1. Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a pressurized chamber, which increases the amount of oxygen that dissolves in the patient's plasma and tissues. This promotes healing and reduces recovery time.
2. HBOT works by increasing oxygen tension in tissues through several physiological effects, including increased angiogenesis and fibroblast proliferation. The increased oxygen aids neutrophils in fighting infection and promotes tissue regrowth.
3. HBOT is used to treat osteoradionecrosis, refractory osteomyelitis, and compromised bone healing after radiation therapy for dental implants through its effects on increasing oxygen delivery and stimulating cell growth in hypoxic tissues.
Hyperbaric oxygen therapy involves placing a patient inside a pressurized chamber and administering 100% oxygen at pressures greater than 1 atmosphere. This allows more oxygen to dissolve in the blood plasma and tissues. The high oxygen levels help oxygenate hypoxic tissues, enhance neutrophil function, suppress bacterial growth, and increase antibiotic effectiveness. There are monoplace and multiplace chambers. Indications for HBOT include decompression sickness, diabetic wounds, radiation injuries, and skin graft enhancement. Contraindications include untreated pneumothorax and certain medications. Potential complications range from mild issues like headaches to more serious problems such as lung damage.
This document provides information about hyperbaric oxygen therapy and the Fremantle Hyperbaric Unit. It discusses the history of hyperbaric medicine and describes multiplace and monoplace hyperbaric chambers. It outlines several recognized indications for hyperbaric oxygen treatment including dysbaric injuries, problem wounds, and delayed radiation injuries. The document discusses mechanisms of action, treatment tables, complications like barotrauma and oxygen toxicity, and two case histories involving decompression illness treated with hyperbaric oxygen.
1. Hyperbaric oxygen therapy involves delivering 100% oxygen to a patient in a pressurized chamber at greater than 1 atmosphere to increase the amount of oxygen dissolved in the patient's plasma.
2. It has a variety of proposed mechanisms of action including increasing oxygen delivery to tissues, generating oxygen free radicals to aid in bacterial killing, and causing vasoconstriction.
3. It has been used to treat conditions like problematic wounds, radiation injury, decompression sickness, and sudden hearing loss. The evidence for its use is strongest for problematic wounds and enhancing graft and flap viability after surgery.
Hyperbaric oxygen therapy involves delivering 100% oxygen to patients inside a pressurized chamber above 1 atmosphere. It has various physiological effects like increasing oxygen levels in tissues and plasma. Common uses include improving outcomes for problematic wounds, compromised grafts/flaps, radiation injury, and sudden hearing loss. Potential risks include barotrauma and fire hazards. Strict protocols are followed to minimize risks while maximizing benefits for approved indications.
This document discusses a case of a 45-year-old male presenting with toe pain secondary to gout who had an IV placed with subsequent air embolism due to failure to flush the IV tubing. It prompts for the diagnosis and treatment. Air embolism would be the diagnosis, and treatment would involve placing the patient in left lateral decubitus position and administering 100% oxygen via non-rebreather mask to reduce the size of the air bubbles and support oxygenation. The document goes on to discuss various topics relating to hyperbaric oxygen therapy including its physics, physiology, indications, disadvantages, evidence for use in emergency medicine, and reimbursement issues.
Hyperbaric oxygen therapy involves breathing 100% oxygen in a pressurized chamber, which increases oxygen levels in the blood to promote healing. During treatment, patients breathe oxygen at pressures equivalent to depths of 40 feet underwater for 90 minutes. This greatly increases oxygen delivery to tissues, reducing bacteria and stimulating healing processes. It is used to treat conditions like diabetic wounds, radiation injuries, and gas embolism when standard care is not effective. Some potential side effects include ear and sinus pain but complications are rare with screening and safety protocols.
Ozone,Oxygen, Prolozone IRB - by Dean Silver MDdeansilvermd
This document discusses Dean Silver's credentials and experience in integrative medicine and cardiology. It covers topics like ozone therapy, mitochondrial function, oxygen utilization, and the NAD/NADH ratio. Ozone therapy is proposed to increase oxygen utilization and reverse the decreasing NAD/NADH ratio seen in aging and disease. This raises ATP and improves mitochondrial function, offering a potential therapy for conditions like obesity and metabolic syndrome.
Hyperbaric oxygen therapy involves placing a patient inside a pressurized chamber and administering 100% oxygen at pressures greater than 1 atmosphere. This allows more oxygen to dissolve in the blood plasma and tissues. The high oxygen levels help oxygenate hypoxic tissues, enhance neutrophil function, suppress bacterial growth, and increase antibiotic effectiveness. There are monoplace and multiplace chambers. Indications for HBOT include decompression sickness, diabetic wounds, radiation injuries, and skin graft enhancement. Contraindications include untreated pneumothorax and certain medications. Potential complications range from mild issues like headaches to more serious problems such as lung damage.
This document provides information about hyperbaric oxygen therapy and the Fremantle Hyperbaric Unit. It discusses the history of hyperbaric medicine and describes multiplace and monoplace hyperbaric chambers. It outlines several recognized indications for hyperbaric oxygen treatment including dysbaric injuries, problem wounds, and delayed radiation injuries. The document discusses mechanisms of action, treatment tables, complications like barotrauma and oxygen toxicity, and two case histories involving decompression illness treated with hyperbaric oxygen.
1. Hyperbaric oxygen therapy involves delivering 100% oxygen to a patient in a pressurized chamber at greater than 1 atmosphere to increase the amount of oxygen dissolved in the patient's plasma.
2. It has a variety of proposed mechanisms of action including increasing oxygen delivery to tissues, generating oxygen free radicals to aid in bacterial killing, and causing vasoconstriction.
3. It has been used to treat conditions like problematic wounds, radiation injury, decompression sickness, and sudden hearing loss. The evidence for its use is strongest for problematic wounds and enhancing graft and flap viability after surgery.
Hyperbaric oxygen therapy involves delivering 100% oxygen to patients inside a pressurized chamber above 1 atmosphere. It has various physiological effects like increasing oxygen levels in tissues and plasma. Common uses include improving outcomes for problematic wounds, compromised grafts/flaps, radiation injury, and sudden hearing loss. Potential risks include barotrauma and fire hazards. Strict protocols are followed to minimize risks while maximizing benefits for approved indications.
