This document summarizes a review on the effects of hyperbaric oxygen therapy (HBO) on sports injuries. HBO involves breathing 100% oxygen inside a pressurized chamber at pressures above 1 atmosphere absolute. While previous studies found HBO promising for treating sports injuries, the sample sizes were small and studies lacked randomization and blinding. The review aims to analyze HBO's contribution to rehabilitation from different sports injuries. However, larger randomized controlled trials are still needed to confirm whether HBO is a safe and effective treatment for sports injuries.
Hyperbaric Oxygen Therapy for Neurological Conditions Ade Wijaya
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen inside a pressurized chamber above sea level pressure. It has been used to treat various neurological conditions such as stroke and traumatic brain injury by reducing mitochondrial membrane permeability and reversing ischemia. However, the Undersea and Hyperbaric Medical Society currently only lists air/gas embolism and intracranial abscess as evidence-based indications, while research continues into other potential applications.
Use of Hyperbaric Oxygen Therapy in Management of Orthopedic DisordersApollo Hospitals
The management of musculoskeletal disorders is an increasing challenge to clinicians. Successful treatment relies on a wide range of multidisciplinary interventions. Adjunctive hyperbaric oxygen (HBO) therapy has been used as an orthopedic treatment for several decades. Positive outcomes have been reported by many authors for orthopedic infections, wound healing, delayed union and non-union of fractures, acute traumatic ischemia of the extremities, compromised grafts, and burn injuries. HBO therapy significantly reduces the length of the patient’s hospital stay, amputation rate, and wound care expenses.
Deepu Mathews is an associate professor at Malabar Dental College & Research Centre in Kerala, India. The document discusses the history, use, and applications of hyperbaric oxygen therapy (HBOT). HBOT involves breathing pure oxygen in a pressurized chamber and has been used since the 17th century to treat conditions such as decompression sickness and gas gangrene. It works by increasing the amount of oxygen dissolved in the blood and tissues. The document reviews research on using HBOT as an adjunctive treatment for periodontal disease.
physiotherapy management for chronic obstructive pulmonary disease Sunil kumar
role of physiotherapy in chronic obstructive pulmonary disease, principles of physical therapy management in copd, physiotherapy assessing and treatment for copd
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above 1 atmosphere. HBOT increases the amount of oxygen dissolved in the blood plasma, allowing greater oxygen delivery to tissues. It has been used since the 17th century to treat various conditions and was established as a treatment for decompression sickness in the 1930s. HBOT works by increasing oxygen to tissues through hyperoxygenation and decreasing bubble size through increased pressure. It has multiple mechanisms of action including vasoconstriction, angiogenesis, and collagen formation.
Physiotherapy management for Bronchiectasis Sunil kumar
The document discusses physiotherapy treatment for bronchiectasis. The goals of treatment include maximizing quality of life and function by educating patients about self-management of their condition and optimizing secretion clearance, ventilation, lung volumes, and exercise capacity. Treatment involves monitoring patients and administering medication before physiotherapy sessions. The primary interventions include aerobic and strengthening exercises, breathing techniques, coughing maneuvers, airway clearance, and education to support long-term self-management.
The biomechanical properties of connective tissues are critical determinants of how mechanical forces acting on the body/organ produce physical changes at the cellular level.
The Biomechanical properties of lung are discussed
Pulmonary rehabilitation in interstitial lung diseaseShradha Khati
Pulmonary rehabilitation programs aim to improve quality of life for patients with interstitial lung disease through education, exercise conditioning, breathing techniques, and psychological support. The goals are to decrease symptoms, encourage self-management, improve physical fitness and emotional well-being, and reduce hospitalizations. Components include exercise to strengthen muscles, breathing exercises, diet counseling, oxygen therapy if needed, and psychological counseling to help with conditions like depression. Studies show pulmonary rehabilitation can effectively improve exercise tolerance and quality of life while reducing hospital admissions for patients with interstitial lung disease.
Hyperbaric Oxygen Therapy for Neurological Conditions Ade Wijaya
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen inside a pressurized chamber above sea level pressure. It has been used to treat various neurological conditions such as stroke and traumatic brain injury by reducing mitochondrial membrane permeability and reversing ischemia. However, the Undersea and Hyperbaric Medical Society currently only lists air/gas embolism and intracranial abscess as evidence-based indications, while research continues into other potential applications.
Use of Hyperbaric Oxygen Therapy in Management of Orthopedic DisordersApollo Hospitals
The management of musculoskeletal disorders is an increasing challenge to clinicians. Successful treatment relies on a wide range of multidisciplinary interventions. Adjunctive hyperbaric oxygen (HBO) therapy has been used as an orthopedic treatment for several decades. Positive outcomes have been reported by many authors for orthopedic infections, wound healing, delayed union and non-union of fractures, acute traumatic ischemia of the extremities, compromised grafts, and burn injuries. HBO therapy significantly reduces the length of the patient’s hospital stay, amputation rate, and wound care expenses.
Deepu Mathews is an associate professor at Malabar Dental College & Research Centre in Kerala, India. The document discusses the history, use, and applications of hyperbaric oxygen therapy (HBOT). HBOT involves breathing pure oxygen in a pressurized chamber and has been used since the 17th century to treat conditions such as decompression sickness and gas gangrene. It works by increasing the amount of oxygen dissolved in the blood and tissues. The document reviews research on using HBOT as an adjunctive treatment for periodontal disease.
physiotherapy management for chronic obstructive pulmonary disease Sunil kumar
role of physiotherapy in chronic obstructive pulmonary disease, principles of physical therapy management in copd, physiotherapy assessing and treatment for copd
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above 1 atmosphere. HBOT increases the amount of oxygen dissolved in the blood plasma, allowing greater oxygen delivery to tissues. It has been used since the 17th century to treat various conditions and was established as a treatment for decompression sickness in the 1930s. HBOT works by increasing oxygen to tissues through hyperoxygenation and decreasing bubble size through increased pressure. It has multiple mechanisms of action including vasoconstriction, angiogenesis, and collagen formation.
Physiotherapy management for Bronchiectasis Sunil kumar
The document discusses physiotherapy treatment for bronchiectasis. The goals of treatment include maximizing quality of life and function by educating patients about self-management of their condition and optimizing secretion clearance, ventilation, lung volumes, and exercise capacity. Treatment involves monitoring patients and administering medication before physiotherapy sessions. The primary interventions include aerobic and strengthening exercises, breathing techniques, coughing maneuvers, airway clearance, and education to support long-term self-management.
The biomechanical properties of connective tissues are critical determinants of how mechanical forces acting on the body/organ produce physical changes at the cellular level.
The Biomechanical properties of lung are discussed
Pulmonary rehabilitation in interstitial lung diseaseShradha Khati
Pulmonary rehabilitation programs aim to improve quality of life for patients with interstitial lung disease through education, exercise conditioning, breathing techniques, and psychological support. The goals are to decrease symptoms, encourage self-management, improve physical fitness and emotional well-being, and reduce hospitalizations. Components include exercise to strengthen muscles, breathing exercises, diet counseling, oxygen therapy if needed, and psychological counseling to help with conditions like depression. Studies show pulmonary rehabilitation can effectively improve exercise tolerance and quality of life while reducing hospital admissions for patients with interstitial lung disease.
Pulmonary rehabilitation is a multidisciplinary treatment for chronic respiratory diseases like COPD. It addresses the respiratory limitations and systemic consequences of the disease through exercise training, education, psychosocial support, and nutrition intervention. Studies show pulmonary rehabilitation improves outcomes like dyspnea, exercise capacity, and quality of life. It is now a standard treatment for COPD alongside bronchodilator therapy.
Adaptive rejuvenation is the essence of mechanism of action of systemic ozone...Eugeny Nazarov
The presentation describes an adaptive approach to explaining the broadest spectrum of pharmacological activity of a course of systemic ozone therapy. This approach is based on the idea of systemic ozone therapy as a form of activation therapy. The difference between ozone therapy and other types of activation therapy is that ozone fixes a specific conditioned-unconditioned reflex of the adaptation system for the pharmacological activity of ozone.
Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP nonin...Ahmed Elberry
This study evaluated the effects of heat and humidification on aerosol drug delivery during automatic continuous positive airway pressure (Auto-CPAP) non-invasive ventilation in patients with chronic obstructive pulmonary disease (COPD). The researchers found no significant difference in the amount of salbutamol absorbed by patients whether the humidifier was switched on or off. However, they did find significant differences between different inhalation devices, with the metered dose inhaler and spacer providing the highest lung deposition and the jet nebulizer providing the lowest. The researchers concluded that delivering aerosol medications to Auto-CPAP patients using humidity is acceptable and will not lower drug delivery as previously suggested by in-vitro studies.
Hyperbaric oxygen therapy involves breathing 100% oxygen in a pressurized chamber and has several proposed mechanisms of action and indications. A review of the literature found:
1) Several randomized controlled trials and case studies provide evidence that HBOT can improve wound healing, graft survival, and reduce amputation rates for conditions like diabetic foot ulcers and crush injuries.
2) However, systematic reviews found the evidence inconclusive on its effectiveness for chronic wounds in general and its cost-effectiveness is unclear.
3) While HBOT shows promise for certain acute and chronic indications, more high-quality research is still needed to identify which patient subgroups are most likely to benefit.
