This document provides details and questions for a homework assignment on genetics concepts. It includes 8 questions covering topics like gene expression, DNA and protein structures, mitotic and meiotic recombination, pedigrees, and mutational consequences. The instructor provides explanations and asks students to answer questions in short responses or by drawing out processes. The goal is for students to integrate and apply their understanding of core genetics topics.
Genetic Information Transfer (Biology for Engineers)Dr. Arun Sharma
Information Transfer: Purpose: The molecular basis of coding and
decoding genetic information is universal. Molecular basis of information
transfer. DNA as a genetic material. Hierarchy of DNA structure- from
single stranded to double helix to nucleosomes. Concept of genetic code.
Universality and degeneracy of genetic code. Define gene in terms of
complementation and recombination.
USMLE Step 1 Molecular Biology and Biochemistry reviewAbril Santos
This is a review for the USMLE Step 1 exam for Molecular Biology and Biochemistry.
It contains anything you need to know for your exam in pictures, tables and diagrams.
A GENE is the basic physical and functional unit of heredity. Genes are made up of DNA. Some genes act as instructions to make molecules called proteins. However, many genes do not code for proteins. In humans, genes vary in size from a few hundred DNA bases to more than 2 million bases.
GENE MUTATIONS
A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people. Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes.
Dr. Karthikeyan Pethusamy MD DNB (Biochemistry) explains the genetic code for the undergraduate students. Don't miss the YouTube video attached. The video is made with the same power point file.
Genetic Information Transfer (Biology for Engineers)Dr. Arun Sharma
Information Transfer: Purpose: The molecular basis of coding and
decoding genetic information is universal. Molecular basis of information
transfer. DNA as a genetic material. Hierarchy of DNA structure- from
single stranded to double helix to nucleosomes. Concept of genetic code.
Universality and degeneracy of genetic code. Define gene in terms of
complementation and recombination.
USMLE Step 1 Molecular Biology and Biochemistry reviewAbril Santos
This is a review for the USMLE Step 1 exam for Molecular Biology and Biochemistry.
It contains anything you need to know for your exam in pictures, tables and diagrams.
A GENE is the basic physical and functional unit of heredity. Genes are made up of DNA. Some genes act as instructions to make molecules called proteins. However, many genes do not code for proteins. In humans, genes vary in size from a few hundred DNA bases to more than 2 million bases.
GENE MUTATIONS
A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people. Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes.
Dr. Karthikeyan Pethusamy MD DNB (Biochemistry) explains the genetic code for the undergraduate students. Don't miss the YouTube video attached. The video is made with the same power point file.
Asian Art Museum Visit and AssignmentOn the first Sunday of .docxdavezstarr61655
Asian Art Museum Visit and Assignment
On the first Sunday of every month, admission to the museum’s permanent collection is free. On other days, your student ID will get you discounted admission. ($10) I’d recommend spending at least two hours there whenever you go, but if you get “museum fatigue,” take a break, have some tea, come back later.
The Museum has a wonderful permanent collection of Chinese art. You are only required to go once this semester, but I hope you’ll want to go more than once. Make sure to see the small gilded Buddha, one of their most famous pieces, and the bronze rhinoceros. Their jade collection is also famous. And look at whatever paintings they have out at the moment to see the possible formats: hanging scroll, hand scroll, album paintings. Of course, if you have time, the rest of the museum—the Indian, Southeast Asian, Tibetan, Japanese, Korean, and Mongolian art-- is also wonderful.
Your assignment is to find TWO works of art in the China collection that you like. Describe them briefly and specifically, including both their similarities and their differences. For example, they may be in different media (bronze, painting, jade, etc) or from different periods, or about different subjects. Please include photographs, but don’t rely on the pictures in what you write. Instead, create a word picture of each work. Then explain (1) why you chose these particular pieces and (2) what you learned about Chinese civilization from them. One page total, about 300 words. Please scan and upload this and YOUR MUSEUM TICKET to the iLearn link. DUE ANY TIME DURING THE SEMESTER. GRADING IS CR/NC. THIS COUNTS FOR 5% OF YOUR GRADE.
If this assignment is a hardship for you because of money, work or family responsibilities, please consult me and I’ll figure out an alternative for you.
Name ________________________ Sec._________
Chapter 5: Chromosomes and Inheritance
Module 5.6 Gametes have half as many chromosomes as body cells.
Answer the following questions as you read the module:
1.
is the process that results from the union of gametes from two different parents.
2.