This document discusses a case of a 45-year-old male presenting with toe pain secondary to gout who had an IV placed with subsequent air embolism due to failure to flush the IV tubing. It prompts for the diagnosis and treatment. Air embolism would be the diagnosis, and treatment would involve placing the patient in left lateral decubitus position and administering 100% oxygen via non-rebreather mask to reduce the size of the air bubbles and support oxygenation. The document goes on to discuss various topics relating to hyperbaric oxygen therapy including its physics, physiology, indications, disadvantages, evidence for use in emergency medicine, and reimbursement issues.
Hyperbaric oxygen therapy involves breathing 100% oxygen in a pressurized chamber, which increases oxygen levels in the blood to promote healing. During treatment, patients breathe oxygen at pressures equivalent to depths of 40 feet underwater for 90 minutes. This greatly increases oxygen delivery to tissues, reducing bacteria and stimulating healing processes. It is used to treat conditions like diabetic wounds, radiation injuries, and gas embolism when standard care is not effective. Some potential side effects include ear and sinus pain but complications are rare with screening and safety protocols.
Ozone,Oxygen, Prolozone IRB - by Dean Silver MDdeansilvermd
This document discusses Dean Silver's credentials and experience in integrative medicine and cardiology. It covers topics like ozone therapy, mitochondrial function, oxygen utilization, and the NAD/NADH ratio. Ozone therapy is proposed to increase oxygen utilization and reverse the decreasing NAD/NADH ratio seen in aging and disease. This raises ATP and improves mitochondrial function, offering a potential therapy for conditions like obesity and metabolic syndrome.
This document discusses the use of oxygen/ozone therapy in dentistry. It provides information on the fundamental scientific facts about oxygen/ozone, including its disinfection properties, ability to improve wound healing, activation of red blood cell metabolism and antioxidant systems, anti-inflammatory effects, and ability to increase circulation. The document outlines how ozone is created and its uses in treating dental issues like infections, periodontal disease, root canal therapy, and enhanced wound healing. Ozone therapy is presented as a safe, non-toxic alternative to antibiotics for treating dental problems and infections.
origin, history, mechanism of action, its uses in medicine and dentistry especially in periodontics, its half life and its disinfection action on covid-19
Innovative Case Studies with Ozone Therapy for Treatment of Anosmia, Degenera...Megan Hughes
Ozone therapy can be used to treat various conditions in innovative ways. For anosmia, inhaling glycozone (ozonated olive oil) can help reduce inflammation in the nasal passages and sinuses. Intradiscal injections of ozone combined with nutrients may help degenerative disc disease more than ozone alone. Applying ozonated olive oil to the skin can inhibit bacteria responsible for body odor by slowing lipid breakdown and having antimicrobial effects.
This document discusses the use of ozone in dentistry. It provides a brief history of ozone therapy in dentistry dating back to 1932. It describes the chemistry of ozone and how it works biologically as an antimicrobial and anti-inflammatory agent. Various ozone generating devices for dental use are presented. The goals, indications, contraindications, pros and cons of ozone therapy are outlined. The document concludes that ozone therapy with devices like HealOzone can successfully treat dental issues like caries and root canals in a gentle, painless manner.
Ozone therapy can be an effective supportive treatment for cancer in several ways:
1) It improves oxygenation at the cellular level by increasing red blood cell metabolism and circulation, allowing cancer cells to transition from a hypoxic to normoxic state.
2) It stimulates the immune system and anti-oxidant enzyme production, reducing oxidative stress on cells and enabling the body to better fight cancer.
3) By inducing controlled oxidative stress, ozone therapy can cause apoptosis in cancer cells and act as an autovaccine against tumors.
4) Additional benefits include controlling infections, improving metabolism and quality of life, and reducing side effects from other cancer therapies. Clinical cases demonstrated reductions in tumor size and markers from
Ozone short ppt for Washington Dental Quality Assurance Commission (DQAC) mtg...Jessica Saepoff DDS
Ozone has been used medicinally since the 1840s. While research on risks and benefits is limited, ozone appears to be safely used at low concentrations for dental applications like disinfecting and treating periodontal disease. However, concerns include a lack of standardization in dentist training and some programs expanding dental scopes of practice. Overall, properly used ozone seems to pose little risk, but expanded scopes of practice could theoretically endanger patients.
This document discusses ozone therapy and its uses. It begins by defining ozone and describing how it is created. It then outlines several methods of ozone therapy administration, including major ozone autohemotherapy where blood is ozonated ex vivo and reinfused. Potential applications of ozone therapy are provided, such as for infectious diseases, cardiac issues, and diabetes. Lastly, specific uses for dental caries, AIDS/cancer treatment, and agriculture are mentioned.
Ototoxicity refers to damage to the auditory or vestibular system caused by drugs or chemicals. Many known ototoxins cause cellular damage through generation of reactive oxygen species rather than direct action. The inner ear has limited regenerative ability, so ototoxic injury often leads to permanent hearing or balance problems. Exposure to industrial solvents and heavy metals can also cause ototoxicity. Noise exposure may increase the risk of ototoxicity by lowering the levels of chemicals needed to cause harm. Various antioxidants have shown potential to protect against ototoxicity in animal studies.
Hyperbaric oxygen therapy involves delivering 100% oxygen to patients at increased atmospheric pressures, typically between 2.5 to 3 atmospheres. This increased pressure allows more oxygen to be dissolved in the patient's plasma, increasing oxygen content from 0.3 mL/dL at sea level to 1.5 mL/dL or even 6 mL/dL at higher pressures. The higher pressure also causes gas bubbles like nitrogen to reduce in size. Additionally, the replacement of nitrogen in bubbles with oxygen promotes tissue healing. Some benefits of hyperbaric oxygen therapy include improved wound healing through increased oxygen delivery and free radicals, reduced half-life of carbon monoxide, and antibacterial effects. Potential risks include ear and sinus barotrauma as well
Ozone therapy is a non-invasive dental treatment that uses ozone gas to treat various dental issues. It works by using ozone's anti-microbial and anti-inflammatory properties to eliminate infections and promote healing. Common applications in dentistry include treating cavities, bleaching teeth, root canals, and extracting teeth. While it has many benefits, ozone can be toxic if too much is inhaled. However, with proper administration by a dental professional, ozone therapy provides an effective alternative to traditional dental treatments.
portable hyperbaric
chamber, are used for
altitude sickness and
decompression illness
in remote areas.