Pulmonary function testing (PFT) evaluates the respiratory system through tests, patient history, and exams. PFT identifies the severity of lung impairment and helps clinicians understand lung disease. Tests measure lung volume, air flow, and gas exchange. Abnormal results can indicate conditions like asthma or COPD. PFT is used for diagnosis, monitoring disease progression, and pre-operative evaluation.
The document traces the history and definitions of pulmonary rehabilitation from 1974 to 1999. It summarizes that in 1974 the ACCP first defined pulmonary rehabilitation, which was then included in the ATS's 1981 statement. In 1994 the NIH further formalized the definition, which the ATS later updated in 1999 to define pulmonary rehabilitation as a multidisciplinary program designed to optimize physical and social performance for those with chronic respiratory impairment.
This document discusses the use of non-invasive ventilation (NIV) as a physiotherapeutic approach. It defines NIV as the delivery of oxygen via a face mask without an endotracheal tube. NIV works by creating positive airway pressure to force air into the lungs, reducing respiratory effort. There are two main types of NIV: non-invasive positive pressure ventilation and negative pressure ventilation. The document then discusses specific NIV techniques like CPAP and BiPAP and their indications. It also covers contraindications and how NIV can be used to manage acute respiratory failure, improve secretion removal, exercise capacity, and treat chronic respiratory failure.
Pulmonary rehabilitation is a comprehensive intervention designed to improve the physical and psychological condition of people with chronic respiratory disease. It includes exercise training, education, and behavior change therapies. Pulmonary rehabilitation aims to promote long-term adherence to health-enhancing behaviors. The summary describes restrictive and obstructive lung diseases, as well as various treatments used in pulmonary rehabilitation including exercise, airway clearance techniques, nutrition management, and psychosocial support.
Medical gases, differences and similarities in therapeuticEugeny Nazarov
The document discusses hormoligos, a new approach to understanding the mechanism of action of medical gases like hydrogen, ozone, and xenon. It summarizes that these gases have almost identical pharmacological effects despite different chemical properties. This is explained by their ability to modulate the endocrine system and restore homeostasis. The gases are found to influence hormone levels like cortisol and aldosterone, suggesting hormone modulation underlies their therapeutic effects.
This document discusses aerobic training as part of a pulmonary rehabilitation program for patients with chronic respiratory diseases such as COPD. It provides details on implementing continuous and interval aerobic training, including frequency, intensity, duration, and mode. Both training methods are shown to improve exercise capacity, health-related quality of life, and symptom control, with no significant differences found between moderate and high intensity programs. Ground walking is recommended over stationary cycling to better improve endurance walking capacity.
Novel treatments for asthma corticosteroids and other anti inflammatory agents.pharmaindexing
The document discusses novel treatments for asthma, focusing on corticosteroids and other anti-inflammatory agents. It notes that while inhaled corticosteroids are currently the gold standard for asthma treatment, some patients experience side effects or resistance to the drugs. Researchers are working to develop dissociated corticosteroids that separate anti-inflammatory and side effect mechanisms. Other promising anti-inflammatory treatments discussed include phosphodiesterase 4 inhibitors like roflumilast, which may provide additional treatment options but also have gastrointestinal side effects. Overall the review examines current asthma therapies and novel agents under investigation to improve treatment outcomes.
This document discusses novel approaches for treating chronic obstructive pulmonary disease (COPD). It describes improvements being made to current drug delivery methods and formulations of bronchodilators and inhaled corticosteroids to enhance their efficacy and safety profile. Combination therapies that include multiple agents in a single inhaler are also discussed. The document also outlines several novel targets being explored for developing new anti-inflammatory agents, drugs to enhance lung repair, and treatments for cough and excess mucus in COPD.
Pulmonary rehabilitation in criticaly ill patientsSamiaa Sadek
Pulmonary rehabilitation for critically ill patients aims to decrease complications through early mobilization and physical therapy. It includes mobilization exercises, respiratory muscle training, and pulmonary expansion techniques. Mobilization involves passive and active limb movements, as well as positioning changes, while respiratory training uses devices for resistive breathing and hyperpnea. Pulmonary expansion therapies clear secretions and apply positive airway pressures through various mechanical devices. Together these components address deconditioning, weakness, and lung volume reduction in critically ill survivors.
The document summarizes key aspects of pulmonary ventilation and the respiratory system. It discusses:
1) The process of pulmonary ventilation including the anatomy and mechanisms of inspiration and expiration.
2) Lung volumes and factors that affect them, including differences seen in athletes.
3) Regulation of ventilation during exercise through chemical and neurogenic control and variations from normal breathing patterns like hyperventilation and Valsalva maneuvers.
4) How the respiratory system can limit exercise performance in some cases, such as in individuals with chronic obstructive pulmonary disease or when respiratory muscle work is increased through external loading.
Patient guide: What should I expect from pulmonary rehabilitation?NHS Improvement
This guide explains the concept of PR and how to get referred to a programme, plus what happens at the classes and after the programme finishes
Patient guide December 2012
Incidence of oxygen desaturation with intravenous ketaminearbin joshi
The study evaluated the incidence of oxygen desaturation in children undergoing short surgical procedures with intravenous ketamine anesthesia at two hospitals in Nepal. The incidence of desaturation was 10% at one hospital and 16.1% at the other. Basic airway maneuvers like chin lift improved oxygen saturation in most cases who desaturated, with jaw thrust also effective in some cases. No patients required supplemental oxygen or more advanced airway interventions. The study demonstrated that desaturation is common initially after ketamine administration but easily corrected with basic airway techniques.
Interstitial lung disease (ILD) is a group of diffuse lung diseases that affect the lung parenchyma and cause breathlessness, cough, and fatigue. Physiotherapy plays an important role in managing ILD through pulmonary rehabilitation programs that include aerobic endurance training, resistance training, stretching, and supplemental oxygen as needed. These programs aim to improve exercise capacity, quality of life, and lung function by optimizing ventilation, gas exchange, and muscle strength in patients with ILD.
1) The study compared the effects of an alveolar recruitment maneuver (ARM) plus high PEEP to standard ventilation on oxygenation during laparoscopic bariatric surgery in morbidly obese patients.
2) The ARM group had significantly higher intraoperative oxygen levels (Pao2) and respiratory system compliance compared to controls. However, the benefits disappeared after extubation.
3) The ARM group required more frequent use of vasopressors during surgery.
In 3 sentences, this summary highlights the key findings that the ARM improved intraoperative oxygenation and pulmonary mechanics but the benefits were transient, and it was associated with more vasopressor use during surgery.
1) ARDS is characterized by hypoxemia, bilateral lung infiltrates, and respiratory failure not fully explained by cardiac failure. The Berlin definition classifies ARDS as mild, moderate, or severe based on oxygenation levels.
2) Management of ARDS focuses on treating underlying causes, preventing complications, and using ventilator strategies like low tidal volume ventilation to prevent ventilator-induced lung injury.
3) Other ventilator strategies discussed include prone positioning, neuromuscular blockade, recruitment maneuvers, and extracorporeal membrane oxygenation for severe cases, though evidence on benefits is mixed.
Pulmonary rehabilitation is a multidisciplinary treatment for chronic respiratory diseases like COPD. It addresses the respiratory limitations and systemic consequences of the disease through exercise training, education, psychosocial support, and nutrition intervention. Studies show pulmonary rehabilitation improves outcomes like dyspnea, exercise capacity, and quality of life. It is now a standard treatment for COPD alongside bronchodilator therapy.
Adaptive rejuvenation is the essence of mechanism of action of systemic ozone...Eugeny Nazarov
The presentation describes an adaptive approach to explaining the broadest spectrum of pharmacological activity of a course of systemic ozone therapy. This approach is based on the idea of systemic ozone therapy as a form of activation therapy. The difference between ozone therapy and other types of activation therapy is that ozone fixes a specific conditioned-unconditioned reflex of the adaptation system for the pharmacological activity of ozone.
Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP nonin...Ahmed Elberry
This study evaluated the effects of heat and humidification on aerosol drug delivery during automatic continuous positive airway pressure (Auto-CPAP) non-invasive ventilation in patients with chronic obstructive pulmonary disease (COPD). The researchers found no significant difference in the amount of salbutamol absorbed by patients whether the humidifier was switched on or off. However, they did find significant differences between different inhalation devices, with the metered dose inhaler and spacer providing the highest lung deposition and the jet nebulizer providing the lowest. The researchers concluded that delivering aerosol medications to Auto-CPAP patients using humidity is acceptable and will not lower drug delivery as previously suggested by in-vitro studies.
Hyperbaric oxygen therapy involves breathing 100% oxygen in a pressurized chamber and has several proposed mechanisms of action and indications. A review of the literature found:
1) Several randomized controlled trials and case studies provide evidence that HBOT can improve wound healing, graft survival, and reduce amputation rates for conditions like diabetic foot ulcers and crush injuries.
2) However, systematic reviews found the evidence inconclusive on its effectiveness for chronic wounds in general and its cost-effectiveness is unclear.
3) While HBOT shows promise for certain acute and chronic indications, more high-quality research is still needed to identify which patient subgroups are most likely to benefit.