A skin cell is to a somate as a(n) ________ is to a gamete.
A)
embryo
B)
zygote
C)
brain cell
D)
egg
3.
Determine whether each of the following cells is haploid or diploid.
A)
An egg
B)
A cell from your liver
C)
A zygote
D)
A sperm
E)
A cell from your heart
4. A normal human egg or sperm has 23 chromosomes, which is exactly one half what a somate has. Briefly explain what would happen every generation if gametes were actually diploid.
5._________________contain the same genes at the same locations.
A)
Sex chromosomes
B)
Autosomes
C)
Gametes
D)
Homologous chromosomes
6. Are the two chromosomes shown here homologous? Briefly explain why or why not.
7.
Can a karyotype be used to determine the gender of an individ.
I am Mercy Knowles. Currently associated with nursingassignmenthelp.com as nursing homework helper. After completing my master's from Albany State University, USA, I was in search for an opportunity that expands my area of knowledge hence I decided to help students with their assignments. I have written several Biomolecular assignments till date to help students overcome numerous difficulties they face.
DNA and Genes Lab ActivityComplete your answers in the spaces .docxjacksnathalie
DNA and Genes Lab Activity
Complete your answers in the spaces provided. USE YOUR OWN WORDS – Yes even for definitions! Remember to add your last name and first initial to the file name prior to saving and submitting your completed assignment through Canvas.
Use your textbook, notes and these websites to answer the pre lab questions. http://learn.genetics.utah.edu/units/basics/transcribe/http://www.vcbio.science.ru.nl/en/virtuallessons/cellcycle/trans/
Pre Lab Questions:
1. What is the product of transcription?
2. What is the region of DNA called where transcription begins?
3. What is the product of translation?
4. In your own words define each of the following: Silent mutation
Missense mutation Nonsense mutation Frame shift mutation
5. Where in the cell does translation take place?
Click on the link below to access the online lab.
http://www.mhhe.com/biosci/genbio/virtual_labs_2K8/pages/DNA_And_Genes.html
Download and print the instructions for reference as you work through the lab. As you work through the lab fill in the table below. Use this information to answer the questions that follow contained in this document.
First read through the mutation guide. Once you close the guide you will see the buttons to begin the simulation. Note, you will be translating the mRNA strand into a protein.
As you work through each of the mutations fill in the charts below. You must complete 4 mutations for this lab activity. It’s good practice working with the codon table .
– Aris labs calls the codon table the ‘Genetic Code Chart’. Use the amino acid abbreviation for the protein sequence. For example the amino acid proline is abbreviated as pro.
You have to fill in all the letters AND the resulting amino acid sequence by dragging and dropping before you click the [check] button. Abrieviate STOP as either STP or END.
For each of the three mutations you will complete, fill in the table in this lab document with the original mRNA and amino acid sequence and the mRNA sequence and the resulting amino acid sequence RESULTING FROM the mutation as outlined in the mutation rule.
The various mutations represent missense, nonsense, silent and frame shift mutations. You must complete one of each. The lab will not necessarily present the mutations in this order. You must do the mutation and identify which type it is and make sure you do one of each.
6. Frame Shift Mutation example:
Provide the mutation rule you are following.
Original
A. Acids
Original
mRNA
Mutated
mRNA
Mutated
A. Acids
7. Missense Mutation example:
Provide the mutation rule you are following.
Original
A. Acids
Original
mRNA
Mutated
mRNA
Mutated
A. Acids
8. Nonsense Mutation example:
Provide the mutation rule you are following.
Original
A. Acids
Original
mRNA
Mutated
mRNA
Mutated
A. Acids
9. Silent Mutation example:
Pr ...
Method and Practice in Biological Anthropology 1st Edition Hens Solutions Manualtybozibuto
Full download : http://alibabadownload.com/product/method-and-practice-in-biological-anthropology-1st-edition-hens-solutions-manual/
Method and Practice in Biological Anthropology 1st Edition Hens Solutions Manual
4302019 Lecture Exam 4 Study Sheet Intro Biological Anthrop.docxtroutmanboris
4/30/2019 Lecture Exam 4 Study Sheet: Intro Biological Anthropology E01
https://ucdenver.instructure.com/courses/396703/pages/lecture-exam-4-study-sheet?module_item_id=1696194 1/5
Lecture Exam 4 Study Sheet
Lecture Exam 4 Study Sheet
Module 11
What are mitochondria and ribosomes? What are their functions?