This document discusses the history, basics, indications, contraindications, complications, and applications of hyperbaric oxygen therapy (HBOT). It begins with definitions and the initial discovery of HBOT in the 1600s. It then covers the physics and physiology behind how increased pressure and oxygen concentration improves oxygen delivery to tissues. Common indications for HBOT include carbon monoxide poisoning, decompression sickness, gas embolism, and infections like clostridial myonecrosis. Complications can include barotrauma, seizures from oxygen toxicity, and fire hazards. Applications of HBOT include wound
Use of Hyperbaric Oxygen Therapy in Management of Orthopedic DisordersApollo Hospitals
The management of musculoskeletal disorders is an increasing challenge to clinicians. Successful treatment relies on a wide range of multidisciplinary interventions. Adjunctive hyperbaric oxygen (HBO) therapy has been used as an orthopedic treatment for several decades. Positive outcomes have been reported by many authors for orthopedic infections, wound healing, delayed union and non-union of fractures, acute traumatic ischemia of the extremities, compromised grafts, and burn injuries. HBO therapy significantly reduces the length of the patient’s hospital stay, amputation rate, and wound care expenses.
Hyperbaric oxygen therapy involves patients breathing 100% oxygen in a pressurized chamber at higher than normal atmospheric pressure. This results in increased oxygen levels in tissues and blood. The therapy has several beneficial effects including anti-ischemic, anti-infective, and wound healing properties. It is used to treat conditions like carbon monoxide poisoning, decompression sickness, osteomyelitis, osteoradionecrosis, and compromised grafts or flaps where normal healing is impaired. Treatment involves repeated sessions in monoplace or multiplace hyperbaric chambers at specific pressures and durations depending on the condition.
Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a pressurized chamber at greater than atmospheric pressure. HBOT works by increasing the amount of oxygen that dissolves in the blood plasma, which allows more oxygen to reach tissues. The increased oxygen levels stimulate various cellular functions that promote healing. HBOT has been used to treat conditions like non-healing wounds, radiation injuries, burns, carbon monoxide poisoning, and decompression sickness. While research shows HBOT may help with some conditions, further high-quality studies are still needed to establish its effectiveness for other proposed uses.
HBOT involves breathing 100% oxygen intermittently in a pressurized chamber above sea level pressure. This hyperoxygenation has several benefits including increasing plasma oxygen levels, reducing edema, promoting angiogenesis and collagen synthesis, and killing anaerobic bacteria. Some conditions treated with HBOT include crush injuries, radiation necrosis, chronic wounds, decompression sickness, and gas embolism. While generally safe, common side effects can include ear and sinus pain which are usually preventable.
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above 1 atmosphere. It increases the amount of oxygen dissolved in the blood plasma, which can help treat conditions like carbon monoxide poisoning, gas gangrene, non-healing wounds, and radiation injuries. HBOT works by promoting collagen formation, angiogenesis, antibiotic synergy, and inhibiting toxins and bacteria. It is used in dentistry to treat osteoradionecrosis, osteomyelitis of the jaws, aggressive periodontitis, and for dental implants in irradiated jaws by increasing oxygen levels and promoting healing. Potential side effects include oxygen toxicity, changes in vision, barotrauma, and pulmonary changes
Hyperbaric oxygen therapy (HBOT) has been used successfully in several oral surgery cases at the Naval Central Hospital in Surabaya, Indonesia. HBOT involves breathing 100% oxygen at pressures over 1 atmosphere and has benefits such as increased tissue oxygen levels and accelerated wound healing. Cases that have been treated include severe trauma, jaw osteomyelitis, replanted avulsed teeth, pre-operative prophylaxis, fungal infections, and paresthesia. HBOT has been shown to promote wound repair, stimulate collagen synthesis, reduce swelling and infection risk, and re-establish blood flow and nerve function. It is an effective adjunct treatment in dentistry that shows promise for other applications.
Hyperbaric oxygen therapy a boon for complex post traumatic woundsKETAN VAGHOLKAR
Post-traumatic wounds especially after run over accidents are difficult to manage. The vascularity and regenerative potential of the tissues is severely compromised. Surgical intervention is of limited value. A conservative approach with concomitant hyperbaric oxygen therapy (HBOT) serves as a great salvage in such cases. A case of post-traumatic forefoot gangrene in a 27-year-old laborer is presented to highlight and create an awareness of the potential benefit of HBOT in salvage of distal parts of the lower extremity where the blood supply is severely compromised.
Use of hyperbaric oxygen therapy in management of radiation cystitisApollo Hospitals
Radiation induced tissue injury is a result of progressive endarteritis which leads to hypovascular, hypocellular and
hypoxic tissues. This damage begins as soon as patient is exposed to radiation beam. Most patients experience
some acute side effects and it is rare and serious event when late side effects develop. Radiation cystitis is a late
complication of radiotherapy for pelvic malignancies like prostate and cervix. Although 85% of the cases resolve with conservative management, the remainder become refractory and progress to involve a more extensive area of bony and soft tissue. Hyperbaric oxygen therapy (HBOT) is used to treat various forms of chronic radiation tissue injury and is a potential primary option for management of radiation cystitis by enhancing healing in such cases by increasing vascular density and oxygen levels in irradiated tissues. We report a case of 60-year-old male with radiation cystitis who showed promising improvement and resolution of his symptoms after forty HBOT sessions.
The document discusses various topics related to radiotherapy including oxygenation and reoxygenation effects, time-dose-fractionation relationships, and altered fractionation schemes. Specifically, it covers how oxygen enhances the effects of radiation, the mechanisms of reoxygenation in tumors, factors influencing early and late responding tissues under different fractionation regimens, and approaches like hyperfractionation and accelerated treatment that aim to better separate tumor and normal tissue responses. Large clinical trials on hyperfractionation and accelerated regimens for head and neck cancers are also summarized.