Pulmonary function testing (PFT) evaluates the respiratory system through tests, patient history, and exams. PFT identifies the severity of lung impairment and helps clinicians understand lung disease. Tests measure lung volume, air flow, and gas exchange. Abnormal results can indicate conditions like asthma or COPD. PFT is used for diagnosis, monitoring disease progression, and pre-operative evaluation.
The document traces the history and definitions of pulmonary rehabilitation from 1974 to 1999. It summarizes that in 1974 the ACCP first defined pulmonary rehabilitation, which was then included in the ATS's 1981 statement. In 1994 the NIH further formalized the definition, which the ATS later updated in 1999 to define pulmonary rehabilitation as a multidisciplinary program designed to optimize physical and social performance for those with chronic respiratory impairment.
This document discusses the use of non-invasive ventilation (NIV) as a physiotherapeutic approach. It defines NIV as the delivery of oxygen via a face mask without an endotracheal tube. NIV works by creating positive airway pressure to force air into the lungs, reducing respiratory effort. There are two main types of NIV: non-invasive positive pressure ventilation and negative pressure ventilation. The document then discusses specific NIV techniques like CPAP and BiPAP and their indications. It also covers contraindications and how NIV can be used to manage acute respiratory failure, improve secretion removal, exercise capacity, and treat chronic respiratory failure.
Pulmonary rehabilitation is a comprehensive intervention designed to improve the physical and psychological condition of people with chronic respiratory disease. It includes exercise training, education, and behavior change therapies. Pulmonary rehabilitation aims to promote long-term adherence to health-enhancing behaviors. The summary describes restrictive and obstructive lung diseases, as well as various treatments used in pulmonary rehabilitation including exercise, airway clearance techniques, nutrition management, and psychosocial support.
Medical gases, differences and similarities in therapeuticEugeny Nazarov
The document discusses hormoligos, a new approach to understanding the mechanism of action of medical gases like hydrogen, ozone, and xenon. It summarizes that these gases have almost identical pharmacological effects despite different chemical properties. This is explained by their ability to modulate the endocrine system and restore homeostasis. The gases are found to influence hormone levels like cortisol and aldosterone, suggesting hormone modulation underlies their therapeutic effects.
This document discusses aerobic training as part of a pulmonary rehabilitation program for patients with chronic respiratory diseases such as COPD. It provides details on implementing continuous and interval aerobic training, including frequency, intensity, duration, and mode. Both training methods are shown to improve exercise capacity, health-related quality of life, and symptom control, with no significant differences found between moderate and high intensity programs. Ground walking is recommended over stationary cycling to better improve endurance walking capacity.
Novel treatments for asthma corticosteroids and other anti inflammatory agents.pharmaindexing
The document discusses novel treatments for asthma, focusing on corticosteroids and other anti-inflammatory agents. It notes that while inhaled corticosteroids are currently the gold standard for asthma treatment, some patients experience side effects or resistance to the drugs. Researchers are working to develop dissociated corticosteroids that separate anti-inflammatory and side effect mechanisms. Other promising anti-inflammatory treatments discussed include phosphodiesterase 4 inhibitors like roflumilast, which may provide additional treatment options but also have gastrointestinal side effects. Overall the review examines current asthma therapies and novel agents under investigation to improve treatment outcomes.
This document discusses novel approaches for treating chronic obstructive pulmonary disease (COPD). It describes improvements being made to current drug delivery methods and formulations of bronchodilators and inhaled corticosteroids to enhance their efficacy and safety profile. Combination therapies that include multiple agents in a single inhaler are also discussed. The document also outlines several novel targets being explored for developing new anti-inflammatory agents, drugs to enhance lung repair, and treatments for cough and excess mucus in COPD.
Pulmonary rehabilitation in criticaly ill patientsSamiaa Sadek
Pulmonary rehabilitation for critically ill patients aims to decrease complications through early mobilization and physical therapy. It includes mobilization exercises, respiratory muscle training, and pulmonary expansion techniques. Mobilization involves passive and active limb movements, as well as positioning changes, while respiratory training uses devices for resistive breathing and hyperpnea. Pulmonary expansion therapies clear secretions and apply positive airway pressures through various mechanical devices. Together these components address deconditioning, weakness, and lung volume reduction in critically ill survivors.
The document summarizes key aspects of pulmonary ventilation and the respiratory system. It discusses:
1) The process of pulmonary ventilation including the anatomy and mechanisms of inspiration and expiration.
2) Lung volumes and factors that affect them, including differences seen in athletes.
3) Regulation of ventilation during exercise through chemical and neurogenic control and variations from normal breathing patterns like hyperventilation and Valsalva maneuvers.
4) How the respiratory system can limit exercise performance in some cases, such as in individuals with chronic obstructive pulmonary disease or when respiratory muscle work is increased through external loading.
Patient guide: What should I expect from pulmonary rehabilitation?NHS Improvement
This guide explains the concept of PR and how to get referred to a programme, plus what happens at the classes and after the programme finishes
Patient guide December 2012
Incidence of oxygen desaturation with intravenous ketaminearbin joshi
The study evaluated the incidence of oxygen desaturation in children undergoing short surgical procedures with intravenous ketamine anesthesia at two hospitals in Nepal. The incidence of desaturation was 10% at one hospital and 16.1% at the other. Basic airway maneuvers like chin lift improved oxygen saturation in most cases who desaturated, with jaw thrust also effective in some cases. No patients required supplemental oxygen or more advanced airway interventions. The study demonstrated that desaturation is common initially after ketamine administration but easily corrected with basic airway techniques.
Interstitial lung disease (ILD) is a group of diffuse lung diseases that affect the lung parenchyma and cause breathlessness, cough, and fatigue. Physiotherapy plays an important role in managing ILD through pulmonary rehabilitation programs that include aerobic endurance training, resistance training, stretching, and supplemental oxygen as needed. These programs aim to improve exercise capacity, quality of life, and lung function by optimizing ventilation, gas exchange, and muscle strength in patients with ILD.
1) The study compared the effects of an alveolar recruitment maneuver (ARM) plus high PEEP to standard ventilation on oxygenation during laparoscopic bariatric surgery in morbidly obese patients.
2) The ARM group had significantly higher intraoperative oxygen levels (Pao2) and respiratory system compliance compared to controls. However, the benefits disappeared after extubation.
3) The ARM group required more frequent use of vasopressors during surgery.
In 3 sentences, this summary highlights the key findings that the ARM improved intraoperative oxygenation and pulmonary mechanics but the benefits were transient, and it was associated with more vasopressor use during surgery.
1) ARDS is characterized by hypoxemia, bilateral lung infiltrates, and respiratory failure not fully explained by cardiac failure. The Berlin definition classifies ARDS as mild, moderate, or severe based on oxygenation levels.
2) Management of ARDS focuses on treating underlying causes, preventing complications, and using ventilator strategies like low tidal volume ventilation to prevent ventilator-induced lung injury.
3) Other ventilator strategies discussed include prone positioning, neuromuscular blockade, recruitment maneuvers, and extracorporeal membrane oxygenation for severe cases, though evidence on benefits is mixed.
This case report describes an adolescent male with near fatal asthma who was unresponsive to conventional therapy and required rescue therapy. He presented with severe hypoxemia, hypercapnia, and acidosis. Despite aggressive management including mechanical ventilation, his condition deteriorated further with the development of barotrauma and hemodynamic instability. The introduction of extracorporeal membrane oxygenation (ECMO) dramatically improved his gas exchange and lung mechanics. ECMO allowed his lungs time to recover from inflammation while minimizing ventilator-induced injury. With ECMO support for 72 hours, the patient was successfully weaned from ventilation and made a full recovery.
Nebulizers and spacers for aerosol delivery through adult nasal cannula at lo...Ahmed Elberry
This study evaluated the delivery of aerosolized salbutamol through different devices (vibrating mesh nebulizer, jet nebulizer, metered dose inhalers with spacers) connected to a high flow nasal cannula system at a low oxygen flow rate of 5 L/min. An in-vitro experiment was set up using a breathing simulator connected to a filter to measure the total delivered dose. The vibrating mesh nebulizer (Aerogen Solo) delivered the highest dose of around 35% of the nebulizer charge with fine particle fractions. The jet nebulizer and metered dose inhaler with Combihaler spacer delivered around 18% dose. The metered dose in
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a pressurized chamber above normal atmospheric pressure. This increases the amount of oxygen dissolved in the blood and tissues up to 15 times normal levels. The high oxygen levels and pressure have physiological effects that can help treat conditions like carbon monoxide poisoning, gas embolism, and non-healing wounds by promoting angiogenesis and fighting infection. HBOT is administered in multi-place or monoplace chambers and can cause potential side effects from higher pressure and oxygen levels if not done properly.
Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a pressurized chamber at greater than atmospheric pressure. HBOT works by increasing the amount of oxygen that dissolves in the blood plasma, which allows more oxygen to reach tissues. The increased oxygen levels stimulate various cellular functions that promote healing. HBOT has been used to treat conditions like non-healing wounds, radiation injuries, burns, carbon monoxide poisoning, and decompression sickness. While research shows HBOT may help with some conditions, further high-quality studies are still needed to establish its effectiveness for other proposed uses.
1. Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a pressurized chamber, which increases the amount of oxygen that dissolves in the patient's plasma and tissues. This promotes healing and reduces recovery time.
2. HBOT works by increasing oxygen tension in tissues through several physiological effects, including increased angiogenesis and fibroblast proliferation. The increased oxygen aids neutrophils in fighting infection and promotes tissue regrowth.
3. HBOT is used to treat osteoradionecrosis, refractory osteomyelitis, and compromised bone healing after radiation therapy for dental implants through its effects on increasing oxygen delivery and stimulating cell growth in hypoxic tissues.
Hyperbaric oxygen therapy involves exposing patients to oxygen at pressures higher than atmospheric pressure in a pressurized chamber. This increases the amount of oxygen that can be dissolved in the blood and has physiological effects like vasoconstriction and inhibition of endothelial cell adhesion. Anesthesia considerations for hyperbaric oxygen therapy include the pressure reversal effects of high pressure on anesthesia and the need to monitor drug effects and schedules of therapy to avoid oxygen toxicity. Common indications for hyperbaric oxygen therapy include carbon monoxide poisoning, gas embolism, and infections like clostridial myonecrosis.
Hyperbaric oxygen therapy involves patients breathing 100% oxygen in a pressurized chamber at higher than normal atmospheric pressure. This results in increased oxygen levels in tissues and blood. The therapy has several beneficial effects including anti-ischemic, anti-infective, and wound healing properties. It is used to treat conditions like carbon monoxide poisoning, decompression sickness, osteomyelitis, osteoradionecrosis, and compromised grafts or flaps where normal healing is impaired. Treatment involves repeated sessions in monoplace or multiplace hyperbaric chambers at specific pressures and durations depending on the condition.
This document provides information about acute respiratory distress syndrome (ARDS) including its definition, causes, pathophysiology, symptoms, diagnostic evaluation, management, and prognosis. ARDS is a life-threatening lung condition caused by fluid buildup in the lungs which prevents proper oxygen exchange. The document outlines the three phases of ARDS, symptoms, diagnostic tests, treatment options including ventilation strategies and positioning, and complications. Prone positioning is highlighted as an effective strategy to improve outcomes when used early in patients with severe hypoxemia.
This document provides an overview of acute respiratory distress syndrome (ARDS). It defines ARDS and discusses its causes, pathophysiology, diagnosis, incidence, prognosis and long-term outcomes. Treatment focuses on supportive care including mechanical ventilation with low tidal volumes, conservative fluid management, prone positioning and other strategies to improve oxygenation. Corticosteroids are not recommended for treatment due to lack of proven benefit. With treatment, prognosis depends on the underlying cause, but many ARDS survivors can expect to return to normal lifestyles within a year.
This document discusses chronic obstructive pulmonary disease (COPD) and long-acting beta-2 agonists for its treatment. It notes that COPD is a leading cause of death worldwide and its burden has increased significantly in recent decades. Long-acting beta-2 agonists like formoterol and salmeterol are recommended as first-line therapy for COPD as they provide smooth muscle relaxation and anti-inflammatory effects when dosed twice daily, improving symptoms and quality of life compared to short-acting treatments. The document reviews the mechanisms of benefit, formulations, and clinical studies of long-acting beta-2 agonists for COPD management.
Dr. Milan Kharel and Dr. Madhu Gyawali discussed the history and concepts of inhalational anesthetics. Some key points include:
- Diethyl ether was the first anesthetic used in 1846. Chloroform was also used but discontinued due to toxicity.
- Halothane was synthesized in 1951 and was widely used for decades. Other common agents introduced later include enflurane, isoflurane, sevoflurane, and desflurane.
- Minimal alveolar concentration (MAC) is used to compare anesthetic potency, with halothane having a MAC of 0.75%.
- Inhalational agents are transferred from inspired air to alveoli and tissues based on factors like blood
Dr. Milan Kharel presented on inhalational anesthetic agents. He discussed the history of anesthesia including the first agents used like ether and chloroform. He then covered the basic concepts of MAC, vapor pressure, factors affecting uptake and distribution of gases. The ideal characteristics of an anesthetic were noted. Various agents were classified and discussed in detail including nitrous oxide, halothane, enflurane, isoflurane, sevoflurane and desflurane.
This document provides an overview of acute respiratory distress syndrome (ARDS). It begins by defining ARDS as a sudden respiratory failure characterized by hypoxemia and diffuse lung infiltrates. Risk factors include age over 65, smoking history, sepsis, trauma and pneumonia. The pathophysiology involves three phases: exudative, proliferative and fibrotic. Management requires supportive care in an ICU including mechanical ventilation, positioning, fluids and antibiotics. The nursing priorities are to improve breathing and tissue perfusion while preventing complications like infection and skin breakdown.
The document provides information about acute respiratory distress syndrome (ARDS). It begins with a brief history of ARDS and provides the clinical definition. It describes the diagnostic criteria and etiology, including that most cases are caused by sepsis, pneumonia, or trauma. It then discusses the normal lung physiology and pathophysiology of ARDS, which involves three phases: exudative, proliferative, and fibrotic. The management section outlines the principles of therapy to provide adequate gas exchange while avoiding secondary injury, including mechanical ventilation protocols, fluid management, and other strategies. It concludes with a discussion of prognosis and recent advances in ARDS management such as protective ventilation strategies.
Anesthesia For Patients Requiring Advanced Ventilatory Supportsxbenavides
This document discusses anesthesia considerations for patients requiring advanced ventilatory support. It begins with definitions of respiratory failure and hypoxia. It then reviews the physiology of mechanical ventilation, discussing mechanics, management of ventilation and oxygenation, and advanced modes available in intensive care units. It focuses on pressure-controlled ventilation as an important mode that can help maintain pressures below injury thresholds and improve oxygenation through higher mean airway pressures. The challenges of ventilating critically ill patients with lung damage and maintaining oxygenation within safe pressure limits are also addressed.
Repeated open endotracheal suctioning (OS) in a rabbit model of acute respiratory distress syndrome (ARDS) caused a gradual decline in oxygen levels over 6 hours compared to closed endotracheal suctioning (CS). However, OS did not appear to exacerbate lung injury more than CS based on lung morphology and levels of inflammatory cytokines after 6 hours, though OS did cause more derecruitment with each suctioning. The study aimed to determine if repeated OS during mechanical ventilation worsened lung injury more than repeated CS in an ARDS rabbit model over a longer period of 6 hours.
Acute Response of Manual Hyperinflation In Addition To Standard Chest Physiot...iosrjce
Background: Physiotherapists use manual hyperinflation (MHI) as a treatment for the recruitment of
collapsed lung and mobilization of excess pulmonary secretions .Purpose: To investigate the acute effect of
manual hyperinflation (MHI) on oxygenation and volume of secretions cleared in mechanically ventilated
patients.
Subjects and Methods: Manual hyperinflation was delivered in 30 medically stable, mechanically ventilated
patients . patients were randomly selected from Cairo university hospitals (critical care department). Their ages
ranged from 50 to 60 years .The study group A received both manual hyperinflation and standard chest
physiotherapy while control group B received standard chest physiotherapy only. Oxygenation parameters were
recorded before and after 30 minutes of treatment while secretion volume was recorded after 30 minutes of
treatment.
Results: The results of this study revealed statistically significant improvement in oxygenation parameters and
the amount of drained chest secretions in patients of both groups which was highly significant in favor of study
group A with P value ≤ 0.05.
Conclusion: Use of manual hyperinflation in combination with standard chest physiotherapy is a beneficial
method to clear lung secretions and improve oxygenation parameters in mechanically ventilated patients .
The document defines acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) according to criteria from a 1994 consensus conference. It discusses the epidemiology and clinical disorders associated with ALI/ARDS development. Ventilator-based strategies for management include using low tidal volumes (6 ml/kg) and positive end-expiratory pressure (PEEP) of 13-16 cm H2O to reduce ventilator-induced lung injury from overdistension and repetitive opening/closing of alveoli. Recruitment maneuvers involving brief increases in pressure have been used to improve oxygenation by opening collapsed lung regions.
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1. Therapeutic Advances in Musculoskeletal Disease Review
Hyperbaric oxygen effects on sports injuries
Pedro Barata, Mariana Cervaens, Rita Resende, O´
scar Camacho and Frankim Marques
Abstract: In the last decade, competitive sports have taken on a whole new meaning, where
intensity has increased together with the incidence of injuries to the athletes. Therefore, there
is a strong need to develop better and faster treatments that allow the injured athlete to return
to competition faster than with the normal course of rehabilitation, with a low risk of re-injury.
Hyperbaric therapies are methods used to treat diseases or injuries using pressures higher
than local atmospheric pressure inside a hyperbaric chamber. Within hyperbaric therapies,
hyperbaric oxygen therapy (HBO) is the administration of pure oxygen (100%) at pressures
greater than atmospheric pressure, i.e. more than 1 atmosphere absolute (ATA), for
therapeutic reasons. The application of HBO for the treatment of sports injuries has recently
been suggested in the scientific literature as a modality of therapy either as a primary or an
adjunct treatment. Although results have proven to be promising in terms of using HBO as
a treatment modality in sports-related injuries, these studies have been limited due to the
small sample size, lack of blinding and randomization problems. HBO seems to be promising
in the recovery of injuries for high-performance athletes; however, there is a need for larger
samples, randomized, controlled, double-blinded clinical trials combined with studies using
animal models so that its effects and mechanisms can be identified to confirm that it is a safe
and effective therapy for the treatment of sports injuries.