Define gene, locus and allele, and explain the relationship between them
List the DNA nucleotides and discuss how they pair. How is this important for DNA
function?
List the components of a nucleotide.
Describe DNA structure.
Explain protein synthesis including transcription and translation, mRNA and tRNA.
What is a codon?
Where in the cell does transcription take place? Where in the cell does translation take place?
What are the building blocks of a protein? How many different kinds are there? How does the sequence of DNA
determine the order of these building blocks?
Explain the difference between point mutations and frame shift mutations, and discuss their effects on the
information coded in DNA.
List three structural differences between DNA and RNA. What is the difference in function of DNA and RNA?
List the RNA nucleotides and discuss how they pair.
How many chromosomes are found in a normal human somatic cell? How many chromosome pairs are found
in a normal somatic cell? How many chromosomes are found in a human gamete?
What are homologous chromosomes?
4/30/2019 Lecture Exam 4 Study Sheet: Intro Biological Anthropology E01
https://ucdenver.instructure.com/courses/396703/pages/lecture-exam-4-study-sheet?module_item_id=1696194 2/5
What are the two sex chromosomes? Which two do males have? Which two do females have?
Which parent (male or female) determines the sex of the baby? Explain why this is the case.
What mRNA strand would transcribe the following DNA segment:
T A A G A T T G C A T C
Describe two ways that genetic variation is “shuffled” during meiosis.
Describe the process of mitosis.
Describe the process of meiosis.
List the difference between mitosis and meiosis. Be specific about the number of cell divisions, location in the
body, # of daughter cells, how many and what chromosomes in daughter cells, etc.
What are reduction division and crossing over? Why are they important to meiosis?
What is trisomy 21? Explain nondisjunction and how it can lead to trisomy 21.
What is a karyotype?
Define each term and then compare & contrast (i.e., describe how similar or different):
somatic cell vs. gamete cell
prokaryotic vs. eukaryotic cells
autosomal chromosome vs. sex chromosome
point mutation vs. frameshift mutation
nucleus vs. cytoplasm
haploid vs. diploid
Module 12
Define the following terms and be able to identify them functionally in examples: homozygous, heterozygous,
dominant, recessive, genotype, phenotype.
What does it mean if an .
In-class introduction to basic Punnett square set-up and problem s.docxbradburgess22840
In-class introduction to basic Punnett square set-up and problem solving, Part 1
Problem-solving tips:
· A Punnett square allows you to predict the possible genetic outcome of children based on the genetic make-up of the parents.
· First, read the problem and figure out whether the trait of interest or genetic disorder is found on the dominant allele or the recessive allele because that will have an impact on how you interpret the results of the Punnett square.
· Select a letter to represent the trait or disorder and define the dominant and recessive alleles. For example: For eye color, B (dominant) = brown eyes and b (recessive) = blue eyes. For achondroplasia (dwarfism), A (dominant) = achondroplasia and a (recessive) = normal allele.
· If it is a sex-linked question, remember to include the sexual genotypes of the parents (XX for mom and XY for dad).
· Write down all possible genotypes & phenotypes and use this information to help you set up the Punnett square.
1. Practice question on a human trait. In reality, eye color is controlled by multiple genes and is a complex trait. For simplicity, we’ll assume that brown eyes are dominant to blue eyes. Answer the questions below.
a) Select a letter for this trait and define the dominant and recessive alleles.
B (dominant) =
b (recessive) =
b) Write down all possible genotypes and phenotypes for individuals in the population
Possible genotypes
(the 2 alleles an individual has)
Possible phenotypes (the physical appearance of a trait)
Homozygous dominant individuals
Homozygous recessive individuals
Heterozygous individuals
c) Set up the Punnett square and solve this problem. Kristy is heterozygous and Mark has blue eyes. What percentage of their offspring will have blue eyes?
Kristy's genotype
Mark's genotype
a) Select a letter for this genetic condition and define the dominant and recessive alleles.
F (dominant) =
f (recessive) =
b) Write down all possible genotypes and phenotypes for individuals in the population
Possible genotypes
(the 2 alleles an individual has)
Possible phenotypes (the physical appearance of a trait)
Homozygous dominant individuals
Homozygous recessive individuals
Heterozygous individuals
c) Set up the Punnett square and solve this problem. Kristy and Mark are carriers for cystic fibrosis. The term carrier is only used when a condition is on the recessive allele. Carriers are heterozygous individuals who are normal and show no symptoms of the disorder, but they have the ability to pass on the mutated recessive allele to their offspring. What percentage of their children will be normal? What percentage of their children will be carriers?