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above normal atmospheric pressure. This increases the amount of oxygen dissolved in the blood and tissues up to 15 times normal levels. The high oxygen levels and pressure have physiological effects that can help treat conditions like carbon monoxide poisoning, gas embolism, and non-healing wounds by promoting angiogenesis and fighting infection. HBOT is administered in multi-place or monoplace chambers and can cause potential side effects from higher pressure and oxygen levels if not done properly.
The document summarizes the oxygen effect and reoxygenation in radiation therapy. It discusses the mechanism of oxygen enhancement, how oxygen acts at the level of free radicals to fix radiation damage. It describes chronic and acute hypoxia in tumors and the process of reoxygenation that can occur between fractions of radiation therapy. Reoxygenation allows previously hypoxic cells to become oxygenated again and be more susceptible to radiation damage.
This document discusses the use of oxygen/ozone therapy in dentistry. It provides information on the fundamental scientific facts about oxygen/ozone, including its disinfection properties, ability to improve wound healing, activation of red blood cell metabolism and antioxidant systems, anti-inflammatory effects, and ability to increase circulation. The document outlines how ozone is created and its uses in treating dental issues like infections, periodontal disease, root canal therapy, and enhanced wound healing. Ozone therapy is presented as a safe, non-toxic alternative to antibiotics for treating dental problems and infections.
origin, history, mechanism of action, its uses in medicine and dentistry especially in periodontics, its half life and its disinfection action on covid-19
Innovative Case Studies with Ozone Therapy for Treatment of Anosmia, Degenera...Megan Hughes
Ozone therapy can be used to treat various conditions in innovative ways. For anosmia, inhaling glycozone (ozonated olive oil) can help reduce inflammation in the nasal passages and sinuses. Intradiscal injections of ozone combined with nutrients may help degenerative disc disease more than ozone alone. Applying ozonated olive oil to the skin can inhibit bacteria responsible for body odor by slowing lipid breakdown and having antimicrobial effects.
This document discusses the use of ozone in dentistry. It provides a brief history of ozone therapy in dentistry dating back to 1932. It describes the chemistry of ozone and how it works biologically as an antimicrobial and anti-inflammatory agent. Various ozone generating devices for dental use are presented. The goals, indications, contraindications, pros and cons of ozone therapy are outlined. The document concludes that ozone therapy with devices like HealOzone can successfully treat dental issues like caries and root canals in a gentle, painless manner.
Ozone therapy can be an effective supportive treatment for cancer in several ways:
1) It improves oxygenation at the cellular level by increasing red blood cell metabolism and circulation, allowing cancer cells to transition from a hypoxic to normoxic state.
2) It stimulates the immune system and anti-oxidant enzyme production, reducing oxidative stress on cells and enabling the body to better fight cancer.
3) By inducing controlled oxidative stress, ozone therapy can cause apoptosis in cancer cells and act as an autovaccine against tumors.
4) Additional benefits include controlling infections, improving metabolism and quality of life, and reducing side effects from other cancer therapies. Clinical cases demonstrated reductions in tumor size and markers from
Ozone short ppt for Washington Dental Quality Assurance Commission (DQAC) mtg...Jessica Saepoff DDS
Ozone has been used medicinally since the 1840s. While research on risks and benefits is limited, ozone appears to be safely used at low concentrations for dental applications like disinfecting and treating periodontal disease. However, concerns include a lack of standardization in dentist training and some programs expanding dental scopes of practice. Overall, properly used ozone seems to pose little risk, but expanded scopes of practice could theoretically endanger patients.
This document discusses ozone therapy and its uses. It begins by defining ozone and describing how it is created. It then outlines several methods of ozone therapy administration, including major ozone autohemotherapy where blood is ozonated ex vivo and reinfused. Potential applications of ozone therapy are provided, such as for infectious diseases, cardiac issues, and diabetes. Lastly, specific uses for dental caries, AIDS/cancer treatment, and agriculture are mentioned.
Ototoxicity refers to damage to the auditory or vestibular system caused by drugs or chemicals. Many known ototoxins cause cellular damage through generation of reactive oxygen species rather than direct action. The inner ear has limited regenerative ability, so ototoxic injury often leads to permanent hearing or balance problems. Exposure to industrial solvents and heavy metals can also cause ototoxicity. Noise exposure may increase the risk of ototoxicity by lowering the levels of chemicals needed to cause harm. Various antioxidants have shown potential to protect against ototoxicity in animal studies.
Hyperbaric oxygen therapy involves delivering 100% oxygen to patients at increased atmospheric pressures, typically between 2.5 to 3 atmospheres. This increased pressure allows more oxygen to be dissolved in the patient's plasma, increasing oxygen content from 0.3 mL/dL at sea level to 1.5 mL/dL or even 6 mL/dL at higher pressures. The higher pressure also causes gas bubbles like nitrogen to reduce in size. Additionally, the replacement of nitrogen in bubbles with oxygen promotes tissue healing. Some benefits of hyperbaric oxygen therapy include improved wound healing through increased oxygen delivery and free radicals, reduced half-life of carbon monoxide, and antibacterial effects. Potential risks include ear and sinus barotrauma as well
Ozone therapy is a non-invasive dental treatment that uses ozone gas to treat various dental issues. It works by using ozone's anti-microbial and anti-inflammatory properties to eliminate infections and promote healing. Common applications in dentistry include treating cavities, bleaching teeth, root canals, and extracting teeth. While it has many benefits, ozone can be toxic if too much is inhaled. However, with proper administration by a dental professional, ozone therapy provides an effective alternative to traditional dental treatments.
portable hyperbaric
chamber, are used for
altitude sickness and
decompression illness
in remote areas.
