11.Pain after insertion or removal
• For pain after insertion, check that the bandage or gauze on her arm is not too tight.
• Put a new bandage on the arm and advise her to avoid pressing for few days.
• Give her ibuprofen (200–400 mg), paracetamol (500–1000 mg), or other pain
reliever.
34. 32
12.Infection at the insertion site (redness, heat, pain, pus)
• Do not remove the implants.
• Clean the infected area with soap and water or antiseptic.
• Give oral antibiotics for 7 to 10 days.
• Ask the client to return after taking all antibiotics if the infection does not clear. If
the infection has not cleared, remove the implants or refer for removal.
• Expulsion or partial expulsion often follows an infection. Ask the client to return if
she notices an implant coming out.
IF Abscess DEVELOPED (pocket of pus under the skin due to infection)
• Clean the area with antiseptic.
• Cut open (incise) and drain the abscess.
• Treat the wound.
• Give oral antibiotics for 7 to 10 days.
• Ask the client to return after taking all antibiotics if she has heat, redness, pain, or
drainage of the wound. If the infection is present when she returns, remove the
implants or refer for removal.
13.Expulsion (when one or more implants begin to come out of the arm)
• Rare. Usually occurs within a few months of insertion or with infection.
• If no infection is present, replace the expelled rod or capsule through a new incision
near the other rods or capsules, or refer for replacement.
14.Severe pain in lower abdomen
Abdominal pain may be due to
v Surgical problems,
v Gynecological problems such as:
• Enlarged ovarian follicles or cysts.
− A woman can continue to use implants during evaluation.
− There is no need to treat enlarged ovarian follicles or cysts unless they grow
abnormally large, twist, or burst. Reassure the client that they usually disappear
on their own.
− To be sure the problem is resolved, see the client again in 6 weeks, if possible.
• Ectopic pregnancy, which is rare and not caused by implants, but it can be life-
threatening, In the early stages of ectopic pregnancy, symptoms may be absent or
mild, but eventually they will become severe. Following symptoms and signs
increase the suspicion of ectopic pregnancy
− Unusual abdominal pain or tenderness
− Abnormal vaginal bleeding or no monthly bleeding—especially if this is a change
from her usual bleeding pattern , Light-headedness or dizziness, fainting
If ectopic pregnancy or other serious health condition is suspected, escort the patient
for immediate diagnosis and care.
36. 34
New Problems DURING USE That May Require Switching
Methods
May or may not be due to the method:
1. Unexplained vaginal bleeding (that suggests a medical condition, not related to the
method)
• Refer or evaluate by history and pelvic examination. Diagnose and treat as
appropriate.
• If no cause of bleeding can be found, consider stopping implants to make diagnosis
easier. Provide another method of her choice to use until the condition is evaluated
and treated (not progestin-only injectables, or a copper-bearing or hormonal IUD).
• If bleeding is caused by sexually transmitted infection or pelvic inflammatory
disease, she can continue using implants during treatment.
2. Migraine headaches
• If she has migraine headaches without aura, she can continue to use implants if she
wishes.
• If she has migraine aura, remove the implants. Help her choose a method without
hormones.
3. Certain serious health conditions (suspected blood clots in the deep veins of the
legs or lungs, serious liver disease, or breast cancer).
• Remove the implants or refer for removal.
• Give her a backup method to use until her condition is evaluated.
• Refer for diagnosis and care, if not already under care.
4. Heart disease due to blocked or narrowed arteries (ischemic heart disease) or
stroke
• A woman who has one of these conditions can safely start implant. If, however, the
condition develops while she is using implants:
− Remove the implants or refer for removal.
− Help her choose a method without hormones.
− Refer for diagnosis and care, if not already under care.
5. Suspected pregnancy
• Assess for pregnancy, including ectopic pregnancy.
• Remove the implants or refer for removal .
• There are no known risks to a fetus conceived while a woman has implants in place.
37. 35
QUESTIONS AND ANSWERS ABOUT IMPLANTS
1. Do users of implants require follow-up visits?
No. Routine periodic visits are not necessary for implant users. Annual visits may be
helpful for other preventive care, but they are not required. Of course, women are
welcome to return at anytime with questions.
2. Can implants be left permanently in a woman’s arm?
Leaving the implants in place beyond their effective lifespan is generally not
recommended if the woman continues to be at risk of pregnancy. The implants
themselves are not dangerous, but as the hormone levels in the implants drop, they
become less and less effective.
3. Do implants cause cancer?
No. Studies have not shown increased risk of any cancer with the use of implants.
4. How long does it take to become pregnant after the implants are removed?
Women who stop using implants can become pregnant as quickly as women who
stop non-hormonal methods. Implants do not delay the return of a woman’s fertility
after they are removed. The bleeding pattern a woman had before she used implants
generally returns after they are removed. Some women may have to wait a few
months before their usual bleeding pattern returns.
5. Do implants cause birth defects? Will the fetus be harmed if a woman accidentally
becomes pregnant with implants in place?