Kristy's genotype
Mark's genotype
2. Practice question on a genetic condition. Cystic fibrosis (CF) is an autosomal, recessive condition that results in mucus buildup in the lungs and digestive system organs. As a result, CF .
I am Rebecca K. I am a Microbiology Assignment Expert at nursingassignmenthelp.com. I hold a Masters’ in Microbiology, from Bournemouth University, UK. I have been helping students with their assignments for the past 11 years. I solve assignments related to Microbiology.
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Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Generative AI Deep Dive: Advancing from Proof of Concept to ProductionAggregage
Join Maher Hanafi, VP of Engineering at Betterworks, in this new session where he'll share a practical framework to transform Gen AI prototypes into impactful products! He'll delve into the complexities of data collection and management, model selection and optimization, and ensuring security, scalability, and responsible use.
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdfPaige Cruz
Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Le nuove frontiere dell'AI nell'RPA con UiPath Autopilot™UiPathCommunity
In questo evento online gratuito, organizzato dalla Community Italiana di UiPath, potrai esplorare le nuove funzionalità di Autopilot, il tool che integra l'Intelligenza Artificiale nei processi di sviluppo e utilizzo delle Automazioni.
📕 Vedremo insieme alcuni esempi dell'utilizzo di Autopilot in diversi tool della Suite UiPath:
Autopilot per Studio Web
Autopilot per Studio
Autopilot per Apps
Clipboard AI
GenAI applicata alla Document Understanding
👨🏫👨💻 Speakers:
Stefano Negro, UiPath MVPx3, RPA Tech Lead @ BSP Consultant
Flavio Martinelli, UiPath MVP 2023, Technical Account Manager @UiPath
Andrei Tasca, RPA Solutions Team Lead @NTT Data
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
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In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
A tale of scale & speed: How the US Navy is enabling software delivery from l...sonjaschweigert1
Rapid and secure feature delivery is a goal across every application team and every branch of the DoD. The Navy’s DevSecOps platform, Party Barge, has achieved:
- Reduction in onboarding time from 5 weeks to 1 day
- Improved developer experience and productivity through actionable findings and reduction of false positives
- Maintenance of superior security standards and inherent policy enforcement with Authorization to Operate (ATO)
Development teams can ship efficiently and ensure applications are cyber ready for Navy Authorizing Officials (AOs). In this webinar, Sigma Defense and Anchore will give attendees a look behind the scenes and demo secure pipeline automation and security artifacts that speed up application ATO and time to production.
We will cover:
- How to remove silos in DevSecOps
- How to build efficient development pipeline roles and component templates
- How to deliver security artifacts that matter for ATO’s (SBOMs, vulnerability reports, and policy evidence)
- How to streamline operations with automated policy checks on container images
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
Key Trends Shaping the Future of Infrastructure.pdf
Hw2 Rec07answers
1. Class. As I said in class, this homework was difficult. In part it was because it tested what you knew in tricky ways, as I clarify in the answers, and in part because you probably did not understand some of the questions clearly enough (also clarified in the answers). Hopefully the questions stimulated vigorous thought, and useful discussions amongst those who study with others! The virtue of hard homework problems is that you should discuss with others --what the heck is going on is a good start! If you truly understand the answers, you are in good shape for an exam. One way to see if you “truly understand” the answers is to manipulate the questions slightly and see if you still get it. I elaborate below. This serves as a study guide/extra problems. I hope to post more problems on Monday. Change the bases in question 1 and predict consequences. Explain other answers in 1 - write it out …so you have practice in formulating answers! For 1, you should also know which is the template strand for RNA polymerase, and be able to label the polarity of the strands shown, that the ribosome and RNA polymerases are “dumb” to each others function! For question 2, be able to draw out a mitotic recombinant to generate aa bb cells, for example. You can use a simple “X” to indicate where a crossover is, label your centromeres, and show a segregant that yields the desired genotype. Do it neatly!!!! And for meiotic recombination and the Holliday structure…learn how to draw it, using the secret handshake of strand polarity “switcheroo” between MOM and DAD homologs. Know how the mechanism of homologous recombination renders it error-free! Know how to draw the “Big Picture” as well…like we did on the board last week..G1 diploid to G2 diploid, one sister from each homolog pairs, recombines, and segregates in MI and MII. And of course, our blessed RecA and Spo11, where and when they do and don’t act. And homologs…the anaology