Keywords: hyperbaric oxygen therapy, sports injuries
Introduction
In the last decade, competitive sports have taken
on a whole new meaning, where intensity has
increased together with the incidence of injuries
to the athletes. These sport injuries, ranging from
broken bones to disrupted muscles, tendons and
ligaments, may be a result of acute impact forces
in contact sports or the everyday rigors of train-ing
and conditioning [Babul et al. 2003].
Therefore, a need has emerged to discover the
best and fastest treatments that will allow the
injured athlete to return to competition faster
than the normal course of rehabilitation, with a
low risk of re-injury.
Hyperbaric oxygen therapy (HBO) is the thera-peutic
administration of 100% oxygen at pres-sures
higher than 1 absolute atmosphere (ATA).
It is administered by placing the patient in a mul-tiplace
or in a monoplace (one man) chamber
and typically the vessels are pressurized to
1.53.0 ATA for periods between 60 and
120 minutes once or twice a day [Bennett et al.
2005a]. In the monoplace chamber the patient
breathes the oxygen directly from the chamber
but in the multiplace chamber this is done
through a mask. At 2.0 ATA, the blood oxygen
content is increased 2.5% and sufficient oxygen
becomes dissolved in plasma to meet tissue needs
in the absence of haemoglobin-bound oxygen,
increasing tissue oxygen tensions 10-fold
(1000%) [Staples and Clement, 1996]. HBO is
remarkably free of untoward side effects.
Complications such as oxygen toxicity, middle
ear barotrauma and confinement anxiety are
well controlled with appropriate pre-exposure
orientations [Mekjavic et al. 2000].
HBO has been used empirically in the past, but
today information exists for its rational applica-tion.
This review aims to analyse the contribution
of HBO in the rehabilitation of the different
sports injuries.
Hyperbaric oxygen therapy
Hyperbaric therapies are methods used to treat
diseases or injuries using pressures higher than
local atmospheric pressure inside a hyperbaric
chamber. Within hyperbaric therapies, HBO is
Ther Adv Musculoskel Dis
(2011) 3(2) 111121
DOI: 10.1177/
1759720X11399172
! The Author(s), 2011.
Reprints and permissions:
http://www.sagepub.co.uk/
journalsPermissions.nav
Correspondence to:
Pedro Barata
Universidade Fernando
Pessoa, Faculdade
Cieˆncias da Sau´de, Rua
Carlos da Maia 296, Porto
4200, Portugal
pedro.barata@gmail.com
Mariana Cervaens
Universidade Fernando
Pessoa, Faculdade
Cieˆncias da Sau´de, Porto,
Portugal
Rita Resende
Hospital Pedro Hispano,
Unidade Medicina
Hiperba´rica, Porto,
Portugal
O´
scar Camacho
Hospital Pedro Hispano,
Unidade Medicina
Hiperba´rica, Porto,
Portugal
Frankim Marques
Faculdade Farma´cia U.P.,
Biochemistry, Porto,
Portugal
http://tab.sagepub.com 111
2. the administration of pure oxygen (100%) at
pressures greater than atmospheric pressure, i.e.
more than 1 ATA, for therapeutic reasons
[Albuquerque e Sousa, 2007].
In order to be able to perform HBO, special facil-ities
are required, with the capacity for withstand-ing
pressures higher than 1 ATA, known as
hyperbaric chambers, where patients breathe
100% oxygen [Fernandes, 2009].
In the case of single monoplace chambers (with a
capacity for only one person) the oxygen is
inhaled directly from the chambers’ environment
[Fernandes, 2009]. Although much less expen-sive
to install and support, they have the major
disadvantage of not being possible to access the
patient during treatment. It is possible to monitor
blood pressure, arterial waveform and electrocar-diogram
noninvasively, and to provide intrave-nous
medications and fluids. Mechanical
ventilation is possible if chambers are equipped
appropriately, although it is not possible to suc-tion
patients during treatment. Mechanical ven-tilation
in the monoplace chamber is provided by
a modified pressure-cycled ventilator outside of
the chamber [Sheridan and Shank, 1999].
In multiplace chambers, the internal atmosphere
is room air compressed up to 6 ATA. Attendants
in this environment breathe compressed air,
accruing a nitrogen load in their soft tissues, in
the same way as a scuba diver breathing com-pressed
air. These attendants need to decompress
to avoid the decompression illness by using more
complex decompression procedures when the
treatment tables are more extended (e.g. Navy
tables). The patients, on the other hand, are
breathing oxygen while at pressure. This oxygen
can be administered via face mask, a hood or
endotracheal tube. The advantage of such a
chamber is that the patient can be attended to
during treatment, but the installation and sup-port
costs are very high. These high costs pre-clude
the widespread use of multiplace
chambers [Sheridan and Shank, 1999].
Biochemical, cellular and physiological effects
of HBO
The level of consumption of O2 by a given tissue,
on the local blood stream, and the relative dis-tance
of the zone considered from the nearest
arteriole and capillary determines the O2 tension
in this tissue. Indeed, O2 consumption causes
oxygen partial pressure (pO2) to fall rapidly
between arterioles and vennules. This empha-sizes
the fact that in tissues there is a distribution
of oxygen tensions according to a gradient. This
also occurs at the cell level such as in the mito-chondrion,
the terminal place of oxygen con-sumption,
where O2 concentrations range from
1.5 to 3M [Mathieu, 2006].
Before reaching the sites of utilization within the
cell such as the perioxome, mitochondria and
endoplasmic reticulum, the oxygen moves down
a pressure gradient from inspired to alveolar gas,
arterial blood, the capillary bed, across the inter-stitial
and intercellular fluid. Under normobaric
conditions, the gradient of pO2 known as the
‘oxygen cascade’ starts at 21.2 kPa (159mmHg)
and ends up at 0.53 kPa (3.822.5mmHg)
depending on the target tissue [Mathieu, 2006].
The arterial oxygen tension (PaO2) is approxi-mately
90mmHg and the tissue oxygen tension
(PtO2) is approximately 55mmHg [Sheridan and
Shank, 1999]. These values are markedly
increased by breathing pure oxygen at greater
than atmospheric pressure.
HBO is limited by toxic oxygen effects to a
maximum pressure of 300 kPa (3 bar). Partial
pressure of carbon dioxide in the arterial
blood (PaCO2), water vapour pressure and respi-ratory
quotient (RQ) do not vary significantly
between 100 and 300 kPa (1 and 3 bar). Thus,
for example, the inhalation of 100% oxygen at
202.6 kPa (2 ATA) provides an alveolar PO2 of
1423mmHg and, consequently, the alveolar
oxygen passes the alveolarcapillary space and
diffuses into the venous pulmonary capillary
bed according to Fick’s laws of diffusion
[Mathieu, 2006].
Hyperoxya and hyperoxygenation
Oxygen is transported by blood in two ways:
chemically, bound to haemoglobin, and physi-cally,
dissolved in plasma. During normal breath-ing
in the environment we live in, haemoglobin
has an oxygen saturation of 97%, representing a
total oxygen content of about 19.5 ml O2/100 ml
of blood (or 19.5 vol%), because 1 g of 100%
saturated haemoglobin carries 1.34 ml oxygen.
In these conditions the amount of oxygen dis-solved
in plasma is 0.32 vol%, giving a total of
19.82 vol% oxygen. When we offer 85% oxygen
through a Hudson mask or endotracheal intuba-tion
the oxygen content can reach values up to
22.2 vol% [Jain, 2004].
Therapeutic Advances in Musculoskeletal Disease 3 (2)
112 http://tab.sagepub.com
3. The main effect of HBO is hyperoxia. During this
therapy, oxygen is dissolved physically in the
blood plasma. At an ambient pressure of 2.8
ATA and breathing 100% oxygen, the alveolar
oxygen tension (PAO2) is approximately
2180mmHg, the PaO2 is at least 1800mmHg
and the tissue concentration (PtO2) is at least
500 mmHg. The oxygen content of blood is
approximately
([1.34HbgSaO2]þ[0.0031PaO2]),
where Hbg is serum haemoglobin concentration
and SaO2 is arterial oxygen saturation [Sheridan
and Shank, 1999]. At a PaO2 of 1800mmHg, the
dissolved fraction of oxygen in plasma
(0.0031PaO2) is approximately 6 vol%,
which means that 6ml of oxygen will be physi-cally
dissolved in 100 ml of plasma, reaching a
total volume of oxygen in the circulating blood
volume equal to 26.9 vol%, equivalent to basic
oxygen metabolic needs, and the paO2 in the
arteries can reach 2000mmHg. With a normal
lung function and tissue perfusion, a partial pres-sure
of oxygen in the blood (pO2)1000mmHg
could be reached [Mayer et al. 2004]. Breathing
pure oxygen at 2 ATA, the oxygen content in
plasma is 10 times higher than when breathing
air at sea level. Under normal conditions the pO2
is 95 mmHg; under conditions of a hyperbaric
chamber, the pO2 can reach values greater than
2000mmHg [Jain, 2004]. Consequently, during
HBO, Hbg is also fully saturated on the venous
side, and the result is an increased oxygen tension
throughout the vascular bed. Since diffusion is
driven by a difference in tension, oxygen will be
forced further out into tissues from the vascular
bed [Mortensen, 2008] and diffuses to areas
inaccessible to molecules of this gas when trans-ported
by haemoglobin [Albuquerque e Sousa,
2007].
