Powerful Google developer tools for immediate impact! (2023-24 C)
Hw2
1. HW#2 Genetics 320, Fall 07. Due Wed, Sept 12 The rules for this homework are the same: type any answers that involve words, except if you are filling in a table then write CLEARLY, or it will be marked wrong. If you don’t know what CLEARLY means, type your answers in the table. I give you a lot more problems this week than last. Many questions are revised from previous exam questions, to give you an idea what exam questions might look like.
2.
3.
4.
5. 4. Consider the cell 1 and cell 2 with the chromosomes shown. In Cell 1, Gene A is 50cM from the centromere, and in Cell 2 Gene C is 10cM from the centromere. In both cells the wildtype allele is on the top homolog, and the mutant allele on the bottom homolog. This problem involves mitotic recombination . Gene A+ + - a. Will Cell 1 or Cell2 form homozyous mutants at the highest frequency? Explain. b. A new Cell 3 is like Cell 1 except that it has a recessive lethal mutation. d- 10cM to the left of the GeneA+ allele. Where would the D+ allele be in Cell 3? (this should be obvious) c. Will Cell 1 or Cell 3 give the most viable a-/a- mutants? Explain. Cell 1 Cell 2 Gene C + -
6.
7. 6. Explain why a person with a germline genotype of p53+/- is prone to cancer while a person with a germline genotype of CFRT-/+ is not prone to cystic fibrosis. 7. In the pedigree shown below, compare the relative extent of heterology (between any two homologous chromosome) in individual 1, individual 2 and individual 3. 1 2 3
![Page 1 ,[object Object],[object Object],p53 binding site gcgTATAccgctacgtagg c tttATGCGATTTAAACCCTAGcccgcaag +1 +5 Transcribed? Translated (#amino acids) Functional? a. p53+/+ YES YES (full length) YES b. TATAcc to TggAcc c. Delete c at +1 d. Insert T between 7G &8C e. Delete ccc after TAG f. AAA to AAG Enter YES or NO. 1pt each. Enter # of amino acids if different from wildtype gene. You can explain ambiguities on the other side of this sheet (you shouldn’t need to!) g. Explain briefly your answer to c and 2d.](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)