This document discusses the history, basics, indications, contraindications, complications, and applications of hyperbaric oxygen therapy (HBOT). It begins with definitions and the initial discovery of HBOT in the 1600s. It then covers the physics and physiology behind how increased pressure and oxygen concentration improves oxygen delivery to tissues. Common indications for HBOT include carbon monoxide poisoning, decompression sickness, gas embolism, and infections like clostridial myonecrosis. Complications can include barotrauma, seizures from oxygen toxicity, and fire hazards. Applications of HBOT include wound
Use of Hyperbaric Oxygen Therapy in Management of Orthopedic DisordersApollo Hospitals
The management of musculoskeletal disorders is an increasing challenge to clinicians. Successful treatment relies on a wide range of multidisciplinary interventions. Adjunctive hyperbaric oxygen (HBO) therapy has been used as an orthopedic treatment for several decades. Positive outcomes have been reported by many authors for orthopedic infections, wound healing, delayed union and non-union of fractures, acute traumatic ischemia of the extremities, compromised grafts, and burn injuries. HBO therapy significantly reduces the length of the patient’s hospital stay, amputation rate, and wound care expenses.
Hyperbaric oxygen therapy involves patients breathing 100% oxygen in a pressurized chamber at higher than normal atmospheric pressure. This results in increased oxygen levels in tissues and blood. The therapy has several beneficial effects including anti-ischemic, anti-infective, and wound healing properties. It is used to treat conditions like carbon monoxide poisoning, decompression sickness, osteomyelitis, osteoradionecrosis, and compromised grafts or flaps where normal healing is impaired. Treatment involves repeated sessions in monoplace or multiplace hyperbaric chambers at specific pressures and durations depending on the condition.
Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a pressurized chamber at greater than atmospheric pressure. HBOT works by increasing the amount of oxygen that dissolves in the blood plasma, which allows more oxygen to reach tissues. The increased oxygen levels stimulate various cellular functions that promote healing. HBOT has been used to treat conditions like non-healing wounds, radiation injuries, burns, carbon monoxide poisoning, and decompression sickness. While research shows HBOT may help with some conditions, further high-quality studies are still needed to establish its effectiveness for other proposed uses.
HBOT involves breathing 100% oxygen intermittently in a pressurized chamber above sea level pressure. This hyperoxygenation has several benefits including increasing plasma oxygen levels, reducing edema, promoting angiogenesis and collagen synthesis, and killing anaerobic bacteria. Some conditions treated with HBOT include crush injuries, radiation necrosis, chronic wounds, decompression sickness, and gas embolism. While generally safe, common side effects can include ear and sinus pain which are usually preventable.
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above 1 atmosphere. It increases the amount of oxygen dissolved in the blood plasma, which can help treat conditions like carbon monoxide poisoning, gas gangrene, non-healing wounds, and radiation injuries. HBOT works by promoting collagen formation, angiogenesis, antibiotic synergy, and inhibiting toxins and bacteria. It is used in dentistry to treat osteoradionecrosis, osteomyelitis of the jaws, aggressive periodontitis, and for dental implants in irradiated jaws by increasing oxygen levels and promoting healing. Potential side effects include oxygen toxicity, changes in vision, barotrauma, and pulmonary changes
Hyperbaric oxygen therapy (HBOT) has been used successfully in several oral surgery cases at the Naval Central Hospital in Surabaya, Indonesia. HBOT involves breathing 100% oxygen at pressures over 1 atmosphere and has benefits such as increased tissue oxygen levels and accelerated wound healing. Cases that have been treated include severe trauma, jaw osteomyelitis, replanted avulsed teeth, pre-operative prophylaxis, fungal infections, and paresthesia. HBOT has been shown to promote wound repair, stimulate collagen synthesis, reduce swelling and infection risk, and re-establish blood flow and nerve function. It is an effective adjunct treatment in dentistry that shows promise for other applications.
Hyperbaric oxygen therapy a boon for complex post traumatic woundsKETAN VAGHOLKAR
Post-traumatic wounds especially after run over accidents are difficult to manage. The vascularity and regenerative potential of the tissues is severely compromised. Surgical intervention is of limited value. A conservative approach with concomitant hyperbaric oxygen therapy (HBOT) serves as a great salvage in such cases. A case of post-traumatic forefoot gangrene in a 27-year-old laborer is presented to highlight and create an awareness of the potential benefit of HBOT in salvage of distal parts of the lower extremity where the blood supply is severely compromised.
Use of hyperbaric oxygen therapy in management of radiation cystitisApollo Hospitals
Radiation induced tissue injury is a result of progressive endarteritis which leads to hypovascular, hypocellular and
hypoxic tissues. This damage begins as soon as patient is exposed to radiation beam. Most patients experience
some acute side effects and it is rare and serious event when late side effects develop. Radiation cystitis is a late
complication of radiotherapy for pelvic malignancies like prostate and cervix. Although 85% of the cases resolve with conservative management, the remainder become refractory and progress to involve a more extensive area of bony and soft tissue. Hyperbaric oxygen therapy (HBOT) is used to treat various forms of chronic radiation tissue injury and is a potential primary option for management of radiation cystitis by enhancing healing in such cases by increasing vascular density and oxygen levels in irradiated tissues. We report a case of 60-year-old male with radiation cystitis who showed promising improvement and resolution of his symptoms after forty HBOT sessions.
The document discusses various topics related to radiotherapy including oxygenation and reoxygenation effects, time-dose-fractionation relationships, and altered fractionation schemes. Specifically, it covers how oxygen enhances the effects of radiation, the mechanisms of reoxygenation in tumors, factors influencing early and late responding tissues under different fractionation regimens, and approaches like hyperfractionation and accelerated treatment that aim to better separate tumor and normal tissue responses. Large clinical trials on hyperfractionation and accelerated regimens for head and neck cancers are also summarized.
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above normal atmospheric pressure. This increases the amount of oxygen dissolved in the blood and tissues up to 15 times normal levels. The high oxygen levels and pressure have physiological effects that can help treat conditions like carbon monoxide poisoning, gas embolism, and non-healing wounds by promoting angiogenesis and fighting infection. HBOT is administered in multi-place or monoplace chambers and can cause potential side effects from higher pressure and oxygen levels if not done properly.
The document summarizes the oxygen effect and reoxygenation in radiation therapy. It discusses the mechanism of oxygen enhancement, how oxygen acts at the level of free radicals to fix radiation damage. It describes chronic and acute hypoxia in tumors and the process of reoxygenation that can occur between fractions of radiation therapy. Reoxygenation allows previously hypoxic cells to become oxygenated again and be more susceptible to radiation damage.