After removal from the hyperbaric oxygen envi-ronment,
the PaO2 normalizes in minutes, but
the PtO2 may remain elevated for a variable
period. The rate of normalization of PtO2 has
not been clearly described, but is likely measured
in minutes to a few hours, depending on tissue
perfusion [Sheridan and Shank, 1999].
The physiological effects of HBO include short-term
effects such as vasoconstriction and
enhanced oxygen delivery, reduction of oedema,
phagocytosis activation and also an anti-inflam-matory
effect (enhanced leukocyte function).
Neovascularization (angiogenesis in hypoxic soft
tissues), osteoneogenesis as well as stimulation of
P Barata, M Cervaens et al.
collagen production by fibroblasts are known
long-term effects. This is beneficial for wound
healing and recovery from radiation injury
[Mayer et al. 2004; Sheridan and Shank, 1999].
Physiological and therapeutic effects of HBO
In normal tissues, the primary action of oxygen is
to cause general vasoconstriction (especially in
the kidneys, skeletal muscle, brain and skin),
which elicits a ‘Robin Hood effect’ through a
reduction of blood flow to well-oxygenated
tissue [Mortensen, 2008]. HBO not only pro-vides
a significant increase in oxygen availability
at the tissue level, as selective hyperoxic and not
hypoxic vasoconstriction, occurring predomi-nantly
at the level of healthy tissues, with reduced
blood volume and redistribution oedema for
peripheral tissue hypoxia, which can raise the
anti-ischemic and antihypoxic effects to extremi-ties
due to this physiological mechanism
[Albuquerque e Sousa, 2007]. HBO reduces
oedema, partly because of vasoconstriction,
partly due to improved homeostasis mechanisms.
A high gradient of oxygen is a potent stimuli for
angioneogenesis, which has an important contri-bution
in the stimulation of reparative and regen-erative
processes in some diseases [Mortensen,
2008].
Also many cell and tissue functions are depen-dent
on oxygen. Of special interest are leukocytes
ability to kill bacteria, cell replication, collagen
formation, and mechanisms of homeostasis,
such as active membrane transport, e.g. the
sodiumpotassium pump. HBO has the effect
of inhibiting leukocyte adhesion to the endothe-lium,
diminishing tissue damage, which enhances
leukocyte motility and improves microcirculation
[Mortensen, 2008]. This occurs when the pres-ence
of gaseous bubbles in the venous vessels
blocks the flow and induces hypoxia which
causes endothelial stress followed by the release
of nitric oxide (NO) which reacts with superoxide
anions to form peroxynitrine. This, in turn, pro-vokes
oxidative perivascular stress and leads to
the activation of leukocytes and their adhesion
to the endothelium [Antonelli et al. 2009].
Another important factor is hypoxia. Hypoxia is
the major factor stimulating angiogenesis.
However, deposition of collagen is increased by
hyperoxygenation, and it is the collagen matrix
that provides support for the growth of new cap-illary
bed. Two-hour daily treatments with HBO
are apparently responsible for stimulating the
http://tab.sagepub.com 113
4. oxygen in the synthesis of collagen, the remaining
22 h of real or relative hypoxia, in which the
patient is not subjected to HBO, provide the
stimuli for angiogenesis. Thus, the alternation
of states of hypoxia and hyperoxia, observed in
patients during treatment with intermittent
HBO, is responsible for maximum stimulation
of fibroblast activity in ischemic tissues, produc-ing
the development of the matrix of collagen,
essential for neovascularization [Jain, 2004].
The presence of oxygen has the advantage of not
only promoting an environment less hospitable to
anaerobes, but also speeds the process of wound
healing, whether from being required for the pro-duction
of collagen matrix and subsequent angio-genesis,
from the presence and beneficial effects
of reactive oxygen species (ROS), or from yet
undetermined means [Kunnavatana et al. 2005].
Dimitrijevich and colleagues studied the effect of
HBO on human skin cells in culture and in
human dermal and skin equivalents
[Dimitrijevich et al. 1999]. In that study,
normal human dermal fibroblasts, keratinocytes,
melanocytes, dermal equivalents and skin equiv-alents
were exposed to HBO at pressures up to 3
ATA for up to 10 consecutive daily treatments
lasting 90 minutes each. An increase in fibroblast
proliferation, collagen production and keratino-cyte
differentiation was observed at 1 and 2.5
ATA of HBO, but no benefit at 3 ATA. Kang
and colleagues reported that HBO treatment up
to 2.0 ATA enhances proliferation and autocrine
growth factor production of normal human fibro-blasts
grown in a serum-free culture environ-ment,
but showed no benefit beyond or below 2
ATA of HBO [Kang et al. 2004]. Therefore, a
delicate balance between having enough and
too much oxygen and/or atmospheric pressure
is needed for fibroblast growth [Kunnavatana
et al. 2005].
Another important feature to take into account is
the potential antimicrobial effect of HBO. HBO,
by reversing tissue hypoxia and cellular dysfunc-tion,
restores this defence and also increases the
phagocytosis of some bacteria by working syner-gistically
with antibiotics, and inhibiting the
growth of a number of anaerobic and aerobic
organisms at wound sites [Mader et al. 1980].
There is evidence that hyperbaric oxygen is bac-tericidal
for Clostridium perfringens, in addition
to promoting a definitive inhibitory effect
on the growth of toxins in most aerobic and
microaerophilic microorganisms. The action of
HBO on anaerobes is based on the production
of free radicals such as superoxide, dismutase,
catalase and peroxidase. More than 20 different
clostridial exotoxins have been identified, and the
most prevalent is alphatoxine (phospholipase C),
which is haemolytic, tissue necrotizing and lethal.
Other toxins, acting in synergy, promote anae-mia,
jaundice, renal failure, cardiotoxicity and
brain dysfunction. Thetatoxine is responsible
for vascular injury and consequent acceleration
of tissue necrosis. HBO blocks the production
of alphatoxine and thetatoxine and inhibits bac-terial
growth [Jain, 2004].
HBO applications in sports medicine
The healing of a sports injury has its natural
recovery, and follows a fairly constant pattern
irrespective of the underlying cause. Three
phases have been identified in this process: the
inflammatory phase, the proliferative phase and
the remodelling phase. Oxygen has an important
role in each of these phases [Ishii et al. 2005].
In the inflammatory phase, the hypoxia-induced
factor-1a, which promotes, for example, the gly-colytic
system, vascularization and angiogenesis,
has been shown to be important. However, if the
oxygen supply could be controlled without pro-moting
blood flow, the blood vessel permeability
could be controlled to reduce swelling and con-sequently
sharp pain.
In the proliferative phase, in musculoskeletal tis-sues
(except cartilage), the oxygen supply to the
injured area is gradually raised and is essential for
the synthesis of extracellular matrix components
such as fibronectin and proteoglycan.
In the remodelling phase, tissue is slowly replaced
over many hours using the oxygen supply pro-vided
by the blood vessel already built into the
organization of the musculoskeletal system, with
the exception of the cartilage. If the damage is
small, the tissue is recoverable with nearly perfect
organization but, if the extent of the damage is
large, a scar (consisting mainly of collagen) may
replace tissue. Consequently, depending on the
injury, this collagen will become deficiently
hard or loose in the case of muscle or ligament
repair, respectively.
The application of HBO for the treatment
of sports injuries has recently been sug-gested
in the scientific literature as a therapy
Therapeutic Advances in Musculoskeletal Disease 3 (2)
114 http://tab.sagepub.com
5. modality: a primary or an adjunct treatment
[Babul et al. 2003]. Although results have
proven to be promising in terms of using HBO
as a treatment modality in sports-related injuries,
these studies have been limited due to the small
sample sizes, lack of blinding and randomization
problems [Babul and Rhodes, 2000].
Even fewer studies referring to the use of HBO in
high level athletes can be found in the literature.
Ishii and colleagues reported the use of HBO as a
recovery method for muscular fatigue during the
Nagano Winter Olympics [Ishii et al. 2005]. In
this experiment seven Olympic athletes received
HBO treatment for 3040 minutes at 1.3 ATA
with a maximum of six treatments per athlete and
an average of two. It was found that all athletes
benefited from the HBO treatment presenting
faster recovery rates. These results are concor-dant
with those obtained by Fischer and col-leagues
and Haapaniemi and colleagues that
suggested that lactic acid and ammonia were
removed faster with HBO treatment leading to
shorter recovery periods [Haapaniemi et al.
1995; Fischer et al. 1988].
Also in our experience at the Matosinhos
Hyperbaric Unit several situations, namely frac-tures
and ligament injuries, have proved to ben-efit
from faster recovery times when HBO
treatments were applied to the athletes.
Muscle injuries
Muscle injury presents a challenging problem in
traumatology and commonly occurs in sports.
