Immunopathology lecture 2+3 ,final

Disorders of Immunity A- Mechanisms of immune- mediated injury (Hypersensitivity Reactions) B- Autoimmune Diseases C- Immunodeficiency Diseases D- Amyloidosis

[object Object],[object Object],[object Object],[object Object],[object Object],OR Hypersensitivity is a state of altered immune responsiveness in which a severe and harmful immune reaction occurs on exposure to the antigen.

IMMUNE MECHANISMS OF TISSUE INJURY Hypersensitivity reactions/diseases ,[object Object],[object Object]

Type I Hypersensitivity Anaphylaxis; Anaphylactic Reaction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ECF = eosinophil chemotactic factor NCF = neutrophil chemotactic factor PAF = platelet-activating factor

[object Object],[object Object],[object Object]

Type I Hypersensitivity A sequence of Events Photo: Kumar, Cotran, Robbins. Robbins Basic pathology, 7 th ed., Saunders, Philadelphia, 2003.

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity Reaction Clinical Manifestations

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity Reaction Clinical Manifestations Eosinophil

Type II Hypersensitivity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Type II Hypersensitivity 2- Antibody- Dependent Cell- Mediated Cytotoxicity (ADCC) ,[object Object],[object Object]

Type II Hypersensitivity Reaction 3- Antibody- mediated cellular dysfunction ,[object Object],[object Object],[object Object],Antibodies directed against cell surface receptors impirs or dysregulate function without causing cell injury. Ex:

Type II Hypersensitivity Antibody-Mediated Injury ,[object Object],[object Object],Photo: Kumar, Cotran, Robbins. Robbins Basic pathology, 7 th ed., Saunders, Philadelphia, 2003.

Type II Hypersensitivity Reaction Clinical Manifestations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Immune hydrops from Rh hemolysis

Type II Hypersensitivity Reaction Clinical Manifestations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Pemphigoid Pemphigoid

Type III Hypersensitivity Immune Complex Mediated ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Type III Hypersensitivity Immune Complex Mediated ,[object Object],[object Object],[object Object],Common clinical findings: Fever Urticaria Arthralgia Lymphadenopathy Proteinuria

I- Systemic Immune Complex Disease

Immune Complex Mediated (Type III) Damage Systemic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Immune Complex Deposition in Glomerulus Type III Hypersensitivity

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Type IV Hypersensitivity Delayed Hypersensitivity Reaction ,[object Object],[object Object],[object Object],Anti-CD4 Antibodies

Granuloma Formation Multinucleated giant cell

Immunopathology lecture 2+3 ,final

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Immunopathology lecture 2+3 ,final