This document summarizes a review on the effects of hyperbaric oxygen therapy (HBO) on sports injuries. HBO involves breathing 100% oxygen inside a pressurized chamber at pressures above 1 atmosphere absolute. While previous studies found HBO promising for treating sports injuries, the sample sizes were small and studies lacked randomization and blinding. The review aims to analyze HBO's contribution to rehabilitation from different sports injuries. However, larger randomized controlled trials are still needed to confirm whether HBO is a safe and effective treatment for sports injuries.
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above 1 atmosphere. HBOT increases the amount of oxygen dissolved in the blood plasma, allowing greater oxygen delivery to tissues. It has been used since the 17th century to treat various conditions and was established as a treatment for decompression sickness in the 1930s. HBOT works by increasing oxygen to tissues through hyperoxygenation and decreasing bubble size through increased pressure. It has multiple mechanisms of action including vasoconstriction, angiogenesis, and collagen formation.
This study investigated using high-intensity focused ultrasound (HIFU) to destroy Pseudomonas aeruginosa biofilms grown on implant surfaces in order to provide a noninvasive treatment alternative to surgery. The study exposed P. aeruginosa biofilms grown on graphite disks to ultrasound pulses varying exposure time (5, 15, 30 seconds), pulse period (1, 3, 6, 12 milliseconds), and peak pressures (30 and 13 MPa). It identified thresholds for increased bacterial destruction and complete removal. Results showed 30-second exposure and 6-millisecond pulse period were sufficient to destroy biofilms, but 15-second exposure and 3-millisecond pulse period were optimal considering exposure time, efficacy, and safety as they minimized temperature rise at
Dental extractions in irradiated patientsUjwal Gautam
Dental extractions in patients undergoing radiotherapy carry risks of osteoradionecrosis and impaired wound healing due to radiation damage to vasculature, bone marrow, and fibroblasts. Extraction after radiotherapy requires preventive measures like antibiotics and atraumatic technique. Hyperbaric oxygen therapy has been used preventively for extractions, though its effectiveness is less than 100%. Where possible, extractions in irradiated patients should be avoided or meticulous preventive measures undertaken due to osteoradionecrosis risk.
Hyperbaric oxygen therapy (HBOT) can help heal diabetic wounds by increasing oxygen levels in tissues. HBOT promotes wound healing through enhanced tissue oxygenation, decreased edema, improved bacterial killing, increased cellular energy production, potentiated antibiotics, and stimulated angiogenesis and collagen production. Studies have found that HBOT leads to higher wound healing rates and fewer amputations compared to standard care alone. HBOT is generally well-tolerated but risks include barotrauma and oxygen toxicity. It is most effective for wounds with low oxygen levels as measured by transcutaneous oximetry. HBOT reduces healthcare costs by helping wounds heal and avoiding more invasive treatments like amputation.
This document discusses the current role of hyperbaric oxygen therapy (HBOT). It begins by explaining the mechanisms of HBOT, including how it increases oxygen delivery to tissues and reduces gas bubble size. It then describes the techniques used, including chamber pressures and treatment durations. The document outlines the contraindications and complications of HBOT. It concludes by describing the clinical uses of HBOT for conditions like carbon monoxide poisoning, decompression sickness, traumatic injuries, radiation injury, infections, and non-healing wounds.
Studies have shown that hyperbaric oxygen therapy (HBOT) can increase bone mineral density (BMD) and enhance healing during distraction osteogenesis. Three studies on rabbits found that applying HBOT during the consolidation phase of limb lengthening significantly increased BMD compared to controls. A fourth study also found higher BMD in rabbits that received HBOT during distraction at different rates of 1-2 mm/day. HBOT may allow for more rapid bone distraction by promoting angiogenesis and new bone formation.
Hyperbaric Oxygen Therapy for Neurological Conditions Ade Wijaya
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen inside a pressurized chamber above sea level pressure. It has been used to treat various neurological conditions such as stroke and traumatic brain injury by reducing mitochondrial membrane permeability and reversing ischemia. However, the Undersea and Hyperbaric Medical Society currently only lists air/gas embolism and intracranial abscess as evidence-based indications, while research continues into other potential applications.
This document provides an overview of osteomyelitis, including its classification, pathogenesis, diagnosis, and treatment approaches. It begins with definitions and classifications, noting osteomyelitis can be acute or chronic and spread hematogenously, by direct contact, or with vascular insufficiency. Mechanisms of bone destruction and challenges of treating avascular areas are described. Imaging modalities and their roles in diagnosis are reviewed. Treatment involves surgical debridement, antibiotics, and addressing complications. Adjunctive therapies like hyperbaric oxygen and growth factors are also discussed.
Microesthetics in orthodontics refers to the small details considered during and after treatment to enhance a patient's smile. This includes tooth proportions, relationships between width and height, and connector areas between teeth. It also involves shaping gingival contours and maintaining proportional gingival heights. The overall goal of focusing on microesthetics is to achieve an attractive, balanced smile with harmonious dental and gingival components through precise finishing in orthodontic treatment.
The document discusses the process of creating wax patterns for dental restorations using the lost wax technique. Key steps include wax modeling to recreate the original tooth shape, ditching to define the finishing line, constructing the wax pattern with requirements like smoothness and accuracy, adding a sprue for alloy flow, investing in a refractory material, and finally casting with molten metal to produce the final restoration. The document also covers types of wax, sprue design, investing materials, and references for further information.
Co Cr RBD / the path of insertion, block out and relief Ali Khalaf
Cobalt-chromium alloys have become popular materials for removable and fixed dental prosthetics since the 1980s due to their strength, corrosion resistance, and lower cost compared to noble metals. Co-Cr alloys have excellent biocompatibility and provide strength and rigidity while reducing the weight of dental restorations. When fabricating Co-Cr removable partial dentures, it is important to establish a path of insertion that avoids interference and maximizes esthetics and retention. The path is determined by factors like the location of connectors and retentive/guiding surfaces, and the master cast is blocked out accordingly to define the path and prevent interference during seating.
1. A dry socket is a postoperative complication following tooth extraction where the blood clot in the extraction socket becomes partially or fully disintegrated, causing severe pain.
2. Several risk factors can increase the chances of developing a dry socket, including smoking, traumatic extractions, poor oral hygiene, and a history of previous dry sockets.