No. Good evidence shows that implants will not cause birth defects and will not
otherwise harm the fetus if a woman becomes pregnant while using implants or
accidentally has implants inserted when she is already pregnant.
6. Can implants move around within a woman’s body or come out of her arm?
Implants do not move around in a woman’s body. The implants remain where they
are inserted until they are removed. Rarely, a rod may start to come out, more often
in the first 4 months after insertion. This usually happens because they were not
inserted well or because of an infection where they were inserted. In these cases,
the woman will see the implants coming out. Some women may have a sudden
change in bleeding pattern. If a woman notices a rod coming out, she should start
using a backup method and return to the clinic at once.
38. 36
7. Do implants increase the risk of ectopic pregnancy?
No. On the contrary, implants greatly reduce the risk of ectopic pregnancy. Ectopic
pregnancies are extremely rare among implant users. The rate of ectopic pregnancy
among women with implants is 6 per 100,000 women per year. The rate of ectopic
pregnancy among women in the United States using no contraceptive method is 650
per 100,000 women per year. On the very rare occasions that implant fail and
pregnancy occurs, 10 to 17 of every 100 of these pregnancies are ectopic. Thus, the
great majority of pregnancies after implants fail are not ectopic. Still, ectopic
pregnancy can be life-threatening, so a provider should be aware that ectopic
pregnancy is possible if implants fail.
8. How soon can a breastfeeding woman start a progestin-only method—implants,
progestin-only pills or injectable, or LNG-IUD?
WHO guidance calls for waiting until at least 6 weeks after childbirth to start a
progestin-only contraceptive (4 weeks for the LNG-IUD).
9. Should women with high BMI avoid implants?
No. These women should know, however, that studies of Implanon NXT have not
found that weight decreases effectiveness within the lifespan approved for this type
of implant.
10. What should be done if an implant user has an ovarian cyst?
The great majority of cysts are not true cysts but actually fluid-filled structures in the
ovary (follicles) that continue to grow beyond the usual size in a normal menstrual
cycle. They may cause some mild abdominal pain, but they only require treatment if
they grow abnormally large, twist, or burst. These follicles usually go away without
treatment
11. Can a woman work soon after having implants inserted?
Yes, a woman can do her usual work immediately after leaving the clinic as long as
she does not bump the insertion site or get it wet.
12. Must a woman have a pelvic examination before she can have implants inserted?
No. Instead, asking the right questions can help the provider be reasonably certain
she is not pregnant. No condition that can be detected by a pelvic examination rules
out the use of implants.
40. 38
Condition Sub-condition Implant
I C
Age Menarche to >45 1
Anemias a) Thalassemia 1
b) Sickle cell disease‡ 1
c) Iron-deficiency anemia 1
Benign ovarian tumors (including cysts) 1
Breast disease a) Undiagnosed mass 2*
b) Benign breast disease 1
c) Family history of cancer 1
d) Breast cancer‡
i) current 4
ii) past and no evidence of current
disease for 5 years
3
Breastfeeding
(Postpartum)
a) < 1 month postpartum 2*
b) 1 month or more postpartum 1*
Cervical cancer Awaiting treatment 2
Cervical ectropion 1
Cervical intraepithelial
neoplasia
2
Cirrhosis a) Mild (compensated) 1
b) Severe‡ (decompensated) 3
Deep venous thrombosis
(DVT) / Pulmonary
embolism (PE)
a) History of DVT/PE, not on
anticoagulant therapy
i) higher risk for recurrent DVT/PE 2
ii) lower risk for recurrent DVT/PE 2
b) Acute DVT/PE 3
c) DVT/PE and established on
anticoagulant therapy for at least 3
months
i) higher risk for recurrent DVT/PE 2
ii) lower risk for recurrent DVT/PE 2
d) Family history (first-degree
relatives)
1
e) Major surgery
(i) with prolonged immobilization 2
(ii) without prolonged
immobilization
1
f) Minor surgery without
immobilization
1
Depressive disorders 1*
Diabetes mellitus (DM) a) History of gestational DM only 1
b) Non-vascular disease
(i) non-insulin dependent 2
(ii) insulin dependent‡ 2
c) Nephropathy/ retinopathy/
neuropathy‡
2
d) Other vascular disease or diabetes
of >20 years' duration‡
2
41. 39
Endometrial cancer‡ 1