of identical twins “searching for the identical face in tucson”--in an hour-- gives you an idea of how miraculously RecA searches for sequence homology/complementarity to align allelic sequences. Hypothetical problem; if a 10kb sequence is duplicated and inserted at a non-allelic sequence, does this pose a problem for RecA and the cell if either of the sequences experiences a DSB? Discuss briefly. True-false short answer question 3 is one of my favorite formats (which Bruce detests). Note: you only get full credit if you supply a reasonable factoid to explain the true or false. And, any one comment will do..you don’t have to write out all relevant comments, just one to let me know you get the idea(s). It allows be to have a look and see if you understand a broad range of ideas. That mitosis is a conservative process where recombination is rare and occurs following an error, for example, while meiotic recombination is programmed…DSBs made by the Spo11 “pacman” nuclease..and meiosis generates diversity by mixing alleles…not by creating them (which occurs by error…)
2. Question 4 is an elaboration of question 2, asking you to manipulate mitotic recombination, the linkage of different alleles, and the like. I put in some extra questions to answer in the answers I provide. Its mostly about some basics of chromosomes (knowing sisters, homologs, segregation patterns, and simple chromosome geometry (where DSB, alleles of interest, and centromere). Question 5 goes along with a question on the first HW..the idea of domains and mutational consequences. What does a “hot spot” mean? Review the question from the first HW. Note that we must speak in generalities…in general, missense mutations in domains may disrupt their function, while nonsense or frameshift mutations will disrupt their functions. Missense mutations in “linker” regions are less likely to disrupt function. Question 6 . The notion that cells that are heterozygous for a mutation, and that somatic cells will suffer a 2nd inactivating mutation is important to understand. The consequence of that 2nd inactivating mutation depends on the dysfunction of the cell; for p53, a -/- cell has a selective growth advantage over other cells, and will grow, while a CFTR-/- cell does not have a growth advantage, is dysfunction for pumping Cl- but lives amongst millions of other functioning cells so the tissue (lung) performs well enough. This is likely a general trend…mutations that cause cancer can be rare but are a bummer, while mutations that inactivate cell-specific functions but do not lend a selective growth advantage are not a problem. Question 7. Pedigrees . We will deal with these a lot more when Bruce talks about segregation ratios. The idea of what pedigrees would look like for dominant and recessive mutations is something you should be able to understand by classes end. We have not yet discussed dominant and recessive mutations much..we will after the exam. You should know what a recessive mutation is conceptually…an inactivating mutation (which most base pair changes in ORFs are)…and that if an intact, wildtype copy of the gene is present then the cell can function ok, usually (CFTR protein, for example). Question 8: This is was question asking you to integrate several concepts. That recombination could occur between short runs of repeat sequences is something you hopefully understand now…though this kind of reaction is more infrequent than between long streches of identical sequences (i.e between alleles!), it does happen. Then, the issue of reading frame comes up in several parts to this.
3.
4.
5.
6.
7.
8.
9. 6. Explain why a person with a germline genotype of p53+/- is prone to cancer while a person with a germline genotype of CFTR-/+ is not prone to cystic fibrosis. ( typo of CFTR corrected). Cells that are p53+/-, when the wildtype allele mutates by error, will form p53-/- cells that have a selective advantage in growth..and thus proliferate and form a tumor. For CFTR+/- cells, on the other hand, the rare mutant cell will be surrounded by functioning heterozygous cells; the lung tissue, for example, may have ~10 12 cells, and when 1000 become -/- (due to mutation rate of 1 in 10 9 ), the one trillion cells minus 1000 have sufficient function for good lung function. 7. In the pedigree shown below, compare the relative extent of heterology (between any two homologous chromosome) in individual 1, individual 2 and individual 3. I was looking for a qualitative answer here. And to clarify--compare the relative extent of heterology between two homologs in individual 1 (which is 0.1%) , with the heterology between two homologs in individual 2, and then individual 3. The idea is that if individual 1 is a normal, outbred individual (though the argument still holds even if he is inbred..), then individual 2 will inherit some of the same alleles from parent 1, risking being homozyous at many alleles. The perils of inbredding! Individual 3 will be more outbred than 2 because 3 has 1 more generation of outbred parents (see **) . So, homologs in individual 1 are most heterologous (~0.1%), individual 3 the next most (less that 0.1%) , and individual 2 is the least heterologous (much less than 0.1%). ** ** 1 2 3