The injury can occur as a consequence of a
direct mechanical deformation (as contusions,
lacerations and strains) or due to indirect
causes (such as ischemia and neurological
damage) [Li et al. 2001]. These indirect injuries
can be either complete or incomplete [Petersen
and Ho¨lmich, 2005].
In sport events in the United States, the inci-dence
of all injuries ranges from 10% to 55%.
The majority of muscle injuries (more than
90%) are caused either by excessive strain or by
contusions of the muscle [Ja¨rvinen et al. 2000].
A muscle suffers a contusion when it is subjected
to a sudden, heavy compressive force, such as a
direct blow. In strains, however, the muscle is
subjected to an excessive tensile force leading to
the overstraining of the myofibres and, conse-quently,
to their rupture near the myotendinous
junction [Ja¨rvinen et al. 2007].
P Barata, M Cervaens et al.
Muscle injuries represent a continuum from mild
muscle cramp to complete muscle rupture, and
in between is partial strain injury and delayed
onset muscle soreness (DOMS) [Petersen and
Ho¨lmich, 2005]. DOMS usually occurs following
unaccustomed physical activity and is accompa-nied
by a sensation of discomfort within the skel-etal
muscle experienced by the novice or elite
athlete. The intensity of discomfort increases
within the first 24 hours following cessation of
exercise, peaks between 24 and 72 hours, sub-sides
and eventually disappears by 57 days post-exercise
[Cervaens and Barata, 2009].
Oriani and colleagues first suggested that HBO
might accelerate the rate of recovery from injuries
suffered in sports [Oriani et al. 1982]. However,
the first clinical report appeared only in 1993
where results suggested a 55% reduction in lost
days to injury, in professional soccer players in
Scotland suffering from a variety of injuries fol-lowing
the application of HBO. These values
were based on a physiotherapist’s estimation of
the time course for the injury versus the actual
number of days lost with routine therapy and
HBO treatment sessions [James et al. 1993].
Although promising, this study needed a control
group and required a greater homogeneity of
injuries as suggested by Babul and colleagues
[Babul et al. 2000].
DOMS. DOMS describes a phenomenon of
muscle pain, muscle soreness or muscle stiffness
that is generally felt 1248 hours after exercise,
particularly at the beginning of a new exercise
program, after a change in sporting activities, or
after a dramatic increase in the duration or inten-sity
of exercise.
Staples and colleagues in an animal study, used a
downhill running model to induce damage, and
observed significant changes in the myeloperox-idase
levels in rats treated with hyperbaric oxygen
compared with untreated rats [Staples et al.
1995]. It was suggested that hyperbaric oxygen
could have an inhibitory effect on the inflamma-tory
process or the ability to actually modulate
the injury to the tissue.
In 1999, the same group conducted a random-ized,
controlled, double-blind, prospective study
to determine whether intermittent exposures to
hyperbaric oxygen enhanced recovery from
DOMS of the quadriceps by using 66 untrained
men between the ages of 18 and 35 years
http://tab.sagepub.com 115
6. [Staples et al. 1999]. After the induction of
muscle soreness, the subjects were treated in a
hyperbaric chamber over a 5-day period in two
phases: the first phase with four groups (control,
hyperbaric oxygen treatment, delayed treatment
and sham treatment); and in the second phase
three groups (3 days of treatment, 5 days of treat-ment
and sham treatment). The hyperbaric expo-sures
involved 100% oxygen for 1 hour at 2.0
ATA. The sham treatments involved 21%
oxygen for 1 hour at 1.2 ATA. In phase 1, a sig-nificant
difference in recovery of eccentric torque
was noted in the treatment group compared with
the other groups as well as in phase 2, where
there was also a significant recovery of eccentric
torque for the 5-day treatment group compared
with the sham group, immediately after exercise
and up to 96 hours after exercise. However, there
was no significant difference in pain in either
phase. The results suggested that treatment
with hyperbaric oxygen may enhance recovery
of eccentric torque of the quadriceps muscle
from DOMS. This study had a complex protocol
and the experimental design was not entirely
clear (exclusion of some participants and the allo-cation
of groups was not clarified), which makes
interpretation difficult [Bennett et al. 2005a].
Mekjavic and colleagues did not find any recov-ery
from DOMS after HBO. They studied 24
healthy male subjects who were randomly
assigned to a placebo group or a HBO group
after being induced with DOMS in their right
elbow flexors [Mekjavic et al. 2000]. The HBO
group was exposed to 100% oxygen at 2.5 ATA
and the sham group to 8% oxygen at 2.5 ATA
both for 1 hour per day and during 7 days. Over
the period of 10 days there was no difference
in the rate of recovery of muscle strength between
the two groups or the perceived pain. Although
this was a randomized, double-blind trial, this
was a small study [Bennett et al. 2005a].
Harrison and colleagues also studied the effect of
HBO in 21 healthy male volunteers after induc-ing
DOMS in the elbow flexors [Harrison et al.
2001]. The subjects were assigned to three
groups: control, immediate HBO and delayed
HBO. These last two groups were exposed to
2.5 ATA, for 100 min with three periods of 30
min at 100% oxygen intercalated with 5 min with
20.93% oxygen between them. The first group
began the treatments with HBO after 2 hours
and the second group 24 hours postexercise
and both were administered daily for 4 days.
The delayed HBO group were also given a
sham treatment with HBO at day 0 during the
same time as the following days’ treatments but
with 20.93% oxygen at a minimal pressure. The
control group had no specific therapy. There
were no significant differences between groups
in serum creatine kinase (CK) levels, isometric
strength, swelling or pain, which suggested that
HBO was not effective on DOMS. This study
also presented limitations such as a small
sample size and just partial blinding [Bennett
et al. 2005a].
Webster and colleagues wanted to determine
whether HBO accelerated recovery from exer-cise-
induced muscle damage in 12 healthy male
volunteers that underwent strenuous eccentric
exercise of the gastrocnemius muscle [Webster
et al. 2002]. The subjects were randomly
assigned to two groups, where the first was the
sham group who received HBO with atmospheric
air at 1.3 ATA, and the second with 100% oxygen
with 2.5 ATA, both for 60 minutes. The first
treatment was 34 hours after damage followed
by treatments after 24 and 48 hours. There was
little evidence in the recovery measured data,
highlighting a faster recovery in the HBO group
in the isometric torque, pain sensation and
unpleasantness. However, it was a small study
with multiple outcomes and some data were not
used due to difficulties in interpretation [Bennett
et al. 2005a].
Babul and colleagues also conducted a random-ized,
double-blind study in order to find out
whether HBO accelerated the rate of recovery
from DOMS in the quadriceps muscle [Babul
et al. 2003]. This exercise-induced injury was
produced in 16 sedentary female students that
were assigned into two groups: control and
HBO. The first was submitted to 21% oxygen
at 1.2 ATA, and the second to 100% oxygen at
2.0 ATA for 60 minutes at 4, 24, 48 and 72 hours
postinjury. There were no significant differences
between the groups in the measured outcomes.
However, this was also a small study with multi-ple
outcomes, with a complex experimental
design with two distinct phases with somewhat
different therapy arms [Bennett et al. 2005a].
Germain and colleagues had the same objective
as the previous study but this time the sample
had 10 female and 6 male subjects that were ran-domly
assigned into two groups [Germain et al.
2003]: the control group that did not undergo
Therapeutic Advances in Musculoskeletal Disease 3 (2)
116 http://tab.sagepub.com
7. any treatment and the HBO group that was
exposed to 95% oxygen at 2.5 ATA during 100
minutes for five sessions. There were no signifi-cant
differences between the groups which lead to
the conclusion that HBO did not accelerate the
rate of recovery of DOMS in the quadriceps.
Once again, this was a very small and unblinded
study that presented multiple outcomes [Bennett
et al. 2005a].
Muscle stretch injury. In 1998, Best and col-leagues
wanted to analyse whether HBO
improved functional and morphologic recovery
after a controlled induced muscle stretch in the
tibialis anterior muscletendon unit [Best et al.
1998]. They used a rabbit model of injury and
the treatment group was submitted to a 5-day
treatment with 95% oxygen at 2.5 ATA for 60
minutes. Then, after 7 days, this group was com-pared
with a control group that did not undergo
HBO treatment. The results suggested that HBO
administration may play a role in accelerating
recovery after acute muscle stretch injury.
Ischemia. Another muscle injury that is often a
consequence of trauma is ischemia. Normally it is
accompanied by anaerobic glycolysis, the forma-tion
of lactate and depletion of high-energy phos-phates
within the extracellular fluid of the
affected skeletal muscle tissue. When ischemia
is prolonged it can result in loss of cellular
homeostasis, disruption of ion gradients and
breakdown of membrane phospholipids. The
activation of neutrophils, the production of
oxygen radicals and the release of vasoactive fac-tors,
during reperfusion, may cause further
damage to local and remote tissues. However,
the mechanisms of ischemiareperfusion-induced
muscle injury are not fully understood
[Bosco et al. 2007]. These authors aimed to see
the effects of HBO in the skeletal muscle of rats
after ischemia-induced injury and found that
HBO treatment attenuated significantly the
increase of lactate and glycerol levels caused by
ischemia, without affecting glucose concentra-tion,
and modulating antioxidant enzyme activity
in the postischemic skeletal muscle.