Endometrial hyperplasia 1
Endometriosis 1
Epilepsy‡ (see also Drug Interactions) 1*
Gallbladder disease a) Symptomatic
(i) treated by cholecystectomy 2
(ii) medically treated 2
(iii) current 2
b) Asymptomatic 2
Gestational trophoblastic
disease
a) Decreasing or undetectable ß-hCG
levels
1
b) Persistently elevated ß-hCG levels
or
malignant disease‡
1
Headaches a) Non-migrainous 1* 1*
b) Migraine
i) without aura, age <35 2* 2*
ii) without aura, age >35 2* 2*
iii) with aura, any age 2* 3*
History of bariatric surgery ‡
a) Restrictive procedures 1
b) Malabsorptive procedures
1
History of cholestasis a) Pregnancy-related 1
b) Past COC-related 2
History of high blood
pressure
during pregnancy
1
History of pelvic surgery 1
HIV High risk 1
HIV infected (see also Drug
Interactions)‡
1*
AIDS (see also Drug Interactions)‡ 1*
Hyperlipidemias Clinically well on therapy 2*
Hypertension
a) Adequately controlled hypertension 1*
b) Elevated blood pressure levels
(properly taken measurements)
(i) systolic 140-159 or diastolic 90-99 1
(ii) systolic ≥160 or diastolic ≥100‡ 2
c) Vascular disease 2
Inflammatory bowel disease (Ulcerative colitis, Crohn’s disease) 1
Ischemic heart disease‡ Current and history of 2 3
Liver tumors a) Benign
i) Focal nodular hyperplasia 2
ii) Hepatocellular adenoma‡ 3
b) Malignant‡ 3
Malaria
1
Multiple risk factors for
arterial cardiovascular
disease
(such as older age, smoking, diabetes
and hypertension)
2*
Obesity a) >30 kg/m2
body mass index (BMI) 1
42. 40
b) Menarche to < 18 years and > 30
kg/m2
BMI
1
Ovarian cancer‡ 1
Parity a) Nulliparous 1
b) Parous 1
Past ectopic pregnancy 1
Pelvic inflammatory
disease
a) Past, (assuming no current risk
factors of STIs)
(i) with subsequent pregnancy 1
(ii) without subsequent pregnancy 1
b) Current 1
Peripartum cardiomyopathy
‡
a) Normal or mildly impaired cardiac
function
(i) < 6 months 1
(ii) > 6 months 1
b) Moderately or severely impaired
cardiac function
2
Postabortion a) First trimester 1*
b) Second trimester 1*
c) Immediately post-septic abortion 1*
Postpartum
(see also Breastfeeding)
a) < 21 days 1
b) 21 days to 42 days
(i) with other risk factors for VTE 1
(ii) without other risk factors for VTE 1
c) > 42 days 1
Pregnancy NA*
Rheumatoid arthritis a) On immunosuppressive therapy 1
b) Not on immunosuppressive therapy 1
Schistosomiasis a) Uncomplicated 1
b) Fibrosis of the liver‡ 1
Severe dysmenorrhea 1
Sexually transmitted
infections (STIs)
Sexually transmitted
infections
(cont.)
a) Current purulent cervicitis or
chlamydial infection or gonorrhea
1
b) Other STIs (excluding HIV and
hepatitis)
1
c) Vaginitis (including
trichomonasvaginalis and bacterial
vaginosis)
1
d) Increased risk of STIs 1
Smoking a) Age < 35 1
b) Age > 35, < 15 cigarettes/day 1
c) Age > 35, >15 cigarettes/day 1
Solid organ
transplantation‡
a) Complicated 2
b) Uncomplicated 2
Stroke‡ History of cerebro-vascular accident 2 3
Superficial venous
thrombosis
a) Varicose veins 1
b) Superficial thrombophlebitis 1
Systemic lupus
erythematosus‡
a) Positive (or unknown) antiphospho-
lipid antibodies
3
b) Severe thrombocytopenia 2
c) Immunosuppressive treatment 2
43. 41
d) None of the above 2
Thrombogenic mutations‡ 2*
Thyroid disorders Simple goiter/hyperthyroid/
hypothyroid
1
Tuberculosis‡
(see also Drug Interactions)
a) Non-pelvic 1*
b) Pelvic 1*
Unexplained vaginal
bleeding
(suspicious for serious condition)
before evaluation
3*
Uterine fibroids 1
Valvular heart disease a) Uncomplicated 1
b) Complicated‡ 1
Vaginal bleeding patterns a) Irregular pattern without heavy
bleeding
2
b) Heavy or prolonged bleeding 2*
Viral hepatitis a) Acute or flare( with normal LFT) 1
b) Carrier/Chronic 1
Antiretroviral therapy a) Nucleoside reverse transcriptase
inhibitors
1
b) Non-nucleoside reverse
transcriptase inhibitors
2*
c) Ritonavir-boosted protease
inhibitors
2*
Anticonvulsant therapy a)Certain anticonvulsants
(phenytoin, carbamazepine,
barbiturates, primidone,
topiramate, oxcarbazepine)
2*
b) Lamotrigine 1
Antimicrobial
Therapy
a) Broad spectrum antibiotics 1
b) Antifungals 1
c) Antiparasitics 1
d) Rifampicin or rifabutin therapy 2*
I = initiation of contraceptive method;
C = continuation of contraceptive method;
NA = Not applicable
* Please see the complete guidance for a clarification to this classification
‡ Condition that exposes a woman to increased risk as a result of unintended pregnancy.