3. Newer treatments for dry sockets include using concentrated growth factor (CGF) or platelet-rich plasma (PRP), which contain growth factors that promote healing by stimulating cell proliferation, migration, and angiogenesis.
This document discusses dental plaque biofilm and various toothbrushing methods and techniques. It begins by explaining how plaque biofilm leads to dental caries and periodontal diseases if not removed, and discusses the history of toothbrushes from ancient chewing sticks to modern designs. It then describes different manual toothbrushing techniques like the Bass method and Rolling method. Further sections cover powered toothbrushes and recommended toothbrushing time and frequency.
Indirect pulp capping involves removing gross caries while leaving a thin layer over the pulp to avoid exposure. It allows the remaining caries to arrest over 6-8 weeks under a restoration. Direct pulp capping is for small exposures, usually accidental, surrounded by sound dentin. Calcium hydroxide or MTA is placed directly on the exposure. Pulpotomy removes the coronal pulp for carious or mechanical exposures, with various medicaments like formocresol or MTA placed on the remaining pulp stumps. Success requires careful case selection and technique. Indirect capping and MTA pulpotomy show promise but need more long-term research for primary teeth.
Maxillofacial prosthetics are artificial replacements for missing facial structures. There are several types including intraoral and extraoral prosthetics. Impressions must accurately capture defects and undercuts to produce a working cast for fabricating prosthetics. Prosthetics may be removable, fixed, tissue-supported, tooth-supported, or implant-supported depending on the site. Materials selection considers properties like flexibility, color matching, biocompatibility and durability.
The document summarizes complications that can occur with dental implants made of titanium or zirconium. Titanium abutments show less screw loosening than zirconium abutments. Screw loosening is one of the most common mechanical complications and can lead to bacterial infection. Implant fracture is rare but can be caused by defects, overload from bruxism or large forces, or small implant diameter. Peri-implantitis is inflammatory disease around implants that develops over 5 years due to bacterial imbalance. Prevention focuses on proper planning, reducing parafunctional habits, and minimizing cantilevers and occlusal forces.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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2. 1
Introduction
Hyperbaric oxygen therapy (HBOT) facilitates the transfer of oxygen to the
tissues of the human body. By doing so, it promotes healing of wounds and
minimizes the typical recovery time for patients. (1)
At this juncture, strictly within
dental medicine, HBOT indicates the distribution of comprehensive oxygen at
pressures greater than 1.4 atmosphere absolute (ATA), often in a series of
treatments. (2)
This treatment requires the patient to stand within a hyperbaric
chamber with pressure greater than ambient. It has many uses such as patient care,
and wound care within standard medicine and dental medicine. (3)
HBOT exploits numerous physiological principles of how gases and oxygen react
under specific adjustments of pressure. There is a direct relationship between the
concentration of oxygen in solution and the diffusion gradient. The increase in
concentration of oxygen in solution results in the increase of the diffusion
gradient for the delivery into deeper tissue, thus being the basis for HBOT. In
HBOT, the oxygen level is amplified, which highly increases the oxygen tension
in the tissues. When the treatment is concluded, the oxygen tension decreases
allowing for an inundation of neutrophils. Neutrophils are a type of white blood
cells which specifically aid in fighting off infection and tissue regrowth.
Conclusively, the increase in dissolved oxygen generated by HBOT has potential
to alter tissue responses to disease and injury. (4)
Mechanism of action
The effects caused by hyperbaric oxygen on the body can be divided into primary
or direct effects like increased oxygen tension and diffusion in the tissue;
secondary or immediate effects like vasoconstriction, angiogenesis, fibroblast
proliferation and increased leukocyte oxidative killing. (5)
These effects are based
on the gas laws, physiological and biochemical effects of hyper oxygenation.
Henry’s Law states that the amount of gas which is dissolved in a liquid or tissue
is proportional to the partial pressure of that gas which is in contact with liquid
3. 2
or tissue. (6)
In hyperbaric oxygen therapy, the increased amounts of oxygen
which is supplied, increases the oxygen tension in the tissues, thus explaining the
effects of hyperoxia in hypoxic tissues.
When the oxygen tension decreases, there is influx of neutrophils. The activated
neutrophils consume enormous amount of oxygen, leading to further decrease in
oxygen levels in the hypoxic tissues. Very low levels of oxygen can cause tissue
injuries. Hyperbaric oxygen therapy reverses the hypoxic tissue injuries by
increasing the oxygen concentration, thereby helping the neutrophils by
supplying oxygen and accelerating the healing process. (7,8)
Hyper oxygenation
causes vasoconstriction in the normal tissues.
Equipment
HBO therapy is administered in a hyperbaric chamber. (9)
They are of two types:
Monoplace chambers: It is transparent, made up of acrylic, can accommodate a
single patient and the patient does not require a mask. Primary advantage: Cost
and space requirements. Fig.1
Multiplace chambers: Usually of steel (some may be made up of aluminum),
can accommodate more than two people and is pressurized with air, while the
patients breathe O2 from a tight fitting mask/circuit. Advantage: Is suitable for
critically ill patients requiring ventilation, monitoring and constant attendance.
Pressure and duration: It depends upon the indication. It ranges from 2 to 6 ATA
for 2-6 h. Decompression sickness/gas embolism may require prolonged,
continuous saturation protocols. Emergency indications for HBO therapy
generally require only 2-3 separate chamber treatments. Fig.2
Fig.2 Multiplace chambersFig.1 Monoplace chambers
4. 3
Practical aspects of care in a chamber
● Fire safety: Maintaining electrical components outside the chamber. Passing
cables through insulated pass throughs.