A similar study was performed in 1996
[Haapaniemi et al. 1996] in which the authors
concluded that HBO had positive aspects for at
least 48 hours after severe injury, by raising the
levels of high-energy phosphate compounds,
which indicated a stimulation of aerobic oxida-tion
in the mitochondria. This maintains the
P Barata, M Cervaens et al.
transport of ions and molecules across the cell
membrane and optimizes the possibility of pre-serving
the muscle cell structure.
Gregorevic and colleagues induced muscle
degeneration in rats in order to see whether
HBO hastens the functional recovery and myofi-ber
regeneration of the skeletal muscle
[Gregorevic et al. 2000]. The results of this
study demonstrated that the mechanism of
improved functional capacity is not associated
with the reestablishment of a previously compro-mised
blood supply or with the repair of associ-ated
nerve components, as seen in ischemia, but
with the pressure of oxygen inspired with a cru-cial
role in improving the maximum force-produ-cing
capacity of the regenerating muscle fibres
after this myotoxic injury. In addition, there
were better results following 14 days of HBO
treatment at 3 ATA than at 2 ATA.
Ankle sprains
In 1995 a study conducted at the Temple
University suggested that patients treated with
HBO returned approximately 30% faster than
the control group after ankle sprain. The authors
stated, however, that there was a large variability
in this study design due to the difficulty in quan-tifying
the severity of sprains [Staples and
Clement, 1996].
Interestingly, Borromeo and colleagues, in a ran-domized,
double-blinded study, observed in 32
patients who had acute ankle sprains the effects
of HBO in its rehabilitation [Borromeo et al.
1997]. The HBO group was submitted to 100%
oxygen at 2 ATA for 90 minutes for the first ses-sion
and 60 minutes for the other two. The pla-cebo
group was exposed to ambient air, at 1.1
ATA for 90 minutes, both groups for three ses-sions
over 7 days. The HBO group had an
improvement in joint function. However, there
were no significant differences between groups
in the subjective pain, oedema, passive or active
range of motion or time to recovery. This study
included an average delay of 34 hours from the
time of injury to treatment, and it had short treat-ment
duration [Bennett et al. 2005a].
Medical collateral ligament
Horn and colleagues in an animal study surgi-cally
lacerated medial collateral ligament of 48
rats [Horn et al. 1999]. Half were controls with-out
intervention and the other half were
exposed to HBO at 2.8 ATA for 1.5 hours
http://tab.sagepub.com 117
8. a day over 5 days. Six rats from each group were
euthanized at 2, 4, 6 and 8 weeks and at 4 weeks
a statistically greater force was required to cause
failure of the previously divided ligaments for
those exposed to HBO than in the control
group. After 4 weeks, an interesting contribution
from HBO could be seen in that it promoted the
return of normal stiffness of the ligament.
Ishii and colleagues induced ligament lacerations
in the right limb of 44 rats and divided them into
four groups [Ishii et al. 2002]: control group,
where animals breathed room air at 1 ATA for
60 min; HBO treatment at 1.5 ATA for 30 min
once a day; HBO treatment at 2 ATA for 30 min
once a day; and 2 ATA for 60 min once a day.
After 14 days postinjury, of the three exposures
the last group was more effective in promoting
healing by enhancing extracellular matrix deposi-tion
as measured by collagen synthesis.
Mashitori and colleagues removed a 2-mm seg-ment
of the medial collateral ligament in 76 rats
[Mashitori et al. 2004]. Half of these rats were
exposed to HBO at 2.5 ATA for 2 hours for 5
days per week and the remaining rats were
exposed to room air. The authors observed that
HBO promotes scar tissue formation by increas-ing
type I procollagen gene expression, at 7 and
14 days after the injury, which contribute for the
improvement of their tensile properties.
In a randomized, controlled and double-blind
study, Soolsma examined the effect of HBO at
the recovery of a grade II medial ligament of
the knee presented in patients within 72 hours
of injury. After one group was exposed to HBO
at 2 ATA for 1 hour and the control group at 1.2
ATA, room air, for 1 hour, both groups for 10
sessions, the data suggested that, at 6 weeks,
HBO had positive effects on pain and functional
outcomes, such as decreased volume of oedema,
a better range of motion and maximum flexion
improvement, compared with the sham group
[Soolsma, 1996].
Anterior cruciate ligament
Yeh and colleagues used an animal model to
investigate the effects of HBO on neovasculariza-tion
at the tendonbone junction, collagen fibres
of the tendon graft and the tendon graftbony
interface which is incorporated into the osseous
tunnel [Yeh et al. 2007]. The authors used 40
rabbits that were divided into two groups: the
control group that was maintained in cages at
normal air and the HBO group that was exposed
to 100% oxygen at 2.5 ATA for 2 hours, for 5
days. The authors found that the HBO group had
significantly increased the amount of trabecular
bone around the tendon graft, increasing its
incorporation to the bone and therefore increas-ing
the tensile loading strength of the tendon
graft. They assumed that HBO contributes to
the angiogenesis of blood vessels, improving the
blood supply which leads to the observed
outcomes.
Takeyama and colleagues studied the effects of
HBO on gene expressions of procollagen and
tissue inhibitor of metalloproteinase (TIMPS)
in injured anterior cruciate ligaments
[Takeyama et al. 2007]. After surgical injury ani-mals
were divided into a control group and a
group that was submitted to HBO, 2.5 ATA for
2 hours, for 5 days. It was found that even though
none of the lacerated anterior cruciate ligaments
(ACLs) united macroscopically, there was an
increase of the gene expression of type I procolla-gen
and of TIMPS 1 and 2 for the group treated
with HBO. These results indicate that HBO
enhances structural protein synthesis and inhibits
degradative processes. Consequently using HBO
as an adjunctive therapy after primary repair of
the injured ACL is likely to increase success, a
situation that is confirmed by the British
Medical Journal Evidence Center [Minhas,
2010].
Fractures
Classical treatment with osteosynthesis and bone
grafting is not always successful and the attempt
to heal nonunion and complicated fractures,
where the likelihood of infection is increased, is
a challenge.
A Cochrane review [Bennett et al. 2005b] stated
that there is not sufficient evidence to support
hyperbaric oxygenation for the treatment of pro-moting
fracture healing or nonunion fracture as
no randomized evidence was found. During the
last 10 years this issue has not been the subject of
many studies.
Okubo and colleagues studied a rat model in
which recombinant human bone morphogenetic
protein-2 was implanted in the form of lyophi-lized
discs, the influence of HBO [Okubo et al.
2001]. The group treated with HBO, exposed to
2 ATA for 60 min daily, had significantly
increased new bone formation compared with
Therapeutic Advances in Musculoskeletal Disease 3 (2)
118 http://tab.sagepub.com
9. the control group and the cartilage was present at
the outer edge of the implanted material after 7
days.
Komurcu and colleagues reviewed retrospectively
14 cases of infected tibial nonunion that were
treated successfully [Komurcu et al. 2002].
Management included aggressive debridement
and correction of defects by corticotomy and
internal bone transport. The infection occurred
in two patients after the operation which was suc-cessfully
resolved after 2030 sessions of HBO.
Muhonen and colleagues aimed to study, in a
rabbit mandibular distraction osteogenesis
model, the osteogenic and angiogenic response
to irradiation and HBO [Muhonen et al. 2004].
One group was exposed to 18 sessions of HBO
until the operation that was performed 1 month
after irradiation. The second group did not
receive HBO and the controls underwent surgery
receiving neither irradiation nor HBO. The
authors concluded that previous irradiation sup-presses
osteoblastic activity and HBO changes
the pattern of bone-forming activity towards
that of nonirradiated bone.
Wang and colleagues, in a rabbit model, were
able to demonstrate that distraction segments of
animals treated with HBO had increased bone
mineral density and superior mechanical proper-ties
comparing to the controls and yields better
results when applied during the early stage of the
tibial healing process [Wang et al. 2005].
Conclusion
In the various studies, the location of the injury
seemed to have an influence on the effectiveness
of treatment. After being exposed to HBO, for
example, injuries at the muscle belly seem to
have less benefit than areas of reduced perfusion
such as muscletendon junctions and ligaments.
With regards to HBO treatment, it is still neces-sary
to determine the optimal conditions for
these orthopaedic indications, such as the atmo-sphere
pressure, the duration of sessions, the fre-quency
of sessions and the duration of treatment.
Differences in the magnitude of the injury and in
the time between injury and treatment may also
affect outcomes.
Injuries studies involving bones, muscles and lig-aments
with HBO treatment seem promising.
However, they are comparatively scarce and the
P Barata, M Cervaens et al.
quality of evidence for the efficacy of HBO is low.
Orthopaedic indications for HBO will become
better defined with perfection of the techniques
for direct measurement of tissue oxygen tensions
and intramuscular compartment pressures.
Despite evidence of interesting results when
treating high-performance athletes, these treat-ments
are multifactorial and are rarely published.
Therefore, there is a need for larger samples, ran-domized,
controlled, double-blind clinical trials
of human (mainly athletes) and animal models
in order to identify its effects and mechanisms
to determine whether it is a safe and effective
therapy for sports injuries treatments.
Funding
This research received no specific grant from any
funding agency in the public, commercial, or not-for-
profit sectors.
Conflict of interest statement
None declared.
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