This document discusses the role of IL-17A in atherosclerosis and myocardial infarction (MI). It notes that cardiovascular diseases are a leading cause of death worldwide and in countries like the US and Iran. It then reviews risk factors for MI and symptoms. Diagnosis involves ECG, cardiac enzyme tests, and echocardiography. Treatments include medications, PCI, and CABG. The document discusses how the immune system relates to atherosclerosis and MI, and how IL-17A can induce inflammation and progression of atherosclerosis by increasing cytokines and immune cell recruitment. Studies have shown increased IL-17A and related cytokines in patients with acute coronary syndrome or MI. IL-17A expression is also enhanced after ischemia-reperfusion

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2. IL-17A in Atherosclerosis / MI
Presented by: Safoora Pordel
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3.  Cardiovascular diseases are the most common cause of
death in most countries of the world. (Roger, 2012)
 Heart diseases are the first cause of death in US.
(Health United States, 2014)
 Almost 50% of deaths in Iran is due to coronary artery
disease. (Hatami, 2007)
 Cardiovascular diseases are the first cause of death Iran.
(Saadat, 2015)
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4. Age
Male sex
Blood lipids levels
Diabetes
Genes
Hypertension
 Smoking
Risk factors of MI
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5. Symptoms of MI
 chest pain
 Dyspnea (shortness of breath(
 Face seems gray
 Coughing
 Nausea
 Vomiting
 Dizziness
 Restlessness & Anxiety
 The patient is clammy and sweaty
Symptom of MI
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6. ECG (Electrocardiograph)
 Cardiac enzyme tests
Echocardiography
Diagnosis of MI
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7. Treatment
Medication
Aspirin
Thrombolytic
Anti-plateletagents
Surgical and other procedure
PCI
CABG
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8. Relation between immune system and Atherosclerosis / MI
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 IL-17A induce expression of inflammatory cytokines and chemokines and increased
recruitment of neutrophils and monocytes and the progression of atherosclerosis. (Eid RE,
2007/de Boer OJ, 2010/Taleb S,2009)
 Increased of Th-17 memory cells in Atherosclerosis patients (Behnamfar N, 2014)
 In patients with acute coronary syndrome (acute myocardial infarction and unstable
angina) was observed increased of Th-17 and its related cytokines IL-17 and -23 and IL-6
(Jafarzadeh A, 2009/ Liang J,2009)

10. MI
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11. Injury during ischemia and reperfusion
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 Ischemia-reperfusion injury in the heart caused enhancement of expression of IL-17RA
receptors and IL-17A and IL-17F & Increased signaling through activation of MAPK kinase ;
increased expression of proinflammatory downstream targets, such as the CXCL1 and IL-6.
(Barry SP; 2013/ Hamacher-Brady A;2006)
 In vivo studies in mouse models have shown that neutralizing IL-17 to reduce necrosis and
apoptosis .
 Treatment with Monoclonal Antibody Anti-IL-17A and IL-17A genetic defect improved
ischemia-reperfusion injury, reduced the size of the damaged tissue, reduced Cardiac troponin
T levels and improve heart function. (Liao Y-H, 2012)

13. IL-17A signaling pathway
TRAF3IP2
rs33980500
rs13210247
IL-17A
G197A
rs2275913
NF-κB1-94
ins/del ATTG
rs28362491

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