● Electrical defibrillation: In a hyperbaric chamber defibrillation is controversial,
because of the possibility of poor skin contact, arcing and risk of fire. Large metal
environment may predispose attendants to shock. Chambers needs to be
decompressed prior to use of a defibrillator. (10)
Cellular and biochemical benefits of hyperbaric oxygen
• Promotes angiogenesis and wound healing
• Kills certain anaerobes
• Prevents growth of species such as Pseudomonas
• Prevents production of clostridial alpha-toxin
• Restores neutrophil mediated bacterial killing in previously hypoxic tissues
• Reduces leucocyte adhesion in reperfusion injury preventing the release of
proteases and free radicals which cause vasoconstriction and cellular damage. (10)
1. Osteoradionecrosis
Osteoradionecrosis of the mandible is a significant complication of radiation
therapy for head and neck cancer. In this condition, bone within radiation field
becomes devitalized and exposed through overlying skin or mucosa, persisting as
a nonhealing wound for 3 months or more. In 1983, Marx proposed the first
staging system for ORN that also served as a treatment protocol. This protocol
advocated that patients whose disease progressed following conservative therapy
(HBO, local wound care, and debridement) were advanced to a radical resection
with a staged reconstruction utilizing a nonvascularized bone graft. The purpose
of HBO is to increase the blood-tissue oxygen gradient, which enhances the
diffusion of oxygen into hypoxic tissues. The increased oxygen supply stimulates
Hyperbaric oxygen therapy in dentistry is used in:
5. 4
fibroblast proliferation, angiogenesis, and collagen formation. In addition,
Increased oxygen tension is bactericidal and bacteriostatic. The use of HBO in
early and intermediate ORN remains important because the benefit seems clear
based on numerous retrospective studies. The morbidity of HBO is minimal
including transient myopia, middle ear barotrauma and seizures. Absolute
contraindications for HBO include optic neuritis, history of chronic obstructive
pulmonary disease or congenital pulmonary blebs. (11)
2. Periodontal disease
The effect of hyperbaric oxygen on aggressive periodontitis and subgingival
anaerobes in Chinese patients, documented the effect of hyperbaric oxygen
therapy. This assessment was done by measuring plaque index, gingival index,
probing depth and attachment loss, two years after hyperbaric oxygen therapy
was indicated. It was concluded in this study, that HBO could inhibit the growth
of subgingival obligate anaerobes, facultative anaerobes and Bacteroides
melaninogenicus, thus promoting healing of peridontium, which could help in the
treatment of aggressive periodontitis. (12)
The use of hyperbaric oxygen as a adjunct to scaling and root planning in patients
with generalized chronic periodontitis, is found to improve the clinical parameters
like probing depth and attachment level, thus indicating the beneficial effects of
hyperbaric oxygen on the periodontium. (13)
In a study, hyperbaric oxygen was found to stimulate the proliferation of
osteoblastic cells in vitro, in presence of 10% foetal calf serum (FCS) and an
inhibitory effect was observed in presence of 2% (FCS). (14)
3. Refractory Osteomyelitis
The jaw bone osteomyelitis represents about one third of all diagnosed cases of
osteomyelitis. This is due to the presence of the teeth which are often the source
of infection. The main complication in osteomyelitis is the presence of a barrier
between the host and the infection. This barrier can be suppuration, necrotic bone,
6. 5
but it can limit the action of the host’s immune system. In refractory
osteomyelitis, antibiotics which are used to destroy the microorganisms in the
soft tissues around the sites of infections and surgery are used for the macroscopic
removal of necrotic bone. But hyperbaric oxygen therapy aims at the improval of
the host response and at making the environment more favourable for the action
of the inflammatory cells. In a study which was done on the treatment of chronic
refractory osteomyelitis, 11 out of 14 patients were successively treated with
hyperbaric oxygen therapy without any complications. (15)
4. Implants in irradiated bone
Dental implants offer an alternative for tooth replacement. Dental implants are
directly inserted into the bone which replaces the missing teeth. The adjacent
bone around the implant should fuse well into the implant surface by forming new
bone. But in an individual who has already undergone radiation therapy, the
implant is likely to fail, because the bone formation is compromised after
radiation. In an experimental study done on implants inserted into irradiated bone,
to assess the effects of hyperbaric oxygen therapy on the capacity of bone
formation, hyperbaric oxygen therapy was found to stimulate effective bone
formation. According to histomorphometric studies done on effects of bone
reactions on titanium implants, it was found that the woven bone was not replaced
by lamellar bone in irradiated patients. (16)
Contraindications of HBO
The various contraindications of hyperbaric oxygen therapy are:
Absolute contraindications: Untreated tension pneumothorax
Relative contraindications: Upper restrictive tract infections / Emphysema with
carbon dioxide retentions / Asymptomatic pulmonary lesions which are seen on
chest X- ray / History of thoracic or ear surgery / Uncontrolled hyperthermia /
Pregnancy / Claustrophobia / Seizure disorder. (17)
7. 6
Complication
Though hyperbaric oxygen therapy has widespread applications, complications
in the usage do occur. In hyperbaric oxygen therapy, there are pressure
equalization problems which predominantly affect the middle ear and the nasal
sinus, which cause barotraumatic lesions. In a study which was done to analyze
the side effects of hyperbaric oxygen therapy, oxygen toxicity and ocular
disturbances were reported.
Non-emergent patients who are treated routinely with hyperbaric oxygen, with
oxygen being administered via a head hood, have a potential risk of CNS oxygen
toxicity which is three fold greater than is normally quoted. But the complications
which were observed were transient and they were limited mostly within the
duration of the treatment. (18)
Conclusion
HBO provides the most benefit in tissues with vessels which have good blood
flow. The anatomical structure of the mouth with its rich vascular beds is an
advantage to benefit from the treatment, which supports the intent to use this
therapy in dentistry. HBO proved its worth as an adjuvant therapy in multiple
dental indications. HBO application also proved its preventive worth in case of
tooth extraction at the site after irradiation. Tissue devastation after the head and
neck tumors treatment requires functional and aesthetic reconstruction. Success
of implants retention in the given site is significantly higher after HBO
application. As an adjuvant therapy, HBO proved its worth in treatment of
refractory osteomyelitis. HBO inhibits the growth of anaerobes in gingival
pockets which is probably the cause of the effect in the treatment of aggressive
periodontitis. Studies evaluating the positive effect of HBO in dentistry mostly
recommend it as an adjuvant therapy. Despite promissing results of experimental
works, the use of HBO in dentistry still has room for improvement. The effect
objectification for its more extensive use will require further studies. (19)
8. 7
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ADF Health. 2000;1:64-72.
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University Review, Vol. 10, 2016, No. 3, p. 7-11